-
1
-
-
84878532557
-
Signal integration by mTORC1 coordinates nutrient input with biosynthetic output
-
PMID: 23728461
-
Dibble CC, Manning BD. Signal integration by mTORC1 coordinates nutrient input with biosynthetic output. Nat Cell Biol 2013; 15: 555-64; PMID: 23728461; http://dx. doi. org/10. 1038/ncb2763.
-
(2013)
Nat Cell Biol
, vol.15
, pp. 555-564
-
-
Dibble, C.C.1
Manning, B.D.2
-
2
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
PMID: 15718470
-
Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005; 307: 1098-101; PMID: 15718470; http://dx. doi. org/10. 1126/science. 1106148.
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
3
-
-
84880566446
-
A growing role for mTOR in promoting anabolic metabolism
-
PMID: 23863154
-
Howell JJ, Ricoult SJ, Ben-Sahra I, Manning BD. A growing role for mTOR in promoting anabolic metabolism. Biochem Soc Trans 2013; 41: 906-12; PMID: 23863154; http://dx. doi. org/10. 1042/BST20130041.
-
(2013)
Biochem Soc Trans
, vol.41
, pp. 906-912
-
-
Howell, J.J.1
Ricoult, S.J.2
Ben-Sahra, I.3
Manning, B.D.4
-
4
-
-
79955631150
-
Autophagy in the cellular energetic balance
-
PMID: 21531332
-
Singh R, Cuervo AM. Autophagy in the cellular energetic balance. Cell Metab 2011; 13: 495-504; PMID: 21531332; http://dx. doi. org/10. 1016/j. cmet. 2011. 04. 004.
-
(2011)
Cell Metab
, vol.13
, pp. 495-504
-
-
Singh, R.1
Cuervo, A.M.2
-
5
-
-
67349217986
-
Molecular mechanisms of mTORmediated translational control
-
PMID: 19339977
-
Ma XM, Blenis J. Molecular mechanisms of mTORmediated translational control. Nat Rev Mol Cell Biol 2009 10: 307-18; PMID: 19339977; http://dx. doi. org/10. 1038/nrm2672.
-
(2009)
Nat Rev Mol Cell Biol
, vol.10
, pp. 307-318
-
-
Ma, X.M.1
Blenis, J.2
-
6
-
-
84874995247
-
Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1
-
PMID: 23429703
-
Ben-Sahra I, Howell JJ, Asara JM, Manning BD. Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1. Science 2013; 339: 1323-8; PMID: 23429703; http://dx. doi. org/10. 1126/science. 1228792.
-
(2013)
Science
, vol.339
, pp. 1323-1328
-
-
Ben-Sahra, I.1
Howell, J.J.2
Asara, J.M.3
Manning, B.D.4
-
7
-
-
84874961313
-
Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis
-
PMID: 23429704
-
Robitaille AM, Christen S, Shimobayashi M, Cornu M, Fava LL, Moes S, Prescianotto-Baschong C, Sauer U, Jenoe P, Hall MN. Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis. Science 2013; 339: 1320-3; PMID: 23429704; http://dx. doi. org/10. 1126/science. 1228771.
-
(2013)
Science
, vol.339
, pp. 1320-1323
-
-
Robitaille, A.M.1
Christen, S.2
Shimobayashi, M.3
Cornu, M.4
Fava, L.L.5
Moes, S.6
Prescianotto-Baschong, C.7
Sauer, U.8
Jenoe, P.9
Hall, M.N.10
-
8
-
-
84891745585
-
Autophagy regulation by nutrient signaling
-
PMID: 24343578
-
Russell RC, Yuan HX, Guan KL. Autophagy regulation by nutrient signaling. Cell Res 2014; 24: 42-57; PMID: 24343578; http://dx. doi. org/10. 1038/cr. 2013. 166.
-
(2014)
Cell Res
, vol.24
, pp. 42-57
-
-
Russell, R.C.1
Yuan, H.X.2
Guan, K.L.3
-
9
-
-
50049116472
-
SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth
-
PMID: 18762023
-
Porstmann T, Santos CR, Griffiths B, Cully M, Wu M, Leevers S, Griffiths JR, Chung YL, Schulze A. SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth. Cell Metab 2008; 8: 224-36; PMID: 18762023; http://dx. doi. org/10. 1016/j. cmet. 2008. 07. 007.
-
(2008)
Cell Metab
, vol.8
, pp. 224-236
-
-
Porstmann, T.1
Santos, C.R.2
Griffiths, B.3
Cully, M.4
Wu, M.5
Leevers, S.6
Griffiths, J.R.7
Chung, Y.L.8
Schulze, A.9
-
10
-
-
77955483125
-
Activation of a metabolic gene regulatory network downstream of mTOR complex 1
-
PMID: 20670887
-
Duvel K, Yecies JL, Menon S, Raman P, Lipovsky AI, Souza AL, Triantafellow E, Ma Q, Gorski R, Cleaver S, et al. Activation of a metabolic gene regulatory network downstream of mTOR complex 1. Mol Cell 2010; 39: 171-83; PMID: 20670887; http://dx. doi. org/10. 1016/j. molcel. 2010. 06. 022.
