A custom tailored model to investigate skin penetration in porcine skin and its comparison with human skin

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 95, Issue , 2015, Pages 99-109

  Herbig, Michael E ^a   Houdek, Pia ^b   Gorissen, Sascha ^a   Zorn Kruppa, Michaela ^b   Wladykowski, Ewa ^b   Volksdorf, Thomas ^b   Grzybowski, Stephan ^c   Kolios, Georgios ^c   Willers, Christoph ^a   Mallwitz, Henning ^a   Moll, Ingrid ^b   Brandner, Johanna M ^b  

^a Almirall Hermal   (Germany)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^c Unit of Orthopaedic Surgery   (Germany)

Author keywords

Cutaneous absorption; Dermal penetration; Diclofenac; Differentiation; Human skin; Porcine skin; Skin model; Terbinafine; Tight junctions; Viability

Indexed keywords

2 PROPANOL; CLAUDIN 1; CYTOKERATIN 10; CYTOKERATIN 5; DICLOFENAC; FILAGGRIN; LORICRIN; METRONIDAZOLE; OCCLUDIN; PROPYLENE GLYCOL; TAZAROTENE; TERBINAFINE; NAPHTHALENE DERIVATIVE;

ANIMAL TISSUE; ARTICLE; DERMIS; DRUG BIOAVAILABILITY; DRUG FORMULATION; DRUG METABOLISM; DRUG PENETRATION; DRUG SOLUBILITY; EPIDERMIS; EXPERIMENTAL PIG; HUMAN; HUMAN TISSUE; LIPOPHILICITY; MTT ASSAY; NONHUMAN; PH; PHYSICAL CHEMISTRY; SKIN PENETRATION; SKIN SURFACE; SKINFOLD THICKNESS; SOFT TISSUE INFLAMMATION; STRATUM CORNEUM; ANIMAL; COMPARATIVE STUDY; CYTOLOGY; DRUG EFFECTS; FEMALE; INTRADERMAL DRUG ADMINISTRATION; METABOLISM; ORGAN CULTURE TECHNIQUE; PHYSIOLOGY; PIG; SKIN; SKIN ABSORPTION; SPECIES DIFFERENCE;

ADMINISTRATION, CUTANEOUS; ANIMALS; FEMALE; HUMANS; NAPHTHALENES; ORGAN CULTURE TECHNIQUES; SKIN; SKIN ABSORPTION; SPECIES SPECIFICITY; SWINE;

EID: 84944276211     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2015.03.030     Document Type: Article

References (36)

