The primary outcome measure and its importance in clinical trials

Journal of Clinical Psychiatry

Volumn 76, Issue 10, 2015, Pages e1320-e1323

  Andrade, Chittaranjan ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH AND NEUROSCIENCES   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDEPRESSANT AGENT; HALOPERIDOL; PLACEBO; RISPERIDONE; PSYCHOTROPIC AGENT;

ARTICLE; CLINICAL ASSESSMENT; CLINICAL GLOBAL IMPRESSION SCALE; DEPENDENT VARIABLE; FALSE NEGATIVE RESULT; FALSE POSITIVE RESULT; HAMILTON DEPRESSION RATING SCALE; HUMAN; MAJOR DEPRESSION; MONTGOMERY ASBERG DEPRESSION RATING SCALE; NEUROPSYCHOLOGICAL TEST; OUTCOME ASSESSMENT; PRIMARY OUTCOME MEASURE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); RISK REDUCTION; SAMPLE SIZE; SCHIZOPHRENIA; SECONDARY OUTCOME MEASURE; STATISTICAL ANALYSIS; TREATMENT OUTCOME; MENTAL DISORDERS; PROCEDURES; STANDARDS;

HUMANS; MENTAL DISORDERS; PSYCHOTROPIC DRUGS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TREATMENT OUTCOME;

EID: 84945356967     PISSN: 01606689     EISSN: 15552101     Source Type: Journal    
DOI: 10.4088/JCP.15f10377     Document Type: Article

References (10)

1. Sedgwick P. Primary and secondary outcome measures. BMJ. 2010;340:c1938.
2. Freemantle N. Interpreting the results of secondary end points and subgroup analyses in clinical trials: should we lock the crazy aunt in the attic? BMJ. 2001;322(7292):989-991.
3. De Los Reyes A, Kundey SM, Wang M. The end of the primary outcome measure: a research agenda for constructing its replacement. Clin Psychol Rev. 2011;31(5):829-838.
4. Vedula SS, Bero L, Scherer RW, et al. Outcome reporting in industry-sponsored trials of gabapentin for off-label use. N Engl J Med. 2009;361(20):1963-1971.
5. Andrade C. Antidepressants and testicular cancer: cause versus association. J Clin Psychiatry. 2014;75(3):e198-e200.
6. Kurinji S, Andrade C. ECS seizure threshold: normal variations, and kindling effects of subconvulsive stimuli. J ECT. 2003;19(1):31-37.
7. Andrade C, Akki A, Nandakumar N, et al. Confirmation of whole-brain kindling with repeated subthreshold electroconvulsive shocks: a controlled study. J ECT. 2003;19(2):81-83.
8. Andrade C. In vigorous defense of whole brain kindling and a reconsideration on naming the phenomenon. J ECT. 2004;20(4):275-276.
9. Calabrese JR, Bowden CL, Sachs GS, et al. A double-blind placebo-controlled study of lamotrigine monotherapy in outpatients with bipolar I depression. Lamictal 602 Study Group. J Clin Psychiatry. 1999;60(2):79-88.
10. Geddes JR, Calabrese JR, Goodwin GM. Lamotrigine for treatment of bipolar depression: independent meta-analysis and meta-regression of individual patient data from five randomised trials. Br J Psychiatry. 2009;194(1):4-9.