Behavioural effects of fetal antidepressant exposure in a Norwegian cohort of discordant siblings

International Journal of Epidemiology

Volumn 44, Issue 4, 2015, Pages 1397-1407

  Brandlistuen, Ragnhild Eek ^a,b   Ystrom, Eivind ^a,b   Eberhard Gran, Malin ^b   Nulman, Irena ^c   Koren, Gideon ^c   Nordeng, Hedvig ^a,b  

^a UNIVERSITY OF OSLO   (Norway)

^b NORWEGIAN INSTITUTE OF PUBLIC HEALTH   (Norway)

^c HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Antidepressants; Child behaviour; Depression; Norwegian mother and child cohort study (MoBa); Pregnancy; Sibling design

Indexed keywords

ANTIDEPRESSANT AGENT;

BEHAVIORAL RESPONSE; CHILD DEVELOPMENT; CHILD HEALTH; COHORT ANALYSIS; DRUG; ENVIRONMENTAL RISK; MATERNAL EFFECT; PREGNANCY; QUESTIONNAIRE SURVEY; SIBLING; SPATIOTEMPORAL ANALYSIS; SYMPTOM;

ADULT; AGGRESSION; ANXIETY; ARTICLE; ATTENTION DISTURBANCE; CHILD; CHILD BEHAVIOR CHECKLIST; COHORT ANALYSIS; EMOTIONALITY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MOTHER; POPULATION RESEARCH; PRENATAL EXPOSURE; PRIORITY JOURNAL; PUERPERAL DEPRESSION; RISK FACTOR; SIBLING; SLEEP DISORDER; STATISTICAL MODEL; ADVERSE EFFECTS; CHILD BEHAVIOR DISORDERS; CHILD DEVELOPMENT; DEPRESSION; DRUG EFFECTS; INFANT; MALE; MATERNAL EXPOSURE; NORWAY; PREGNANCY; PREGNANCY COMPLICATIONS; PRESCHOOL CHILD; PSYCHOLOGY; QUESTIONNAIRE;

NORWAY;

ADULT; ANTIDEPRESSIVE AGENTS; CHILD BEHAVIOR DISORDERS; CHILD DEVELOPMENT; CHILD, PRESCHOOL; COHORT STUDIES; DEPRESSION; FEMALE; HUMANS; INFANT; MALE; MATERNAL EXPOSURE; MOTHERS; NORWAY; PREGNANCY; PREGNANCY COMPLICATIONS; PRENATAL EXPOSURE DELAYED EFFECTS; RISK FACTORS; SIBLINGS; SURVEYS AND QUESTIONNAIRES;

EID: 84943784078     PISSN: 03005771     EISSN: 14643685     Source Type: Journal    
DOI: 10.1093/ije/dyv030     Document Type: Article

References (41)

