Diagnostic accuracy of C-reactive protein and procalcitonin in suspected community-acquired pneumonia adults visiting emergency department and having a systematic thoracic CT scan

Critical Care

Volumn 19, Issue 1, 2015, Pages

  Le Bel, Josselin ^a,b   Hausfater, Pierre ^c,d   Chenevier Gobeaux, Camille ^e   Blanc, François Xavier ^f,g   Benjoar, Mikhael ^h   Ficko, Cécile ⁱ   Ray, Patrick ^h   Choquet, Christophe ^j   Duval, Xavier ^a,b,j   Claessens, Yann Erick ^k   Bouvard, E ^l   Carette, M F ^l   Debray, M P ^l   Mayaud, C ^l   Leport, C ^l   Houhou, N ^l   Tubiana, S ^l   Brun, A L ^l   Epelboin, L ^l   Khalil, A ^l   Lefloch, H ^l   Naccache, J M ^l   Rammaert, B ^l   Abry, A ^l   Allo, J C ^l   Andre, S ^l   Andreotti, C ^l   Baarir, N ^l   Bendahou, M ^l   Benlafia, L ^l   Bernard, J ^l   Berthoumieu, A ^l   Billemont, M E ^l   Bokobza, J ^l   Burggraff, E ^l   Canavaggio, P ^l   Casalino, E ^l   Castro, S ^l   Clement H ^l   Colosi, L ^l   Dabreteau, A ^l   Damelincourt, S ^l   Dautheville, S ^l   Delay, M ^l   Delerme, S ^l   Depierre, L ^l   Djamouri, F ^l   Dumas, F ^l   Fadel, R S M ^l   Feydey, A ^l   Freund, Y ^l   Garcia, L ^l   Goulet, H ^l   Ilic Habensus, E ^l   Josse, M O ^l   Kansao, J ^l   Kieffer, Y ^l   Lecomte, F ^l   Lemkarane, K ^l   Madonna, P ^l   Meyniard, O ^l   Mzabi, L ^l   Pariente, D ^l   Pernet, J ^l   Perruche, F ^l   Piquet, J M ^l   Ranerison, R ^l   Renai, F ^l   Rouff, E ^l   Saget, D ^l   Saidi K ^l   Sauvin, G ^l   Trabattoni, E ^l   Trimech, N ^l   Auger, C ^l   Pasquet, B ^l   S Tamazirt, ^l   Treluyer, J M ^l   F Tubach, ^l   Wang, J ^l   more..

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b UNIVERSITÉ PARIS DIDEROT   (France)

^c SORBONNE UNIVERSITÉ   (France)

^d PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^e HÔTEL DIEU   (France)

^f UNIVERSITÉ DE NANTES   (France)

^g L INSTITUT DU THORAX   (France)

^h HÔPITAL TENON   (France)

ⁱ Military Teaching Hospital Begin   (France)

^j BICHAT HOSPITAL   (France)

^k CENTRE HOSPITALIER PRINCESSE GRACE   (Monaco)

^l Hospital Princesse Grace ^*

more..

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; C REACTIVE PROTEIN; PROCALCITONIN; BIOLOGICAL MARKER; CALCA PROTEIN, HUMAN; CALCITONIN; CALCITONIN GENE RELATED PEPTIDE; PROTEIN PRECURSOR;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL FEATURE; COMMUNITY ACQUIRED PNEUMONIA; COMORBIDITY; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; COUGHING; CRACKLE; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; DYSPNEA; EMERGENCY WARD; FEMALE; HUMAN; IMAGE ANALYSIS; LUNG AUSCULTATION; LUNG INFILTRATE; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PNEUMONIA SEVERITY INDEX; POLYMERASE CHAIN REACTION; PREDICTIVE VALUE; PRIORITY JOURNAL; PROBABILITY; PROSPECTIVE STUDY; SENSITIVITY ANALYSIS; SENSITIVITY AND SPECIFICITY; SYMPTOMATOLOGY; THORAX RADIOGRAPHY; AGED; BLOOD; COMMUNITY-ACQUIRED INFECTIONS; MIDDLE AGED; PATHOLOGY; PNEUMONIA; PROCEDURES; SECRETION (PROCESS); VERY ELDERLY; X-RAY COMPUTED TOMOGRAPHY;

