Sympathetic nervous system signaling in heart failure and cardiac aging

Pathophysiology and Pharmacotherapy of Cardiovascular Disease

Volumn , Issue , 2015, Pages 83-105

  Santulli, Gaetano ^a,b  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b College of Physicians and Surgeons Columbia University Medical Center ^*  (United States)

Author keywords

Adrenergic receptors; Aging; Arrhythmias; Cardiomyocytes; Endothelium; GRKs; Heart failure; Hypertension; Sympathetic nervous system

Indexed keywords

EID: 84944072396     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-3-319-15961-4_5     Document Type: Chapter

References (150)

1. Santulli G. Epidemiology of cardiovascular disease in the 21st century: updated numbers and updated facts. J Cardiovasc Dis (JCvD). 2013;1(1):1-2.
2. Rosca MG, Hoppel CL. Mitochondria in heart failure. Cardiovasc Res. 2010;88(1):40-50. PubMed PMID: 20668004. Pubmed Central PMCID: 3025720.
3. Santulli G, Ciccarelli M, Trimarco B, Iaccarino G. Physical activity ameliorates cardiovascular health in elderly subjects: the functional role of the beta adrenergic system. Front Physiol. 2013;4:209. PubMed PMID: 23964243. Pubmed Central PMCID: 3740240. Epub 2013/08/22. eng.
4. Czuriga D, Paulus WJ, Czuriga I, Edes I, Papp Z, Borbely A. Cellular mechanisms for diastolic dysfunction in the human heart. Curr Pharm Biotechnol. 2012;13(13):2532-8. PubMed PMID: 22280428.
5. Rahman F, Kwan GF, Benjamin EJ. Global epidemiology of atrial fibrillation. Nat Rev Cardiol. 2014;11:639-54. PubMed PMID: 25113750.
6. D’Ascia SL, D’Ascia C, Marino V, Lombardi A, Santulli R, Chiariello M, et al. Cardiac resynchronisation therapy response predicts occurrence of atrial fibrillation in non-ischaemic dilated cardiomyopathy. Int J Clin Pract. 2011;65(11):1149-55. PubMed PMID: 21995693. Epub 2011/10/15. eng.
7. Santulli G, D’Ascia SL, D’Ascia C. Development of atrial fibrillation in recipients of cardiac resynchronization therapy: the role of atrial reverse remodelling. Can J Cardiol. 2012;28(2):245, author reply e17-8. PubMed PMID: 22244772. Epub 2012/01/17. eng.
8. Lanni F, Santulli G, Izzo R, Rubattu S, Zanda B, Volpe M, et al. The Pl(A1/A2) polymorphism of glycoprotein IIIa and cerebrovascular events in hypertension: increased risk of ischemic stroke in high-risk patients. J Hypertens. 2007;25(3):551-6. PubMed PMID: 17278970.
9. Sorriento D, Santulli G, Fusco A, Anastasio A, Trimarco B, Iaccarino G. Intracardiac injection of AdGRK5-NT reduces left ventricular hypertrophy by inhibiting NF-kappaB-dependent hypertrophic gene expression. Hypertension. 2010;56(4):696-704. PubMed PMID: 20660817. Epub 2010/07/28. eng.
10. Hees PS, Fleg JL, Lakatta EG, Shapiro EP. Left ventricular remodeling with age in normal men versus women: novel insights using three-dimensional magnetic resonance imaging. Am J Cardiol. 2002;90(11):1231-6. PubMed PMID: 12450604.
11. Gorelick PB, Scuteri A, Black SE, Decarli C, Greenberg SM, Iadecola C, et al. Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke association. Stroke J Cereb Circ. 2011;42(9):2672-713. PubMed PMID: 21778438. Pubmed Central PMCID: 3778669.
12. Cantini C, Kieffer P, Corman B, Liminana P, Atkinson J, Lartaud-Idjouadiene I. Aminoguanidine and aortic wall mechanics, structure, and composition in aged rats. Hypertension. 2001;38(4):943-8. PubMed PMID: 11641314. Epub 2001/10/20. eng.
13. Sonkusare SK, Bonev AD, Ledoux J, Liedtke W, Kotlikoff MI, Heppner TJ, et al. Elementary Ca2+ signals through endothelial TRPV4 channels regulate vascular function. Science. 2012;336(6081):597-601. PubMed PMID: 22556255. Pubmed Central PMCID: 3715993. Epub 2012/05/05. eng.
14. Santulli G, Wronska A, Kunihiro U, Diacovo T, Gao M, Marx S, et al. A selective microRNA- based strategy inhibits restenosis while preserving endothelial function. J Clin Invest. 2014;124:4102-14. eng.
15. Santulli G, Cipolletta E, Sorriento D, Del Giudice C, Anastasio A, Monaco S, et al. CaMK4 gene deletion induces hypertension. J Am Heart Assoc. 2012;1(4):e001081. PubMed PMID: 23130158. Pubmed Central PMCID: 3487344. Epub 2012/11/07. eng.
16. Iaccarino G, Ciccarelli M, Sorriento D, Cipolletta E, Cerullo V, Iovino GL, et al. AKT participates in endothelial dysfunction in hypertension. Circulation. 2004;109(21):2587-93. PubMed PMID: 15136501.
17. Santulli G, Lombardi A, Sorriento D, Anastasio A, Del Giudice C, Formisano P, et al. Age- related impairment in insulin release: the essential role of beta(2)-adrenergic receptor. Diabetes. 2012;61(3):692-701. PubMed PMID: 22315324. Pubmed Central PMCID: 3282797.
