Augmented renal clearance in critical illness: "the Elephant in the ICU"?

Minerva Anestesiologica

Volumn 81, Issue 10, 2015, Pages 1050-1052

  Baptista, J P ^a   Udy, A A ^b,c  

^a CENTRO HOSPITALAR E UNIVERSITÁRIO DE COIMBRA   (Portugal)

^b ALFRED HOSPITAL   (Australia)

^c MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC RESISTANCE; ANTIBIOTIC THERAPY; BLEEDING; BURN; CONSENSUS; CREATININE CLEARANCE; CREATININE URINE LEVEL; CRITICAL ILLNESS; CRITICALLY ILL PATIENT; GLOMERULUS FILTRATION; HUMAN; INJURY; INTENSIVE CARE UNIT; KIDNEY FUNCTION; RENAL CLEARANCE; RENAL REPLACEMENT THERAPY; REVIEW; SEPSIS; ANIMAL; ELEPHANT; KIDNEY FUNCTION TEST;

CREATININE;

ANIMALS; CREATININE; CRITICAL ILLNESS; ELEPHANTS; HUMANS; INTENSIVE CARE UNITS; KIDNEY FUNCTION TESTS;

EID: 84945180336     PISSN: 03759393     EISSN: 18271596     Source Type: Journal    
DOI: None     Document Type: Review

References (19)

1. Loirat P, Rohan J, Baillet A, Beaufils F, David R, Chapman A. Increased glomerular filtration rate in patients with major burns and its effect on the pharmacokinetics of tobramycin. N Engl J Med 1978;299:915-9.
2. Udy AA, Roberts JA, Shorr AF, Boots RJ, Lipman J. Augmented renal clearance in septic and traumatized patients with normal plasma creatinine concentrations: identifying at-risk patients. Crit Care 2013;17:R35.
3. May CC, Arora S, Parli SE, Fraser JF, Bastin MT, Cook AM. Augmented renal clearance in patients with subarachnoid hemorrhage. Neurocrit Care 2015 [Epub ahead of print].
4. Conil JM, Georges B, Lavit M, Laguerre J, Samii K, Houin G et al: A population pharmacokinetic approach to ceftazidime use in burn patients: influence of glomerular filtration, gender and mechanical ventilation. Br J Clin Pharmaco 2007;64:27-35.
5. Udy AA, Baptista JP, Lim NL, Joynt GM, Jarrett P, Wockner L et al. Augmented renal clearance in the icu: results of a multicenter observational study of renal function in critically ill patients with normal plasma creatinine concentrations. Crit Care Med 2014;42:520-7.
6. Baptista JP, Neves M, Rodrigues L, Teixeira L, Pinho J, Pimentel J. Accuracy of the estimation of glomerular filtration rate within a population of critically ill patients. J Nephrol 2014;27:403-10.
7. Baptista JP, Sousa E, Martins PJ, Pimentel JM. Augmented renal clearance in septic patients and implications for vancomycin optimisation. Int J Antimicrob Agents 2012;39:420-3.
8. Udy AA, Varghese JM, Altukroni M, Briscoe S, McWhinney BC, Ungerer JP et al. Subtherapeutic initial beta-lactam 2015 concentrations in select critically ill patients: association between augmented renal clearance and low trough drug concentrations. Chest 2012;142:30-9.
9. Ocampos-Martinez E, Penaccini L, Scolletta S, Abdelhadii A, Devigili A, Cianferoni S et al. Determinants of early inadequate vancomycin concentrations during continuous infusion in septic patients. Int J Antimicrob Agents 2012;39:332-7.
10. Campassi ML, Gonzalez MC, Masevicius FD, Vazquez AR, Moseinco M, Navarro NC et al. [Augmented renal clearance in critically ill patients: incidence, associated factors and effects on vancomycin treatment]. Rev Bras Ter Intensiva 2014;26:13-20.
11. Huttner A, Von Dach E, Renzoni A, Huttner BD, Affaticati M, Pagani L et al. Augmented renal clearance, low beta-lactam concentrations and clinical outcomes in the critically ill: An observational prospective cohort study. Int J Antimicrob Agents 2015;45:385-92.
12. Claus BO, Hoste EA, Colpaert K, Robays H, Decruyenaere J, De Waele JJ. Augmented renal clearance is a common finding with worse clinical outcome in critically ill patients receiving antimicrobial therapy. J Crit Care 2013;28:695-700.
13. De Waele JJ, Dumoulin A, Janssen A, Hoste EA. Epidemiology of augmented renal clearance in mixed ICU patients. Minerva Anestesiol 2015;81:1079-85.
14. Vincent JL, Rello J, Marshall J, Silva E, Anzueto A, Martin CD et al. International study of the prevalence and outcomes of infection in intensive care units. JAMA 2009;302:2323-9.
15. Prowle JR: Does augmented creatinine clearance accurately reflect glomerular hyperfiltration in critical illness? Crit Care Med 2014;42:674-5.
16. Baptista J, Roberts JA, Sousa E, Freitas R, Deveza N, Pimentel J. Decreasing the time to achieve therapeutic vancomycin concentrations in critically Ill patients: developing and testing of a dosing nomogram. Crit Care 2014;18:654.
17. Pea F, Viale P, Cojutti P, Furlanut M. Dosing nomograms for attaining optimum concentrations of meropenem by continuous infusion in critically ill patients with severe gram-negative infections: a pharmacokinetics/pharmacodynamics-based approach. Antimicrob Agents Chemother 2012;56:6343-8.
18. Grootaert V, Willems L, Debaveye Y, Meyfroidt G, Spriet I. Augmented renal clearance in the critically ill: how to assess kidney function. Ann Pharmacother 2012;46:952-9.
19. Lautrette A, Phan TN, Ouchchane L, Aithssain A, Tixier V, Heng AE et al. High creatinine clearance in critically ill patients with community-acquired acute infectious meningitis. BMC Nephro 2012;13:124.