The effect of co-administration of intravenous calcium chloride and oxytocin on maternal hemodynamics and uterine tone following cesarean delivery: A double-blinded, randomized, placebo-controlled trial

International Journal of Obstetric Anesthesia

Volumn 24, Issue 3, 2015, Pages 217-224

  Farber, M K ^a   Schultz, R ^a   Lugo, L ^a   Liu, X ^a   Huang, C ^a   Tsen, L C ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Calcium chloride; Hemodynamics; Oxytocin; Uterine tone

Indexed keywords

CALCIUM CHLORIDE; CALCIUM ION; CARBOPROST TROMETAMOL; METHYLERGOMETRINE MALEATE; OXYTOCIN;

ADULT; ARTICLE; BODY MASS; CALCIUM BLOOD LEVEL; CESAREAN SECTION; CONTROLLED STUDY; DEPRESSED BLOOD PRESSURE; DIASTOLIC BLOOD PRESSURE; FEMALE; HEART RATE; HEMATOCRIT; HEMODYNAMICS; HUMAN; MAJOR CLINICAL STUDY; MEAN ARTERIAL PRESSURE; NAUSEA; POSTOPERATIVE HEMORRHAGE; RANDOMIZED CONTROLLED TRIAL; SMOOTH MUSCLE TONE; SPINAL ANESTHESIA; SYSTOLIC BLOOD PRESSURE; UTERINE ATONY; UTERINE TONE; UTERUS CONTRACTILITY; UTERUS CONTRACTION; UTERUS FUNCTION; VOMITING; BLOOD; DOUBLE BLIND PROCEDURE; DRUG EFFECTS; PHYSIOLOGY; PREGNANCY; UTERUS;

ADULT; CALCIUM CHLORIDE; CESAREAN SECTION; DOUBLE-BLIND METHOD; FEMALE; HEMODYNAMICS; HUMANS; OXYTOCIN; PREGNANCY; UTERUS;

EID: 84944358229     PISSN: 0959289X     EISSN: 15323374     Source Type: Journal    
DOI: 10.1016/j.ijoa.2015.03.007     Document Type: Article

References (39)

