Circulating tumor cells as trigger to hematogenous spreads and potential biomarkers to predict the prognosis in ovarian cancer

Tumor Biology

Volumn 37, Issue 1, 2016, Pages 71-75

  Gasparri, Maria Luisa ^a   Savone, Delia ^a   Besharat, Raad Aris ^a   Farooqi, Ammad Ahmad ^b   Bellati, Filippo ^a   Ruscito, Ilary ^a   Panici, Pierluigi Benedetti ^a   Papadia, Andrea ^c  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b Laboratory for Translational Oncology and Personalized Medicine   (Pakistan)

^c UNIVERSITY OF BERN   (Switzerland)

Author keywords

Circulating tumor cells; Immunoediting; Ovarian cancer; Prognostic markers; Tumor immunology

Indexed keywords

TUMOR MARKER;

CANCER PROGNOSIS; CELL FUNCTION; CELL SELECTION; CIRCULATING TUMOR CELL; DISEASE ASSOCIATION; HUMAN; METASTASIS; OUTCOME ASSESSMENT; OVARY CANCER; PRIORITY JOURNAL; REVIEW; ANIMAL; BLOOD; DISEASE FREE SURVIVAL; FEMALE; IMMUNE SYSTEM; IMMUNOLOGY; OVARIAN NEOPLASMS; PATHOLOGY; PROGNOSIS; REGULATORY T LYMPHOCYTE; TREATMENT OUTCOME; TUMOR EMBOLISM; TUMOR RECURRENCE;

ANIMALS; BIOMARKERS, TUMOR; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; IMMUNE SYSTEM; NEOPLASM RECURRENCE, LOCAL; NEOPLASTIC CELLS, CIRCULATING; OVARIAN NEOPLASMS; PROGNOSIS; T-LYMPHOCYTES, REGULATORY; TREATMENT OUTCOME;

EID: 84945264439     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-015-4299-9     Document Type: Review

References (48)