-
(2010)
Mol Cell
, vol.39
, pp. 171-183
-
-
Duvel, K.1
Yecies, J.L.2
Menon, S.3
Raman, P.4
Lipovsky, A.I.5
Souza, A.L.6
Triantafellow, E.7
Ma, Q.8
Gorski, R.9
Cleaver, S.10
-
11
-
-
84867067610
-
Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase
-
PMID: 22927400
-
Owen JL, Zhang Y, Bae SH, Farooqi MS, Liang G, Hammer RE, Goldstein JL, Brown MS. Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase. Proc Natl Acad Sci U S A 2012; 109: 16184-9; PMID: 22927400; http://dx. doi. org/10. 1073/pnas. 1213343109.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 16184-16189
-
-
Owen, J.L.1
Zhang, Y.2
Bae, S.H.3
Farooqi, M.S.4
Liang, G.5
Hammer, R.E.6
Goldstein, J.L.7
Brown, M.S.8
-
12
-
-
84906898355
-
Coordinated regulation of protein synthesis and degradation by mTORC1
-
PMID: 25043031
-
Zhang Y, Nicholatos J, Dreier JR, Ricoult SJ, Widenmaier SB, Hotamisligil GS, Kwiatkowski DJ, Manning BD. Coordinated regulation of protein synthesis and degradation by mTORC1. Nature 2014; 513: 440-3; PMID: 25043031; http://dx. doi. org/10. 1038/nature13492.
-
(2014)
Nature
, vol.513
, pp. 440-443
-
-
Zhang, Y.1
Nicholatos, J.2
Dreier, J.R.3
Ricoult, S.J.4
Widenmaier, S.B.5
Hotamisligil, G.S.6
Kwiatkowski, D.J.7
Manning, B.D.8
-
13
-
-
84896834460
-
Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome
-
PMID: 24409289
-
Fok WC, Chen Y, Bokov A, Zhang Y, Salmon AB, Diaz V, Javors M, Wood WH 3rd, Zhang Y, Becker KG, et al. Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome. PLoS One 2014; 9: e83988; PMID: 24409289; http://dx. doi. org/10. 1371/journal. pone. 0083988.
-
(2014)
PLoS One
, vol.9
-
-
Fok, W.C.1
Chen, Y.2
Bokov, A.3
Zhang, Y.4
Salmon, A.B.5
Diaz, V.6
Javors, M.7
Wood, W.H.8
Zhang, Y.9
Becker, K.G.10
-
14
-
-
84896800569
-
Rapamycin extends life and health in C57BL/6 mice
-
PMID: 23682161
-
Zhang Y, Bokov A, Gelfond J, Soto V, Ikeno Y, Hubbard G, Diaz V, Sloane L, Maslin K, Treaster S, et al. Rapamycin extends life and health in C57BL/6 mice. J Gerontol A Biol Sci Med Sci 2014; 69: 119-30; PMID: 23682161; http://dx. doi. org/10. 1093/gerona/glt056.
-
(2014)
J Gerontol A Biol Sci Med Sci
, vol.69
, pp. 119-130
-
-
Zhang, Y.1
Bokov, A.2
Gelfond, J.3
Soto, V.4
Ikeno, Y.5
Hubbard, G.6
Diaz, V.7
Sloane, L.8
Maslin, K.9
Treaster, S.10
-
15
-
-
77950366349
-
Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells
-
PMID: 20385086
-
Radhakrishnan SK, Lee CS, Young P, Beskow A, Chan JY, Deshaies RJ. Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells. Mol Cell 2010; 38: 17-28; PMID: 20385086; http://dx. doi. org/10. 1016/j. molcel. 2010. 02. 029.
-
(2010)
Mol Cell
, vol.38
, pp. 17-28
-
-
Radhakrishnan, S.K.1
Lee, C.S.2
Young, P.3
Beskow, A.4
Chan, J.Y.5
Deshaies, R.J.6
-
16
-
-
77957341511
-
Proteasomal degradation is transcriptionally controlled by TCF11 via an ERAD-dependent feedback loop
-
PMID: 20932482
-
Steffen J, Seeger M, Koch A, Kruger E. Proteasomal degradation is transcriptionally controlled by TCF11 via an ERAD-dependent feedback loop. Mol Cell 2010; 40: 147-58; PMID: 20932482; http://dx. doi. org/10. 1016/j. molcel. 2010. 09. 012.
-
(2010)
Mol Cell
, vol.40
, pp. 147-158
-
-
Steffen, J.1
Seeger, M.2
Koch, A.3
Kruger, E.4
-
17
-
-
0032518185
-
Interaction of the CNC-bZIP factor TCF11/LCR-F1/Nrf1 with MafG: Binding-site selection and regulation of transcription
-
PMID: 9421508
-
Johnsen O, Murphy P, Prydz H, Kolsto, AB. Interaction of the CNC-bZIP factor TCF11/LCR-F1/Nrf1 with MafG: binding-site selection and regulation of transcription. Nucleic Acids Res 1998; 26: 512-20; PMID: 9421508; http://dx. doi. org/10. 1093/nar/26. 2. 512.
-
(1998)
Nucleic Acids Res
, vol.26
, pp. 512-520
-
-
Johnsen, O.1
Murphy, P.2
Prydz, H.3
Kolsto, A.B.4
-
18
-
-
77649275112
-
Role of Nrf1 in antioxidant response element-mediated gene expression and beyond
-
PMID: 19665035
-
Biswas M, Chan JY. Role of Nrf1 in antioxidant response element-mediated gene expression and beyond. Toxicol Appl Pharmacol 2010; 244: 16-20; PMID: 19665035; http://dx. doi. org/10. 1016/j. taap. 2009. 07. 034.