18. Ciccarelli M, Rusciano MR, Sorriento D, Basilicata F, Santulli G, Campiglia P, et al. CaMKII protects MKP-1 from proteasome degradation in endothelial cells. Cell Signal. 2014;26:2167- 74. PubMed PMID: 25007998.
19. Kasai RS, Kusumi A. Single-molecule imaging revealed dynamic GPCR dimerization. Curr Opin Cell Biol. 2014;27:78-86. PubMed PMID: 24480089.
20. Santulli G, Trimarco B, Iaccarino G. G-protein-coupled receptor kinase 2 and hypertension: molecular insights and pathophysiological mechanisms. High Blood Press Cardiovasc Prev Off J Ital Soc Hypertens. 2013;20(1):5-12. PubMed PMID: 23532739.
21. Penela P, Ribas C, Mayor Jr F. Mechanisms of regulation of the expression and function of G protein-coupled receptor kinases. Cell Signal. 2003;15(11):973-81. PubMed PMID: 14499340.
22. Iaccarino G, Barbato E, Cipolletta E, De Amicis V, Margulies KB, Leosco D, et al. Elevated myocardial and lymphocyte GRK2 expression and activity in human heart failure. Eur Heart J. 2005;26(17):1752-8. PubMed PMID: 16055494. Epub 2005/08/02. eng.
23. Harris DM, Cohn HI, Pesant S, Eckhart AD. GPCR signalling in hypertension: role of GRKs. Clin Sci (Lond). 2008;115(3):79-89. PubMed PMID: 18593382. Epub 2008/07/03. eng.
24. Mei Y, Yin N, Jin X, He J, Yin Z. The regulatory role of the adrenergic agonists phenylephrine and isoproterenol on fetal hemoglobin expression and erythroid differentiation. Endocrinology. 2013;154(12):4640-9. PubMed PMID: 24080366.
25. Lampri E, Ioachim E. Angiogenesis: something old, something new. In: Santulli G, editor. Angiogenesis: insight from a systematic overview. New York: Nova Science Publishers; 2013. p. 1-30.
26. O’Connell TD, Jensen BC, Baker AJ, Simpson PC. Cardiac alpha1-adrenergic receptors: novel aspects of expression, signaling mechanisms, physiologic function, and clinical importance. Pharmacol Rev. 2014;66(1):308-33. PubMed PMID: 24368739. Pubmed Central PMCID: 3880467.
27. Ruuskanen JO, Laurila J, Xhaard H, Rantanen VV, Vuoriluoto K, Wurster S, et al. Conserved structural, pharmacological and functional properties among the three human and five zebraf- ish alpha 2-adrenoceptors. Br J Pharmacol. 2005;144(2):165-77. PubMed PMID: 15655522. Pubmed Central PMCID: 1575993.
28. Vicco MH, Pujato N, Bontempi I, Rodeles L, Marcipar I, Bottasso OA. beta1-selective adrenoceptor antagonists increase plasma levels of anti-p2beta antibodies and decrease cardiac involvement in chronic progressive Chagas heart disease. Can J Cardiol. 2014;30(3):332-7. PubMed PMID: 24370375.
29. Santulli G, Iaccarino G. Pinpointing beta adrenergic receptor in ageing pathophysiology: victim or executioner? Evidence from crime scenes. Immun Ageing I A. 2013;10(1):10. PubMed PMID: 23497413. Pubmed Central PMCID: 3763845. Epub 2013/03/19. eng.
30. Belge C, Hammond J, Dubois-Deruy E, Manoury B, Hamelet J, Beauloye C, et al. Enhanced expression of beta3-adrenoceptors in cardiac myocytes attenuates neurohormone-induced hypertrophic remodeling through nitric oxide synthase. Circulation. 2014;129(4):451-62. PubMed PMID: 24190960.
31. Xiao RP. Beta-adrenergic signaling in the heart: dual coupling of the beta2-adrenergic receptor to G(s) and G(i) proteins. Sci STKE Signal Transduct Knowl Environ. 2001;2001(104):re15. PubMed PMID: 11604549. Epub 2001/10/18. eng.
32. Sun Y, Huang J, Xiang Y, Bastepe M, Juppner H, Kobilka BK, et al. Dosage-dependent switch from G protein-coupled to G protein-independent signaling by a GPCR. EMBO J. 2007;26(1):53-64. PubMed PMID: 17170700. Pubmed Central PMCID: 1782364. Epub 2006/12/16. eng.
33. Kaya AI, Onaran HO, Ozcan G, Ambrosio C, Costa T, Balli S, et al. Cell contact-dependent functional selectivity of beta2-adrenergic receptor ligands in stimulating cAMP accumulation and extracellular signal-regulated kinase phosphorylation. J Biol Chem. 2012;287(9):6362- PubMed PMID: 22241475. Pubmed Central PMCID: 3307305. Epub 2012/01/14. eng.
34. Li H, Ma XQ, Ye F, Zhang J, Zhou X, Wang ZH, et al. Expressions of cardiac sympathetic norepinephrine transporter and beta1-adrenergic receptor decreased in aged rats. J Zhejiang Univ Sci B. 2009;10(3):203-10. PubMed PMID: 19283875. Pubmed Central PMCID: 2650030.
35. White M, Roden R, Minobe W, Khan MF, Larrabee P, Wollmering M, et al. Age-related changes in beta-adrenergic neuroeffector systems in the human heart. Circulation. 1994;90(3):1225-38. PubMed PMID: 8087932. Epub 1994/09/01. eng.
