Prognostic impact of preoperative platelets to lymphocytes ratio (PLR) on survival for oesophageal and junctional carcinoma treated with neoadjuvant chemotherapy: A retrospective monocentric study on 153 patients

European Journal of Surgical Oncology

Volumn 41, Issue 10, 2015, Pages 1316-1323

  Messager, M ^a,b   Neofytou, K ^a   Chaudry, M A ^a   Allum, W H ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b LILLE UNIVERSITY HOSPITAL   (France)

Author keywords

Biomarker; Gastro esophageal junctional cancer; Lymphocytes; Oesophageal cancer; Platelets

Indexed keywords

CAPECITABINE; CISPLATIN; EPIRUBICIN; FLUOROURACIL; ANTINEOPLASTIC AGENT;

ADJUVANT THERAPY; ARTICLE; CANCER ADJUVANT THERAPY; CANCER MORTALITY; CANCER PROGNOSIS; CANCER RECURRENCE; CANCER STAGING; CANCER SURVIVAL; DISEASE MARKER; ESOPHAGEAL ADENOCARCINOMA; ESOPHAGEAL AND JUNCTIONAL CARCINOMA; ESOPHAGUS CARCINOMA; HUMAN; MAJOR CLINICAL STUDY; MULTIPLE CYCLE TREATMENT; OVERALL SURVIVAL; PLATELET LYMPHOCYTE RATIO; PRIORITY JOURNAL; TREATMENT PLANNING; ADENOCARCINOMA; ADULT; AGED; BLOOD; COHORT ANALYSIS; DISEASE FREE SURVIVAL; ESOPHAGEAL NEOPLASMS; ESOPHAGUS RESECTION; FEMALE; LOWER ESOPHAGUS SPHINCTER; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; PATHOLOGY; PREOPERATIVE PERIOD; PROGNOSIS; RECEIVER OPERATING CHARACTERISTIC; RETROSPECTIVE STUDY; SURGERY; SURVIVAL RATE; THROMBOCYTE COUNT; VERY ELDERLY;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CAPECITABINE; CISPLATIN; COHORT STUDIES; DISEASE-FREE SURVIVAL; EPIRUBICIN; ESOPHAGEAL NEOPLASMS; ESOPHAGECTOMY; ESOPHAGOGASTRIC JUNCTION; FEMALE; FLUOROURACIL; HUMANS; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; NEOADJUVANT THERAPY; NEOPLASM STAGING; PLATELET COUNT; PREOPERATIVE PERIOD; PROGNOSIS; RETROSPECTIVE STUDIES; ROC CURVE; SURVIVAL RATE;

EID: 84943818426     PISSN: 07487983     EISSN: 15322157     Source Type: Journal    
DOI: 10.1016/j.ejso.2015.06.007     Document Type: Article

References (29)