1. Siegel R, Naishadham D, Jemal A. Cancer statistics. CA Cancer J Clin. 2013;63(1):11–30.
2. Papadia A, Morotti M. Diaphragmatic surgery during cytoreduction for primary or recurrent epithelial ovarian cancer: a review of the literature. Arch Gynecol Obstet. 2013;287(4):733–41.
3. Armstrong DK, Bundy B, Wenzel L, Huang HQ, Baergen R, Lele S, et al. Intraperitoneal cisplatin and paclitaxel in ovarian cancer. N Engl J Med. 2006;354(1):34–43.
4. Burger RA, Brady MF, Bookman MA, Fleming GF, Monk BJ, Huang H, et al. Incorporation of bevacizumab in the primary treatment of ovarian cancer. N Engl J Med. 2011;365(26):2473–83.
5. Verri E, Guglielmini P, Puntoni M, Perdelli L, Papadia A, Lorenzi P, et al. HER2/neu oncoprotein overexpression in epithelial ovarian cancer: evaluation of its prevalence and prognostic significance. Clinical study. Oncology. 2005;68(2–3):154–61.
6. Gasparri ML, Attar R, Palaia I, Perniola G, Marchetti C, Di Donato V, et al. Tumor infiltrating lymphocytes in ovarian cancer. Asian Pac J Cancer Prev. 2015;16(9):3635–8.
7. Emerson RO, Sherwood AM, Rieder MJ, Guenthoer J, Williamson DW, Carlson CS, et al. High-throughput sequencing of T-cell receptors reveals a homogeneous repertoire of tumour-infiltrating lymphocytes in ovarian cancer. J Pathol. 2013;231(4):433–40.
8. Kan CW, Hahn MA, Gard GB, Maidens J, Huh JY, Marsh DJ, et al. Elevated levels of circulating microRNA-200 family members correlate with serous epithelial ovarian cancer. BMC Cancer. 2012;12:627.
9. Martignetti JA, Camacho-Vanegas O, Priedigkeit N, Camacho C, Pereira E, Lin L, et al. Personalized ovarian cancer disease surveillance and detection of candidate therapeutic drug target in circulating tumor DNA. Neoplasia. 2014;16(1):97–103.
10. Attar R, Gasparri ML, Donato VD, Yaylim I, Halim TA, Zaman F, et al. Ovarian cancer: interplay of vitamin D signaling and miRNA action. Asian Pac J Cancer Prev. 2014;15(8):3359–62.
11. Allard WJ, Matera J, Miller MC, Repollet M, Connelly MC, Rao C, et al. Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with nonmalignant diseases. Clin Cancer Res. 2004;10(20):6897–904.
12. Pukazhendhi G, Glück S. Circulating tumor cells in breast cancer. J Carcinog. 2014;13:8.
13. Romiti A, Raffa S, Di Rocco R, Roberto M, Milano A, Zullo A, et al. Circulating tumor cells count predicts survival in colorectal cancer patients. J Gastrointestin Liver Dis. 2014;23(3):279–84.
14. Fiorelli A, Accardo M, Carelli E, Angioletti D, Santini M, Di Domenico M. Circulating tumor cells in diagnosing lung cancer: clinical and morphologic analysis. Ann Thorac Surg. 2015;99(6):1899–905.
15. Reeh M, Effenberger KE, Koenig AM, Riethdorf S, Eichstädt D, Vettorazzi E, Uzunoglu FG, Vashist YK, Izbicki JR, Pantel K, Bockhorn M. Circulating tumor cells as a biomarker for preoperative prognostic staging in patients with esophageal cancer. Ann Surg 2015.
16. Liu Y, Wang YR, Wang L, Song RM, Zhou B, Song ZS. Significance of detecting circulating hepatocellular carcinoma cells in peripheral blood of hepatocellular carcinoma patients by nested reverse transcription-polymerase chain reaction and its clinical value: a retrospective study. Tumori. 2014;100(5):536–40.
17. Tjensvoll K, Nordgård O, Smaaland R. Circulating tumor cells in pancreatic cancer patients: methods of detection and clinical implications. Int J Cancer. 2014;134(1):1–8.
18. Goodman Jr OB, Symanowski JT, Loudyi A, Fink LM, Ward DC, Vogelzang NJ. Circulating tumor cells as a predictive biomarker in patients with hormone-sensitive prostate cancer. Clin Genitourin Cancer. 2011;9(1):31–8.
19. Bogani G, Liu MC, Dowdy SC, Cliby WA, Kerr SE, Kalli KR, et al. Detection of circulating tumor cells in high-risk endometrial cancer. Anticancer Res. 2015;35(2):683–7.
20. Obermayr E, Castillo-Tong DC, Pils D, Speiser P, Braicu I, Van Gorp T, et al. Molecular characterization of circulating tumor cells in patients with ovarian cancer improves their prognostic significance—a study of the OVCAD consortium. Gynecol Oncol. 2013;128(1):15–21.
21. Cain JM, Ellis GK, Collins C, Greer BE, Tamimi HK, Figge DC, et al. Bone marrow involvement in epithelial ovarian cancer by immunocytochemical assessment. Gynecol Oncol. 1990;38(3):442–5.
22. Fidler IJ. The pathogenesis of cancer metastasis: the ‘seed and soil’ hypothesis revisited. Nat Rev Cancer. 2003;3(6):453–8.
23. Cui L, Kwong J, Wang CC. Prognostic value of circulating tumor cells and disseminated tumor cells in patients with ovarian cancer: a systematic review and meta-analysis. J Ovarian Res. 2015;8(1):38.
24. Obermayr E, Sanchez-Cabo F, Tea MK, Singer CF, Krainer M, Fischer MB, et al. Assessment of a six gene panel for the molecular detection of circulating tumor cells in the blood of female cancer patients. BMC Cancer. 2010;10:666.
25. Ring AE, Zabaglo L, Ormerod MG, Smith IE, Dowsett M. Detection of circulating epithelial cells in the blood of patients with breast cancer: comparison of three techniques. Br J Cancer. 2005;92(5):906–12.
