Structural alterations in white-matter tracts connecting (para-)limbic and prefrontal brain regions in borderline personality disorder

Psychological Medicine

Volumn 45, Issue 15, 2015, Pages 3171-3180

  Lischke, A ^a   Domin, M ^a   Freyberger, H J ^a,b   Grabe, H J ^a,b   Mentel, R ^a   Bernheim, D ^c   Lotze, M ^a  

^a UNIVERSITY OF GREIFSWALD   (Germany)

^b HELIOS Hospital   (Germany)

^c UNIVERSITY OF ULM   (Germany)

Author keywords

Amygdala; anterior cingulate cortex; borderline personality disorder; diffusion tensor imaging; prefrontal cortex; uncinate fasciculus; white matter

Indexed keywords

ADULT; AMYGDALA; BORDERLINE STATE; CINGULATE GYRUS; DIFFUSION TENSOR IMAGING; FEMALE; HUMAN; NERVE TRACT; PATHOLOGY; PREFRONTAL CORTEX; WHITE MATTER; YOUNG ADULT;

ADULT; AMYGDALA; BORDERLINE PERSONALITY DISORDER; DIFFUSION TENSOR IMAGING; FEMALE; GYRUS CINGULI; HUMANS; NEURAL PATHWAYS; PREFRONTAL CORTEX; WHITE MATTER; YOUNG ADULT;

EID: 84944276566     PISSN: 00332917     EISSN: 14698978     Source Type: Journal    
DOI: 10.1017/S0033291715001142     Document Type: Article

References (60)

