Different T cells’ distribution and activation degree of th17 CD4+ cells in peripheral blood in patients with osteoarthritis, rheumatoid arthritis, and healthy donors: Preliminary results of the magenta clicao study

Open Access Rheumatology: Research and Reviews

Volumn 7, Issue , 2015, Pages 63-68

  Lurati, Alfredomaria ^a   Laria, Antonella ^a   Gatti, Arianna ^b   Brando, Bruno ^b   Scarpellini, Magda ^a  

^a Ospedale G Fornaroli   (Italy)

^b Legnano Hospital   (Italy)

Author keywords

Flow cytometry; Osteoarthritis; Th17

Indexed keywords

CD3 ANTIGEN; CD38 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CHEMOKINE RECEPTOR CCR6; CHEMOKINE RECEPTOR CXCR3; HLA DR ANTIGEN;

ADULT; ARTICLE; BLOOD ANALYSIS; CD4+ T LYMPHOCYTE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; FEMALE; HIP OSTEOARTHRITIS; HUMAN; HUMAN CELL; KNEE OSTEOARTHRITIS; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; RHEUMATOID ARTHRITIS; T LYMPHOCYTE SUBPOPULATION; TH17 CELL;

EID: 84944731348     PISSN: None     EISSN: 1179156X     Source Type: Journal    
DOI: 10.2147/OARRR.S81905     Document Type: Article

References (41)