-
(2010)
Toxicol Appl Pharmacol
, vol.244
, pp. 16-20
-
-
Biswas, M.1
Chan, J.Y.2
-
19
-
-
0030995597
-
The bZIP transcription factor LCR-F1 is essential for mesoderm formation in mouse development
-
PMID: 9087432
-
Farmer SC, Sun CW, Winnier GE, Hogan BL, Townes TM. The bZIP transcription factor LCR-F1 is essential for mesoderm formation in mouse development. Genes Dev 1997; 11: 786-98; PMID: 9087432; http://dx. doi. org/10. 1101/gad. 11. 6. 786.
-
(1997)
Genes Dev
, vol.11
, pp. 786-798
-
-
Farmer, S.C.1
Sun, C.W.2
Winnier, G.E.3
Hogan, B.L.4
Townes, T.M.5
-
20
-
-
0032536783
-
Targeted disruption of the ubiquitous CNCbZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice
-
PMID: 9501099
-
Chan JY, Kwong M, Lu R, Chang J, Wang B, Yen TS, Kan YW. Targeted disruption of the ubiquitous CNCbZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice. EMBO J 1998; 17: 1779-87; PMID: 9501099; http://dx. doi. org/10. 1093/emboj/17. 6. 1779.
-
(1998)
EMBO J
, vol.17
, pp. 1779-1787
-
-
Chan, J.Y.1
Kwong, M.2
Lu, R.3
Chang, J.4
Wang, B.5
Yen, T.S.6
Kan, Y.W.7
-
21
-
-
57749120460
-
Nrf1 and Nrf2 play distinct roles in activation of antioxidant response elementdependent genes
-
PMID: 18826952
-
Ohtsuji M, Katsuoka F, Kobayashi A, Aburatani H, Hayes JD, Yamamoto M. Nrf1 and Nrf2 play distinct roles in activation of antioxidant response elementdependent genes. J Biol Chem 2008; 283: 33554-62; PMID: 18826952; http://dx. doi. org/10. 1074/jbc. M804597200.
-
(2008)
J Biol Chem
, vol.283
, pp. 33554-33562
-
-
Ohtsuji, M.1
Katsuoka, F.2
Kobayashi, A.3
Aburatani, H.4
Hayes, J.D.5
Yamamoto, M.6
-
22
-
-
84904990897
-
Proteasome-mediated processing of Nrf1 is essential for coordinate induction of all proteasome subunits and p97
-
PMID: 24998528
-
Sha Z, Goldberg AL. Proteasome-mediated processing of Nrf1 is essential for coordinate induction of all proteasome subunits and p97. Curr Biol 2014; 24: 1573-83; PMID: 24998528; http://dx. doi. org/10. 1016/j. cub. 2014. 06. 004.
-
(2014)
Curr Biol
, vol.24
, pp. 1573-1583
-
-
Sha, Z.1
Goldberg, A.L.2
-
23
-
-
79551614016
-
Diverse transcription factor binding features revealed by genome-wide ChIP-seq in C. elegans
-
PMID: 21177963
-
Niu W, Lu ZJ, Zhong M, Sarov M, Murray JI, Brdlik CM, Janette J, Chen C, Alves P, Preston E. Diverse transcription factor binding features revealed by genome-wide ChIP-seq in C. elegans. Genome Res 2011; 21: 245-54; PMID: 21177963; http://dx. doi. org/10. 1101/gr. 114587. 110.
-
(2011)
Genome Res
, vol.21
, pp. 245-254
-
-
Niu, W.1
Lu, Z.J.2
Zhong, M.3
Sarov, M.4
Murray, J.I.5
Brdlik, C.M.6
Janette, J.7
Chen, C.8
Alves, P.9
Preston, E.10
-
24
-
-
70350625466
-
Condition-adapted stress and longevity gene regulation by Caenorhabditis elegans SKN-1/Nrf
-
PMID: 19575768
-
Oliveira RP, Porter Abate J, Dilks K, Landis J, Ashraf J, Murphy CT, Blackwell TK. Condition-adapted stress and longevity gene regulation by Caenorhabditis elegans SKN-1/Nrf. Aging Cell 8: 524-41 2009; PMID: 19575768; http://dx. doi. org/10. 1111/j. 1474-9726. 2009. 00501. x.
-
(2009)
Aging Cell
, vol.8
, pp. 524-541
-
-
Oliveira, R.P.1
Porter Abate, J.2
Dilks, K.3
Landis, J.4
Ashraf, J.5
Murphy, C.T.6
Blackwell, T.K.7
-
25
-
-
66149175591
-
Oxidative stress and longevity in Caenorhabditis elegans as mediated by SKN-1
-
Park SK, Tedesco PM, Johnson TE. Oxidative stress and longevity in Caenorhabditis elegans as mediated by SKN-1. Aging Cell 2009; 8: 258-69.
-
(2009)
Aging Cell
, vol.8
, pp. 258-269
-
-
Park, S.K.1
Tedesco, P.M.2
Johnson, T.E.3
-
26
-
-
84860461929
-
TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO
-
PMID: 22560223
-
Robida-Stubbs S, Glover-Cutter K, Lamming DW, Mizunuma M, Narasimhan SD, Neumann-Haefelin E, Sabatini DM, Blackwell TK. TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO. Cell Metab 2012; 15: 713-24; PMID: 22560223; http://dx. doi. org/10. 1016/j. cmet. 2012. 04. 007.