1. Bohus M, Kleindienst N, Limberger MF, Stieglitz RD, Domsalla M, Chapman AL, Steil R, Philipsen A, Wolf M (2009). The short version of the Borderline Symptom List (BSL-23): development and initial data on psychometric properties. Psychopathology 42, 32-39.
2. Bohus M, Limberger MF, Frank U, Chapman AL, Kuhler T, Stieglitz RD (2007). Psychometric properties of the Borderline Symptom List (BSL). Psychopathology 40, 126-132.
3. Bruehl H, Preissler S, Heuser I, Heekeren HR, Roepke S, Dziobek I (2013). Increased prefrontal cortical thickness is associated with enhanced abilities to regulate emotions in PTSD-free women with borderline personality disorder. PLoS One 8, e65584.
4. Carrasco JL, Tajima-Pozo K, Diaz-Marsa M, Casado A, Lopez-Ibor JJ, Arrazola J, Yus M (2012). Microstructural white matter damage at orbitofrontal areas in borderline personality disorder. Journal of Affective Disorders 139, 149-153.
5. Crowell SE, Beauchaine TP, Linehan MM (2009). A biosocial developmental model of borderline personality: elaborating and extending Linehan's theory. Psychological Bulletin 135, 495-510.
6. Diaz-Marsa M, Macdowell KS, Guemes I, Rubio V, Carrasco JL, Leza JC (2012). Activation of the cholinergic anti-inflammatory system in peripheral blood mononuclear cells from patients with borderline personality disorder. Journal of Psychiatric Research 46, 1610-1617.
7. Domin M, Langner S, Hosten N, Lotze M (2014). Comparison of parameter threshold combinations for diffusion tensor tractography in chronic stroke patients and healthy subjects. PLoS ONE 9, e98211.
8. Fani N, King TZ, Jovanovic T, Glover EM, Bradley B, Choi K, Ely T, Gutman DA, Ressler KJ (2012). White matter integrity in highly traumatized adults with and without post-traumatic stress disorder. Neuropsychopharmacology 37, 2740-2746.
9. Fydrich T, Renneberg B, Schmitz B, Wittchen HU (1997). SKID-II-Strukturiertes Klinisches Interview für DSM-IV Achse II: Persönlichkeitsstörungen. Hogrefe: Göttingen.
10. Garcia-Bueno B, Caso JR, Leza JC (2008). Stress as a neuroinflammatory condition in brain: damaging and protective mechanisms. Neuroscience & Biobehavioral Reviews 32, 1136-1151.
11. Goldin PR, Manber T, Hakimi S, Canli T, Gross JJ (2009). Neural bases of social anxiety disorder: emotional reactivity and cognitive regulation during social and physical threat. Archives of General Psychiatry 66, 170-180.
12. Grant JE, Correia S, Brennan-Krohn T, Malloy PF, Laidlaw DH, Schulz SC (2007). Frontal white matter integrity in borderline personality disorder with self-injurious behavior. Journal of Neuropsychiatry & Clinical Neurosciences 19, 383-390.
13. Hautzinger M, Bailer M, Worall H, Keller F (1995). Beck-Depressions-Inventar (BDI). Testhandbuch. Huber: Bern.
14. Hazlett EA, New AS, Newmark R, Haznedar MM, Lo JN, Speiser LJ, Chen AD, Mitropoulou V, Minzenberg M, Siever LJ, Buchsbaum MS (2005). Reduced anterior and posterior cingulate gray matter in borderline personality disorder. Biological Psychiatry 58, 614-623.
15. Hazlett EA, Zhang J, New AS, Zelmanova Y, Goldstein KE, Haznedar MM, Meyerson D, Goodman M, Siever LJ, Chu KW (2012). Potentiated amygdala response to repeated emotional pictures in borderline personality disorder. Biological Psychiatry 72, 448-456.
16. Herpertz SC, Dietrich TM, Wenning B, Krings T, Erberich SG, Willmes K, Thron A, Sass H (2001). Evidence of abnormal amygdala functioning in borderline personality disorder: a functional MRI study. Biological Psychiatry 50, 292-298.
17. Kahl KG, Bens S, Ziegler K, Rudolf S, Dibbelt L, Kordon A, Schweiger U (2006). Cortisol, the cortisol-dehydroepiandrost-erone ratio, and pro-inflammatory cytokines in patients with current major depressive disorder comorbid with borderline personality disorder. Biological Psychiatry 59, 667-671.
18. Koenigsberg HW, Fan J, Ochsner KN, Liu X, Guise KG, Pizzarello S, Dorantes C, Guerreri S, Tecuta L, Goodman M, New A, Siever LJ (2009a). Neural correlates of the use of psychological distancing to regulate responses to negative social cues: a study of patients with borderline personality disorder. Biological Psychiatry 66, 854-863.
19. Koenigsberg HW, Siever LJ, Lee H, Pizzarello S, New AS, Goodman M, Cheng H, Flory J, Prohovnik I (2009b). Neural correlates of emotion processing in borderline personality disorder. Psychiatry Research 172, 192-199.
20. Krause-Utz A, Winter D, Niedtfeld I, Schmahl C (2014). The latest neuroimaging findings in borderline personality disorder. Current Psychiatry Reports 16, 438.
21. Laux L, Glanzmann P, Schaffner P, Spielberger CD (1981). Das State-Trait-Angstinventar. Beltz: Weinheim.
