The Role of Radiotherapy in the Treatment of Small-Cell Lung Cancer

Current Treatment Options in Oncology

Volumn 16, Issue 12, 2015, Pages

  Nosaki, Kaname ^a   Seto, Takashi ^a  

^a NATIONAL KYUSHU CANCER CENTER   (Japan)

Author keywords

Prophylactic cranial irradiation; Small cell lung cancer; Thoracic radiotherapy

Indexed keywords

ANTINEOPLASTIC AGENT; CARBOPLATIN; CISPLATIN; ETOPOSIDE; IRINOTECAN; PLATINUM COMPLEX;

ALOPECIA; AMNESIA; ANOREXIA; BRAIN METASTASIS; CANCER INCIDENCE; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER REGRESSION; CANCER SURVIVAL; CLINICAL EFFECTIVENESS; COMMUNICATION DISORDER; DISEASE FREE SURVIVAL; DIZZINESS; DYSPNEA; FATIGUE; HEADACHE; HUMAN; INTELLECTUAL IMPAIRMENT; MALAISE; MEMORY DISORDER; NEUROTOXICITY; NUCLEAR MAGNETIC RESONANCE IMAGING; OVERALL SURVIVAL; PHASE 3 CLINICAL TRIAL (TOPIC); POSITRON EMISSION TOMOGRAPHY; PRACTICE GUIDELINE; PROGRESSION FREE SURVIVAL; RADIATION DOSE FRACTIONATION; RADIATION INJURY; RADIATION SICKNESS; REVIEW; SKIN DISEASE; SKULL IRRADIATION; SMALL CELL LUNG CANCER; SURVIVAL RATE; TREATMENT RESPONSE; VOMITING; WEAKNESS; ADVERSE EFFECTS; BRAIN NEOPLASMS; CHEMORADIOTHERAPY; JAPAN; MULTIMODALITY CANCER THERAPY; PATHOLOGY; REMISSION; SMALL CELL LUNG CARCINOMA;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BRAIN NEOPLASMS; CHEMORADIOTHERAPY; COMBINED MODALITY THERAPY; CRANIAL IRRADIATION; DISEASE-FREE SURVIVAL; ETOPOSIDE; GUIDELINES AS TOPIC; HUMANS; JAPAN; REMISSION INDUCTION; SMALL CELL LUNG CARCINOMA;

EID: 84945184447     PISSN: 15272729     EISSN: 15346277     Source Type: Journal    
DOI: 10.1007/s11864-015-0372-2     Document Type: Review

References (25)