ADULT; AGED; AGED, 80 AND OVER; BIOMARKERS; C-REACTIVE PROTEIN; CALCITONIN; CALCITONIN GENE-RELATED PEPTIDE; COMMUNITY-ACQUIRED INFECTIONS; FEMALE; HUMANS; MALE; MIDDLE AGED; PNEUMONIA; PROSPECTIVE STUDIES; PROTEIN PRECURSORS; RADIOGRAPHY, THORACIC; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84944899353     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/s13054-015-1083-6     Document Type: Article

References (30)

1. Mandell LA. Epidemiology and etiology of community-acquired pneumonia. Infect Dis Clin North Am. 2004;18:761-76. vii.
2. Houck PM, Bratzler DW, Nsa W, Ma A, Bartlett JG. Timing of antibiotic administration and outcomes for Medicare patients hospitalized with community-acquired pneumonia. Arch Intern Med. 2004;164:637-44.
3. Wunderink RG, Waterer GW. Community-acquired pneumonia. N Engl J Med. 2014;370:1863.
4. Gennis P, Gallagher J, Falvo C, Baker S, Than W. Clinical criteria for the detection of pneumonia in adults: guidelines for ordering chest roentgenograms in the emergency department. J Emerg Med. 1989;7:263-8.
5. Metlay JP, Fine MJ. Testing strategies in the initial management of patients with community-acquired pneumonia. Ann Intern Med. 2003;138:109-18.
6. Dorca J, Torres A. Lower respiratory tract infections in the community: towards a more rational approach. Eur Respir J. 1996;9:1588-9.
7. Musher DM, Thorner AR. Community-acquired pneumonia. N Engl J Med. 2014;371:1619-28.
8. Albaum MN, Hill LC, Murphy M, Li YH, Fuhrman CR, Britton CA, et al. Interobserver reliability of the chest radiograph in community-acquired pneumonia. PORT Investigators. Chest. 1996;110:343-50.
9. Hopstaken RM, Witbraad T, van Engelshoven JMA, Dinant GJ. Inter-observer variation in the interpretation of chest radiographs for pneumonia in community-acquired lower respiratory tract infections. Clin Radiol. 2004;59:743-52.
10. Young M, Marrie TJ. Interobserver variability in the interpretation of chest roentgenograms of patients with possible pneumonia. Arch Intern Med. 1994;154:2729-32.
11. Claessens YE, Debray MP, Tubach F, Brun AL, Rammaert B, Hausfater P, et al. Early chest CT-scan to assist diagnosis and guide treatment decision for suspected community-acquired pneumonia. Am J Respir Crit Care Med. 2015. [Epub ahead of print].
12. Das D, Le Floch H, Houhou N, Epelboin L, Hausfater P, Khalil A, et al. Viruses detected by systematic multiplex polymerase chain reaction in adults with suspected community-acquired pneumonia attending emergency departments in France. Clin Microbiol Infect. 2015;21:608. e1-8.
13. Ortqvist A, Hedlund J, Wretlind B, Carlström A, Kalin M. Diagnostic and prognostic value of interleukin-6 and C-reactive protein in community-acquired pneumonia. Scand J Infect Dis. 1995;27:457-62.
14. Van der Meer V, Neven AK, van den Broek PJ, Assendelft WJ. Diagnostic value of C reactive protein in infections of the lower respiratory tract: systematic review. BMJ. 2005;331:26.
15. Christ-Crain M, Jaccard-Stolz D, Bingisser R, Gencay MM, Huber PR, Tamm M, et al. Effect of procalcitonin-guided treatment on antibiotic use and outcome in lower respiratory tract infections: cluster-randomised, single-blinded intervention trial. Lancet. 2004;363:600-7.