-
(2012)
Cell Metab
, vol.15
, pp. 713-724
-
-
Robida-Stubbs, S.1
Glover-Cutter, K.2
Lamming, D.W.3
Mizunuma, M.4
Narasimhan, S.D.5
Neumann-Haefelin, E.6
Sabatini, D.M.7
Blackwell, T.K.8
-
27
-
-
79959823394
-
Specific SKN-1/Nrf stress responses to perturbations in translation elongation and proteasome activity
-
PMID: 21695230
-
Li X, Matilainen O, Jin C, Glover-Cutter KM, Holmberg CI, Blackwell TK. Specific SKN-1/Nrf stress responses to perturbations in translation elongation and proteasome activity. PLoS genetics 2011; 7: e1002119; PMID: 21695230; http://dx. doi. org/10. 1371/journal. pgen. 1002119.
-
(2011)
PLoS genetics
, vol.7
-
-
Li, X.1
Matilainen, O.2
Jin, C.3
Glover-Cutter, K.M.4
Holmberg, C.I.5
Blackwell, T.K.6
-
28
-
-
33745807575
-
Nrf1 is targeted to the endoplasmic reticulum membrane by an N-terminal transmembrane domain. Inhibition of nuclear translocation and transacting function
-
PMID: 16687406
-
Wang W, Chan JY. Nrf1 is targeted to the endoplasmic reticulum membrane by an N-terminal transmembrane domain. Inhibition of nuclear translocation and transacting function. J Biol Chem 2006; 281: 19676-87; PMID: 16687406; http://dx. doi. org/10. 1074/jbc. M602802200.
-
(2006)
J Biol Chem
, vol.281
, pp. 19676-19687
-
-
Wang, W.1
Chan, J.Y.2
-
29
-
-
84898769387
-
p97-dependent retrotranslocation and proteolytic processing govern formation of active Nrf1 upon proteasome inhibition
-
PMID: 24448410
-
Radhakrishnan SK, den Besten W, Deshaies RJ. p97-dependent retrotranslocation and proteolytic processing govern formation of active Nrf1 upon proteasome inhibition. Elife 2014; 3: e01856; PMID: 24448410; http://dx. doi. org/10. 7554/eLife. 01856.
-
(2014)
Elife
, vol.3
-
-
Radhakrishnan, S.K.1
den Besten, W.2
Deshaies, R.J.3
-
30
-
-
84943201007
-
SREBP maintains lipid biosynthesis and viability of cancer cells under lipid-and oxygen-deprived conditions and defines a gene signature associated with poor survival in glioblastoma multiforme
-
Lewis CA, Brault C, Peck B, Bensaad K, Griffiths B, Mitter R, Chakravarty P, East P, Dankworth B, Alibhai D, et al. SREBP maintains lipid biosynthesis and viability of cancer cells under lipid-and oxygen-deprived conditions and defines a gene signature associated with poor survival in glioblastoma multiforme. Oncogene 2015; http://dx. doi. org/10. 1038/onc. 2014. 439onc2014439.
-
(2015)
Oncogene
-
-
Lewis, C.A.1
Brault, C.2
Peck, B.3
Bensaad, K.4
Griffiths, B.5
Mitter, R.6
Chakravarty, P.7
East, P.8
Dankworth, B.9
Alibhai, D.10
-
31
-
-
48249123867
-
Genome-wide occupancy of SREBP1 and its partners NFY and SP1 reveals novel functional roles and combinatorial regulation of distinct classes of genes
-
PMID: 18654640
-
Reed BD, Charos AE, Szekely AM, Weissman SM, Snyder M. Genome-wide occupancy of SREBP1 and its partners NFY and SP1 reveals novel functional roles and combinatorial regulation of distinct classes of genes. PLoS genetics 2008; 4: e1000133; PMID: 18654640; http://dx. doi. org/10. 1371/journal. pgen. 1000133.
-
(2008)
PLoS genetics
, vol.4
-
-
Reed, B.D.1
Charos, A.E.2
Szekely, A.M.3
Weissman, S.M.4
Snyder, M.5
-
32
-
-
57049172674
-
Microarray analyses of SREBP-1a and SREBP-1c target genes identify new regulatory pathways in muscle
-
PMID: 18559965
-
Rome S, Lecomte V, Meugnier E, Rieusset J, Debard C, Euthine V, Vidal H, Lefai E. Microarray analyses of SREBP-1a and SREBP-1c target genes identify new regulatory pathways in muscle. Physiol Genomics 2008; 34: 327-37; PMID: 18559965; http://dx. doi. org/10. 1152/physiolgenomics. 90211. 2008.
-
(2008)
Physiol Genomics
, vol.34
, pp. 327-337
-
-
Rome, S.1
Lecomte, V.2
Meugnier, E.3
Rieusset, J.4
Debard, C.5
Euthine, V.6
Vidal, H.7
Lefai, E.8
-
33
-
-
0036251153
-
SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in the liver
-
PMID: 11994399
-
Horton JD, Goldstein JL, Brown MS. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 2002; 109: 1125-31; PMID: 11994399; http://dx. doi. org/10. 1172/JCI0215593.
