Temporal changes in blood-brain barrier permeability and cerebral perfusion in lacunar/subcortical ischemic stroke

BMC Neurology

Volumn 15, Issue 1, 2015, Pages

  Yang, Jun ^a,b   d'Esterre, Christopher ^c   Ceruti, Stefano ^d   Roversi, Gloria ^e   Saletti, Andrea ^d   Fainardi, Enrico ^d   Lee, Ting Yim ^a,b,c  

^a LAWSON HEALTH RESEARCH INSTITUTE   (Canada)

^b ROBARTS RESEARCH INSTITUTE   (Canada)

^c UNIVERSITY OF CALGARY   (Canada)

^d UNIVERSITY HOSPITAL OF FERRARA   (Italy)

^e UNIVERSITY OF FERRARA   (Italy)

Author keywords

Blood brain barrier; Cerebral blood flow; Cerebral small vessel disease; CT perfusion; Lacunar subcortical infarct

Indexed keywords

AGED; ARTICLE; BASAL GANGLION; BLOOD BRAIN BARRIER; BLOOD VOLUME; BRAIN BLOOD FLOW; BRAIN INFARCTION; BRAIN ISCHEMIA; BRAIN PERFUSION; CEREBRAL BLOOD VOLUME; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; FEMALE; FOLLOW UP; HUMAN; HYPEREMIA; LACUNAR STROKE; MALE; NEUROIMAGING; SUBCORTICAL ISCHEMIC STROKE; THALAMUS; BRAIN CIRCULATION; CAPILLARY PERMEABILITY; CASE CONTROL STUDY; CEREBROVASCULAR ACCIDENT; COHORT ANALYSIS; DISEASE COURSE; METABOLISM; MIDDLE AGED; PERMEABILITY; PROSPECTIVE STUDY; SCINTIGRAPHY; TIME FACTOR; VASCULARIZATION; VERY ELDERLY; X-RAY COMPUTED TOMOGRAPHY;

AGED; AGED, 80 AND OVER; BASAL GANGLIA; BLOOD-BRAIN BARRIER; CAPILLARY PERMEABILITY; CASE-CONTROL STUDIES; CEREBROVASCULAR CIRCULATION; COHORT STUDIES; DISEASE PROGRESSION; FEMALE; HUMANS; MALE; MIDDLE AGED; PERFUSION IMAGING; PERMEABILITY; PROSPECTIVE STUDIES; STROKE; STROKE, LACUNAR; THALAMUS; TIME FACTORS; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84944737112     PISSN: None     EISSN: 14712377     Source Type: Journal    
DOI: 10.1186/s12883-015-0468-0     Document Type: Article

References (34)