22. Lehrl S, Triebig G, Fischer B (1995). Multiple choice vocabulary test MWT as a valid and short test to estimate premorbid intelligence. Acta Neurologica Scandinavica 91, 335-345.
23. Lobbestael J, Arntz A, Bernstein DP (2010). Disentangling the relationship between different types of childhood maltreatment and personality disorders. Journal of Personality Disorders 24, 285-295.
24. Mauchnik J, Schmahl C (2010). The latest neuroimaging findings in borderline personality disorder. Current Psychiatry Reports 12, 46-55.
25. McGlashan TH, Grilo CM, Skodol AE, Gunderson JG, Shea MT, Morey LC, Zanarini MC, Stout RL (2000). The Collaborative Longitudinal Personality Disorders Study: baseline Axis I/II and II/II diagnostic co-occurrence. Acta Psychiatrica Scandinavica 102, 256-264.
26. McGowan A, King H, Frankenburg FR, Fitzmaurice G, Zanarini MC (2012). The course of adult experiences of abuse in patients with borderline personality disorder and Axis II comparison subjects: a 10-year follow-up study. Journal of Personality Disorders 26, 192-202.
27. Merrill JE, Benveniste EN (1996). Cytokines in inflammatory brain lesions: helpful and harmful. Trends in Neurosciences 19, 331-338.
28. Mori S, Oishi K, Jiang H, Jiang L, Li X, Akhter K, Hua K, Faria AV, Mahmood A, Woods R, Toga AW, Pike GB, Neto PR, Evans A, Zhang J, Huang H, Miller MI, van Zijl P, Mazziotta J (2008). Stereotaxic white matter atlas based on diffusion tensor imaging in an ICBM template. Neuroimage 40, 570-582.
29. Mori S, Zhang J (2006). Principles of diffusion tensor imaging and its applications to basic neuroscience research. Neuron 51, 527-539.
30. New AS, Carpenter DM, Perez-Rodriguez MM, Ripoll LH, Avedon J, Patil U, Hazlett EA, Goodman M (2013). Developmental differences in diffusion tensor imaging parameters in borderline personality disorder. Journal of Psychiatric Research 47, 1101-1109.
31. New AS, Fan J, Murrough JW, Liu X, Liebman RE, Guise KG, Tang CY, Charney DS (2009). A functional magnetic resonance imaging study of deliberate emotion regulation in resilience and posttraumatic stress disorder. Biological Psychiatry 66, 656-664.
32. New AS, Hazlett EA, Buchsbaum MS, Goodman M, Mitelman SA, Newmark R, Trisdorfer R, Haznedar MM, Koenigsberg HW, Flory J, Siever LJ (2007). Amygdala-prefrontal disconnection in borderline personality disorder. Neuropsychopharmacology 32, 1629-1640.
33. Niedtfeld I, Kirsch P, Schulze L, Herpertz SC, Bohus M, Schmahl C (2012). Functional connectivity of pain-mediated affect regulation in Borderline Personality Disorder. PLoS ONE 7, e33293.
34. Niedtfeld I, Schulze L, Kirsch P, Herpertz SC, Bohus M, Schmahl C (2010). Affect regulation and pain in borderline personality disorder: a possible link to the understanding of self-injury. Biological Psychiatry 68, 383-391.
35. Niedtfeld I, Schulze L, Krause-Utz A, Demirakca T, Bohus M, Schmahl C (2013). Voxel-based morphometry in women with borderline personality disorder with and without comorbid posttraumatic stress disorder. PLoS ONE 8, e65824.
36. Ochsner KN, Silvers JA, Buhle JT (2012). Functional imaging studies of emotion regulation: a synthetic review and evolving model of the cognitive control of emotion. Annals of the New York Academy of Sciences 1251, E1-E24.
37. Oishi K, Zilles K, Amunts K, Faria A, Jiang H, Li X, Akhter K, Hua K, Woods R, Toga AW, Pike GB, Rosa-Neto P, Evans A, Zhang J, Huang H, Miller MI, van Zijl PC, Mazziotta J, Mori S (2008). Human brain white matter atlas: identification and assignment of common anatomical structures in superficial white matter. Neuroimage 43, 447-457.
38. Pagano ME, Skodol AE, Stout RL, Shea MT, Yen S, Grilo CM, Sanislow CA, Bender DS, McGlashan TH, Zanarini MC, Gunderson JG (2004). Stressful life events as predictors of functioning: findings from the collaborative longitudinal personality disorders study. Acta Psychiatrica Scandinavica 110, 421-429.
39. Phan KL, Orlichenko A, Boyd E, Angstadt M, Coccaro EF, Liberzon I, Arfanakis K (2009). Preliminary evidence of white matter abnormality in the uncinate fasciculus in generalized social anxiety disorder. Biological Psychiatry 66, 691-694.
40. Rusch N, Luders E, Lieb K, Zahn R, Ebert D, Thompson PM, Toga AW, van Elst LT (2007a). Corpus callosum abnormalities in women with borderline personality disorder and comorbid attention-deficit hyperactivity disorder. Journal of Psychiatry & Neuroscience 32, 417-422.