-
(2002)
J Clin Invest
, vol.109
, pp. 1125-1131
-
-
Horton, J.D.1
Goldstein, J.L.2
Brown, M.S.3
-
34
-
-
79960960007
-
Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways
-
PMID: 21723501
-
Yecies JL, Zhang HH, Menon S, Liu S, Yecies D, Lipovsky AI, Gorgun C, Kwiatkowski DJ, Hotamisligil GS, Lee CH, et al. Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways. Cell Metab 2011; 14: 21-32; PMID: 21723501; http://dx. doi. org/10. 1016/j. cmet. 2011. 06. 002.
-
(2011)
Cell Metab
, vol.14
, pp. 21-32
-
-
Yecies, J.L.1
Zhang, H.H.2
Menon, S.3
Liu, S.4
Yecies, D.5
Lipovsky, A.I.6
Gorgun, C.7
Kwiatkowski, D.J.8
Hotamisligil, G.S.9
Lee, C.H.10
-
35
-
-
79961165137
-
mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway
-
PMID: 21816276
-
Peterson TR, Sengupta SS, Harris TE, Carmack AE, Kang SA, Balderas E, Guertin DA, Madden KL, Carpenter AE, Finck BN, et al. mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway. Cell 2011; 146: 408-20; PMID: 21816276; http://dx. doi. org/10. 1016/j. cell. 2011. 06. 034.
-
(2011)
Cell
, vol.146
, pp. 408-420
-
-
Peterson, T.R.1
Sengupta, S.S.2
Harris, T.E.3
Carmack, A.E.4
Kang, S.A.5
Balderas, E.6
Guertin, D.A.7
Madden, K.L.8
Carpenter, A.E.9
Finck, B.N.10
-
36
-
-
84877961669
-
Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth
-
PMID: 24280005
-
Griffiths B, Lewis CA, Bensaad K, Ros S, Zhang Q, Ferber EC, Konisti S, Peck B, Miess H, East P, et al. Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth. Cancer Metab 2013; 1: 3, doi: 10. 1186/2049-3002-1-3; PMID: 24280005; http://dx. doi. org/10. 1186/2049-3002-1-3.
-
(2013)
Cancer Metab
, vol.1
, pp. 3
-
-
Griffiths, B.1
Lewis, C.A.2
Bensaad, K.3
Ros, S.4
Zhang, Q.5
Ferber, E.C.6
Konisti, S.7
Peck, B.8
Miess, H.9
East, P.10
-
37
-
-
84877984661
-
Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stress
-
PMID: 23699409
-
Young RM, Ackerman D, Quinn ZL, Mancuso A, Gruber M, Liu L, Giannoukos DN, Bobrovnikova-Marjon E, Diehl JA, Keith B, et al. Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stress. Genes Dev 2013; 27: 1115-31; PMID: 23699409; http://dx. doi. org/10. 1101/gad. 198630. 112.
-
(2013)
Genes Dev
, vol.27
, pp. 1115-1131
-
-
Young, R.M.1
Ackerman, D.2
Quinn, Z.L.3
Mancuso, A.4
Gruber, M.5
Liu, L.6
Giannoukos, D.N.7
Bobrovnikova-Marjon, E.8
Diehl, J.A.9
Keith, B.10
-
38
-
-
84880327440
-
Nuclear factor-erythroid 2-related factor 1 regulates expression of proteasome genes in hepatocytes and protects against endoplasmic reticulum stress and steatosis in mice
-
PMID: 23702335
-
Lee CS, Ho DV, Chan JY. Nuclear factor-erythroid 2-related factor 1 regulates expression of proteasome genes in hepatocytes and protects against endoplasmic reticulum stress and steatosis in mice. FEBS J 2013; 280: 3609-20; PMID: 23702335; http://dx. doi. org/10. 1111/febs. 12350.
-
(2013)
FEBS J
, vol.280
, pp. 3609-3620
-
-
Lee, C.S.1
Ho, D.V.2
Chan, J.Y.3
-
39
-
-
82255161944
-
Road to ruin: Targeting proteins for degradation in the endoplasmic reticulum
-
PMID: 22116878
-
Smith MH, Ploegh HL, Weissman JS. Road to ruin: targeting proteins for degradation in the endoplasmic reticulum. Science 2011; 334: 1086-90; PMID: 22116878; http://dx. doi. org/10. 1126/science. 1209235.
-
(2011)
Science
, vol.334
, pp. 1086-1090
-
-
Smith, M.H.1
Ploegh, H.L.2
Weissman, J.S.3
-
40
-
-
15244359632
-
Liver-specific inactivation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasia
-
PMID: 15738389
-
Xu Z, Chen L, Leung L, Yen TS, Lee C, Chan JY. Liver-specific inactivation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasia. Proc Natl Acad Sci U S A 2005; 102: 4120-5; PMID: 15738389; http://dx. doi. org/10. 1073/pnas. 0500660102.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 4120-4125
-
-
Xu, Z.1
Chen, L.2
Leung, L.3
Yen, T.S.4
Lee, C.5
Chan, J.Y.6
-
41
-
-
84864003934
-
NFE2-related factor 1 (Nrf1) serves as a novel regulator of hepatic lipid metabolism through regulation of the Lipin1 and PGC-1beta genes
-
PMID: 22586274
-
Hirotsu Y, Hataya N, Katsuoka F, Yamamoto M. NFE2-related factor 1 (Nrf1) serves as a novel regulator of hepatic lipid metabolism through regulation of the Lipin1 and PGC-1beta genes. Mol Cell Biol 2012; 32: 2760-70; PMID: 22586274; http://dx. doi. org/10. 1128/MCB. 06706-11.