1. Thom T, Haase N, Rosamond W, Howard VJ, Rumsfeld J, Manolio T, et al. Heart disease and stroke statistics-2006 update a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2006;113(6):e85-151.
2. Selnes OA, Vinters HV. Vascular cognitive impairment. Nat Clin Pract Neurol. 2006;2(10):538-47.
3. Wardlaw J, Sandercock P, Dennis M, Starr J. Is breakdown of the blood-brain barrier responsible for lacunar stroke, leukoaraiosis, and dementia? Stroke. 2003;34(3):806-12.
4. Norrving B. Long-term prognosis after lacunar infarction. Lancet Neurology. 2003;2(4):238-45.
5. Wen HM, Mok VC, Fan YH, Lam WW, Tang WK, Wong A, et al. Effect of white matter changes on cognitive impairment in patients with lacunar infarcts. Stroke. 2004;35(8):1826-30.
6. Farrall AJ, Wardlaw JM. Blood-brain barrier: ageing and microvascular disease-systematic review and meta-analysis. Neurobiol Aging. 2009;30(3):337-52.
7. Taheri S, Gasparovic C, Huisa BN, Adair JC, Edmonds E, Prestopnik J, et al. Blood-brain barrier permeability abnormalities in vascular cognitive impairment. Stroke. 2011;42(8):2158-63.
8. Topakian R, Barrick T, Howe F, Markus H. Blood-brain barrier permeability is increased in normal-appearing white matter in patients with lacunar stroke and leucoaraiosis. J Neurol Neurosurg Psychiatry. 2010;81(2):192-7.
9. Wardlaw JM, Doubal F, Armitage P, Chappell F, Carpenter T, Muñoz Maniega S, et al. Lacunar stroke is associated with diffuse blood-brain barrier dysfunction. Ann Neurol. 2009;65(2):194-202.
10. Wardlaw JM, Farrall A, Armitage PA, Carpenter T, Chappell F, Doubal F, et al. Changes in background blood-brain barrier integrity between lacunar and cortical ischemic stroke subtypes. Stroke. 2008;39(4):1327-32.
11. Benisty S, Gouw AA, Porcher R, Madureira S, Hernandez K, Poggesi A, et al. Location of lacunar infarcts correlates with cognition in a sample of non-disabled subjects with age-related white-matter changes: the LADIS study. J Neurol Neurosurg Psychiatry. 2009;80(5):478-83.
12. Gold G, Kövari E, Herrmann FR, Canuto A, Hof PR, Michel J-P, et al. Cognitive consequences of thalamic, basal ganglia, and deep white matter lacunes in brain aging and dementia. Stroke. 2005;36(6):1184-8.
13. d'Esterre C, Fainardi E, Aviv R, Lee T. Improving acute stroke management with computed tomography perfusion: a review of imaging basics and applications. Translational Stroke Research. 2012;3(2):205-20.
14. Hoeffner EG, Case I, Jain R, Gujar SK, Shah GV, Deveikis JP, et al. Cerebral perfusion CT: technique and clinical applications 1. Radiology. 2004;231(3):632-44.
15. Wintermark M, Sesay M, Barbier E, Borbély K, Dillon WP, Eastwood JD, et al. Comparative overview of brain perfusion imaging techniques. Stroke. 2005;36(9):e83-99.
16. Brott T, Adams H, Olinger CP, Marler JR, Barsan WG, Biller J, et al. Measurements of acute cerebral infarction: a clinical examination scale. Stroke. 1989;20(7):864-70.
17. Van Swieten J, Koudstaal P, Visser M, Schouten H, Van Gijn J. Interobserver agreement for the assessment of handicap in stroke patients. Stroke. 1988;19(5):604-7.
18. Lee T-Y. Functional CT: physiological models. Trends Biotechnol. 2002;20(8):S3-10.
19. St. Lawrence K, Lee T-Y. An adiabatic approximation to the tissue homogeneity model for water exchange in the brain: I. Theoretical derivation. J Cereb Blood Flow Metab. 1998;18(12):1365-77.
20. Wardlaw JM, Doubal FN, Valdes-Hernandez M, Wang X, Chappell FM, Shuler K, et al. Blood-brain barrier permeability and long-term clinical and imaging outcomes in cerebral small vessel disease. Stroke. 2013;44(2):525-7.
21. Snowdon DA, Greiner LH, Mortimer JA, Riley KP, Greiner PA, Markesbery WR. Brain infarction and the clinical expression of Alzheimer disease: the Nun Study. JAMA. 1997;277(10):813-7.
22. Markus H, Lythgoe D, Ostegaard L, O'sullivan M, Williams S. Reduced cerebral blood flow in white matter in ischaemic leukoaraiosis demonstrated using quantitative exogenous contrast based perfusion MRI. J Neurol Neurosurg Psychiatry. 2000;69(1):48-53.
23. O'sullivan M, Lythgoe D, Pereira A, Summers P, Jarosz J, Williams S, et al. Patterns of cerebral blood flow reduction in patients with ischemic leukoaraiosis. Neurology. 2002;59(3):321-6.
24. Lin C-Y, Chang C, Cheung W-M, Lin M-H, Chen J-J, Hsu CY, et al. Dynamic changes in vascular permeability, cerebral blood volume, vascular density, and size after transient focal cerebral ischemia in rats: evaluation with contrast-enhanced magnetic resonance imaging. J Cereb Blood Flow Metab. 2008;28(8):1491-501.
25. Durukan A, Marinkovic I, Strbian D, Pitkonen M, Pedrono E, Soinne L, et al. Post-ischemic blood-brain barrier leakage in rats: one-week follow-up by MRI. Brain Res. 2009;1280:158-65.
26. Yang G-Y, Betz AL. Reperfusion-induced injury to the blood-brain barrier after middle cerebral artery occlusion in rats. Stroke. 1994;25(8):1658-64.
27. Kaur J, Tuor UI, Zhao Z, Barber PA. Quantitative MRI reveals the elderly ischemic brain is susceptible to increased early blood-brain barrier permeability following tissue plasminogen activator related to claudin 5 and occludin disassembly. J Cereb Blood Flow Metab. 2011;31(9):1874-85.
28. Yepes M, Roussel BD, Ali C, Vivien D. Tissue-type plasminogen activator in the ischemic brain: more than a thrombolytic. Trends Neurosci. 2009;32(1):48-55.
29. Shahi V, Fugate J, Kallmes D, Rabinstein A. Early basal ganglia hyperperfusion on CT perfusion in acute ischemic stroke: a marker of irreversible damage? Am J Neuroradiol. 2014;35(9):1688-92.
30. Shen Q, Du F, Huang S, Duong TQ. Spatiotemporal characteristics of postischemic hyperperfusion with respect to changes in T1, T2, diffusion, angiography, and blood-brain barrier permeability. J Cereb Blood Flow Metab. 2011;31(10):2076-85.
31. Wallin A, Blennow K, Fredman P, Gottfries C, Karlsson I, Svennerholm L. Blood brain barrier function in vascular dementia. Acta Neurol Scand. 1990;81(4):318-22.
32. O'Connor JPB, Tofts PS, Miles KA, Parkes LM, Thompson G, Jackson A. Dynamic contrast-enhanced imaging techniques: CT and MRI. Br J Radiol. 2011;84(S2):S112-20.
33. Hara AK, Paden RG, Silva AC, Kujak JL, Lawder HJ, Pavlicek W. Iterative reconstruction technique for reducing body radiation dose at CT: feasibility study. Am J Roentgenol. 2009;193(3):764-71.
34. Murphy A, So A, Lee T-Y, Symons S, Jakubovic R, Zhang L, et al. Low dose CT perfusion in acute ischemic stroke. Neuroradiology. 2014;56(12):1055-62.