36. Mika D, Richter W, Westenbroek RE, Catterall WA, Conti M. PDE4B mediates local feedback regulation of beta(1)-adrenergic cAMP signaling in a sarcolemmal compartment of cardiac myocytes. J Cell Sci. 2014;127(Pt 5):1033-42. PubMed PMID: 24413164. Pubmed Central PMCID: 3937773. Epub 2014/01/15. eng.
37. Bruzzone A, Sauliere A, Finana F, Senard JM, Luthy I, Gales C. Dosage-dependent regulation of cell proliferation and adhesion through dual beta2-adrenergic receptor/cAMP signals. FASEB J Off Publ Fed Am Soc Exp Biol. 2014;28(3):1342-54. PubMed PMID: 24308976. Epub 2013/12/07. eng.
38. Xie W, Santulli G, Guo X, Gao M, Chen BX, Marks AR. Imaging atrial arrhythmic intracellular calcium in intact heart. J Mol Cell Cardiol. 2013;64:120-3. PubMed PMID: 24041536. Epub 2013/09/18. eng.
39. Kirk JA, Holewinski RJ, Kooij V, Agnetti G, Tunin RS, Witayavanitkul N, et al. Cardiac resynchronization sensitizes the sarcomere to calcium by reactivating GSK-3beta. J Clin Invest. 2014;124(1):129-38. PubMed PMID: 24292707. Pubmed Central PMCID: 3871225.
40. Wright PT, Nikolaev VO, O’Hara T, Diakonov I, Bhargava A, Tokar S, et al. Caveolin-3 regulates compartmentation of cardiomyocyte beta2-adrenergic receptor-mediated cAMP signaling. J Mol Cell Cardiol. 2014;67:38-48. PubMed PMID: 24345421.
41. Santulli G. Adrenal signaling in heart failure: something more than a distant ship’s smoke on the horizon. Hypertension. 2014;63(2):215-6. PubMed PMID: 24218430.
42. Izzo R, Cipolletta E, Ciccarelli M, Campanile A, Santulli G, Palumbo G, et al. Enhanced GRK2 expression and desensitization of betaAR vasodilatation in hypertensive patients. Clin Transl Sci. 2008;1(3):215-20. PubMed PMID: 20443852. Epub 2008/12/01. eng.
43. Santulli G, Basilicata MF, De Simone M, Del Giudice C, Anastasio A, Sorriento D, et al. Evaluation of the anti-angiogenic properties of the new selective alphaVbeta3 integrin antagonist RGDechiHCit. J Transl Med. 2011;9:7. PubMed PMID: 21232121. Epub 2011/01/15. eng.
44. Sorriento D, Santulli G, Del Giudice C, Anastasio A, Trimarco B, Iaccarino G. Endothelial cells are able to synthesize and release catecholamines both in vitro and in vivo. Hypertension. 2012;60(1):129-36. PubMed PMID: 22665130.
45. Iaccarino G, Ciccarelli M, Sorriento D, Galasso G, Campanile A, Santulli G, et al. Ischemic neoangiogenesis enhanced by beta2-adrenergic receptor overexpression: a novel role for the endothelial adrenergic system. Circ Res. 2005;97(11):1182-9. PubMed PMID: 16239589. Epub 2005/10/22. eng.
46. Ritchie RH, Leo CH, Qin C, Stephenson EJ, Bowden MA, Buxton KD, et al. Low intrinsic exercise capacity in rats predisposes to age-dependent cardiac remodeling independent of macrovascular function. Am J Physiol Heart Circ Physiol. 2013;304(5):H729-39. PubMed PMID: 23262135. Pubmed Central PMCID: 3833993. Epub 2012/12/25. eng.
47. Santulli G. Coronary heart disease risk factors and mortality. JAMA J Am Med Assoc. 2012;307(11):1137. PubMed PMID: 22436947. author reply 8. Epub 2012/03/23. eng.
48. Vu TH, Stamler J, Liu K, McDermott MM, Lloyd-Jones DM, Pirzada A, et al. Prospective relationship of low cardiovascular risk factor profile at younger ages to ankle-brachial index: 39-year follow-up-the chicago healthy aging study. J Am Heart Assoc. 2012;1(6):e001545. PubMed PMID: 23316312. Pubmed Central PMCID: 3540658.
49. Sardu C, Marfella R, Santulli G. Impact of diabetes mellitus on the clinical response to cardiac resynchronization therapy in elderly people. J Cardiovasc Transl Res. 2014;7(3):362-8. PubMed PMID: 24500410. Epub 2014/02/07. eng.
50. Begum N, Shen W, Manganiello V. Role of PDE3A in regulation of cell cycle progression in mouse vascular smooth muscle cells and oocytes: implications in cardiovascular diseases and infertility. Curr Opin Pharmacol. 2011;11(6):725-9. PubMed PMID: 22051884. Pubmed Central PMCID: 3225595.
51. Lavi S, Nevo O, Thaler I, Rosenfeld R, Dayan L, Hirshoren N, et al. Effect of aging on the cardiovascular regulatory systems in healthy women. Am J Physiol Regul Integr Comp Physiol. 2007;292(2):R788-93. PubMed PMID: 16946083.
52. Menotti A, Lanti M, Mancini M, Zanchetti A, Laurenzi M, Terradura Vagnarelli O, et al. Moderate leisure time physical activity and occurrence of cardiovascular events: a 10-year follow-up in the Gubbio population study. J Cardiovasc Dis. 2014;2(5):218-24.
53. Heinonen I, Wendelin-Saarenhovi M, Kaskinoro K, Knuuti J, Scheinin M, Kalliokoski KK. Inhibition of alpha-adrenergic tone disturbs the distribution of blood flow in the exercising human limb. Am J Physiol Heart Circ Physiol. 2013;305(2):H163-72. PubMed PMID: 23666670.