1. American College of Obstetricians and Gynecologists. ACOG Practice Bulletin: Clinical Management Guidelines for Obstetrician-Gynecologists Number 76, October 2006: Postpartum Hemorrhage. Obstet Gynecol 2006;108:1039-47.
2. Chou MM, MacKenzie IZ. A prospective, double-blind, randomized comparison of prophylactic intramyometrial 15-methyl prostaglandin F2 alpha, 125 micrograms, and intravenous oxytocin, 20 units, for the control of blood loss at elective cesarean section. Am J Obstet Gynecol 1994;171:1356-60.
3. Cooper GM, Lewis G, Neilson J. Confidential enquiries into maternal deaths, 1997-1999. Br J Anaesth 2002;89:369-72.
4. Royal College of Obstetrics and Gynaecology. Postpartum hemorrhage prevention and management. Green-top guideline 52. London: RCOG press, 2009. https://www.rcog.org.uk/en/guidelines-research-services/guidelines/gtg52/ [accessed March 2015].
5. West R, West S, Simons R, McGlennan A. Impact of dose-finding studies on administration of oxytocin during cesarean section in the U.K. Anaesthesia 2013;68:1021-5.
6. Dyer RA, van Dyk D, Dresner A. The use of uterotonic drugs during caesarean section. Int J Obstet Anesth 2010;19: 313-9.
7. Butwick AJ, Coleman L, Cohen SE, Riley ET, Carvalho B. Minimum effective bolus dose of oxytocin during elective Caesarean delivery. Br J Anaesth 2010;104:338-43.
8. Archer TL, Knape K, Liles D, Wheeler AS, Carter B. The hemodynamics of oxytocin and other vasoactive agents during neuraxial anesthesia for cesarean delivery: findings in six cases. Int J Obstet Anesth 2008;17:247-54.
9. Langesaeter E, Rosseland LA, Stubhaug A. Haemodynamic effects of repeated doses of oxytocin during Caesarean delivery in healthy parturients. Br J Anaesth 2009;103:260-2.
10. Erdmann E, Reuschel-Janetschek E. Calcium for resuscitation? Br J Anaesth 1991;67:178-84.
11. Royster RL, Butterworth JFt, Prielipp RC, et al. A randomized, blinded, placebo-controlled evaluation of calcium chloride and epinephrine for inotropic support after emergence from cardiopulmonary bypass. Anesth Analg 1992;74:3-13.
12. 2+ level and mechanical activity in rat uterine smooth muscle. Eur J Pharmacol 1992;221:9-15.
13. Murthy JN, Hicks JM, Soldin SJ. Evaluation of i-STAT portable clinical analyzer in a neonatal and pediatric intensive care unit. Clin Biochem 1997;30:385-9.
14. Saravanan S, Kocarev M, Wilson RC, Watkins E, Columb MO, Lyons G. Equivalent dose of ephedrine and phenylephrine in the prevention of post-spinal hypotension in Caesarean section. Br J Anaesth 2006;96:95-9.
15. Butterworth 4th JF, Strickland RA, Mark LJ, Kon ND, Zaloga GP. Calcium does not augment phenylephrine's hypertensive effects. Crit Care Med 1990;18:603-6.
16. Denlinger JK, Kaplan JA, Lecky JH, Wollman H. Cardiovascular responses to calcium administered intravenously to man during halothane anesthesia. Anesthesiology 1975;42:390-7.
17. Eriksen C, Sorensen MB, Bille-Brahe NE, Skovsted P, Lunding M. Haemodynamic effects of calcium chloride administered intravenously to patients with and without cardiac disease during neurolept anaesthesia. Acta Anaesthesiol Scand 1983;27:13-7.
18. Schoen MD, Parker RB, Hoon TJ, Hariman RJ, Bauman JL, Beckman KJ. Evaluation of the pharmacokinetics and electrocardiographic effects of intravenous verapamil with intravenous calcium chloride pretreatment in normal subjects. Am J Cardiol 1991;67:300-4.
19. Weiss AT, Lewis BS, Halon DA, Hasin Y, Gotsman MS. The use of calcium with verapamil in the management of supraventricular tachyarrhythmias. Int J Cardiol 1983;4:275-84.
20. Drop LJ. Ionized calcium, the heart, and hemodynamic function. Anesth Analg 1985;64:432-51.
21. Horwitz LD, Lifschitz MD. Role of the autonomic nervous system in pressor response to calcium in conscious dogs. Cardiovasc Res 1980;14:522-9.
22. Buttterworth JF, Piccione W, Berrizbeitia LD, Dance G, Shemin L, Cohn L. Augmentation of venous return by adrenergic agonists during spinal anesthesia. Anesth Analg 1986;64:612-6.
23. Osa T, Maruta K. Postpartum changes in the mechanical responses of the circular muscle of rat uterus. Jpn J Physiol 1988;38:329-44.
24. Osa T, Maruta K. Comparative effects of Mg, Ca, Sr, and verapamil on the uterine longitudinal muscle of spayed and estrogen-treated rats. Jpn J Physiol 1986;36:871-89.
25. Kawarabayashi T, Tsukamoto T, Shojo H, Nakamura S, Sujimori H. Changes in responsiveness of freshly isolated longitudinal muscle cells from rat uterus towards oxytocin during gestation: contractility and calcium signaling. Mol Cell Endocrinol 1997;128:77-84.
26. 2+ level and mechanical activity in rat uterine smooth muscle. Eur J Pharmacol 1992;221:9-15.
27. Kawarabayashi T, Kishikawa T, Sugimori H. Effects of external calcium, magnesium, and temperature on spontaneous contractions of pregnant human myometrium. Biol Reprod 1989;40:942-8.
28. 2+]i signaling in pregnant human myometrium. Am J Physiol 1994;267:E77-87.
29. National Institute for Health and Care Excellence. Caesarean Section: Clinical Guidelines. 2011 https://www.nice.org.uk/guidance/cg132 [accessed March 2015].
30. Carvalho JC, Balki M, Kingdom J, Windrim R. Oxytocin requirements at elective cesarean delivery: a dose-finding study. Obstet Gyecol 2004;104(5 Pt. 1):1005-10.
31. 2+ in human myometrium. Am J Obstet Gynecol 2006;195:1404-6.
32. Maresh M, James DK, Neales K. Critical care of the obstetric patient. In: James DK, Steer PJ, Weiner CP, Gonik B, editors. High risk pregnancy management options. 2nd ed. London: W.B. Saunders Company, Ltd.; 1999. p. 1303.
33. Fomin VP, Gibbs SG, Vanam R, Morimiya A, Hurd WW. Effect of magnesium sulfate on contractile force and intracellular calcium concentration in pregnant human myometrium. Am J Obstet Gynecol 2006;194:1384-90.
34. Khan MM, Gupta S, Radford P, Male DA. Dose of oxytocin after Caesarean section. Anaesthesia 2002;57:723-4.
35. Secher NJ, Arnsbo P, Wallin L. Haemodynamic effects of oxytocin (syntocinon) and methyl ergometrine (methergin) on the systemic and pulmonary circulations of pregnant anaesthetized women. Acta Obstet Gynecol Scand 1978;57:97-103.
36. Petty MA, Lang RE, Unger T, Ganten D. The cardiovascular effects of oxytocin in conscious male rats. Eur J Pharmacol 1985;112:203-10.
37. Edwards BR, La Rochelle Jr FT. Antidiuretic effect of endogenous oxytocin in dehydrated Brattleboro homozygous rats. Am J Physiol 1984;247:F453-65.
38. Heytens L, Camu F. Pulmonary edema during cesarean section related to the use of oxytocic drugs. Acta Anaesthesiol Belg 1984;35:155-64.
39. Shahin J, Guharoy SR. Pulmonary edema possibly developing secondary to the intravenous administration of oxytocin. Vet Hum Toxicol 1991;33:587-8.