Effect of the oral thrombin inhibitor dabigatran on allergic lung inflammation induced by repeated house dust mite administration in mice

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 309, Issue 8, 2015, Pages L768-L775

  de Boer, Johannes D ^a   Berkhout, Lea C ^a   de Stoppelaar, Sacha F ^a   Yang, Jack ^a   Ottenhoff, Roelof ^a   Meijers, Joost C M ^a,b   Roelofs, Joris J T H ^a   van’t Veer, Cornelis ^a   van der Poll, Tom ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b SANQUIN RESEARCH   (Netherlands)

Author keywords

Asthma; Dabigatran; House dust mite; Thrombin

Indexed keywords

DABIGATRAN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G1; INTERLEUKIN 4; INTERLEUKIN 5; PLACEBO; ALLERGEN; ANTITHROMBIN; ANTITHROMBIN III; ANTITHROMBIN III-PROTEASE COMPLEX; AUTACOID; FIBRIN DEGRADATION PRODUCT; FIBRIN FRAGMENT D; HOUSE DUST ALLERGEN; PEPTIDE HYDROLASE;

ALLERGIC PNEUMONITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD CLOTTING; DERMATOPHAGOIDES; DRUG EFFECT; EOSINOPHIL; HUMAN; LUNG LAVAGE; MOUSE; MUCUS; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; TH2 CELL; ANIMAL; ASTHMA; BLOOD; BRONCHOALVEOLAR LAVAGE FLUID; C57BL MOUSE; DERMATOPHAGOIDES PTERONYSSINUS; DISEASE MODEL; DRUG EFFECTS; FEMALE; IMMUNOLOGY; LUNG; MALE; METABOLISM; ORAL DRUG ADMINISTRATION; PATHOLOGY;

ADMINISTRATION, ORAL; ALLERGENS; ANIMALS; ANTIGENS, DERMATOPHAGOIDES; ANTITHROMBIN III; ANTITHROMBINS; ASTHMA; BLOOD COAGULATION; BRONCHOALVEOLAR LAVAGE FLUID; DABIGATRAN; DERMATOPHAGOIDES PTERONYSSINUS; DISEASE MODELS, ANIMAL; FEMALE; FIBRIN FIBRINOGEN DEGRADATION PRODUCTS; HUMANS; INFLAMMATION MEDIATORS; LUNG; MALE; MICE; MICE, INBRED C57BL; PEPTIDE HYDROLASES;

EID: 84944474531     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00102.2015     Document Type: Article

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