41. Rusch N, Weber M, Il'yasov KA, Lieb K, Ebert D, Hennig J, van Elst LT (2007b). Inferior frontal white matter microstructure and patterns of psychopathology in women with borderline personality disorder and comorbid attention-deficit hyperactivity disorder. Neuroimage 35, 738-747.
42. Schmahl CG, Vermetten E, Elzinga BM, Bremner JD (2003). Magnetic resonance imaging of hippocampal and amygdala volume in women with childhood abuse and borderline personality disorder. Psychiatry Research 122, 193-198.
43. Schulze L, Domes G, Kruger A, Berger C, Fleischer M, Prehn K, Schmahl C, Grossmann A, Hauenstein K, Herpertz SC (2011). Neuronal correlates of cognitive reappraisal in borderline patients with affective instability. Biological Psychiatry 69, 564-573.
44. Shea MT, Stout RL, Yen S, Pagano ME, Skodol AE, Morey LC, Gunderson JG, McGlashan TH, Grilo CM, Sanislow CA, Bender DS, Zanarini MC (2004). Associations in the course of personality disorders and Axis I disorders over time. Journal of Abnormal Psychology 113, 499-508.
45. Silbersweig D, Clarkin JF, Goldstein M, Kernberg OF, Tuescher O, Levy KN, Brendel G, Pan H, Beutel M, Pavony MT, Epstein J, Lenzenweger MF, Thomas KM, Posner MI, Stern E (2007). Failure of frontolimbic inhibitory function in the context of negative emotion in borderline personality disorder. American Journal of Psychiatry 164, 1832-1841.
46. Song SK, Sun SW, Ju WK, Lin SJ, Cross AH, Neufeld AH (2003). Diffusion tensor imaging detects and differentiates axon and myelin degeneration in mouse optic nerve after retinal ischemia. Neuroimage 20, 1714-1722.
47. Song SK, Sun SW, Ramsbottom MJ, Chang C, Russell J, Cross AH (2002). Dysmyelination revealed through MRI as increased radial (but unchanged axial) diffusion of water. Neuroimage 17, 1429-1436.
48. Sun SW, Liang HF, Trinkaus K, Cross AH, Armstrong RC, Song SK (2006). Noninvasive detection of cuprizone induced axonal damage and demyelination in the mouse corpus callosum. Magnetic Resonance in Medicine 55, 302-308.
49. Tebartz van Elst L, Hesslinger B, Thiel T, Geiger E, Haegele K, Lemieux L, Lieb K, Bohus M, Hennig J, Ebert D (2003). Frontolimbic brain abnormalities in patients with borderline personality disorder: a volumetric magnetic resonance imaging study. Biological Psychiatry 54, 163-171.
50. Townsend JD, Torrisi SJ, Lieberman MD, Sugar CA, Bookheimer SY, Altshuler LL (2013). Frontal-amygdala connectivity alterations during emotion downregulation in bipolar I disorder. Biological Psychiatry 73, 127-135.
51. Tromp DP, Grupe DW, Oathes DJ, McFarlin DR, Hernandez PJ, Kral TR, Lee JE, Adams M, Alexander AL, Nitschke JB (2012). Reduced structural connectivity of a major frontolimbic pathway in generalized anxiety disorder. Archives of General Psychiatry 69, 925-934.
52. Versace A, Almeida JR, Hassel S, Walsh ND, Novelli M, Klein CR, Kupfer DJ, Phillips ML (2008). Elevated left and reduced right orbitomedial prefrontal fractional anisotropy in adults with bipolar disorder revealed by tract-based spatial statistics. Archives of General Psychiatry 65, 1041-1052.
53. Wakana S, Jiang H, Nagae-Poetscher LM, van Zijl PC, Mori S (2004). Fiber tract-based atlas of human white matter anatomy. Radiology 230, 77-87.
54. Weniger G, Lange C, Sachsse U, Irle E (2009). Reduced amygdala and hippocampus size in trauma-exposed women with borderline personality disorder and without posttraumatic stress disorder. Journal of Psychiatry, Neuroscience 34, 383-388.
55. Wingenfeld K, Spitzer C, Rullkotter N, Lowe B (2009). Borderline personality disorder: hypothalamus pituitary adrenal axis and findings from neuroimaging studies. Psychoneuroendocrinology 35, 154-170.
56. Wittchen HU, Pflister H (1997). Diagnostisches Expertensystem für psychische Störungen. Swets, Zeitlinge: Frankfurt.
57. Zanarini MC, Frankenburg FR, Dubo ED, Sickel AE, Trikha A, Levin A, Reynolds V (1998). Axis I comorbidity of borderline personality disorder. American Journal of Psychiatry 155, 1733-1739.
58. Zanarini MC, Frankenburg FR, Hennen J, Reich DB, Silk KR (2004). Axis I comorbidity in patients with borderline personality disorder: 6-year follow-up and prediction of time to remission. American Journal of Psychiatry 161, 2108-2114.
59. Zanarini MC, Horz S, Frankenburg FR, Weingeroff J, Reich DB, Fitzmaurice G (2011). The 10-year course of PTSD in borderline patients and axis II comparison subjects. Acta Psychiatrica Scandinavica 124, 349-356.
60. Zhang A, Leow A, Ajilore O, Lamar M, Yang S, Joseph J, Medina J, Zhan L, Kumar A (2012). Quantitative tract-specific measures of uncinate and cingulum in major depression using diffusion tensor imaging. Neuropsychopharmacology 37, 959-967.