-
(2012)
Mol Cell Biol
, vol.32
, pp. 2760-2770
-
-
Hirotsu, Y.1
Hataya, N.2
Katsuoka, F.3
Yamamoto, M.4
-
42
-
-
84859778293
-
mTOR signaling in growth control and disease
-
PMID: 22500797
-
Laplante M, Sabatini DM. mTOR signaling in growth control and disease. Cell 2012; 149: 274-93; PMID: 22500797; http://dx. doi. org/10. 1016/j. cell. 2012. 03. 017.
-
(2012)
Cell
, vol.149
, pp. 274-293
-
-
Laplante, M.1
Sabatini, D.M.2
-
43
-
-
84862777192
-
The translational landscape of mTOR signalling steers cancer initiation and metastasis
-
PMID: 22367541
-
Hsieh AC, Liu Y, Edlind MP, Ingolia NT, Janes MR, Sher A, Shi EY, Stumpf CR, Christensen C, Bonham MJ, et al. The translational landscape of mTOR signalling steers cancer initiation and metastasis. Nature 2012; 485: 55-61; PMID: 22367541; http://dx. doi. org/10. 1038/nature10912.
-
(2012)
Nature
, vol.485
, pp. 55-61
-
-
Hsieh, A.C.1
Liu, Y.2
Edlind, M.P.3
Ingolia, N.T.4
Janes, M.R.5
Sher, A.6
Shi, E.Y.7
Stumpf, C.R.8
Christensen, C.9
Bonham, M.J.10
-
44
-
-
0028207001
-
Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family
-
PMID: 8183928
-
Jefferies HB, Reinhard C, Kozma SC, Thomas G. Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family. Proc Natl Acad Sci U S A 1994; 91: 4441-5; PMID: 8183928; http://dx. doi. org/10. 1073/pnas. 91. 10. 4441.
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, pp. 4441-4445
-
-
Jefferies, H.B.1
Reinhard, C.2
Kozma, S.C.3
Thomas, G.4
-
45
-
-
84860527756
-
A unifying model for mTORC1-mediated regulation of mRNA translation
-
PMID: 22552098
-
Thoreen CC, Chantranupong L, Keys HR, Wang T, Gray NS, Sabatini DM. A unifying model for mTORC1-mediated regulation of mRNA translation. Nature 2012; 485: 109-13; PMID: 22552098; http://dx. doi. org/10. 1038/nature11083.
-
(2012)
Nature
, vol.485
, pp. 109-113
-
-
Thoreen, C.C.1
Chantranupong, L.2
Keys, H.R.3
Wang, T.4
Gray, N.S.5
Sabatini, D.M.6
-
46
-
-
66449083078
-
ULK1. ATG13. FIP200 complex mediates mTOR signaling and is essential for autophagy
-
PMID: 19258318
-
Ganley IG, Lam du H, Wang J, Ding X, Chen S, Jiang X. ULK1. ATG13. FIP200 complex mediates mTOR signaling and is essential for autophagy. J Biol Chem 2009; 284: 12297-305; PMID: 19258318.
-
(2009)
J Biol Chem
, vol.284
, pp. 12297-12305
-
-
Ganley, I.G.1
Lam du, H.2
Wang, J.3
Ding, X.4
Chen, S.5
Jiang, X.6
-
47
-
-
65249119430
-
Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy
-
PMID: 19211835
-
Hosokawa N, Hara T, Kaizuka T, Kishi C, Takamura A, Miura Y, Iemura S, Natsume T, Takehana K, Yamada N, et al. Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. Mol Biol Cell 2009; 20: 1981-91; PMID: 19211835; http://dx. doi. org/10. 1091/mbc. E08-12-1248.
-
(2009)
Mol Biol Cell
, vol.20
, pp. 1981-1991
-
-
Hosokawa, N.1
Hara, T.2
Kaizuka, T.3
Kishi, C.4
Takamura, A.5
Miura, Y.6
Iemura, S.7
Natsume, T.8
Takehana, K.9
Yamada, N.10
-
48
-
-
65249176304
-
ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery
-
PMID: 19225151
-
Jung CH, Jun CB, Ro SH, Kim YM, Otto NM, Cao J, Kundu M, Kim DH. ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. Mol Biol Cell 2009; 20: 1992-2003; PMID: 19225151; http://dx. doi. org/10. 1091/mbc. E08-12-1249.
-
(2009)
Mol Biol Cell
, vol.20
, pp. 1992-2003
-
-
Jung, C.H.1
Jun, C.B.2
Ro, S.H.3
Kim, Y.M.4
Otto, N.M.5
Cao, J.6
Kundu, M.7
Kim, D.H.8
-
49
-
-
79551598347
-
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
-
PMID: 21258367
-
Kim J, Kundu M, Viollet B, Guan KL. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol 2011; 13: 132-41; PMID: 21258367; http://dx. doi. org/10. 1038/ncb2152.