54. Wu L, Liu L. Systematic review and meta-analysis evaluating the impact of vitamin D on the risk of heart failure: new evidence from population-based studies. J Cardiovasc Dis. 2014;2(3):159-73.
55. Al Maluli H, DeStephan C. Hemodynamic monitoring in the intensive care unit. J Cardiovasc Dis. 2014;2(2):101-15.
56. Latini R, Masson S, Staszewsky L, Barlera S. Neurohormonal modulation in heart failure of ischemic etiology: correlates with left ventricular remodeling. Curr Heart Fail Rep. 2006;3(4):157-63. PubMed PMID: 17129508. Epub 2006/11/30. eng.
57. Sardu C, Marfella R, Santulli G, Paolisso G. Functional role of miRNA in cardiac resynchronization therapy. Pharmacogenomics. 2014;15(8):1159-68. PubMed PMID: 25084208.
58. Senni M, Paulus WJ, Gavazzi A, Fraser AG, Diez J, Solomon SD, et al. New strategies for heart failure with preserved ejection fraction: the importance of targeted therapies for heart failure phenotypes. Eur Heart J. 2014;35:2797-815. PubMed PMID: 25104786.
59. Perez-Alvarez A, Hernandez-Vivanco A, Albillos A. Past, present and future of human chromaffin cells: role in physiology and therapeutics. Cell Mol Neurobiol. 2010;30(8):1407-15. PubMed PMID: 21107679. Epub 2010/11/26. eng.
60. Deo SH, Jenkins NT, Padilla J, Parrish AR, Fadel PJ. Norepinephrine increases NADPH oxidase-derived superoxide in human peripheral blood mononuclear cells via alpha-adrenergic receptors. Am J Physiol Regul Integr Comp Physiol. 2013;305(10):R1124-32. PubMed PMID: 24068047. Pubmed Central PMCID: 3841802.
61. Ma Y, Krueger JJ, Redmon SN, Uppuganti S, Nyman JS, Hahn MK, et al. Extracellular norepinephrine clearance by the norepinephrine transporter is required for skeletal homeostasis. J Biol Chem. 2013;288(42):30105-13. PubMed PMID: 24005671. Pubmed Central PMCID: 3798479.
62. Thireau J, Karam S, Roberge S, Roussel J, Aimond F, Cassan C, et al. Beta-adrenergic blockade combined with subcutaneous B-type natriuretic peptide: a promising approach to reduce ventricular arrhythmia in heart failure? Heart. 2014;100(11):833-41. PubMed PMID: 24667281.
63. Staroukine M, Devriendt J, Decoodt P, Verniory A. Relationships between plasma epinephrine, norepinephrine, dopamine and angiotensin II concentrations, renin activity, hemodynamic state and prognosis in acute heart failure. Acta Cardiol. 1984;39(2):131-8. PubMed PMID: 6375223.
64. Yuan Q, Chen Z, Santulli G, Gu L, Yang ZG, Yuan ZQ, et al. Functional Role of Calstabin2 in Age-related Cardiac Alterations. Scientific reports. 2014;4:7425. PubMed PMID: 25502776.
65. Moussouttas M, Mearns E, Walters A, DeCaro M. Plasma catecholamine profile of subarachnoid hemorrhage patients with neurogenic cardiomyopathy: a prospective study. J Cardiovasc Dis. 2014;2(3):125-30.
66. Santulli G. Importance of HDL increase in long-term cardiovascular effects of low- carbohydrate diet. Ann Intern Med. 2015; In press.
67. Huang CJ, Webb HE, Zourdos MC, Acevedo EO. Cardiovascular reactivity, stress, and physical activity. Front Physiol. 2013;4:314. PubMed PMID: 24223557. Pubmed Central PMCID: 3819592.
68. Weng TP, Fu TC, Wang CH, Hsu CC, Wang JS. Activation of lymphocyte autophagy/apoptosis reflects haemodynamic inefficiency and functional aerobic impairment in patients with heart failure. Clin Sci. 2014;127(10):589-602. PubMed PMID: 24863428.
69. Berezin A, Kremzer A, Samura T, Martovitskaya Y. Apoptotic microparticles to progenitor mononuclear cells ratio in heart failure: relevance of clinical status and outcomes. J Cardiovasc Dis. 2014;2(2):50-7.
70. Ciccarelli M, Santulli G, Campanile A, Galasso G, Cervero P, Altobelli GG, et al. Endothelial alpha 1-adrenoceptors regulate neo-angiogenesis. Br J Pharmacol. 2008;153(5):936-46. PubMed PMID: 18084315. Epub 2007/12/18. eng.
71. Gao W, Li J. Femoral artery occlusion increases muscle pressor reflex and expression of hypoxia-inducible factor-1a in sensory neurons. J Cardiovasc Dis. 2014;1(2):34-40.
72. Brinks H, Koch WJ. betaARKct: a therapeutic approach for improved adrenergic signaling and function in heart disease. J Cardiovasc Transl Res. 2010;3(5):499-506. PubMed PMID: 20623214.
73. Gurdal H, Friedman E, Johnson MD. Beta-adrenoceptor-G alpha S coupling decreases with age in rat aorta. Mol Pharmacol. 1995;47(4):772-8. PubMed PMID: 7723738. Epub 1995/04/01. eng.
74. Seals DR, Dinenno FA. Collateral damage: cardiovascular consequences of chronic sympathetic activation with human aging. Am J Physiol Heart Circ Physiol. 2004;287(5):H1895- 905. PubMed PMID: 15475526.