26. Lowes LE, Allan AL. Recent advances in the molecular characterization of circulating tumor cells. Cancers (Basel). 2014;6(1):595–624.
27. Wimberger P, Heubner M, Otterbach F, Fehm T, Kimmig R, Kasimir-Bauer S. Influence of platinum-based chemotherapy on disseminated tumor cells in blood and bone marrow of patients with ovarian cancer. Gynecol Oncol. 2007;107(2):331–8.
28. Judson PL, Geller MA, Bliss RL, Boente MP, Downs Jr LS, Argenta PA, et al. Preoperative detection of peripherally circulating cancer cells and its prognostic significance in ovarian cancer. Gynecol Oncol. 2003;91(2):389–94.
29. Aktas B, Kasimir-Bauer S, Heubner M, Kimmig R, Wimberger P. Molecular profiling and prognostic relevance of circulating tumor cells in the blood of ovarian cancer patients at primary diagnosis and after platinum-based chemotherapy. Int J Gynecol Cancer. 2011;21(5):822–30.
30. Sang M, Wu X, Fan X, Sang M, Zhou X, Zhou N. Multiple MAGE-A genes as surveillance marker for the detection of circulating tumor cells in patients with ovarian cancer. Biomarkers. 2014;19(1):34–42.
31. Pearl ML, Zhao Q, Yang J, Dong H, Tulley S, Zhang Q, et al. Prognostic analysis of invasive circulating tumor cells (iCTCs) in epithelial ovarian cancer. Gynecol Oncol. 2014;134(3):581–90.
32. Kuhlmann JD, Wimberger P, Bankfalvi A, Keller T, Schöler S, Aktas B, et al. ERCC1-positive circulating tumor cells in the blood of ovarian cancer patients as a predictive biomarker for platinum resistance. Clin Chem. 2014;60(10):1282–9.
33. Fehm T, Banys M, Rack B, Janni W, Marth C, Blassl C, et al. Pooled analysis of the prognostic relevance of disseminated tumor cells in the bone marrow of patients with ovarian cancer. Int J Gynecol Cancer. 2013;23(5):839–45.
34. Schindlbeck C, Hantschmann P, Zerzer M, Jahns B, Rjosk D, Janni W, et al. Prognostic impact of KI67, p53, human epithelial growth factor receptor 2, topoisomerase IIalpha, epidermal growth factor receptor, and nm23 expression of ovarian carcinomas and disseminated tumor cells in the bone marrow. Int J Gynecol Cancer. 2007;17(5):1047–55.
35. Dauplat J, Hacker NF, Nieberg RK, Berek JS, Rose TP, Sagae S. Distant metastases in epithelial ovarian carcinoma. Cancer. 1987;60(7):1561–6.
36. Fan T, Zhao Q, Chen JJ, Chen WT, Pearl ML. Clinical significance of circulating tumor cells detected by an invasion assay in peripheral blood of patients with ovarian cancer. Gynecol Oncol. 2009;112(1):185–91.
37. Bellati F, Visconti V, Napoletano C, Antonilli M, Frati L, Panici PB, et al. Immunology of gynecologic neoplasms: analysis of the prognostic significance of the immune status. Curr Cancer Drug Targets. 2009;9(4):541–65.
38. Gasparri ML, Bellati F, Napoletano C, Panici PB, Nuti M. Interaction between Treg cells and angiogenesis: a dark double track. Int J Cancer. 2013;132(10):2469.
39. Poveda A, Kaye SB, McCormack R, Wang S, Parekh T, Ricci D, et al. Circulating tumor cells predict progression free survival and overall survival in patients with relapsed/recurrent advanced ovarian cancer. Gynecol Oncol. 2011;122(3):567–72.
40. Zhou Y, Bian B, Yuan X, Xie G, Ma Y, Shen L. Prognostic value of circulating tumor cells in ovarian cancer: a meta-analysis. PLoS One. 2015;10(6):e0130873. eCollection 2015.
41. Zeng L, Liang X, Liu Q, Yang Z. The predictive value of circulating tumor cells in ovarian cancer: a meta analysis. Int J Gynecol Cancer 2015.
42. Behbakht K, Sill MW, Darcy KM, Rubin SC, Mannel RS, Waggoner S, et al. Phase II trial of the mTOR inhibitor, temsirolimus and evaluation of circulating tumor cells and tumor biomarkers in persistent and recurrent epithelial ovarian and primary peritoneal malignancies: a Gynecologic Oncology Group study. Gynecol Oncol. 2011;123(1):19–26.
43. Liu JF, Hirsch MS, Lee H, Matulonis UA. Prognosis and hormone receptor status in older and younger patients with advanced-stage papillary serous ovarian carcinoma. Gynecol Oncol. 2009;115(3):401–6.
44. Marchetti C, Imperiale L, Gasparri ML, Palaia I, Pignata S, Boni T, et al. Olaparib, PARP1 inhibitor in ovarian cancer. Expert Opin Invest Drugs. 2012;21(10):1575–84.
45. Leone Roberti Maggiore U, Bellati F, Ruscito I, Gasparri ML, Alessandri F, Venturini PL, et al. Monoclonal antibodies therapies for ovarian cancer. Expert Opin Biol Ther. 2013;13(5):739–64.
46. Bellati F, Napoletano C, Gasparri ML, Visconti V, Zizzari IG, Ruscito I, Caccetta J, Rughetti A, Benedetti-Panici P, Nuti M. Monoclonal antibodies in gynecological cancer: a critical point of view. Clin Dev Immunol 2011; 890758. Epub 2011 Dec 26. Review.
47. Bellati F, Napoletano C, Gasparri ML, Ruscito I, Marchetti C, Pignata S, et al. Current knowledge and open issues regarding bevacizumab in gynaecological neoplasms. Crit Rev Oncol Hematol. 2012;83(1):35–46.
48. Bellati F, Napoletano C, Ruscito I, Visconti V, Antonilli M, Gasparri ML, et al. Past, present and future strategies of immunotherapy in gynecological malignancies. Curr Mol Med. 2013;13(4):648–69.