Glutamic acid decarboxylase autoantibodies are dominant but insufficient to identify most Chinese with adult-onset non-insulin requiring autoimmune diabetes: LADA China study 5

Acta Diabetologica

Volumn 52, Issue 6, 2015, Pages 1121-1127

  Xiang, Yufei ^a   Huang, Gan ^a   Shan, Zhongyan ^b   Pan, Linlin ^a   Luo, Shuoming ^a   Yang, Liyong ^c   Shi, Lixin ^d   Li, Qifu ^e   Leslie, R David ^f   Zhou, Zhiguang ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b CHINA MEDICAL UNIVERSITY   (China)

^c FUJIAN MEDICAL UNIVERSITY   (China)

^d GUIZHOU MEDICAL UNIVERSITY   (China)

^e THE FIRST AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIVERSITY   (China)

^f QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Glutamic acid decarboxylase antibody (GADA); Insulin autoantibody (IAA); Latent autoimmune diabetes of adults (LADA); Protein tyrosine phosphatase 2 antibody (IA 2A); Zinc transporter 8 autoantibody (ZnT8A)

Indexed keywords

AUTOANTIBODY; C PEPTIDE; GLUTAMATE DECARBOXYLASE; GLUTAMATE DECARBOXYLASE ANTIBODY; PROTEIN TYROSINE PHOSPHATASE SHP 2; RADIOLIGAND; ZINC TRANSPORTER; BIOLOGICAL MARKER; CATION TRANSPORT PROTEIN; PHOSPHOPROTEIN PHOSPHATASE 2; SLC30A8 PROTEIN, HUMAN;

ADULT; ADULT ONSET NON INSULIN REQUIRING AUTOIMMUNE DIABETES; ARTICLE; CHINA; CHINESE; CLINICAL FEATURE; CONTROLLED STUDY; FEMALE; HUMAN; IMMUNOASSAY; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; MICROTITER PLATE ASSAY; MULTICENTER STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; PREVALENCE; PRIORITY JOURNAL; RADIOIMMUNOASSAY; UNIVERSITY HOSPITAL; AGED; ASIAN CONTINENTAL ANCESTRY GROUP; CLINICAL TRIAL; DIABETES MELLITUS, TYPE 2; IMMUNOLOGY; MIDDLE AGED; PANCREAS ISLET;

ADULT; AGED; ASIAN CONTINENTAL ANCESTRY GROUP; AUTOANTIBODIES; BIOMARKERS; CATION TRANSPORT PROTEINS; CHINA; DIABETES MELLITUS, TYPE 2; FEMALE; GLUTAMATE DECARBOXYLASE; HUMANS; ISLETS OF LANGERHANS; MALE; MIDDLE AGED; PREVALENCE; PROTEIN PHOSPHATASE 2;

EID: 84945454327     PISSN: 09405429     EISSN: 14325233     Source Type: Journal    
DOI: 10.1007/s00592-015-0799-8     Document Type: Article

References (23)