75. Santulli G, Campanile A, Spinelli L, di Panzillo Assante E, Ciccarelli M, Trimarco B, et al. G protein-coupled receptor kinase 2 in patients with acute myocardial infarction. Am J Cardiol. 2011;107(8):1125-30. PubMed PMID: 21296320. Epub 2011/02/08. eng.
76. Buroker N. ADRBK1 (GRK2) rSNPs, transcriptional factor binding sites and cardiovascular disease in the black population. J Cardiovasc Dis. 2014;2(2):62-7.
77. Borkowski KR, Gros R, Schneider H. Vascular beta-adrenoceptor-mediated responses in hypertension and ageing in rats. J Auton Pharmacol. 1992;12(6):389-401. PubMed PMID: 1335455. Epub 1992/12/01. eng.
78. Zhao L, Yang F, Xu K, Cao H, Zheng GY, Zhang Y, et al. Common genetic variants of the beta2-adrenergic receptor affect its translational efficiency and are associated with human longevity. Aging Cell. 2012;11(6):1094-101. PubMed PMID: 23020224. Pubmed Central PMCID: 3633790.
79. Renard P, Kovalski JL, Cochereau I, Jaulerry S, Williamson W, Elena PP, et al. Comparison of carteolol plasmatic levels after repeated instillations of long-acting and regular formulations of carteolol 2% in glaucoma patients. Graefes Arch Clin Exp Ophthalmol Albrecht von Graefes Arch Klin Exp Ophthalmol. 2005;243(12): 1221-7. PubMed PMID: 16003515. Epub 2005/07/09. eng.
80. Tang-Liu DD, Shackleton M, Richman JB. Ocular metabolism of levobunolol. J Ocul Pharmacol. 1988;4(3):269-78. PubMed PMID: 3058836. Epub 1988/01/01. eng.
81. Heel RC, Brogden RN, Pakes GE, Speight TM, Avery GS. Nadolol: a review of its pharmacological properties and therapeutic efficacy in hypertension and angina pectoris. Drugs. 1980;20(1):1-23. PubMed PMID: 6105067. Epub 1980/07/01. eng.
82. Muller FO, Hundt HK, Bromley PA, Torres J, Vanderbeke O. Single and divided doses of penbutolol. Clin Pharmacol Ther. 1979;25(5 Pt 1):528-35. PubMed PMID: 436357. Epub 1979/05/01. eng.
83. Golightly LK. Pindolol: a review of its pharmacology, pharmacokinetics, clinical uses, and adverse effects. Pharmacotherapy. 1982;2(3):134-47. PubMed PMID: 6133267. Epub 1982/05/01. eng.
84. Mackichan JJ, Pyszczynski DR, Jusko WJ. Dose-dependent disposition of oral propranolol in normal subjects. Biopharm Drug Dispos. 1980;1(4):159-66. PubMed PMID: 7448344. Epub 1980/04/01. eng.
85. Schnelle K, Klein G, Schinz A. Studies on the pharmacokinetics and pharmacodynamics of the beta-adrenergic blocking agent sotalol in normal man. J Clin Pharmacol. 1979;19(8-9 Pt 2):516-22. PubMed PMID: 489770. Epub 1979/08/01. eng.
86. Else OF, Sorenson H, Edwards IR. Plasma timolol levels after oral and intravenous administration. Eur J Clin Pharmacol. 1978;14(6):431-4. PubMed PMID: 738350. Epub 1978/12/18. eng.
87. Singh BN, Thoden WR, Wahl J. Acebutolol: a review of its pharmacology, pharmacokinetics, clinical uses, and adverse effects. Pharmacotherapy. 1986;6(2):45-63. PubMed PMID: 3012486. Epub 1986/03/01. eng.
88. Wan SH, Koda RT, Maronde RF. Pharmacokinetics, pharmacology of atenolol and effect of renal disease. Br J Clin Pharmacol. 1979;7(6):569-74. PubMed PMID: 465278. Pubmed Central PMCID: 1429677. Epub 1979/06/01. eng.
89. Frishman WH, Tepper D, Lazar EJ, Behrman D. Betaxolol: a new long-acting beta 1-selective adrenergic blocker. J Clin Pharmacol. 1990;30(8):686-92. PubMed PMID: 2205635. Epub 1990/08/01. eng.
90. Le Coz F, Sauleman P, Poirier JM, Cuche JL, Midavaine M, Rames A, et al. Oral pharmacokinetics of bisoprolol in resting and exercising healthy volunteers. J Cardiovasc Pharmacol. 1991;18(1):28-34. PubMed PMID: 1719288. Epub 1991/07/01. eng.
91. Garnock-Jones KP. Esmolol: a review of its use in the short-term treatment of tachyarrhythmias and the short-term control of tachycardia and hypertension. Drugs. 2012;72(1):109-32. PubMed PMID: 22191799. Epub 2011/12/24. eng.
92. Kukin ML, Mannino MM, Freudenberger RS, Kalman J, Buchholz-Varley C, Ocampo O. Hemodynamic comparison of twice daily metoprolol tartrate with once daily metoprolol succinate in congestive heart failure. J Am Coll Cardiol. 2000;35(1):45-50. PubMed PMID: 10636257. Epub 2000/01/15. eng.
93. Andreka P, Aiyar N, Olson LC, Wei JQ, Turner MS, Webster KA, et al. Bucindolol displays intrinsic sympathomimetic activity in human myocardium. Circulation. 2002;105(20):2429-34 PubMed PMID: 12021232. Epub 2002/05/22. eng.
