Chronic treadmill running does not enhance mitochondrial oxidative capacity in the cortex or striatum

Metabolism: Clinical and Experimental

Volumn 64, Issue 11, 2015, Pages 1419-1425

  Herbst, Eric A F ^a   Roussakis, Christina ^a   Matravadia, Sarthak ^a   Holloway, Graham P ^a  

^a UNIVERSITY OF GUELPH   (Canada)

Author keywords

Biogenesis; Brain; Exercise; Mitochondria; mtDNA

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MITOCHONDRIAL DNA; MITOCHONDRIAL PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA;

ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOGENESIS; BRAIN CORTEX; BRAIN MITOCHONDRION; CHRONIC EXERCISE; CONTROLLED STUDY; CORPUS STRIATUM; EXERCISE; GENE DOSAGE; MALE; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN PHOSPHORYLATION; RESPIRATORY CHAIN; SEDENTARY LIFESTYLE; TREADMILL EXERCISE; VASTUS LATERALIS MUSCLE; ANIMAL; C57BL MOUSE; METABOLISM; MITOCHONDRION; OXIDATION REDUCTION REACTION;

ANIMALS; CEREBRAL CORTEX; CORPUS STRIATUM; DNA, MITOCHONDRIAL; MALE; MICE; MICE, INBRED C57BL; MITOCHONDRIA; OXIDATION-REDUCTION; OXIDATIVE PHOSPHORYLATION; PHYSICAL CONDITIONING, ANIMAL;

EID: 84944442259     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2015.07.002     Document Type: Article

References (36)

