CXorf61 is a target for T cell based immunotherapy of triplenegative breast cancer

Oncotarget

Volumn 6, Issue 28, 2015, Pages 25356-25367

  Paret, Claudia ^a   Simon, Petra ^b   Vormbrock, Kirsten ^a   Bender, Christian ^a   Kölsch, Anne ^b   Breitkreuz, Andrea ^b   Yildiz, Özlem ^b   Omokoko, Tana ^b   Hubich Rau, Stefanie ^a   Hartmann, Christoph ^a   Häcker, Sabine ^a   Wagner, Meike ^a   Roldan, Diana Barea ^a   Selmi, Abderaouf ^a   Türeci, Özlem ^a   Sahin, Ugur ^a,b  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b BIONTECH AG   (Germany)

Author keywords

CD8+ T cell epitope; CXorf61; Immunotherapy; T cell receptor cloning; TNBC

Indexed keywords

CANCER TESTIS ANTIGEN; DECITABINE; EPITOPE; HLA A ANTIGEN; MESSENGER RNA; PROTEIN CXORF61; RNA; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; CANCER VACCINE; HLA A2 ANTIGEN; HLA-A*02 ANTIGEN; HLA-A*02:01 ANTIGEN; KITA-KYUSHU LUNG CANCER ANTIGEN 1, HUMAN; LYMPHOCYTE ANTIGEN RECEPTOR; RECOMBINANT VACCINE; TUMOR ANTIGEN;

ADULT; AGED; ANIMAL EXPERIMENT; ARTICLE; BREAST CANCER CELL LINE; CANCER IMMUNOTHERAPY; CD8+ T LYMPHOCYTE; CELL ISOLATION; CONTROLLED STUDY; DENDRITIC CELL; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNIZATION; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MALE; MOLECULAR CLONING; MONOCYTE; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TESTIS; TRANSGENIC MOUSE; TRIPLE NEGATIVE BREAST CANCER; VACCINATION; VERY ELDERLY; ANIMAL; COCULTURE; DNA METHYLATION; EPITOPE MAPPING; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; HEK293 CELL LINE; IMMUNOLOGY; K-562 CELL LINE; METABOLISM; MIDDLE AGED; TRIPLE NEGATIVE BREAST NEOPLASMS; TUMOR ASSOCIATED LEUKOCYTE;

ADULT; AGED; AGED, 80 AND OVER; ANIMALS; ANTIGENS, NEOPLASM; CANCER VACCINES; CD8-POSITIVE T-LYMPHOCYTES; CLONING, MOLECULAR; COCULTURE TECHNIQUES; DNA METHYLATION; EPITOPE MAPPING; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HEK293 CELLS; HLA-A2 ANTIGEN; HUMANS; IMMUNIZATION SCHEDULE; K562 CELLS; LYMPHOCYTES, TUMOR-INFILTRATING; MICE, TRANSGENIC; MIDDLE AGED; RECEPTORS, ANTIGEN, T-CELL; RNA, MESSENGER; TRANSFECTION; TRIPLE NEGATIVE BREAST NEOPLASMS; VACCINES, SYNTHETIC;

EID: 84944458235     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.4516     Document Type: Article

References (29)