94. Sehrt D, Meineke I, Tzvetkov M, Gultepe S, Brockmoller J. Carvedilol pharmacokinetics and pharmacodynamics in relation to CYP2D6 and ADRB pharmacogenetics. Pharmacogenomics. 2011;12(6):783-95. PubMed PMID: 21599570. Epub 2011/05/24. eng.
95. Riddell JG, Shanks RG, Brogden RN. Celiprolol. A preliminary review of its pharmacodynamic and pharmacokinetic properties and its therapeutic use in hypertension and angina pectoris. Drugs. 1987;34(4):438-58. PubMed PMID: 2890513. Epub 1987/10/01. eng.
96. Lalonde RL, O’Rear TL, Wainer IW, Drda KD, Herring VL, Bottorff MB. Labetalol pharmacokinetics and pharmacodynamics: evidence of stereoselective disposition. Clin Pharmacol Ther. 1990;48(5):509-19. PubMed PMID: 2225711. Epub 1990/11/01. eng.
97. de Nigris F, Mancini FP, Balestrieri ML, Byrns R, Fiorito C, Williams-Ignarro S, et al. Therapeutic dose of nebivolol, a nitric oxide-releasing beta-blocker, reduces atherosclerosis in cholesterol-fed rabbits. Nitric Oxide Biol Chem Off J Nitric Oxide Soc. 2008;19(1):57-63. PubMed PMID: 18435936. Epub 2008/04/26. eng.
98. Llewellyn TL, Sharma NM, Zheng H, Patel KP. Effects of exercise training on SFO-mediated sympathoexcitation during chronic heart failure. Am J Physiol Heart Circ Physiol. 2014;306(1):H121-31. PubMed PMID: 24163080. Pubmed Central PMCID: 3920154. Epub 2013/10/29. eng.
99. Kukin ML. Beta-blockers in chronic heart failure: considerations for selecting an agent. Mayo Clin Proc. 2002;77(11):1199-206. PubMed PMID: 12440556. Epub 2002/11/21. eng.
100. Ellison KE, Gandhi G. Optimising the use of beta-adrenoceptor antagonists in coronary artery disease. Drugs. 2005;65(6):787-97. PubMed PMID: 15819591. Epub 2005/04/12. eng.
101. Rochais F, Vilardaga JP, Nikolaev VO, Bunemann M, Lohse MJ, Engelhardt S. Real-time optical recording of beta1-adrenergic receptor activation reveals supersensitivity of the Arg389 variant to carvedilol. J Clin Invest. 2007;117(1):229-35. PubMed PMID: 17200720. Pubmed Central PMCID: 1751291. Epub 2007/01/04. eng.
102. DeGeorge Jr BR, Koch WJ. Beta blocker specificity: a building block toward personalized medicine. J Clin Invest. 2007;117(1):86-9. PubMed PMID: 17200711. Pubmed Central PMCID: 1716219. Epub 2007/01/04. eng.
103. Podowski M, Calvi C, Metzger S, Misono K, Poonyagariyagorn H, Lopez-Mercado A, et al. Angiotensin receptor blockade attenuates cigarette smoke-induced lung injury and rescues lung architecture in mice. J Clin Invest. 2012;122(1):229-40. PubMed PMID: 22182843. Pubmed Central PMCID: 3248282. Epub 2011/12/21. eng.
104. Santulli G. Beta-Blockers in diabetic patients with heart failure. JAMA Intern Med. 2015; In press.
105. Lazalde-Ramos BP, Martinez-Fierro Mde L, Galaviz-Hernandez C, Garza-Veloz I, Naranjo ME, Sosa-Macias M, et al. CYP2D6 gene polymorphisms and predicted phenotypes in eight indigenous groups from northwestern Mexico. Pharmacogenomics. 2014;15(3):339-48. PubMed PMID: 24533713. Epub 2014/02/19. eng.
106. Sim SC, Kacevska M, Ingelman-Sundberg M. Pharmacogenomics of drug-metabolizing enzymes: a recent update on clinical implications and endogenous effects. Pharmacogenomics J. 2013;13(1):1-11. PubMed PMID: 23089672. Epub 2012/10/24. eng.
107. Tendera M, Ochala A. Overview of the results of recent beta blocker trials. Curr Opin Cardiol. 2001;16(3):180-5. PubMed PMID: 11357013. Epub 2001/05/18. eng.
108. Kurdi M, Booz GW. Carvedilol protects the infarcted heart by upregulating miR-133: first evidence that disease state affects beta-adrenergic arrestin-biased signaling? J Mol Cell Cardiol. 2014;76:12-24. PubMed PMID: 25128784. Epub 2014/08/17. Eng.
109. Vaidya V, Patel P. Health expenditure comparison of extended-release metoprolol succinate and immediate-release metoprolol tartrate. Clinico Econ Outcomes Res CEOR. 2012;4:49-56 PubMed PMID: 22359463. Pubmed Central PMCID: 3284258. Epub 2012/02/24. eng.
110. Zhao N, Zidan A, Tawakkul M, Sayeed VA, Khan M. Tablet splitting: product quality assessment of metoprolol succinate extended release tablets. Int J Pharm. 2010;401(1-2):25-31. PubMed PMID: 20849940. Epub 2010/09/21. eng.
111. Cheng JW. A review of isosorbide dinitrate and hydralazine in the management of heart failure in black patients, with a focus on a new fixed-dose combination. Clin Ther. 2006;28(5): 666-78. PubMed PMID: 16861089. Epub 2006/07/25. eng.
112. Oparil S, Davis BR, Cushman WC, Ford CE, Furberg CD, Habib GB, et al. Mortality and morbidity during and after antihypertensive and lipid-lowering treatment to prevent heart attack trial: results by sex. Hypertension. 2013;61(5):977-86. PubMed PMID: 23529173. Pubmed Central PMCID: 4114223. Epub 2013/03/27. eng.