1. Zelen M. Keynote address on biostatistics and data retrieval. Cancer Chemother Rep. 1973;3(4):31–42.
2. Hansen HH. Should initial treatment of small cell carcinoma include systemic chemotherapy and brain irradiation? Cancer Chemother Rep. 1973;3(4):239–41.
3. Auperin A, Arriagada R, Pignon JP, Le Pechoux C, Gregor A, Stephens RJ, et al. Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission. Prophylactic Cranial Irradiation Overview Collaborative Group. N Engl J Med. 1999;341:476–84.
4. Slotman B, Faivre-Finn C, Kramer G, Rankin E, Snee M, Hatton M, et al. Prophylactic cranial irradiation in extensive small-cell lung cancer. N Engl J Med. 2007;357:664–72. This randomised phase III study shows a survival benefit of PCI for ED-SCLC.
5. Seto T, Takahashi T, Yamanaka T, Harada H, Nokihara H, Saka H, et al. Prophylactic cranial irradiation (PCI) has a detrimental effect on the overall survival (OS) of patients (pts) with extensive disease small cell lung cancer (ED-SCLC): Results of a Japanese randomized phase III trial. J Clin Oncol ASCO Ann Meet Abstr. 2014;32:7503. This randomised phase III study fails to demonstrate a survival benefit of PCI for ED-SCLC.
6. Aroney RS, Aisner J, Wesley MN, Whitacre MY, Van Echo DA, Slawson RG, et al. Value of prophylactic cranial irradiation given at complete remission in small cell lung carcinoma. Cancer Treat Rep. 1983;67:675–82.
7. Ohonoshi T, Ueoka H, Kawahara S, Kiura K, Kamei H, Hiraki Y, et al. Comparative study of prophylactic cranial irradiation in patients with small cell lung cancer achieving a complete response: a long-term follow-up result. Lung Cancer. 1993;10:47–54.
8. Arriagada R, Le Chevalier T, Borie F, Riviere A, Chomy P, Monnet I, et al. Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission. J Natl Cancer Inst. 1995;87:183–90.
9. Wagner H, Kim K, Turrisi A. A randomized phase III study of prophylactic cranial irradiation versus observation in patients with small cell lung cancer achieving a complete response: final report of an incomplete trial by the Eastern Cooperative Oncology Group and Radiation Therapy Oncology Group (E3589/R92-01). Proc Am Soc Clin Oncol. 1996;15:376.
10. Gregor A, Cull A, Stephens RJ, Kirkpatrick JA, Yarnold JR, Girling DJ, et al. Prophylactic cranial irradiation is indicated following complete response to induction therapy in small cell lung cancer: results of a multicentre randomised trial. United Kingdom Coordinating Committee for Cancer Research (UKCCCR) and the European Organization for Research and Treatment of Cancer (EORTC). Eur J Cancer. 1997;33:1752–8.
11. Laplanche A, Monnet I, Santos-Miranda JA, Bardet E, Le Pechoux C, Tarayre M, et al. Controlled clinical trial of prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission. Lung Cancer. 1998;21:193–201.
12. Suwinski R, Lee SP, Withers HR. Dose–response relationship for prophylactic cranial irradiation in small cell lung cancer. Int J Radiat Oncol Biol Phys. 1998;40:797–806.
13. Kotalik J, Yu E, Markman BR, Evans WK. Practice guideline on prophylactic cranial irradiation in small-cell lung cancer. Int J Radiat Oncol Biol Phys. 2001;50:309–16.
14. Le Pechoux C, Dunant A, Senan S, Wolfson A, Quoix E, Faivre-Finn C, et al. Standard-dose versus higher-dose prophylactic cranial irradiation (PCI) in patients with limited-stage small-cell lung cancer in complete remission after chemotherapy and thoracic radiotherapy (PCI 99–01, EORTC 22003–08004, RTOG 0212, and IFCT 99–01): a randomised clinical trial. Lancet Oncol. 2009;10:467–74.
15. Le Pechoux C, Laplanche A, Faivre-Finn C, Ciuleanu T, Wanders R, Lerouge D, et al. Clinical neurological outcome and quality of life among patients with limited small-cell cancer treated with two different doses of prophylactic cranial irradiation in the intergroup phase III trial (PCI99-01, EORTC 22003–08004, RTOG 0212 and IFCT 99–01). Ann Oncol. 2011;22:1154–63.
16. Wolfson AH, Bae K, Komaki R, Meyers C, Movsas B, Le Pechoux C, et al. Primary analysis of a phase II randomized trial Radiation Therapy Oncology Group (RTOG) 0212: impact of different total doses and schedules of prophylactic cranial irradiation on chronic neurotoxicity and quality of life for patients with limited-disease small-cell lung cancer. Int J Radiat Oncol Biol Phys. 2011;81:77–84.
17. Ahles TA, Silberfarb PM, Herndon 2nd J, Maurer LH, Kornblith AB, Aisner J, et al. Psychologic and neuropsychologic functioning of patients with limited small-cell lung cancer treated with chemotherapy and radiation therapy with or without warfarin: a study by the Cancer and Leukemia Group B. J Clin Oncol. 1998;16:1954–60.
18. Crossen JR, Garwood D, Glatstein E, Neuwelt EA. Neurobehavioral sequelae of cranial irradiation in adults: a review of radiation-induced encephalopathy. J Clin Oncol. 1994;12:627–42.
19. Vines EF, Le Pechoux C, Arriagada R. Prophylactic cranial irradiation in small cell lung cancer. Semin Oncol. 2003;30:38–46.
20. Grosshans DR, Meyers CA, Allen PK, Davenport SD, Komaki R. Neurocognitive function in patients with small cell lung cancer: effect of prophylactic cranial irradiation. Cancer. 2008;112:589–95.
21. Slotman BJ, van Tinteren H, Praag JO, Knegjens JL, El Sharouni SY, Hatton M, et al. Use of thoracic radiotherapy for extensive stage small-cell lung cancer: a phase 3 randomised controlled trial. Lancet. 2014.This randomised phase III study demonstrate survival benefit at 2 year of TRT for ED-SCLC
22. Sheehan J, Kondziolka D, Flickinger J, Lunsford LD. Radiosurgery for patients with recurrent small cell lung carcinoma metastatic to the brain: outcomes and prognostic factors. J Neurosurg. 2005;102(Suppl):247–54.
23. Rava P, Sioshansi S, DiPetrillo T, Cosgrove R, Melhus C, Wu J, et al. Local recurrence and survival following stereotactic radiosurgery for brain metastases from small cell lung cancer. Pract Radiat Oncol. 2014.
24. Zhu H, Bi Y, Han A, Luo J, Li M, Shi F, et al. Risk factors for brain metastases in completely resected small cell lung cancer: a retrospective study to identify patients most likely to benefit from prophylactic cranial irradiation. Radiat Oncol. 2014;9:216.
25. Kalm M, Abel E, Wasling P, Nyman J, Hietala MA, Bremell D, et al. Neurochemical evidence of potential neurotoxicity after prophylactic cranial irradiation. Int J Radiat Oncol Biol Phys. 2014;89:607–14.