1. Ververs T, Kaasenbrood H, Visser G, Schobben F, Jong-van den Berg L, Egberts T. Prevalence and patterns of antidepressant drug use during pregnancy. Eur J Clin Pharmacol 2006;62:863-70.
2. Cooper WO, Willy ME, Pont SJ, Ray WA. Increasing use of antidepressants in pregnancy. Am J Obstet Gynecol 2007;196:544 e1-5.
3. Andrade SE, Raebel MA, Brown J et al. Use of antidepressant medications during pregnancy: a multisite study. Am J Obstet Gynecol 2008;198:194 e1-5.
4. O'Hara MW, Wisner KL. Perinatal mental illness: Definition, description and aetiology. Best Pract Res Clin Obstet Gynaecol 2014;28:3-12.
5. Rampono J, Simmer K, Ilett KF et al. Placental transfer of SSRI and SNRI antidepressants and effects on the neonate. Pharmacopsychiatry 2009;42:95-100.
6. Hendrick V, Stowe ZN, Altshuler LL, Hwang S, Lee E, Haynes D. Placental passage of antidepressant medications. Am J Psychiatry 2003;160:993-96.
7. Oberlander TF, Warburton W, Misri S, Aghajanian J, Hertzman C. Neonatal outcomes after prenatal exposure to selective serotonin reuptake inhibitor antidepressants and maternal depression using population-based linked health data. Arch Gen Psychiatry 2006;63:898-906.
8. Field T, Diego M, Dieter J et al. Prenatal depression effects on the fetus and the newborn. Infant Behav Dev 2004;27:216-29.
9. Nulman I, Rovet J, Stewart DE et al. Neurodevelopment of children exposed in utero to antidepressant drugs. N Engl J Med 1997;336:258-62.
10. Nulman I, Rovet J, Stewart DE et al. Child development following exposure to tricyclic antidepressants or fluoxetine throughout fetal life: a prospective, controlled study. Am J Psychiatry 2002;159:1889-95.
11. Nulman I, Koren G, Rovet J et al. Neurodevelopment of children following prenatal exposure to venlafaxine, selective serotonin reuptake inhibitors, or untreated maternal depression. Am J Psychiatry 2012;169:1165-74.
12. Hanley GE, Brain U, Oberlander TF. Infant developmental outcomes following prenatal exposure to antidepressants, and maternal depressed mood and positive affect. Early Hum Dev 2013; 89:519-24.
13. Oberlander TF, Papsdorf M, Brain UM, Misri S, Ross C, Grunau RE. Prenatal effects of selective serotonin reuptake inhibitor antidepressants, serotonin transporter promoter genotype (SLC6A4), and maternal mood on child behavior at 3 years of age. Arch Pediatr Adolesc Med 2010;164:444-51.
14. Croen LA, Grether JK, Yoshida CK, Odouli R, Hendrick V. Antidepressant use during pregnancy and childhood autism spectrum disorders. Arch Gen Psychiatry 2011;68:1104-12.
15. Rai D, Lee BK, Dalman C, Golding J, Lewis G, Magnusson C. Parental depression, maternal antidepressant use during pregnancy, and risk of autism spectrum disorders: population based case-control study. BMJ 2013;346:f2059.
16. Clements CC, Castro VM, Blumenthal SR et al. Prenatal antidepressant exposure is associated with risk for attention-deficit hyperactivity disorder but not autism spectrum disorder in a large health system. Mol Psychiatry 2014, Aug 26. PubMed PMID: 25155880. [Epub.]
17. Nulman I, Koren G, Rovet J et al. Neurodevelopment of children following prenatal exposure to venlafaxine, selective serotonin reuptake inhibitors, or untreated maternal depression. Am J Psychiatry 2012;169:1165-74.
18. O'Connor TG, Heron J, Glover V, Team AS. Antenatal anxiety predicts child behavioral/emotional problems independently of postnatal depression. J Am Acad Child Adolesc Psychiatry 2002; 41:1470-77.
19. Bayer JK, Hiscock H, Ukoumunne OC, Price A, Wake M. Early childhood aetiology of mental health problems: a longitudinal population-based study. J Child Psychol Psychiatry 2008;49:1166-74.
20. Goodman SH, Gotlib IH. Risk for psychopathology in the children of depressed mothers: A developmental model for understanding mechanisms of transmission. Psychol Rev 1999;106:458-90.