113. Gavras I, Manolis AJ, Gavras H. The alpha2 -adrenergic receptors in hypertension and heart failure: experimental and clinical studies. J Hypertens. 2001;19(12):2115-24. PubMed PMID: 11725152. Epub 2001/11/29. eng.
114. Pocock S, Wilhelmsen L, Dickstein K, Francis G, Wittes J. The data monitoring experience in the MOXCON trial. Eur Heart J. 2004;25(22):1974-8. PubMed PMID: 15541832.
115. Frantz RP, Lowes BD, Grayburn PA, White M, Krause-Steinrauf H, Krishnan V, et al. Baseline and serial neurohormones in patients with congestive heart failure treated with and without bucindolol: results of the neurohumoral substudy of the Beta-Blocker Evaluation of Survival Study (BEST). J Card Fail. 2007;13(6):437-44. PubMed PMID: 17675057.
116. Deneer VH, van Hemel NM. Is antiarrhythmic treatment in the elderly different? a review of the specific changes. Drugs Aging. 2011;28(8):617-33. PubMed PMID: 21812498. Epub 2011/08/05. eng.
117. Chaney E, Shaw A. Pathophysiology of fluid retention in heart failure. Contrib Nephrol. 2010;164:46-53. PubMed PMID: 20427993. Epub 2010/04/30. eng.
118. Struthers AD, MacDonald TM. Review of aldosterone- and angiotensin II-induced target organ damage and prevention. Cardiovasc Res. 2004;61(4):663-70. PubMed PMID: 14985063. Epub 2004/02/27. eng.
119. Chrissobolis S, Drummond GR, Faraci FM, Sobey CG. Chronic aldosterone administration causes Nox2-mediated increases in reactive oxygen species production and endothelial dysfunction in the cerebral circulation. J Hypertens. 2014;32(9):1815-21. PubMed PMID: 24991871. Epub 2014/07/06. eng.
120. Galmiche G, Pizard A, Gueret A, El Moghrabi S, Ouvrard-Pascaud A, Berger S, et al. Smooth muscle cell mineralocorticoid receptors are mandatory for aldosterone-salt to induce vascular stiffness. Hypertension. 2014;63(3):520-6. PubMed PMID: 24296280. Epub 2013/12/04. eng.
121. Gradman AH, Papademetriou V. Combined renin-angiotensin-aldosterone system inhibition in patients with chronic heart failure secondary to left ventricular systolic dysfunction. Am Heart J. 2009;157(6 Suppl):S17-23. PubMed PMID: 19450720.
122. Regnault V, Lagrange J, Pizard A, Safar ME, Fay R, Pitt B, et al. Opposite predictive value of pulse pressure and aortic pulse wave velocity on heart failure with reduced left ventricular ejection fraction: insights from an Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS) substudy. Hypertension. 2014;63(1): 105-11. PubMed PMID: 24126172.
123. Wittes J, Palensky J, Asner D, Julian D, Boissel JP, Furberg CD, et al. Experience collecting interim data on mortality: an example from the RALES study. Curr Control Trials Cardiovasc Med. 2001;2(1):59-62. PubMed PMID: 11806773. Pubmed Central PMCID: 56203.
124. Wang HJ, Wang W, Cornish KG, Rozanski GJ, Zucker IH. Cardiac sympathetic afferent denervation attenuates cardiac remodeling and improves cardiovascular dysfunction in rats with heart failure. Hypertension. 2014;64:745-55. PubMed PMID: 24980663.
125. Katayama T, Sueta D, Kataoka K, Hasegawa Y, Koibuchi N, Toyama K, et al. Long-term renal denervation normalizes disrupted blood pressure circadian rhythm and ameliorates cardiovascular injury in a rat model of metabolic syndrome. J Am Heart Assoc. 2013;2(4):e000197. PubMed PMID: 23974905. Pubmed Central PMCID: 3828797.
126. Molon G, Marczyk J, Virzi G, Bellazzi R, Malovini A, Accardi F, et al. Analysis of ECG by means of complexity index and association with clinical response to cardiac resynchronization therapy. J Cardiovasc Dis. 2014;2(3):147-52.
127. Cha YM, Chareonthaitawee P, Dong YX, Kemp BJ, Oh JK, Miyazaki C, et al. Cardiac sympathetic reserve and response to cardiac resynchronization therapy. Circ Heart Fail. 2011;4(3):339-44. PubMed PMID: 21421772.
128. Santulli G, D’Ascia S, D’Ascia C. Regarding the impact of left ventricular size on response to cardiac resynchronization therapy. Am Heart J. 2012;163(4):e11. PubMed PMID: 22520543. Epub 2012/04/24. eng.
129. Santulli G, D’Ascia C. Atrial remodelling in echocardiographic super-responders to cardiac resynchronization therapy. Heart. 2012;98(6):517. author reply PubMed PMID: 22350031. Epub 2012/02/22. eng.
130. Szepietowska B, Zhu W, Czyzyk J, Eid T, Sherwin RS. EphA5-EphrinA5 interactions within the ventromedial hypothalamus influence counterregulatory hormone release and local glutamine/glutamate balance during hypoglycemia. Diabetes. 2013;62(4):1282-8. PubMed PMID: 23274893. Pubmed Central PMCID: 3609598.
131. Neglia D, De Caterina A, Marraccini P, Natali A, Ciardetti M, Vecoli C, et al. Impaired myocardial metabolic reserve and substrate selection flexibility during stress in patients with idiopathic dilated cardiomyopathy. Am J Physiol Heart Circ Physiol. 2007;293(6):H3270-8. PubMed PMID: 17921325.
