Prescription Opioid Misuse, Abuse, Morbidity, and Mortality: Balancing Effective Pain Management and Safety

Pain Medicine (United States)

Volumn 16, Issue , 2015, Pages S3-S8

  Cheatle, Martin D ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Abuse; Chronic Pain; Misuse; Opioid Use Disorder; Opioids; Overdose

Indexed keywords

ANTIDEPRESSANT AGENT; BENZODIAZEPINE DERIVATIVE; HYPNOTIC SEDATIVE AGENT; METHADONE; NARCOTIC ANALGESIC AGENT; PLACEBO;

CHRONIC DRUG ADMINISTRATION; CHRONIC PAIN; DEPRESSION; DRUG DOSE TITRATION; DRUG FATALITY; DRUG MISUSE; DRUG OVERDOSE; DRUG TOLERANCE; DRUG WITHDRAWAL; FALLING; FRACTURE; HUMAN; LOW BACK PAIN; MEDICATION ERROR; MORTALITY; NARCOTIC DEPENDENCE; PREVALENCE; RESPIRATION DEPRESSION; REVIEW; RISK REDUCTION; SELF MEDICATION; SEXUAL DYSFUNCTION; SUICIDE; UNSPECIFIED SIDE EFFECT; WITHDRAWAL SYNDROME; ADVERSE EFFECTS; ANALGESIA; PRESCRIPTION; PRESCRIPTION DRUG MISUSE;

ANALGESICS, OPIOID; CHRONIC PAIN; DRUG OVERDOSE; HUMANS; PAIN MANAGEMENT; PRESCRIPTION DRUG MISUSE; PRESCRIPTIONS;

EID: 84944165872     PISSN: 15262375     EISSN: 15264637     Source Type: Journal    
DOI: 10.1111/pme.12904     Document Type: Review

References (33)