-
(2011)
Nat Cell Biol
, vol.13
, pp. 132-141
-
-
Kim, J.1
Kundu, M.2
Viollet, B.3
Guan, K.L.4
-
50
-
-
11244351579
-
Function and regulation of cullin-RING ubiquitin ligases
-
PMID: 15688063
-
Petroski MD, Deshaies RJ. Function and regulation of cullin-RING ubiquitin ligases. Nat Rev Mol Cell Biol 2005; 6: 9-20; PMID: 15688063; http://dx. doi. org/10. 1038/nrm1547.
-
(2005)
Nat Rev Mol Cell Biol
, vol.6
, pp. 9-20
-
-
Petroski, M.D.1
Deshaies, R.J.2
-
51
-
-
84870885054
-
Amino acid sensing in dietary-restriction-mediated longevity: Roles of signal-transducing kinases GCN2 and TOR
-
PMID: 23216249
-
Gallinetti J, Harputlugil E, Mitchell JR. Amino acid sensing in dietary-restriction-mediated longevity: roles of signal-transducing kinases GCN2 and TOR. Biochem J 2013; 449: 1-10; PMID: 23216249; http://dx. doi. org/10. 1042/BJ20121098.
-
(2013)
Biochem J
, vol.449
, pp. 1-10
-
-
Gallinetti, J.1
Harputlugil, E.2
Mitchell, J.R.3
-
52
-
-
60149091189
-
Regulation of translation initiation in eukaryotes: Mechanisms and biological targets
-
PMID: 19239892
-
Sonenberg N, Hinnebusch AG. Regulation of translation initiation in eukaryotes: mechanisms and biological targets. Cell 2009; 136: 731-45; PMID: 19239892; http://dx. doi. org/10. 1016/j. cell. 2009. 01. 042.
-
(2009)
Cell
, vol.136
, pp. 731-745
-
-
Sonenberg, N.1
Hinnebusch, A.G.2
-
53
-
-
33749620749
-
A balance of protein synthesis and proteasome-dependent degradation determines the maintenance of LTP
-
PMID: 17046687
-
Fonseca R, Vabulas RM, Hartl FU, Bonhoeffer T, Nagerl UV. A balance of protein synthesis and proteasome-dependent degradation determines the maintenance of LTP. Neuron 2006; 52: 239-45; PMID: 17046687; http://dx. doi. org/10. 1016/j. neuron. 2006. 08. 015.
-
(2006)
Neuron
, vol.52
, pp. 239-245
-
-
Fonseca, R.1
Vabulas, R.M.2
Hartl, F.U.3
Bonhoeffer, T.4
Nagerl, U.V.5
-
54
-
-
84868148725
-
Failure of amino acid homeostasis causes cell death following proteasome inhibition
-
PMID: 22959274
-
Suraweera A, Munch C, Hanssum A, Bertolotti A. Failure of amino acid homeostasis causes cell death following proteasome inhibition. Mol Cell 2012; 48: 242-53; PMID: 22959274; http://dx. doi. org/10. 1016/j. molcel. 2012. 08. 003.
-
(2012)
Mol Cell
, vol.48
, pp. 242-253
-
-
Suraweera, A.1
Munch, C.2
Hanssum, A.3
Bertolotti, A.4
-
55
-
-
0038493550
-
Characterization of chronic low-level proteasome inhibition on neural homeostasis
-
PMID: 12871590
-
Ding Q, Dimayuga E, Martin S, Bruce-Keller AJ, Nukala V, Cuervo AM, Keller JN. Characterization of chronic low-level proteasome inhibition on neural homeostasis. J Neurochem 2003; 86: 489-97; PMID: 12871590; http://dx. doi. org/10. 1046/j. 1471-4159. 2003. 01885. x.
-
(2003)
J Neurochem
, vol.86
, pp. 489-497
-
-
Ding, Q.1
Dimayuga, E.2
Martin, S.3
Bruce-Keller, A.J.4
Nukala, V.5
Cuervo, A.M.6
Keller, J.N.7
-
56
-
-
84930746830
-
The Biology of Proteostasis in Aging and Disease
-
PMID: 25784053
-
Labbadia J, Morimoto RI. The Biology of Proteostasis in Aging and Disease. Annu Rev Biochem 2015; 84: 32. 1-32. 30; PMID: 25784053; http://dx. doi. org/10. 1146/annurev-biochem-060614-033955.
-
(2015)
Annu Rev Biochem
, vol.84
, pp. 1-30
-
-
Labbadia, J.1
Morimoto, R.I.2
-
57
-
-
72949083368
-
Common corruption of the mTOR signaling network in human tumors
-
Menon S, Manning BD. Common corruption of the mTOR signaling network in human tumors. Oncogene 2009; 27: S43-S51; http://dx. doi. org/10. 1038/onc. 2009. 352.
-
(2009)
Oncogene
, vol.27
, pp. 43-51
-
-
Menon, S.1
Manning, B.D.2
-
58
-
-
84872527628
-
mTOR is a key modulator of ageing and age-related disease
-
PMID: 23325216
-
Johnson SC, Rabinovitch PS, Kaeberlein M. mTOR is a key modulator of ageing and age-related disease. Nature 2013; 493: 338-45; PMID: 23325216; http://dx. doi. org/10. 1038/nature11861.
