Investigating molecular alterations to profile short- and long-term recurrence-free survival in patients with primary glioblastoma

Oncology Letters

Volumn 10, Issue 6, 2015, Pages 3599-3606

  Franceschi, Sara ^a,b   Mazzanti, Chiara M ^b   Lessi, Francesca ^b   Aretini, Paolo ^b   Carbone, Francesco G ^a   La Ferla, Marco ^b   Scatena, Cristian ^a   Ortenzi, Valerio ^a   Vannozzi, Riccardo ^a   Fanelli, Giovanni ^a   Pasqualetti, Francesco ^a   Bevilacqua, Generoso ^a   Zavaglia, Katia ^a   Naccarato, Antonio G ^a  

^a UNIVERSITY HOSPITAL OF PISA   (Italy)

^b Science Foundation of Pisa   (Italy)

Author keywords

Gene expression; Glioblastoma; Molecular alterations; Outcome prediction; Recurrence

Indexed keywords

DISINTEGRIN; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; ISOCITRATE DEHYDROGENASE 1; METALLOPROTEINASE; MICRORNA; MICRORNA 150 5P; MICRORNA 328 3P; THROMBOSPONDIN 1; UNCLASSIFIED DRUG; VON WILLEBRAND FACTOR CLEAVING PROTEINASE;

ADULT; ARTICLE; BRAIN REGION; CLINICAL ARTICLE; COPY NUMBER VARIATION; FEMALE; GENE EXPRESSION; GLIOBLASTOMA; HUMAN; LONG TERM SURVIVAL; MALE; MOLECULAR GENETICS; OUTCOME ASSESSMENT; POLYMERASE CHAIN REACTION; PRIMARY TUMOR; PROGRESSION FREE SURVIVAL; PROMOTER REGION; RECURRENCE FREE SURVIVAL; RNA EXTRACTION; SHORT TERM SURVIVAL; TUMOR LOCALIZATION; TUMOR VOLUME;

EID: 84944809855     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2015.3738     Document Type: Article

References (22)

1. Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJ, Belanger K, Brandes AA, Marosi C, Bogdahn U, et al; European Organisation for Research and Treatment of Cancer Brain Tumor and Radiotherapy Groups; and National Cancer Institute of Canada Clinical Trials Group: Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 352: 987-996, 2005.
2. Grossman SA, Ye X, Piantadosi S, Desideri S, Nabors LB, Rosenfeld M and Fisher J; NABTT CNS Consortium: Survival of patients with newly diagnosed glioblastoma treated with radiation and temozolomide on research studies in the United States. Clin Cancer Res 16: 2443-2449, 2010.
3. Hou LC, Veeravagu A, Hsu AR and Tse VC: Recurrent glioblastoma multiforme: A review of natural history and management options. Neurosurg Focus 20: E5, 2006.
4. Wong ET, Hess KR, Gleason MJ, Jaeckle KA, Kyritsis AP, Prados MD, Levin VA and Yung WK: Outcomes and prognostic factors in recurrent glioma patients enrolled onto phase II clinical trials. J Clin Oncol 17: 2572-2578, 1999.
5. Lamborn KR, Yung WK, Chang SM, Wen PY, Cloughesy TF, DeAngelis LM, Robins HI, Lieberman FS, Fine HA, Fink KL, et al; North American Brain Tumor Consortium: Progression-free survival: An important end point in evaluating therapy for recurrent high-grade gliomas. Neuro Oncol 10: 162-170, 2008.
6. Zhang W, Zhang J, Yan W, You G, Bao Z, Li S, Kang C, Jiang C, You Y, Zhang Y, et al: Whole-genome microRNA expression profiling identifies a 5-microRNA signature as a prognostic biomarker in Chinese patients with primary glioblastoma multiforme. Cancer 119: 814-824, 2013.
7. Knott JC, Mahesparan R, Garcia-Cabrera I, B�lge Tysnes B, Edvardsen K, Ness GO, M�rk S, Lund-Johansen M and Bjerkvig R: Stimulation of extracellular matrix components in the normal brain by invading glioma cells. Int J Cancer 75: 864-872, 1998.
8. Freije WA, Castro-Vargas FE, Fang Z, Horvath S, Cloughesy T, Liau LM, Mischel PS and Nelson SF: Gene expression profiling of gliomas strongly predicts survival. Cancer Res 64: 6503-6510, 2004.
9. Phillips HS, Kharbanda S, Chen R, Forrest WF, Soriano RH, Wu TD, Misra A, Nigro JM, Colman H, Soroceanu L, et al: Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. Cancer Cell 9: 157-173, 2006.
10. Berens ME and Giese A: ‘...those left behind.’ Biology and oncology of invasive glioma cells. Neoplasia 1: 208-219, 1999.
11. Besse A, Sana J, Fadrus P and Slaby O: MicroRNAs involved in chemo- and radioresistance of high-grade gliomas. Tumour Biol 34: 1969-1978, 2013.
12. Ambros V: MicroRNAs: Tiny regulators with great potential. Cell 107: 823-826, 2001.
13. Yin AA, Zhang LH, Cheng JX, Dong Y, Liu BL, Han N and Zhang X: The predictive but not prognostic value of MGMT promoter methylation status in elderly glioblastoma patients: A meta-analysis. PLoS One 9: e85102, 2014.
14. Colen RR, Vangel M, Wang J, Gutman DA, Hwang SN, Wintermark M, Jain R, Jilwan-Nicolas M, Chen JY, Raghavan P, et al; TCGA Glioma Phenotype Research Group: Imaging genomic mapping of an invasive MRI phenotype predicts patient outcome and metabolic dysfunction: A TCGA glioma phenotype research group project. BMC Med Genomics 7: 30, 2014.
15. Qiagen: Glioma Copy Number PCR Array. http://www.sabiosciences.com/copynumber_product/HTML/VAHS-0053Z.html.
16. Louis DN, Ohgaki H, Wiestler OD, Cavenee WB, Burger PC, Jouvet A, Scheithauer BW and Kleihues P: The 2007 WHO classification of tumours of the central nervous system. Acta Neuropatho 114: 97-109, 2007.
17. Jolliffe IT: Springer Series in Statistics: Principal Component Analysis. 2nd edition. Springer, NY, p28, 2002. ISBN 978-0-387-95442-4.
18. Ohgaki H and Kleihues P: The definition of primary and secondary glioblastoma. Clin Cancer Res 19: 764-772, 2013.
19. Moh MC and Shen S: The roles of cell adhesion molecules in tumor suppression and cell migration: A new paradox. Cell Adhes Migr 3: 334-336, 2009.
20. Huang S, Chen Y, Wu W, Ouyang N, Chen J, Li H, Liu X, Su F, Lin L and Yao Y: miR-150 promotes human breast cancer growth and malignant behavior by targeting the pro-apoptotic purinergic P2X7 receptor. PLoS One 8: e80707, 2013.
21. Caramuta S, Lee L, Ozata DM, Ak�akaya P, Georgii-Hemming P, Xie H, Amini RM, Lawrie CH, Enblad G, Larsson C, et al: Role of microRNAs and microRNA machinery in the pathogenesis of diffuse large B-cell lymphoma. Blood Cancer J 3: e152, 2013.
22. Wu Z, Sun L, Wang H, Yao J, Jiang C, Xu W and Yang Z: MiR-328 expression is decreased in high-grade gliomas and is associated with worse survival in primary glioblastoma. PLoS One 7: e47270, 2012.