Telomere length shortening and Alzheimer disease-A mendelian randomization study

JAMA Neurology

Volumn 72, Issue 10, 2015, Pages 1202-1203

  Zhan, Yiqiang ^a   Song, Ci ^a   Karlsson, Robert ^a   Tillander, Annika ^a   Reynolds, Chandra A ^b   Pedersen, Nancy L ^a   Hägg, Sara ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; DISEASE ASSOCIATION; GENE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOMICS; HUMAN; LETTER; MENDELIAN RANDOMIZATION ANALYSIS; OBFC1 GENE; PATHOGENESIS; PLEIOTROPY; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; TELOMERE HOMEOSTASIS; TELOMERE SHORTENING; TERT GENE; COMPLICATION; GENETIC SCREENING; GENETICS; RANDOMIZATION; RISK; TELOMERE;

ALZHEIMER DISEASE; GENETIC TESTING; HUMANS; POLYMORPHISM, SINGLE NUCLEOTIDE; RANDOM ALLOCATION; RISK; TELOMERE;

EID: 84944043892     PISSN: 21686149     EISSN: 21686157     Source Type: Journal    
DOI: 10.1001/jamaneurol.2015.1513     Document Type: Letter

References (6)

1. Blasco MA. Telomeres and human disease: ageing, cancer and beyond. Nat Rev Genet. 2005;6(8):611-622.
2. Honig LS, Kang MS, Schupf N, Lee JH, Mayeux R. Association of shorter leukocyte telomere repeat length with dementia and mortality. Arch Neurol. 2012;69(10):1332-1339.
3. Fall T, Hägg S, Mägi R, et al; European Network for Genetic and Genomic Epidemiology (ENGAGE) consortium. The role of adiposity in cardiometabolic traits: a Mendelian randomization analysis. PLoS Med. 2013;10(6):e1001474.
4. Codd V, Nelson CP, Albrecht E, et al. Identification of seven loci affecting mean telomere length and their association with disease. Nat Genet. 2013;45(4):422-427, e1-e2.
5. Lambert JC, Ibrahim-Verbaas CA, Harold D, et al; European Alzheimer's Disease Initiative (EADI); Genetic and Environmental Risk in Alzheimer's Disease; Alzheimer's Disease Genetic Consortium; Cohorts for Heart and Aging Research in Genomic Epidemiology. Meta-analysis of 74, 046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. Nat Genet. 2013;45(12):1452-1458.
6. Burgess S, Scott RA, Timpson NJ, Davey Smith G, Thompson SG; EPIC-InterAct Consortium. Using published data in Mendelian randomization: a blueprint for efficient identification of causal risk factors. Eur J Epidemiol. 2015;30(7):543-552.