-
(2013)
Nature
, vol.493
, pp. 338-345
-
-
Johnson, S.C.1
Rabinovitch, P.S.2
Kaeberlein, M.3
-
59
-
-
84908232014
-
The neurology of mTOR
-
PMID: 25374355
-
Lipton JO, Sahin M. The neurology of mTOR. Neuron 2014; 84: 275-91; PMID: 25374355; http://dx. doi. org/10. 1016/j. neuron. 2014. 09. 034.
-
(2014)
Neuron
, vol.84
, pp. 275-291
-
-
Lipton, J.O.1
Sahin, M.2
-
60
-
-
84882254367
-
The role of autophagy in neurodegenerative disease
-
PMID: 23921753
-
Nixon RA. The role of autophagy in neurodegenerative disease. Nat Med 2013; 19: 983-97; PMID: 23921753; http://dx. doi. org/10. 1038/nm. 3232.
-
(2013)
Nat Med
, vol.19
, pp. 983-997
-
-
Nixon, R.A.1
-
61
-
-
84925436842
-
mTOR Signaling in Aging and Neurodegeneration: At the Crossroad between Metabolism dysfunction and Impairment of autophagy
-
Perluigi M, Di Domenico F, Butterfield DA. mTOR Signaling in Aging and Neurodegeneration: At the Crossroad between Metabolism dysfunction and Impairment of autophagy. Neurobiol Dis 2015; http://dx. doi. org/S0969-9961(15)00086-8; pii10. 1016/j. nbd. 2015. 03. 014.
-
(2015)
Neurobiol Dis
-
-
Perluigi, M.1
Di Domenico, F.2
Butterfield, D.A.3
-
62
-
-
66149154785
-
Human muscle protein synthesis and breakdown during and after exercise
-
PMID: 19164770
-
Kumar V, Atherton P, Smith K, Rennie MJ. Human muscle protein synthesis and breakdown during and after exercise. J Appl Physiol 1985 2009; 106: 2026-39; PMID: 19164770; http://dx. doi. org/10. 1152/japplphysiol. 91481. 2008.
-
(2009)
J Appl Physiol 1985
, vol.106
, pp. 2026-2039
-
-
Kumar, V.1
Atherton, P.2
Smith, K.3
Rennie, M.J.4
-
63
-
-
44449161481
-
The TSC1-TSC2 complex: A molecular switchboard controlling cell growth
-
PMID: 18466115
-
Huang J, Manning BD. The TSC1-TSC2 complex: a molecular switchboard controlling cell growth. Biochem J 2008; 412: 179-90; PMID: 18466115; http://dx. doi. org/10. 1042/BJ20080281.
-
(2008)
Biochem J
, vol.412
, pp. 179-190
-
-
Huang, J.1
Manning, B.D.2
-
64
-
-
0025115736
-
Abnormally high expression of proteasomes in human leukemic cells
-
PMID: 2205851
-
Kumatori A, Tanaka K, Inamura N, Sone S, Ogura T, Matsumoto T, Tachikawa T, Shin S, Ichihara A, et al. Abnormally high expression of proteasomes in human leukemic cells. Proc Natl Acad Sci U S A 1990; 87: 7071-5; PMID: 2205851; http://dx. doi. org/10. 1073/pnas. 87. 18. 7071.
-
(1990)
Proc Natl Acad Sci U S A
, vol.87
, pp. 7071-7075
-
-
Kumatori, A.1
Tanaka, K.2
Inamura, N.3
Sone, S.4
Ogura, T.5
Matsumoto, T.6
Tachikawa, T.7
Shin, S.8
Ichihara, A.9
-
65
-
-
11144280578
-
-
PMID: 15720800
-
Pilarsky C, Wenzig M, Specht T, Saeger HD, Grutzmann R. Identification and validation of commonly overexpressed genes in solid tumors by comparison of microarray data. Neoplasia New York, N. Y 2004; 6: 744-50; PMID: 15720800; http://dx. doi. org/10. 1593/neo. 04277.
-
(2004)
Identification and validation of commonly overexpressed genes in solid tumors by comparison of microarray data. Neoplasia New York, N
, vol.6
, pp. 744-750
-
-
Pilarsky, C.1
Wenzig, M.2
Specht, T.3
Saeger, H.D.4
Grutzmann, R.5
-
66
-
-
21344469230
-
Increased proteasome activity, ubiquitin-conjugating enzymes, and eEF1A translation factor detected in breast cancer tissue
-
PMID: 15994932
-
Chen L, Madura K. Increased proteasome activity, ubiquitin-conjugating enzymes, and eEF1A translation factor detected in breast cancer tissue. Cancer Res 2005; 65: 5599-606; PMID: 15994932; http://dx. doi. org/10. 1158/0008-5472. CAN-05-0201.
-
(2005)
Cancer Res
, vol.65
, pp. 5599-5606
-
-
Chen, L.1
Madura, K.2
-
67
-
-
84875740314
-
Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal
-
PMID: 23550210
-
Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO, Sun Y, Jacobsen A, Sinha R, Larsson E, et al. Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal 2013; 6: pl1; PMID: 23550210; http://dx. doi. org/10. 1126/scisignal. 2004088.
-
(2013)
Sci Signal
, vol.6
-
-
Gao, J.1
Aksoy, B.A.2
Dogrusoz, U.3
Dresdner, G.4
Gross, B.5
Sumer, S.O.6
Sun, Y.7
Jacobsen, A.8
Sinha, R.9
Larsson, E.10
|