16. Van Vugt SF, Broekhuizen BD, Lammens C, Zuithoff NP, de Jong PA, Coenen S, et al. Use of serum C reactive protein and procalcitonin concentrations in addition to symptoms and signs to predict pneumonia in patients presenting to primary care with acute cough: diagnostic study. BMJ. 2013;346:f2450.
17. Holm A, Pedersen SS, Nexoe J, Obel N, Nielsen LP, Koldkjaer O, et al. Procalcitonin versus C-reactive protein for predicting pneumonia in adults with lower respiratory tract infection in primary care. Br J Gen Pract. 2007;57:555-60.
18. Niederman MS. Biological markers to determine eligibility in trials for community-acquired pneumonia: a focus on procalcitonin. Clin Infect Dis. 2008;47:S127-32.
19. Chalmers JD, Singanayagam A, Akram AR, Mandal P, Short PM, Choudhury G, et al. Severity assessment tools for predicting mortality in hospitalised patients with community-acquired pneumonia. Systematic review and meta-analysis. Thorax. 2010;65:878-83.
20. Schuetz P, Christ-Crain M, Thomann R, Falconnier C, Wolbers M, Widmer I, et al. Effect of procalcitonin-based guidelines vs standard guidelines on antibiotic use in lower respiratory tract infections: the ProHOSP randomized controlled trial. JAMA. 2009;302:1059-66.
21. Metlay JP, Schulz R, Li YH, Singer DE, Marrie TJ, Coley CM, et al. Influence of age on symptoms at presentation in patients with community-acquired pneumonia. Arch Intern Med. 1997;157:1453-9.
22. Fine MJ, Auble TE, Yealy DM, Hanusa BH, Weissfeld LA, Singer DE, et al. A prediction rule to identify low-risk patients with community-acquired pneumonia. N Engl J Med. 1997;336:243-50.
23. Liu YF, Gao Y, Chen MF, Cao B, Yang XH, Wei L. Etiological analysis and predictive diagnostic model building of community-acquired pneumonia in adult outpatients in Beijing, China. BMC Infect Dis. 2013;13:309.
24. Noorani HZ, Adams E, Pitrak D, Belinson S, Aronson N. Future research needs on procalcitonin-guided antibiotic therapy: identification of future research needs from comparative effectiveness review No. 78 [Internet]. Rockville: Agency for Healthcare Research and Quality (US); 2013.
25. Hedlund J, Hansson LO. Procalcitonin and C-reactive protein levels in community-acquired pneumonia: correlation with etiology and prognosis. Infection. 2000;28:68-73.
26. Müller B, Harbarth S, Stolz D, Bingisser R, Mueller C, Leuppi J, et al. Diagnostic and prognostic accuracy of clinical and laboratory parameters in community-acquired pneumonia. BMC Infect Dis. 2007;7:10.
27. Rothberg MB, Pekow PS, Lahti M, Brody O, Skiest DJ, Lindenauer PK. Antibiotic therapy and treatment failure in patients hospitalized for acute exacerbations of chronic obstructive pulmonary disease. JAMA. 2010;303:2035-42.
28. Justo D, Lachmi S, Saar N, Joffe E, Atzmony L, Mashav N, et al. C-reactive protein velocity following antibiotics in patients with chronic obstructive pulmonary disease exacerbation and community acquired pneumonia. Eur J Intern Med. 2009;20:518-21.
29. Albrich WC, Müller B, Harbarth S. Antibiotic therapy in patients hospitalized with acute chronic obstructive pulmonary disease. JAMA. 2010;304:1326. author reply 1326-7.
30. Jain S, Self WH, Wunderink RG, Fakhran S, Balk R, Bramley AM, et al. Community-acquired pneumonia requiring hospitalization among U.S. adults. N Engl J Med. 2015;373:415-27.