132. Dias P, Terracciano CM. Hyperpolarization-activated cyclic nucleotide-gated channels and ventricular arrhythmias in heart failure: a novel target for therapy? J Am Heart Assoc. 2013;2(3):e000287. PubMed PMID: 23747794. Pubmed Central PMCID: 3698796.
133. Li YF, Shi ST. Age-dependent differential crosstalk between alpha(1)-adrenergic and angiotensin receptors. Can J Cardiol. 2009;25(8):481-5. PubMed PMID: 19668783. Pubmed Central PMCID: 2732376.
134. Ciccarelli M, Santulli G, Pascale V, Trimarco B, Iaccarino G. Adrenergic receptors and metabolism: role in development of cardiovascular disease. Front Physiol. 2013;4:265. PubMed PMID: 24106479. Pubmed Central PMCID: 3789271.
135. Chakraborty M, Phillips A, Macdonald J, Windsor J, Hickey A. Mitochondrial respiration in mononuclear cells and heart fibers in spontaneously hypertensive rats. J Cardiovasc Dis. 2014;2(1):7-14.
136. Santulli G, Marks AR. Essential roles of intracellular calcium release channels in muscle, brain, metabolism, and aging. Current Molecular Pharmacology. 2015; In press.
137. Fu Q, Xu B, Liu Y, Parikh D, Li J, Li Y, et al. Insulin inhibits cardiac contractility by inducing a Gi-biased beta2 adrenergic signaling in hearts. Diabetes. 2014;63:2676-2689. PubMed PMID: 24677713.
138. Msolly A, Miled A, Kassab A. Hydrogen peroxide: an oxidant stress indicator in Type 2 diabetes mellitus. J Cardiovasc Dis. 2014;1(2):48-52.
139. Oriente F, Iovino S, Cassese A, Romano C, Miele C, Troncone G, et al. Overproduction of phosphoprotein enriched in diabetes (PED) induces mesangial expansion and upregulates protein kinase C-beta activity and TGF-beta1 expression. Diabetologia. 2009;52(12):2642-2652 PubMed PMID: 19789852. Epub 2009/10/01. eng.
140. Azevedo PS, Minicucci MF, Santos PP, Paiva SA, Zornoff LA. Energy metabolism in cardiac remodeling and heart failure. Cardiol Rev. 2013;21(3):135-40. PubMed PMID: 22990373.
141. Shimizu I, Minamino T, Toko H, Okada S, Ikeda H, Yasuda N, et al. Excessive cardiac insulin signaling exacerbates systolic dysfunction induced by pressure overload in rodents. J Clin Invest. 2010; 120(5): 1506-14. PubMed PMID: 20407209. Pubmed Central PMCID: 2860916.
142. Badimon L, Hernandez Vera R, Vilahur G. Determinants of cardiovascular risk in diabetes beyond hyperglycemia. J Cardiovasc Dis. 2014;1(2):53-62.
143. Masuo K, Rakugi H, Ogihara T, Lambert GW. Different mechanisms in weight loss-induced blood pressure reduction between a calorie-restricted diet and exercise. Hypertens Res Off J Japan Soc Hypertens. 2012;35(1):41-7. PubMed PMID: 21814218. Epub 2011/08/05. eng.
144. Quinones MJ, Nicholas SB, Lyon CJ. Insulin resistance and the endothelium. Curr Diab Rep. 2005;5(4):246-53. PubMed PMID: 16033673.
145. Mongillo M, John AS, Leccisotti L, Pennell DJ, Camici PG. Myocardial pre-synaptic sympathetic function correlates with glucose uptake in the failing human heart. Eur J Nucl Med Mol Imaging. 2007;34(8):1172-7. PubMed PMID: 17294189.
146. Larsen TM, Toubro S, van Baak MA, Gottesdiener KM, Larson P, Saris WH, et al. Effect of a 28-d treatment with L-796568, a novel beta(3)-adrenergic receptor agonist, on energy expenditure and body composition in obese men. Am J Clin Nutr. 2002;76(4):780-8. PubMed PMID: 12324291.
147. Fusco A, Santulli G, Sorriento D, Cipolletta E, Garbi C, Dorn 2nd GW, et al. Mitochondrial localization unveils a novel role for GRK2 in organelle biogenesis. Cell Signal. 2012;24(2):468-75. PubMed PMID: 21983013. Pubmed Central PMCID: 3237777.
148. Chen M, Sato PY, Chuprun JK, Peroutka RJ, Otis NJ, Ibetti J, et al. Prodeath signaling of G protein-coupled receptor kinase 2 in cardiac myocytes after ischemic stress occurs via extracellular signal-regulated kinase-dependent heat shock protein 90-mediated mitochondrial targeting. Circ Res. 2013; 112(8): 1121-34. PubMed PMID: 23467820. Pubmed Central PMCID: 3908784.
149. Taguchi K, Sakata K, Ohashi W, Imaizumi T, Imura J, Hattori Y. Tonic inhibition by G protein-coupled receptor kinase 2 of Akt/endothelial nitric-oxide synthase signaling in human vascular endothelial cells under conditions of hyperglycemia with high insulin levels. J Pharmacol Exp Ther. 2014;349(2):199-208. PubMed PMID: 24570070.
150. Hata JA, Williams ML, Koch WJ. Genetic manipulation of myocardial beta-adrenergic receptor activation and desensitization. J Mol Cell Cardiol. 2004;37(1):11-21. PubMed PMID: 15242731.