Ngn1 inhibits astrogliogenesis through induction of miR-9 during neuronal fate specification

eLife

Volumn 4, Issue AUGUST2015, 2015, Pages

  Zhao, Jing ^a   Lin, Quan ^a,b   Kim, Kevin J ^a   Dardashti, Faranak D ^a   Kim, Jennifer ^a   He, Fei ^a   Sun, Yi ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

JANUS KINASE 1; MICRORNA 9; NEUROGENIN 1; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; GLYCOPROTEIN GP 130; JAK1 PROTEIN, MOUSE; LEUKEMIA INHIBITORY FACTOR RECEPTOR ALPHA; LIFR PROTEIN, MOUSE; MICRORNA; MIRN9 MICRORNA, MOUSE; NERVE PROTEIN; NEUROG1 PROTEIN, MOUSE;

ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASTROGLIOGENESIS; BINDING SITE; CELL MATURATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DOWN REGULATION; ELECTROPORATION; EPIGENETICS; IMAGE PROCESSING; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INTRACELLULAR SIGNALING; LUCIFERASE ASSAY; MALE; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; RNA ISOLATION; SITE SPECIFIC REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANTAGONISTS AND INHIBITORS; ASTROCYTE; BIOSYNTHESIS; CELL DIFFERENTIATION; GENE EXPRESSION REGULATION; METABOLISM; PHYSIOLOGY;

ASTROCYTES; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL DIFFERENTIATION; CYTOKINE RECEPTOR GP130; GENE EXPRESSION REGULATION; JANUS KINASE 1; LEUKEMIA INHIBITORY FACTOR RECEPTOR ALPHA SUBUNIT; MICRORNAS; NERVE TISSUE PROTEINS;

EID: 84943812316     PISSN: None     EISSN: 2050084X     Source Type: Journal    
DOI: 10.7554/eLife.06885     Document Type: Article

References (12)

1. Bonni A, Sun Y, Nadal-Vicens M, Bhatt A, Frank DA, Rozovsky I, Stahl N, Yancopoulos GD, Greenberg ME. 1997. Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway. Science 278:477-483. doi: 10.1126/science.278.5337.477.
2. Britz O, Mattar P, Nguyen L, Langevin LM, Zimmer C, Alam S, Guillemot F, Schuurmans C. 2006. A role for proneural genes in the maturation of cortical progenitor cells. Cerebral Cortex 16(Suppl 1):i138-i151. doi: 10.1093/cercor/bhj168.
3. Ebert MS, Neilson JR, Sharp PA. 2007. MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells. Nature Methods 4:721-726. doi: 10.1038/nmeth1079.
4. Ge W, He F, Kim KJ, Blanchi B, Coskun V, Nguyen L, Wu X, Zhao J, Heng JI, Martinowich K, Tao J, Wu H, Castro D, Sobeih MM, Corfas G, Gleeson JG, Greenberg ME, Guillemot F, Sun YE. 2006. Coupling of cell migration with neurogenesis by proneural bHLH factors. Proceedings of the National Academy of Sciences of USA 103:1319-1324. doi: 10.1073/pnas.0510419103.
5. He F, Ge W, Martinowich K, BeckerCatania S, Coskun V, Zhu W, Wu H, Castro D, Guillemot F, Fan G, de Vellis J, Sun YE. 2005. A positive autoregulatory loop of Jak-STAT signaling controls the onset of astrogliogenesis. Nature Neuroscience 8:616-625. doi: 10.1038/nn1440.
6. Krichevsky AM, Sonntag KC, Isacson O, Kosik KS. 2006. Specific microRNAs modulate embryonic stem cell-derived neurogenesis. Stem Cells 24:857-864. doi:10.1634/stemcells.2005-0441.
7. Lee RC, Feinbaum RL, Ambros V. 1993. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75:843-854. doi: 10.1016/0092-8674(93)90529-Y.
8. Miller FD, Gauthier AS. 2007. Timing is everything: making neurons versus glia in the developing cortex. Neuron 54:357-369. doi: 10.1016/j.neuron.2007.04.019.
9. Sauvageot CM, Stiles CD. 2002. Molecular mechanisms controlling cortical gliogenesis. Current Opinion in Neurobiology 12:244-249. doi: 10.1016/S0959-4388(02)00322-7.
10. Shibata M, Kurokawa D, Nakao H, Ohmura T, Aizawa S. 2008. MicroRNA-9 modulates Cajal-Retzius cell differentiation by suppressing Foxg1 expression in mouse medial pallium. The Journal of Neuroscience 28:10415-10421. doi: 10.1523/JNEUROSCI.3219-08.2008.
11. Sun Y, Nadal-Vicens M, Misono S, Lin MZ, Zubiaga A, Hua X, Fan G, Greenberg ME. 2001. Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms. Cell 104:365-376. doi: 10.1016/S0092-8674(01)00224-0.
12. Wightman B, Ha I, Ruvkun G. 1993. Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell 75:855-862. doi: 10.1016/0092-8674(93)90530-4.