1. Zhou Z, Xiang Y, Ji L et al (2013) Frequency, immunogenetics, and clinical characteristics of latent autoimmune diabetes in China (LADA China study): a nationwide, multicenter, clinic-based cross-sectional study. Diabetes 62:543–550
2. Fourlanos S, Dotta F, Greenbaum CJ et al (2005) Latent autoimmune diabetes in adults (LADA) should be less latent. Diabetologia 48:2206–2212
3. Hawa MI, Kolb H, Schloot N et al (2012) Adult-onset autoimmune diabetes in Europe is prevalent with a broad clinical phenotype: action LADA 7. Diabetes Care 36:908–913
4. Yang L, Zhou ZG, Huang G, Ouyang LL, Li X, Yan X (2005) Six-year follow-up of pancreatic beta cell function in adults with latent autoimmune diabetes. World J Gastroenterol 11:2900–2905
5. Lundgren VM, Isomaa B, Lyssenko V et al (2010) GAD antibody positivity predicts type 2 diabetes in an adult population. Diabetes 59:416–422
6. Lyssenko V, Almgren P, Anevski D et al (2005) Predictors of and longitudinal changes in insulin sensitivity and secretion preceding onset of type 2 diabetes. Diabetes 54:166–174
7. Roh MO, Jung CH, Kim BY, Mok JO, Kim CH (2013) The prevalence and characteristics of latent autoimmune diabetes in adults (LADA) and its relation with chronic complications in a clinical department of a university hospital in Korea. Acta Diabetol 50:129–134
8. Liao Y, Xiang Y, Zhou Z (2012) Diagnostic criteria of latent autoimmune diabetes in adults (LADA): a review and reflection. Front Med 6:243–247
9. Zhou Z, Ouyang L, Peng J et al (1999) Diagnostic role of antibodies to glutamic acid decarboxylase in latent autoimmune diabetes mellitus in adults. Chin Med J (Engl) 112:554–557
10. Dong F, Yang G, Pan HW et al (2014) The association of PTPN22 rs2476601 polymorphism and CTLA-4 rs231775 polymorphism with LADA risks: a systematic review and meta-analysis. Acta Diabetol 51:691–703
11. Lendrum R, Walker G, Cudworth AG, Woodrow JC, Gamble DR (1976) HLA-linked genes and islet-cell antibodies in diabetes mellitus. Br Med J 1:1565–1567
12. Gottlieb DI, Chang YC, Schwob JE (1986) Monoclonal antibodies to glutamic acid decarboxylase. Proc Natl Acad Sci USA 83:8808–8812
13. Li X, Yang L, Zhou Z, Huang G, Yan X (2003) Glutamic acid decarboxylase 65 autoantibody levels discriminate two subtypes of latent autoimmune diabetes in adults. Chin Med J (Engl) 116:1728–1732
14. Palmer JP, Asplin CM, Clemons P et al (1983) Insulin antibodies in insulin-dependent diabetics before insulin treatment. Science 222:1337–1339
15. Huang G, Wang X, Li Z, Li H, Li X, Zhou Z (2010) Insulin autoantibody could help to screen latent autoimmune diabetes in adults in phenotypic type 2 diabetes mellitus in Chinese. Acta Diabetol 49:327–331
16. Wenzlau JM, Juhl K, Yu L et al (2007) The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes. Proc Natl Acad Sci USA 104:17040–17045
17. Huang G, Xiang Y, Pan L, Li X, Luo S, Zhou Z (2013) Zinc transporter 8 autoantibody (ZnT8A) could help differentiate latent autoimmune diabetes in adults (LADA) from phenotypic type 2 diabetes mellitus. Diabetes Metab Res Rev 29:363–368
18. Yang L, Luo S, Huang G et al (2010) The diagnostic value of zinc transporter 8 autoantibody (ZnT8A) for type 1 diabetes in Chinese. Diabetes Metab Res Rev 26:579–584
19. Xiang Y, Zhou Z, Deng C, Leslie RD (2013) Latent autoimmune diabetes in adults in Asians: similarities and differences between East and West. J Diabetes 5:118–126
20. Long AE, Gillespie KM, Rokni S, Bingley PJ, Williams AJ (2012) Rising incidence of type 1 diabetes is associated with altered immunophenotype at diagnosis. Diabetes 61:683–686
21. Torn C, Landin-Olsson M, Ostman J et al (2000) Glutamic acid decarboxylase antibodies (GADA) is the most important factor for prediction of insulin therapy within 3 years in young adult diabetic patients not classified as Type 1 diabetes on clinical grounds. Diabetes Metab Res Rev 16:442–447
22. Desai M, Cull CA, Horton VA et al (2007) GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77. Diabetologia 50:2052–2060
23. Lampasona V, Petrone A, Tiberti C et al (2010) Zinc transporter 8 antibodies complement GAD and IA-2 antibodies in the identification and characterization of adult-onset autoimmune diabetes: non Insulin Requiring Autoimmune Diabetes (NIRAD) 4. Diabetes Care 33:104–108