1. T.J. Franz, P.A. Lehman, and S.G. Raney Use of excised human skin to assess the bioequivalence of topical products Skin Pharmacol. Physiol. 22 2009 276 286
2. M. Denda, J. Sato, Y. Masuda, T. Tsuchiya, J. Koyama, M. Kuramoto, P.M. Elias, and K.R. Feingold Exposure to a dry environment enhances epidermal permeability barrier function J. Invest. Dermatol. 111 1998 858 863
3. H. Wagner, K.H. Kostka, C.M. Lehr, and U.F. Schaefer Drug distribution in human skin using two different in vitro test systems: comparison with in vivo data Pharm. Res. 17 2000 1475 1481
4. H. Wagner, K.H. Kostka, C.M. Lehr, and U.F. Schaefer Interrelation of permeation and penetration parameters obtained from in vitro experiments with human skin and skin equivalents J. Contr. Release 75 2001 283 295
5. F. Netzlaff, U.F. Schaefer, C.M. Lehr, P. Meiers, J. Stahl, M. Kietzmann, and F. Niedorf Comparison of bovine udder skin with human and porcine skin in percutaneous permeation experiments Alt. Lab. Anim. 34 2006 499 513
6. W.F. Pittermann, and M. Kietzmann Bovine udder skin (BUS): testing of skin compatibility and skin protection Altex 23 2006 65 71
7. K. Ackermann, S.L. Borgia, H.C. Korting, K.R. Mewes, and M. Schafer-Korting The Phenion full-thickness skin model for percutaneous absorption testing Skin Pharmacol. Physiol. 23 2010 105 112
8. M. Schäfer-Korting, U. Bock, W. Diembeck, H.J. Dusing, A. Gamer, E. Haltner-Ukomadu, C. Hoffmann, M. Kaca, H. Kamp, S. Kersen, M. Kietzmann, H.C. Korting, H.U. Krachter, C.M. Lehr, M. Liebsch, A. Mehling, C. Muller-Goymann, F. Netzlaff, F. Niedorf, M.K. Rubbelke, U. Schafer, E. Schmidt, S. Schreiber, H. Spielmann, A. Vuia, and M. Weimer The use of reconstructed human epidermis for skin absorption testing: results of the validation study Alt. Lab. Anim. 36 2008 161 187
9. G. Ottaviani, S. Martel, and P.A. Carrupt Parallel artificial membrane permeability assay: a new membrane for the fast prediction of passive human skin permeability J. Med. Chem. 49 2006 3948 3954
10. M. Manconi, C. Caddeo, C. Sinico, D. Valenti, M.C. Mostallino, G. Biggio, and A.M. Fadda Ex vivo skin delivery of diclofenac by transcutol containing liposomes and suggested mechanism of vesicle-skin interaction Eur. J. Pharm. Biopharm. 78 2011 27 35
11. R. Marks Pharmacokinetics and safety review of tazarotene J. Am. Acad. Dermatol. 39 1998 S134 138
12. F.P. Schmook, J.G. Meingassner, and A. Billich Comparison of human skin or epidermis models with human and animal skin in in-vitro percutaneous absorption Int. J. Pharm. 215 2001 51 56
13. D.D. Tang-Liu, R.M. Matsumoto, and J.I. Usansky Clinical pharmacokinetics and drug metabolism of tazarotene: a novel topical treatment for acne and psoriasis Clin. Pharmacokinet. 37 1999 273 287
14. 2+-homeostasis of human keratinocytes: implications for tumorigenesis PLoS ONE 8 2013 e55116
15. OECD, OECD Guideline for the testing of chemicals, No 107. Partition Coefficient (n-octanol/water): Shake Flask Method, 1995.
16. M.E. Herbig, and D.H. Evers Correlation of hydrotropic solubilization by urea with log D of drug molecules and utilization of this effect for topical formulations Eur. J. Pharm. Biopharm. 85 2013 158 160
17. A.C. Allenby, J. Fletcher, C. Schock, and T.F.S. Tees The effect of heat, pH and or-ganic solvents on the electrical impedance and permeability of excised human skin Br. J. Dermatol. 81 s4 1969 31 39
18. H. Lambers, S. Piessens, A. Bloem, H. Pronk, and P. Finkel Natural skin surface pH is on average below 5, which is beneficial for its resident flora Int. J. Cosmet. Sci. 28 2006 359 370
19. J. Hadgraft, and C. Valenta PH, pK(a) and dermal delivery Int. J. Pharm. 200 2000 243 247
20. M.H. Abraham, and F. Martins Human skin permeation and partition: general linear free-energy relationship analyses J. Pharm. Sci. 93 2004 1508 1523
21. M.E. Lane Skin penetration enhancers Int. J. Pharm. 447 2013 12 21
22. A.C. Williams, and B.W. Barry Penetration enhancers Adv. Drug Deliv. Rev. 56 2004 603 618
23. P. Santos, A.C. Watkinson, J. Hadgraft, and M.E. Lane Influence of penetration enhancer on drug permeation from volatile formulations Int. J. Pharm. 439 2012 260 268
24. A. Billich, H. Aschauer, A. Aszodi, and A. Stuetz Percutaneous absorption of drugs used in atopic eczema: pimecrolimus permeates less through skin than corticosteroids and tacrolimus Int. J. Pharm. 269 2004 29 35
25. F.M. Bätz, W. Klipper, H.C. Korting, F. Henkler, R. Landsiedel, A. Luch, U. von Fritschen, G. Weindl, and M. Schäfer-Korting Esterase activity in excised and reconstructed human skin-biotransformation of prednicarbate and the model dye fluorescein diacetate Eur. J. Pharm. Biopharm. 84 2013 374 385
26. M. Zorn-Kruppa, P. Houdek, E. Wladykowski, M. Engelke, M. Bartok, K.R. Mewes, I. Moll, and J.M. Brandner Determining the depth of injury in bioengineered tissue models of cornea and conjunctiva for the prediction of all three ocular GHS categories PLoS ONE 9 2014 e114181
27. S. Kezic, N. Novak, I. Jakasa, J.M. Jungersted, M. Simon, J.M. Brandner, M.A. Middelkamp-Hup, and S. Weidinger Skin barrier in atopic dermatitis Front. Biosci. 19 2014 542 556 (Landmark ed)
28. N. Kirschner, and J.M. Brandner Barriers and more: functions of tight junction proteins in the skin Ann. N. Y. Acad. Sci. 1257 2012 158 166
29. N. Kirschner, R. Rosenthal, M. Furuse, I. Moll, M. Fromm, and J.M. Brandner Contribution of tight junction proteins to ion, macromolecule, and water barrier in keratinocytes J. Invest. Dermatol. 133 2013 1161 1169
30. E. Proksch, J.M. Brandner, and J.M. Jensen The skin: an indispensable barrier Exp. Dermatol. 17 2008 1063 1072
31. J.M. Brandner, S. Kief, C. Grund, M. Rendl, P. Houdek, C. Kuhn, E. Tschachler, W.W. Franke, and I. Moll Organization and formation of the tight junction system in human epidermis and cultured keratinocytes Eur. J. Cell Biol. 81 2002 253 263
32. S. Küchler, D. Henkes, K.M. Eckl, K. Ackermann, J. Plendl, H.C. Korting, H.C. Hennies, and M. Schafer-Korting Hallmarks of atopic skin mimicked in vitro by means of a skin disease model based on FLG knock-down Alt. Lab. Anim. 39 2011 471 480
33. V.S. Thakoersing, G.S. Gooris, A. Mulder, M. Rietveld, A. El Ghalbzouri, and J.A. Bouwstra Unraveling barrier properties of three different in-house human skin equivalents Tissue Eng., Part C, Methods 18 2012 1 11
34. T. Yuki, A. Komiya, A. Kusaka, T. Kuze, Y. Sugiyama, and S. Inoue Impaired tight junctions obstruct stratum corneum formation by altering polar lipid and profilaggrin processing J. Dermatol. Sci. 69 2013 148 158
35. M. Gschwandtner, M. Mildner, V. Mlitz, F. Gruber, L. Eckhart, T. Werfel, R. Gutzmer, P.M. Elias, and E. Tschachler Histamine suppresses epidermal keratinocyte differentiation and impairs skin barrier function in a human skin model Allergy 68 2013 37 47
36. N. Kirschner, P. Houdek, M. Fromm, I. Moll, and J.M. Brandner Tight junctions form a barrier in human epidermis Eur. J. Cell Biol. 89 2010 839 842