1. Porter J, Jick H. Addiction rare in patients treated with narcotics. N Engl J Med 1980;302:123
2. Agency for Health Care Quality and Research. Acute pain management: Operative or medical procedures and trauma, Part 1. Clin Pharmacol 1992;11:309-31.
3. Agency for Health Care Quality and Research. Acute pain management: Operative or medical procedures and trauma, Part 2. Clin Pharmacol 1992;11:391-414.
4. CDC. Vital signs: Overdoses of prescription opioid pain relievers-United States, 1999-2008. MMWR 2011;60:1487-92.
5. Frenk SM, Porter KS, Paulozzi LJ. Prescription opioid analgesic use among adults: United States, 1999-2012. NCHS Data Brief 2015:1-8.
6. Substance Abuse and Mental Health Services Administration, Results from the 2012 National Survey on Drug Use and Health: Summary of National Findings, NSDUH Series H-46, HHS Publication No. (SMA) 13-4795. Rockville, MD: Substance Abuse and Mental Health Services Administration; 2013.
7. Substance Abuse and Mental Health Services Administration, Drug Abuse Warning Network, 2011:National Estimates of Drug-Related Emergency Department Visits. HHS Publication No. (SMA) 13-4760, DAWN Series D-39. Rockville, MD: Substance Abuse and Mental Health Services Administration; 2013.
8. Substance Abuse and Mental Health Services Administration, Center for Behavioral Health Statistics and Quality. Treatment Episode Data Set (TEDS): 2001-2011. National Admissions to Substance Abuse Treatment Services. BHSIS Series S-65, HHS Publication No. (SMA) 13-4772. Rockville, MD: Substance Abuse and Mental Health Services Administration; 2013.
9. Jones CM, Mack KA, Paulozzi LJ. Pharmaceutical overdose deaths, United States, 2010. JAMA 2013;309:657-9.
10. Chen LH, Hedegaard H, Warner M. Drug-poisoning deaths involving opioid analgesics: United States, 1999-2011. NCHS Data Brief 2014:1-8.
11. Noble M, Treadwell JR, Tregear SJ, et al. Long-term opioid management for chronic noncancer pain. Cochrane Database System Rev; 2010. Art. No.: CD006605.
12. Chaparro LE, Furlan AD, Deshpande A, et al. Opioids compared to placebo or other treatments for chronic low-back pain. Cochrane Database of Systematic Reviews 2013. Art. No.: CD004959.
13. Chou R, Turner JA, Devine EB, et al. The effectiveness and risks of long-term opioid therapy for chronic pain: A systematic review for a National Institutes of Health Pathways to Prevention Workshop. Ann Intern Med 2015;162:276-86.
14. Ives TJ, Chelminski PR, Hammett-Stabler CA, et al. Predictors of opioid misuse in patients with chronic pain: A prospective cohort study. BMC Health Serv Res 2006;6:46
15. Fishbain DA, Cole B, Lewis J, Rosomoff HI, Rosomoff RS. What percentage of chronic nonmalignant pain patients exposed to chronic opioid analgesic therapy develop abuse/addiction and/or aberrant drug-related behaviors? A structured evidence-based review. Pain Med 2008;9:444-59.
16. Martell BA, O'Connor PG, Kerns RD, et al. Systematic review: Opioid treatment for chronic back pain: Prevalence, efficacy, and association with addiction. Ann Intern Med 2007;146:116-27.
17. Cheatle MD, O'Brien CP. Opioid therapy in patients with chronic noncancer pain: Diagnostic and clinical challenges. Adv Psychosom Med 2011;30:61-91.
18. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision. Washington, DC: American Psychiatric Association; 2000.
19. Heit HA. Addiction, physical dependence, and tolerance: Precise definitions to help clinicians evaluate and treat chronic pain patients. J Pain Palliat Care Pharmacother 2003;17:15-29.
20. American Pain Society: Definitions related to the use of opioids for the treatment of pain. A consensus document from the American Academy of Pain Medicine, the American Pain Society, and the American Society of Addiction Medicine. Glenview, American Academy of Pain Medicine; 2001
21. Wasan AD, Butler SF, Budman SH, et al. Does report of craving opioid medication predict aberrant drug behavior among chronic pain patients?. Clin J Pain 2009;25:193-8.
22. Smith SM, Dart RC, Katz NP, et al. NovAnalgesic, Anesthetic, and Addiction Clinical Trials, Translations, Innovations, Opportunities, and Networks (ACTTION) public-private partnership. Classification and definition of misuse, abuse, and related events in clinical trials: ACTTION systematic review and recommendations. Pain 2013;154:2287-96.
23. American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 5th edition. Washington, DC: American Psychiatric Association; 2013.
24. Boscarino JA, Rukstalis MR, Hoffman SN, et al. Prevalence of prescription opioid-use disorder among chronic pain patients: Comparison of the DSM-5 vs. DSM-4 diagnostic criteria. J Addict Dis 2011;30:185-94.
25. Palmer RE, Carrell DS, Cronkite D, et al. The prevalence of problem opioid use in patients receiving chronic opioid therapy: Computer-assisted review of electronic health record clinical notes. Pain 2015;156:1208-14. Jul;
26. Vowles KE, McEntee ML, Julnes PS, et al. Rates of opioid misuse, abuse, and addiction in chronic pain: A systematic review and data synthesis. Pain 2015;156:569-76.
27. Webster LR, Cochella S, Dasgupta N, et al. An analysis of the root causes for opioid-related overdose deaths in the United States. Pain Med 2011;2:S26-35.
28. Park TW, Saitz R, Ganoczy D, Ilgen MA, Bohnert AS. Benzodiazepine prescribing patterns and deaths from drug overdose among US veterans receiving opioid analgesics: Case-cohort study. BMJ 2015;350:1-7.
29. Jones CM, Paulozzi LJ, Mack KA. Centers for Disease Control and Prevention (CDC). Alcohol involvement in opioid pain reliever and benzodiazepine drug abuse-related emergency department visits and drug-related deaths, United States, 2010.MMWR Morb Mortal Wkly Rep 2014;63:881-5.
30. Turner BJ, Liang Y. Drug overdose in a retrospective cohort with non-cancer pain treated with opioids, antidepressants, and/or sedative-hypnotics: Interactions with mental health disorders. J Gen Intern Med 2015;30:1081-96.
31. Miller M, Barber CW, Leatherman S, et al. Prescription opioid duration of action and the risk of unintentional overdose among patients receiving opioid therapy. JAMA Intern Med 2015;175:608-15.
32. Bohnert AS, Valenstein M, Bair MJ, et al. Association between opioid prescribing patterns and opioid overdose-related deaths. JAMA 2011;305:1315-21.
33. Cheatle MD. Depression, chronic pain, and suicide by overdose: On the edge. Pain Med 2011;S43-8.