1. Perou CM, Sorlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, Pollack JR, Ross DT, Johnsen H, Akslen LA, Fluge O, Pergamenschikov A, Williams C, et al. Molecular portraits of human breast tumours. Nature. 2000; 406:747-752.
2. Hudis CA, Gianni L. Triple-negative breast cancer: an unmet medical need. Oncologist. 2011; 16:1-11.
3. Liu S, Lachapelle J, Leung S, Gao D, Foulkes WD, Nielsen TO. CD8+ lymphocyte infiltration is an independent favorable prognostic indicator in basal-like breast cancer. Breast Cancer Res. 2012; 14:R48.
4. Caballero OL, Chen YT. Cancer/testis (CT) antigens: potential targets for immunotherapy. Cancer Sci. 2009; 100:2014-2021.
5. Scanlan MJ, Gure AO, Jungbluth AA, Old LJ, Chen YT. Cancer/testis antigens: an expanding family of targets for cancer immunotherapy. Immunol Rev. 2002; 188:22-32.
6. Novellino L, Castelli C, Parmiani G. A listing of human tumor antigens recognized by T cells: March 2004 update. Cancer Immunol Immunother. 2005; 54:187-207.
7. Simon P, Omokoko TA, Breitkreuz A, Hebich L, Kreiter S, Attig S, Konur A, Britten CM, Paret C, Dhaene K, Tureci O, Sahin U. Functional TCR retrieval from single antigenspecific human T cells reveals multiple novel epitopes. Cancer Immunol Res. 2014; 2:1230-1244.
8. Tureci O, Mack U, Luxemburger U, Heinen H, Krummenauer F, Sester M, Sester U, Sybrecht GW, Sahin U. Humoral immune responses of lung cancer patients against tumor antigen NY-ESO-1. Cancer Lett. 2006; 236:64-71.
9. Grigoriadis A, Caballero OL, Hoek KS, da Silva L, Chen YT, Shin SJ, Jungbluth AA, Miller LD, Clouston D, Cebon J, Old LJ, Lakhani SR, Simpson AJ, et al. CT-X antigen expression in human breast cancer. Proc Natl Acad Sci U S A. 2009; 106:13493-13498.
10. Fukuyama T, Hanagiri T, Takenoyama M, Ichiki Y, Mizukami M, So T, Sugaya M, Sugio K, Yasumoto K. Identification of a new cancer/germline gene, KK-LC-1, encoding an antigen recognized by autologous CTL induced on human lung adenocarcinoma. Cancer Res. 2006; 66:4922-4928.
11. Yao J, Caballero OL, Yung WK, Weinstein JN, Riggins GJ, Strausberg RL, Zhao Q. Tumor subtypespecific cancer-testis antigens as potential biomarkers and immunotherapeutic targets for cancers. Cancer Immunol Res. 2014; 2:371-379.
12. Spurgeon SL, Jones RC, Ramakrishnan R. High throughput gene expression measurement with real time PCR in a microfluidic dynamic array. PLoS One. 2008; 3:e1662.
13. Anders CK, Carey LA. Biology, metastatic patterns, and treatment of patients with triple-negative breast cancer. Clin Breast Cancer. 2009; 9:S73-81.
14. Dent R, Trudeau M, Pritchard KI, Hanna WM, Kahn HK, Sawka CA, Lickley LA, Rawlinson E, Sun P, Narod SA. Triple-negative breast cancer: clinical features and patterns of recurrence. Clin Cancer Res. 2007; 13:4429-4434.
15. Chavez KJ, Garimella SV, Lipkowitz S. Triple negative breast cancer cell lines: one tool in the search for better treatment of triple negative breast cancer. Breast Dis. 2010; 32:35-48.
16. Kraus MH, Popescu NC, Amsbaugh SC, King CR. Overexpression of the EGF receptor-related proto-oncogene erbB-2 in human mammary tumor cell lines by different molecular mechanisms. EMBO J. 1987; 6:605-610.
17. Rammensee H, Bachmann J, Emmerich NP, Bachor OA, Stevanovic S. SYFPEITHI: database for MHC ligands and peptide motifs. Immunogenetics. 1999; 50:213-219.
18. Hofmann O, Caballero OL, Stevenson BJ, Chen YT, Cohen T, Chua R, Maher CA, Panji S, Schaefer U, Kruger A, Lehvaslaiho M, Carninci P, Hayashizaki Y, et al. Genome-wide analysis of cancer/testis gene expression. Proc Natl Acad Sci U S A. 2008; 105:20422-20427.
19. Morgan RA, Chinnasamy N, Abate-Daga D, Gros A, Robbins PF, Zheng Z, Dudley ME, Feldman SA, Yang JC, Sherry RM, Phan GQ, Hughes MS, Kammula US, et al. Cancer regression and neurological toxicity following anti-MAGE-A3 TCR gene therapy. J Immunother. 2013; 36:133-151.
20. Ademuyiwa FO, Bshara W, Attwood K, Morrison C, Edge SB, Karpf AR, James SA, Ambrosone CB, O'Connor TL, Levine EG, Miliotto A, Ritter E, Ritter G, et al. NY-ESO-1 cancer testis antigen demonstrates high immunogenicity in triple negative breast cancer. PLoS One. 2012; 7:e38783.
21. Curigliano G, Viale G, Ghioni M, Jungbluth AA, Bagnardi V, Spagnoli GC, Neville AM, Nole F, Rotmensz N, Goldhirsch A. Cancer-testis antigen expression in triple-negative breast cancer. Ann Oncol. 2011; 22:98-103.
22. Zhao M, Ramaswamy B. Mechanisms and therapeutic advances in the management of endocrine-resistant breast cancer. World J Clin Oncol. 2014; 5:248-262.
23. Holtkamp S, Kreiter S, Selmi A, Simon P, Koslowski M, Huber C, Tureci O, Sahin U. Modification of antigenencoding RNA increases stability, translational efficacy, and T-cell stimulatory capacity of dendritic cells. Blood. 2006; 108:4009-4017.
24. Pajot A, Michel ML, Fazilleau N, Pancre V, Auriault C, Ojcius DM, Lemonnier FA, Lone YC. A mouse model of human adaptive immune functions: HLA-A2.1-/HLADR1-transgenic H-2 class I-/class II-knockout mice. Eur J Immunol. 2004; 34:3060-3069.
25. Kreiter S, Selmi A, Diken M, Koslowski M, Britten CM, Huber C, Tureci O, Sahin U. Intranodal vaccination with naked antigen-encoding RNA elicits potent prophylactic and therapeutic antitumoral immunity. Cancer Res. 2010; 70:9031-9040.
26. Bonehill A, Tuyaerts S, Van Nuffel AM, Heirman C, Bos TJ, Fostier K, Neyns B, Thielemans K. Enhancing the T-cell stimulatory capacity of human dendritic cells by co-electroporation with CD40L, CD70 and constitutively active TLR4 encoding mRNA. Mol Ther. 2008; 16:1170-1180.
27. Brochet X, Lefranc MP, Giudicelli V. IMGT/V-QUEST: the highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis. Nucleic Acids Res. 2008; 36:W503-508.
28. Giudicelli V, Chaume D, Lefranc MP. IMGT/GENE-DB: a comprehensive database for human and mouse immunoglobulin and T cell receptor genes. Nucleic Acids Res. 2005; 33:D256-261.
29. Schagger H, von Jagow G. Tricine-sodium dodecyl sulfatepolyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. Anal Biochem.