1. Lories RJ, Luyten FP. The bone-cartilage unit in osteoarthritis. Nat Rev Rheumatol. 2011;7(1):43–49.
2. Egloff C, Hügle T, Valderrabano V. Biomechanics and pathomechanisms of osteoarthritis. Swiss Med Wkly. 2012;142:w13583.
3. Smith MD, Triantafillou S, Parker A, Youssef PP, Coleman M. Synovial membrane inflammation and cytokine production in patients with early osteoarthritis. J Rheumatol. 1997;24(2):365–371.
4. Berembaum F. Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!). Osteoarthritis Cartilage. 2013;21(1):16–21.
5. Revell PA, Mayston V, Lalor P, Mapp P. The synovial membrane in osteoarthritis: a histological study including the characterization of the cellular infiltrate present in inflammatory osteoarthritis using monoclonal antibodies. Ann Rheum Dis. 1988;47(4):300–307.
6. Ayral X, Pickering EH, Woodworth TG, Mackillop N, Dougados M. Synovitis: a potential predictive factor of structural progression of medial tibiofemoral knee osteoarthritis results of a year longitudinal arthroscopic study in 422 patients. Osteoarthritis Cartilage. 2005;13(5):361–367.
7. Hill CL, Hunter DJ, Niu J, et al. Synovitis detected on magnetic resonance imaging and its relation to pain and cartilage loss in knee osteoarthritis. Ann Rheum Dis. 2007;66(12):1599–1603.
8. Haraoui B, Pelletier JP, Cloutier JM, Faure MP, Martel-Pelletier J. Synovial membrane histology and immunopathology in rheumatoid arthritis and osteoarthritis. II. In vivo effects of antirheumatic drugs. Arthritis Rheum. 1991;34(2):153–163.
9. Kennedy ID, Plater-Zyberk C, Partridge TA, Woodrow DF, Maini RN. Morphometric comparison of synovium from patients with osteoarthritis and rheumatoid arthritis. J Clin Pathol. 1988;41(8):847–852.
10. Lindblad S, Hedfors E. Arthroscopic and immunohistologic charac­terization of knee joint synovitis in osteoarthritis. Arthritis Rheum. 1987;30(10):1081–1088.
11. Myers SL, Brandt KD, Ehlich JW, et al. Synovial inflammation in patients with early osteoarthritis of the knee. J Rheumatol. 1990;17(12): 1662–1669.
12. Orita S, Koshi T, Mitsuka T, et al. Associations between proinflammatory cytokines in the synovial fluid and radiographic grading and pain-related scores in 47 consecutive patients with osteoarthritis of the knee. BMC Musculoskelet Disord. 2011;12:144.
13. Lùrati A, Laria A, Mazzocchi D, Re KA, Marrazza M, Scarpellini M. Effects of hyaluronic acid (HA) viscosupplementation on peripheral Th cells in knee and hip osteoarthritis. Osteoarthritis Cartilage. 2015;23(1): 88–93.
14. Ishii H, Tanaka H, Katoh K, Nakamura H, Nagashima M, Yoshino S. Characterization of infiltrating T cells and Th1/Th2 type cytokines in the synovium pf patients with osteoarthritis. Osteoarthritis Cartilage. 2002;10(4):277–281.
15. Sakkas LI, Scanzello C, Johanson N, et al. T cells and T cell cytokine transcripts in the synovial membrane in patients with osteoarthritis. Clin Diagn Lab Immunol. 1988;5(4):430–437.
16. Saito I, Koshino T, Nakashima K, Uesugi M, Saito T. Increased cellular infiltrate in inflammatory synovia of osteoarthritic knees. Osteoarthritis Cartilage. 2002;10(2):156–162.
17. De Lange-Brokaar BJ, Ioan-Facsinay A, van Osch GJ, et al. Synovial inflammation, immune cells and their cytokines in osteoarthritis: a review. Osteoarthritis Cartilage. 2012;20(12):1484–1499.
18. Kuryliszyn-Moskal A. Comparison of blood and synovial fluid lympho­cyte subsets in rheumatoid arthritis and osteoarthritis. Clin Rheumatol. 1995;14(1):43–50.
19. Hussein MR, Fathi NA, El-Din AM, et al. Alterations of the CD4(+), CD8(+) T cell subsets, interleukins-1beta, IL-10, IL-17, tumor necrosis factor-alpha and soluble intercellular adhesion molecule-1 in rheumatoid arthritis and osteoarthritis: preliminary observations. Pathol Oncol Res. 2008;14(3):321–328.
20. Nistala K, Adams S, Cambrook H, et al. Th17 plasticity in human autoimmune arthritis is driven by the inflammatory environment. Proc Natl Acad Sci U S A. 2010;107(33):14751–14756.
21. Maecker HT, McCoy JP, Nussenblatt R. Standardizing immunopheno­typing for the Human Immunology Project. Nat Rev Immunol 2012. Feb 17;12(3):191–200.
22. Conrozier T, Chappuis-Cellier C, Richard M, Mathieu P, Richard S, Vignon E. Increased serum C-reactive protein levels by immunoneph­elometry in patients with rapidly destructive hip osteoarthritis. Rev Rhum Engl Ed. 1998;65(12):759–765.
23. Spector TD, Hart DJ, Nandra D, et al. Low-level increases in serum C-reactive protein are present in early osteoarthritis of the knee and predict progressive disease. Arthritis Rheum. 1997;40(4):723–727.
24. Sharif M, Elson CJ, Dieppe PA, Kirwan JR. Elevated serum C-reactive protein levels in osteoarthritis. Br J Rheumatol. 1997;36(1):140–141.
25. Wolfe F. The C-reactive protein but not erythrocyte sedimentation rate is associated with clinical severity in patients with osteoarthritis of the knee or hip. J Rheumatol. 1997;24(8):1486–1488.
26. Haywood L, McWilliams DF, Pearson CI, et al. Inflammation and angio­genesis in osteoarthritis. Arthritis Rheum. 2003;48(8):2173–2177.
27. Dong W, Zhu P. Functional niche of inflamed synovium for Th17 cell expansion and activation in rheumatoid arthritis:implication to clinical therapeutics. Autoimmun Rev. 2012;11(12):844–851.
28. Jimeno R, Gomariz RP, Garín M, et al. The pathogenic Th profile of human activated memory Th cells in early rheumatoid arthritis can be modulated by VIP. J Mol Med (Berl). 2015;93(4):457–467.
29. Gallelli L, Galasso O, Falcone D, et al. The effects of non-steroidal anti-inflammatory drugs on clinical outcomes, synovial fluid cytokine concentration and signal transduction pathways in knee osteoarthritis. A randomized open label trial. Osteoarthritis Cartilage. 2013;21(9):1400–1408.
30. Farahat MN, Yanni G, Poston R, Panayi GS. Cytokine expression in syn­ovial membranes of patients with rheumatoid arthritis and osteoarthritis. Ann Rheum Dis. 1993;52(12):870–887.
31. Bianchi M, Broggini M, Balzarini P, Franchi S, Sacerdote P. Effects of nimesulide on pain and on synovial fluid concentrations of substance P, interleukin-6 and interleukin-8 in patients with knee osteoarthritis: comparison with celecoxib. Int J Clin Pract. 2007;61(8):1270–1277.
32. Schumacher HR Jr, Meng Z, Sieck M, et al. Effect of a nonsteroidal anti-inflammatory drug on synovial fluid in osteoarthritis. J Rheumatol. 1996;23(10):1774–1777.
33. Alvarez-Soria MA, Largo R, Santillana J, et al. Long term NSAID treatment inhibits COX-2 synthesis in the knee synovial membrane of patients with osteoarthritis: differential pro-inflammatory cytokine profile between celecoxib and aceclofenac. Ann Rheum Dis. 2006;65(8):998–1005.
34. Lubberts E, Koenders MI, Oppers-Walgrenn B, et al. Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion. Arthritis Rheum. 2004;50(2):650–659.
35. Benedetti G, Miossec P. Interleukin 17 contributes to the chronicity of inflammatory diseases such as rheumatoid arthritis. Eur J Immunol. 2014;44(2):339–347.
36. Kim J, Kang S, Kim JK, Kwon G, Koo S. Elevated levels of T helper 17 cells are associated with disease activity in patients with rheumatoid arthritis. Ann Lab Med. 2013;33(1):52–59.
37. Ghoreschi K, Laurence A, Yang XP, Hirahara K, O’Shea JJ. T helper 17 cell heterogeneity and pathogenicity in autoimmune disease. Trends Immunol. 2011;39(9):395–401.
38. Lexberg MH, Taubner A, Albrecht I, et al. IFNγ and IL-12 synergize to convert in vivo generated Th17 into Th1/Th17 cells. Eur J Immunol. 2010;40(11):3017–3027.
39. Annunziato F, Cosmi L, Santarlasci V, et al. Phenotypic and functional features of human Th17 cells. J Exp Med. 2007;204(8):1849–1861.
40. Lee YK, Turner H, Maynard CL, et al. Late developmental plasticity in the T helper 17 lineage. Immunity. 2009;30(1):92–107.
41. Honorati MC, Bovara M, Cattini L, Piacentini A, Facchini A. Contribution of interleukin 17 to human cartilage degradation and synovial inflammation in osteoarthritis. Osteoarthritis Cartilage. 2002; 10(10):799–807.