1. J.O. Holloszy Biochemical adaptations in muscle. Effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscle J Biol Chem 242 1967 2278 2282
2. J.O. Holloszy, and E.F. Coyle Adaptations of skeletal muscle to endurance exercise and their metabolic consequences J Appl Physiol Respir Environ Exerc Physiol 56 1984 831 838
3. I. Irrcher, P.J. Adhihetty, A.M. Joseph, V. Ljubicic, and D.A. Hood Regulation of mitochondrial biogenesis in muscle by endurance exercise Sports Med 33 2003 783 793
4. T. Matsui, S. Soya, M. Okamoto, Y. Ichitani, K. Kawanaka, and H. Soya Brain glycogen decreases during prolonged exercise J Physiol 589 2011 3383 3393
5. L. Kirchner, W.Q. Chen, L. Afjehi-Sadat, A. Viidik, M. Skalicky, H. Hoger, and et al. Hippocampal metabolic proteins are modulated in voluntary and treadmill exercise rats Exp Neurol 212 2008 145 151
6. J.L. Steiner, E.A. Murphy, J.L. McClellan, M.D. Carmichael, and J.M. Davis Exercise training increases mitochondrial biogenesis in the brain J Appl Physiol 111 2011 1066 1071
7. D.A. Hood Invited review: contractile activity-induced mitochondrial biogenesis in skeletal muscle J Appl Physiol 90 2001 1137 1157
8. A. Safdar, J.P. Little, A.J. Stokl, B.P. Hettinga, M. Akhtar, and M.A. Tarnopolsky Exercise increases mitochondrial PGC-1alpha content and promotes nuclear-mitochondrial cross-talk to coordinate mitochondrial biogenesis J Biol Chem 286 2011 10605 10617
9. H. Wu, S.B. Kanatous, F.A. Thurmond, T. Gallardo, E. Isotani, R. Bassel-Duby, and et al. Regulation of mitochondrial biogenesis in skeletal muscle by CaMK Science 296 2002 349 352
10. H. Zong, J.M. Ren, L.H. Young, M. Pypaert, J. Mu, and M.J. Birnbaum AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation Proc Natl Acad Sci U S A 99 2002 15983 15987
11. J. Dine, V.R. Ducourneau, V.S. Fenelon, P. Fossat, A. Amadio, M. Eder, and et al. Extracellular signal-regulated kinase phosphorylation in forebrain neurones contributes to osmoregulatory mechanisms J Physiol 592 2014 1637 1654
12. J. Lisman, H. Schulman, and H. Cline The molecular basis of CaMKII function in synaptic and behavioural memory Nat Rev Neurosci 3 2002 175 190
13. S. Ramamurthy, and G. Ronnett AMP-activated protein kinase (AMPK) and energy-sensing in the brain Exp Neurobiol 21 2012 52 60
14. T. Williams, J. Courchet, B. Viollet, J.E. Brenman, and F. Polleux AMP-activated protein kinase (AMPK) activity is not required for neuronal development but regulates axogenesis during metabolic stress Proc Natl Acad Sci U S A 108 2011 5849 5854
15. S. Amato, X. Liu, B. Zheng, L. Cantley, P. Rakic, and H.Y. Man AMP-activated protein kinase regulates neuronal polarization by interfering with PI 3-kinase localization Science 332 2011 247 251
16. M. Alonso, M. Melani, D. Converso, A. Jaitovich, C. Paz, M.C. Carreras, and et al. Mitochondrial extracellular signal-regulated kinases 1/2 (ERK1/2) are modulated during brain development J Neurochem 89 2004 248 256
17. A. Cheng, Y. Hou, and M.P. Mattson Mitochondria and neuroplasticity ASN Neuro 2 2010 256 [e00045]
18. I. Marques-Aleixo, P.J. Oliveira, P.I. Moreira, J. Magalhaes, and A. Ascensao Physical exercise as a possible strategy for brain protection: evidence from mitochondrial-mediated mechanisms Prog Neurobiol 99 2012 149 162
19. I.G. Onyango, J. Lu, M. Rodova, E. Lezi, A.B. Crafter, and R.H. Swerdlow Regulation of neuron mitochondrial biogenesis and relevance to brain health Biochim Biophys Acta 1802 2010 228 234
20. L. Castellani, J. Root-Mccaig, S. Frendo-Cumbo, M.S. Beaudoin, and D.C. Wright Exercise training protects against an acute inflammatory insult in mouse epididymal adipose tissue J Appl Physiol 116 2014 1272 1280
21. E.A. Herbst, S. Paglialunga, C. Gerling, J. Whitfield, K. Mukai, A. Chabowski, and et al. Omega-3 supplementation alters mitochondrial membrane composition and respiration kinetics in human skeletal muscle J Physiol 592 Pt 6 2014 1341 1352
22. C.G. Perry, D.A. Kane, E.A. Herbst, K. Mukai, D.S. Lark, D.C. Wright, and et al. Mitochondrial creatine kinase activity and phosphate shuttling are acutely regulated by exercise in human skeletal muscle J Physiol 590 2012 5475 5486
23. E.A. Herbst, and G.P. Holloway Permeabilization of brain tissue in situ enables multiregion analysis of mitochondrial function in a single mouse brain J Physiol 593 2015 787 801
24. C.R. Benton, J.G. Nickerson, J. Lally, X.X. Han, G.P. Holloway, J.F. Glatz, and et al. Modest PGC-1alpha overexpression in muscle in vivo is sufficient to increase insulin sensitivity and palmitate oxidation in subsarcolemmal, not intermyofibrillar, mitochondria J Biol Chem 283 2008 4228 4240
25. M. Takimoto, and T. Hamada Acute exercise increases brain region-specific expression of MCT1, MCT2, MCT4, GLUT1, and COX IV proteins J Appl Physiol 116 2014 1238 1250
26. T. Akimoto, S.C. Pohnert, P. Li, M. Zhang, C. Gumbs, P.B. Rosenberg, and et al. Exercise stimulates Pgc-1alpha transcription in skeletal muscle through activation of the p38 MAPK pathway J Biol Chem 280 2005 19587 19593
27. Y. Ho, E. Logue, C.W. Callaway, and D.B. DeFranco Different mechanisms account for extracellular-signal regulated kinase activation in distinct brain regions following global ischemia and reperfusion Neuroscience 145 2007 248 255
28. D.T. Chang, A.S. Honick, and I.J. Reynolds Mitochondrial trafficking to synapses in cultured primary cortical neurons J Neurosci 26 2006 7035 7045
29. A.F. MacAskill, and J.T. Kittler Control of mitochondrial transport and localization in neurons Trends Cell Biol 20 2010 102 112
30. E. Ylikallio, H. Tyynismaa, H. Tsutsui, T. Ide, and A. Suomalainen High mitochondrial DNA copy number has detrimental effects in mice Hum Mol Genet 19 2010 2695 2705
31. A. Safdar, J.M. Bourgeois, D.I. Ogborn, J.P. Little, B.P. Hettinga, M. Akhtar, and et al. Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator mice Proc Natl Acad Sci U S A 108 2011 4135 4140
32. Q. Zhang, Y. Wu, P. Zhang, H. Sha, J. Jia, Y. Hu, and et al. Exercise induces mitochondrial biogenesis after brain ischemia in rats Neuroscience 205 2012 10 17
33. D. Dupret, J.M. Revest, M. Koehl, F. Ichas, F. De Giorgi, P. Costet, and et al. Spatial relational memory requires hippocampal adult neurogenesis PLoS One 3 2008 14 [e1959]
34. C. Nesti, L. Pasquali, F. Vaglini, G. Siciliano, and L. Murri The role of mitochondria in stem cell biology Biosci Rep 27 2007 165 171
35. J.C. St John, A. Amaral, E. Bowles, J.F. Oliveira, R. Lloyd, M. Freitas, and et al. The analysis of mitochondria and mitochondrial DNA in human embryonic stem cells Methods Mol Biol 331 2006 347 374
36. J.C. St John, J. Ramalho-Santos, H.L. Gray, P. Petrosko, V.Y. Rawe, C.S. Navara, and et al. The expression of mitochondrial DNA transcription factors during early cardiomyocyte in vitro differentiation from human embryonic stem cells Cloning Stem Cells 7 2005 141 153