A genetic variant of miR-148a binding site in the SCRN1 3'-UTR is associated with susceptibility and prognosis of gastric cancer

Scientific Reports

Volumn 4, Issue , 2014, Pages

  Song, Peng ^a   Zhu, Haixia ^b,c   Zhang, Dong ^a   Chu, Haiyan ^b,d   Wu, Dongmei ^b,d   Kang, Meiyun ^b,d   Wang, Meilin ^b,d   Gong, Weida ^e   Zhou, Jianwei ^b   Zhang, Zhengdong ^b,d   Zhao, Qinghong ^a  

^a THE SECOND AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

^c NANTONG TUMOR HOSPITAL   (China)

^d Nanjing Medical University   (China)

^e Yixing Cancer Hospital   (China)

Author keywords

[No Author keywords available]

Indexed keywords

3' UNTRANSLATED REGION; MICRORNA; MIRN148 MICRORNA, HUMAN; NERVE PROTEIN; SCRN1 PROTEIN, HUMAN;

3' UNTRANSLATED REGION; AGED; BINDING SITE; FEMALE; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; HUMAN; MALE; METABOLISM; PATHOLOGY; PROGNOSIS; SINGLE NUCLEOTIDE POLYMORPHISM; STOMACH TUMOR; VERY ELDERLY;

3' UNTRANSLATED REGIONS; AGED; AGED, 80 AND OVER; BINDING SITES; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; MICRORNAS; NERVE TISSUE PROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROGNOSIS; STOMACH NEOPLASMS;

EID: 84945338500     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep07080     Document Type: Article

References (30)

1. Blum, M. A., Takashi, T., Suzuki, A.& Ajani, J. A. Management of localized gastric cancer. J Surg Oncol 107, 265-270 (2013).
2. Jemal, A. et al. Global cancer statistics. CA Cancer J Clin 61, 69-90 (2011).
3. Augenlicht, L. H. et al. Environment-gene interactions in intestinal cancer. Eur J Cancer Prev 11 Suppl 2, , S12-17 (2002).
4. Shi, Y. et al. A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1. Nat Genet 43, 1215-1218 (2011).
5. Sakamoto, H. et al. Genetic variation in PSCA is associated with susceptibility to diffuse-type gastric cancer. Nat Genet 40, 730-740 (2008).
6. Cullen, B. R. MicroRNAs as mediators of viral evasion of the immune system. Nat Immunol 14, 205-210 (2013).
7. Mayr, M., Zampetaki, A., Willeit, P., Willeit, J. & Kiechl, S. MicroRNAs within the continuum of postgenomics biomarker discovery. Arterioscler Thromb Vasc Biol 33, 206-214 (2013).
8. Hu, Z. et al. Genetic polymorphisms in the precursor MicroRNA flanking region and non-small cell lung cancer survival. Am J Respir Crit Care Med 183, 641-648 (2011).
9. Christensen, B. C. et al. Mature microRNA sequence polymorphism in MIR196A2 is associated with risk and prognosis of head and neck cancer. Clin Cancer Res 16, 3713-3720 (2010).
10. Wang, W. et al. A miR-570 binding site polymorphism in the B7-H1 gene is associated with the risk of gastric adenocarcinoma. Hum Genet 132, 641-648 (2013).
11. Zheng, B. et al.MicroRNA-148a suppresses tumor cell invasion and metastasis by downregulating ROCK1 in gastric cancer. Clin Cancer Res 17, 7574-7583 (2011).
12. Tchernitsa, O. et al. Systematic evaluation of the miRNA-ome and its downstream effects on mRNA expression identifies gastric cancer progression. J Pathol 222, 310-319 (2010).
13. Cho, W. C. Epigenetic alteration of microRNAs in feces of colorectal cancer and its clinical significance. Expert Rev Mol Diagn 11, 691-694 (2011).
14. Gailhouste, L. et al. miR-148a plays a pivotal role in the liver by promoting the hepatospecific phenotype and suppressing the invasiveness of transformed cells. Hepatology 58, 1153-1165 (2013).
15. Schultz, N. A. et al. Prognostic microRNAs in cancer tissue from patients operated for pancreatic cancer-five microRNAs in a prognostic index. World J Surg 36, 2699-2707 (2012).
16. Aydogdu, E. et al. MicroRNA-regulated gene networks during mammary cell differentiation are associated with breast cancer. Carcinogenesis 33, 1502-1511 (2012).
17. Wotschofsky, Z. et al. Identification of metastamirs as metastasis-associated microRNAs in clear cell renal cell carcinomas. Int J Biol Sci 8, 1363-1374 (2012).
18. Fujita, Y. et al. MiR-148a attenuates paclitaxel resistance of hormone-refractory, drug-resistant prostate cancer PC3 cells by regulating MSK1 expression. J Biol Chem 285, 19076-19084 (2010).
19. Way, G., Morrice, N., Smythe, C.&O'Sullivan, A. J. Purification and identification of secernin, a novel cytosolic protein that regulates exocytosis in mast cells. Mol Biol Cell 13, 3344-3354 (2002).
20. Ashida, S. et al. Molecular features of the transition from prostatic intraepithelial neoplasia (PIN) to prostate cancer: genome-wide gene-expression profiles of prostate cancers and PINs. Cancer Res 64, 5963-5972 (2004).
21. Suda, T. et al. Identification of secernin 1 as a novel immunotherapy target for gastric cancer using the expression profiles of cDNA microarray. Cancer Sci 97, 411-419 (2006).
22. Miyoshi, N. et al. SCRN1 is a novel marker for prognosis in colorectal cancer. J Surg Oncol 101, 156-159 (2010).
23. Suehara, Y. et al. Secernin-1 as a novel prognostic biomarker candidate of synovial sarcoma revealed by proteomics. J Proteomics 74, 829-842 (2011).
24. Chin, L. J. et al. A SNP in a let-7 microRNA complementary site in the KRAS 39 untranslated region increases non-small cell lung cancer risk. Cancer Res 68, 8535-8540 (2008).
25. Song, H. et al. ACVR1, a Therapeutic Target of Fibrodysplasia Ossificans Progressiva, Is Negatively Regulated by miR-148a. Int J Mol Sci 13, 2063-2077 (2012).
26. Zhang, H. et al. MiR-148a promotes apoptosis by targeting Bcl-2 in colorectal cancer. Cell Death Differ 18, 1702-1710 (2011).
27. Murata, T. et al. miR-148a is an androgen-responsive microRNA that promotes LNCaP prostate cell growth by repressing its target CAND1 expression. Prostate Cancer Prostatic Dis 13, 356-361 (2010).
28. Yang, T. P. et al. Genevar: a database and Java application for the analysis and visualization of SNP-gene associations in eQTL studies. Bioinformatics 26, 2474-2476 (2010).
29. Wang, M. et al. Genetic variant in PSCA predicts survival of diffuse-type gastric cancer in a Chinese population. Int J Cancer 129, 1207-1213 (2011).
30. Kruger, J. & Rehmsmeier, M. RNAhybrid: microRNA target prediction easy, fast and flexible. Nucleic Acids Res 34, W451-454 (2006).