1. J. Ferlay, H.R. Shin, F. Bray, and et al. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008 Int J Cancer 127 2010 2893 2917
2. A. Jemal, F. Bray, M.M. Center, and et al. Global cancer statistics CA Cancer J Clin 61 2011 69 90
3. A. Pennathur, M.K. Gibson, B.A. Jobe, and et al. Oesophageal carcinoma Lancet 381 2013 400 412
4. B.J. Dicken, D.L. Bigam, C. Cass, and et al. Gastric adenocarcinoma: review and considerations for future directions Ann Surg 241 2005 27 39
5. A. Mantovani, P. Allavena, A. Sica, and et al. Cancer related inflammation Nature 454 2008 436 444
6. R.Z. Sharaiha, K.J. Halazun, F. Mirza, and et al. Elevated preoperative neutrophil: lymphocyte ratio as a predictor of postoperative disease recurrence in esophageal cancer Ann Surg Oncol 18 2011 3362 3369
7. J. Szkandera, M. Pichler, G. Absenger, and et al. The elevated preoperative platelet to lymphocyte ratio predicts decreased time to recurrence in colon cancer patients Am J Surg 208 2014 210 214
8. K. Neofytou, E.C. Smyth, A. Giakoustidis, and et al. Elevated platelet to lymphocyte ratio predicts poor prognosis after hepatectomy for liver-only colorectal metastases, and it is superior to neutrophil to lymphocyte ratio as an adverse prognostic factor Med Oncol 31 2014 239 248
9. S. Raungkaewmanee, S. Tangjitgamol, S. Manusirivithaya, and et al. Platelet to lymphocyte ratio as a prognostic factor for epithelial ovarian cancer J Gynecol Oncol 23 2012 265 273
10. R.A. Smith, L. Bosonnet, M. Raraty, and et al. Preoperative platelet-lymphocyte ratio is an independent significant prognostic marker in resected pancreatic ductal adenocarcinoma Am J Surg 197 2009 466 472
11. J.F. Feng, Y. Huang, Q. Zhao, and et al. Clinical significance of preoperative neutrophil lymphocyte ratio versus platelet lymphocyte ratio in patients with small cell carcinoma of the esophagus ScientificWorldJournal 504365 2013 1 7
12. F. Noble, J. Hopkins, N. Curtis, and et al. The role of systemic inflammatory and nutritional blood-borne markers in predicting response to neoadjuvant chemotherapy and survival in oesophagogastric cancer Med Oncol 30 2013 596
13. S. Dutta, A.B. Crumley, G.M. Fullarton, and et al. Comparison of the prognostic value of tumour- and patient-related factors in patients undergoing potentially curative resection of oesophageal cancer World J Surg 35 2011 1861 1866
14. L.H. Sobin, M.K. Gospodarowicz, and C. Wittekind TNM classification of malignant tumors 7th ed. 2009 Wiley-Blackwell Oxford
15. W.H. Allum, J.M. Blazeby, S.M. Griffin, and et al. Guidelines for the management of oesophageal and gastric cancer Gut 60 2011 1449 1472
16. S. Grivennikov, F. Greten, and M. Karin Immunity, inflammation, and cancer Cell 140 2010 883 899
17. K. Egan, D. Crowley, P. Smyth, and et al. Platelet adhesion and degranulation induce pro-survival and pro-angiogenic signalling in ovarian cancer cells PLoS One 6 2011 26125
18. K. Suzuki, K. Aiura, M. Ueda, and et al. The influence of platelets on the promotion of invasion by tumor cells and inhibition by antiplatelet agents Pancreas 29 2004 132 140
19. G.P. Dunn, L.J. Old, and R.D. Schreiber The immunobiology of cancer immunosurveillance and immunoediting Immunity 21 2004 137 148
20. S. Lee, S.Y. Oh, S.H. Kim, and et al. Prognostic significance of neutrophil lymphocyte ratio and platelet lymphocyte ratio in advanced gastric cancer patients treated with FOLFOX chemotherapy BMC Cancer 13 2013 350 361
21. M.J. Gooden, G.H. de Bock, N. Leffers, and et al. The prognostic influence of tumour-infiltrating lymphocytes in cancer: a systematic review with meta-analysis Br J Cancer 105 2011 93 103
22. G. De Angulo, C. Yuen, S.L. Palla, and et al. Absolute lymphocyte count is a novel prognostic indicator in ALL and AML: implications for risk stratification and future studies Cancer 112 2008 407 415
23. K. Milne, C. Alexander, J.R. Webb, and et al. Absolute lymphocyte count is associated with survival in ovarian cancer independent of tumor-infiltrating lymphocytes J Transl Med 10 2012 33 45
24. N.M. Rochet, L.A. Kottschade, T.E. Grotz, and et al. The prognostic role of the preoperative absolute lymphocyte count and absolute monocyte count in patients with resected advanced melanoma Am J Clin Oncol 2013 (e-pub ahead of print, 14 June 2013)
25. R. Salgado, P.B. Vermeulen, I. Benoy, and et al. Platelet number and interleukin-6 correlate with VEGF but not with bFGF serum levels of advanced cancer patients Br J Cancer 80 1999 892 897
26. E. Gunsilius, and G. Gastl Platelets and VEGF blood levels in cancer patients Br J Cancer 81 1999 185 186
27. M. Ishizuka, H. Nagata, K. Takagi, and et al. Combination of platelet count and neutrophil to lymphocyte ratio is a useful predictor of postoperative survival in patients with colorectal cancer Br J Cancer 109 2013 401 407
28. R. Li, M. Ren, N. Chen, and et al. Presence of intratumoral platelets is associated with tumor vessel structure and metastasis BMC Cancer 14 2014 167 177
29. V.K. Wong, H.Z. Malik, Z.Z. Hamady, and et al. C-reactive protein as a predictor of prognosis following curative resection for colorectal liver metastases Br J Cancer 96 2007 222 225