21. Connell AM, Goodman SH. The association between psychopathology in fathers versus mothers and children's internalizing and externalizing behavior problems: A meta-analysis. Psychol Bull 2002;128:746-73.
22. Cents RAM, Tiemeier H, Luijk MPCM, Jaddoe VWV, Hofman A, Verhulst FC, et al. Grandparental anxiety and depression predict young children's internalizing and externalizing problems The generation R study. J Affect Disorders. 2011 Jan;128(1-2):95-105. PubMed PMID:WOS:000286408600011. English.
23. Fanous A, Gardner CO, Prescott CA, Cancro R, Kendler KS. Neuroticism, major depression and gender: a population-based twin study. Psychol Med 2002;32:719-28.
24. Ystrom E, Vollrath ME, Nordeng H. Effects of personality on use of medications, alcohol, and cigarettes during pregnancy. Eur J Clin Pharmacol 2012;68:845-51.
25. Susser E, Eide MG, Begg M. Invited commentary: The use of sibship studies to detect familial confounding. Am J Epidemiol 2010;172:537-39.
26. Magnus P, Irgens LM, Haug K, Nystad W, Skjaerven R, Stoltenberg C. Cohort profile: The Norwegian Mother and Child Cohort Study (MoBa). Int J Epidemiol 2006;35:1146-50.
27. Irgens LM. The Medical Birth Registry of Norway. Epidemiological research and surveillance throughout 30 years. Acta Obstet Gynaecol Scand 2000;79:435-39.
28. Achenbach TM. Manual for the Child Behavior Checklist/2-3 and 1992 Profile. Burlington, VT: Department of Psychiatry, University of Vermont, 1992.
29. Zachrisson HD, Dearing E, Lekhal R, Toppelberg CO. Little evidence that time in child care causes externalizing problems during early childhood in Norway. Child Dev 2013;84:1152-70.
30. World Health Organization. The Anatomical Therapeutic Chemical Classification System with Defined Daily Doses (ATC/DDD.) Geneva: WHO, 2012.
31. Strand BH, Dalgard OS, Tambs K, Rognerud M. Measuring the mental health status of the Norwegian population: a comparison of the instruments SCL-25, SCL-10, SCL-5 and MHI-5 (SF-36). Nord J Psychiatry 2003;57:113-18.
32. Kendler KS, Neale MC, Kessler RC, Heath AC, Eaves LJ. The lifetime history of major depression in women. Reliability of diagnosis and heritability. Arch Gen Psychiatry 1993;50:863-70.
33. Nordeng H, van Gelder MM, Spigset O, Koren G, Einarson A, Eberhard-Gran M. Pregnancy outcome after exposure to antidepressants and the role of maternal depression: results from the Norwegian Mother and Child Cohort Study. J Clin Psychopharmacol 2012;32:186-94.
34. Nilsen RM, Vollset SE, Gjessing HK et al. Self-selection and bias in a large prospective pregnancy cohort in Norway. Paediatr Perinat Epidemiol 2009;23:597-608.
35. O'Donnell KJ, Bugge Jensen A, Freeman L, Khalife N, O'Connor TG, Glover V. Maternal prenatal anxiety and downregulation of placental 11beta-HSD2. Psychoneuroendocrinology 2012;37:818-26.
36. Swanson JM, Entringer S, Buss C, Wadhwa PD. Developmental origins of health and disease: environmental exposures. Semin Reprod Med 2009;27:391-402.
37. Schneider ML, Roughton EC, Koehler AJ, Lubach GR. Growth and development following prenatal stress exposure in primates:an examination of ontogenetic vulnerability. Child Dev 1999; 70:263-74.
38. O'Connor TG, Heron J, Golding J, Glover V, Team AS. Maternal antenatal anxiety and behavioural/emotional problems in children: a test of a programming hypothesis. J Child Psychol Psychiatry 2003;44:1025-36.
39. O'Donnell KJ, Glover V, Jenkins J et al. Prenatal maternal mood is associated with altered diurnal cortisol in adolescence. Psychoneuroendocrinology 2013;38:1630-38.
40. Rifkin-Graboi A, Bai J, Chen H et al. Prenatal maternal depression associates with microstructure of right amygdala in neonates at birth. Biol Psychiatry 2013;74:837-44.
41. Skurtveit S, Selmer R, Roth C, Hernandez-Diaz S, Handal M. Prenatal exposure to antidepressants and language competence at age three: results from a large population-based pregnancy cohort in Norway. BJOG 2014;121:1621-31.