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Volumn 11, Issue 19, 2015, Pages 2681-2695

Immunotherapy for non-small-cell lung cancer: The past 10 years

Author keywords

cancer vaccination; checkpoint inhibitors; immunotherapy; non small cell lung cancer; receptors, CTLA 4; receptors, PD L1; review

Indexed keywords

ANTINEOPLASTIC AGENT; AVELUMAB; BELAGENPUMATUCEL L; BMS 936559; DURVALUMAB; IPILIMUMAB; MELANOMA ANTIGEN 3 VACCINE; MONOCLONAL ANTIBODY; MPDL 3280A; NIMOTUZUMAB; NIVOLUMAB; PEMBROLIZUMAB; RACOTUMOMAB; TECEMOTIDE; TG 4010; TICILIMUMAB; UNCLASSIFIED DRUG;

EID: 84943750570     PISSN: 14796694     EISSN: 17448301     Source Type: Journal    
DOI: 10.2217/fon.15.116     Document Type: Review
Times cited : (6)

References (56)
  • 1
    • 84885353689 scopus 로고    scopus 로고
    • Early and locally advanced non-small cell lung cancer (NSCLC): Esmo clinical practice guidelines for diagnosis, treatment and follow-up
    • Vansteenkiste J, De Ruysscher D, Eberhardt W., et al. Early and locally advanced non-small cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann. Oncol. 24(Suppl 6), vi89-vi98 (2013
    • (2013) Ann. Oncol , vol.24 , pp. vi89-vi98
    • Vansteenkiste, J.1    De Ruysscher, D.2    Eberhardt, W.3
  • 2
    • 84911493241 scopus 로고    scopus 로고
    • Metastatic non-smallcell lung cancer (NSCLC): Esmo clinical practice guidelines for diagnosis, treatment and follow-up
    • Reck M, Popat S, Reinmuth N, De Ruysscher D, Kerr KM, Peters S. Metastatic non-smallcell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann. Oncol. 25(Suppl 3), iii27-iii39 (2014
    • (2014) Ann. Oncol , vol.25 , pp. iii27-iii39
    • Reck, M.1    Popat, S.2    Reinmuth, N.3    De Ruysscher, D.4    Kerr, K.M.5    Peters, S.6
  • 3
    • 69949162760 scopus 로고    scopus 로고
    • Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
    • Mok TS, Wu YL, Thongprasert S., et al. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N. Engl. J. Med. 361, 947-957 (2009
    • (2009) N. Engl. J. Med , vol.361 , pp. 947-957
    • Mok, T.S.1    Wu, Y.L.2    Thongprasert, S.3
  • 4
    • 84879071011 scopus 로고    scopus 로고
    • Crizotinib versus chemotherapy in advanced alk-positive lung cancer
    • Shaw AT, Kim DW, Nakagawa K., et al. Crizotinib versus chemotherapy in advanced ALK-positive lung cancer. N. Engl. J. Med. 368, 2385-2394 (2013
    • (2013) N. Engl. J. Med , vol.368 , pp. 2385-2394
    • Shaw, A.T.1    Kim, D.W.2    Nakagawa, K.3
  • 5
    • 84919339224 scopus 로고    scopus 로고
    • A randomized, double-blind phase 3 trial of adjuvant erlotinib (e) versus placebo (p) following complete tumor resection with or without adjuvant chemotherapy in patients (pts) with stage ib-iiia EGFR positive (ihc/ fish) non-small cell lung cancer (NSCLC): Radiant results
    • Abstract 7501
    • Kelly K, Altorki NK, Eberhardt WE., et al A randomized, double-blind Phase 3 trial of adjuvant erlotinib (E) versus placebo (P) following complete tumor resection with or without adjuvant chemotherapy in patients (pts) with stage IB-IIIA EGFR positive (IHC/ FISH) non-small cell lung cancer (NSCLC): RADIANT results. J. Clin. Oncol. 32(Suppl 5), Abstract 7501 (2014
    • (2014) J. Clin. Oncol , vol.32
    • Kelly, K.1    Altorki, N.K.2    Eberhardt, W.E.3
  • 6
    • 84921842851 scopus 로고    scopus 로고
    • Standard-dose versus high-dose conformal radiotherapy with concurrent and consolidation carboplatin plus paclitaxel with or without cetuximab for patients with stage iiia or iiib non-small-cell lung cancer (rtog 0617): A randomised, two-by-Two factorial phase 3 study
    • Bradley JD, Paulus R, Komaki R., et al. Standard-dose versus high-dose conformal radiotherapy with concurrent and consolidation carboplatin plus paclitaxel with or without cetuximab for patients with stage IIIA or IIIB non-small-cell lung cancer (RTOG 0617): a randomised, two-by-Two factorial Phase 3 study. Lancet Oncol. 16(2), 187-199 (2015
    • (2015) Lancet Oncol , vol.16 , Issue.2 , pp. 187-199
    • Bradley, J.D.1    Paulus, R.2    Komaki, R.3
  • 7
    • 84863113633 scopus 로고    scopus 로고
    • Immunotherapies for non-small-cell lung cancer and mesothelioma
    • Thomas A, Hassan R. Immunotherapies for non-small-cell lung cancer and mesothelioma. Lancet Oncol. 13(7), e301-e310 (2012
    • (2012) Lancet Oncol , vol.13 , Issue.7 , pp. e301-e310
    • Thomas, A.1    Hassan, R.2
  • 8
    • 0027949292 scopus 로고
    • A placebo-controlled randomized double-blind study of adjuvant intrapleural bcg in patients with resected t1n0, t1n1, or t2n0 squamous cell carcinoma, adenocarcinoma, or large cell carcinoma of the lung
    • Gail MH A placebo-controlled randomized double-blind study of adjuvant intrapleural BCG in patients with resected T1N0, T1N1, or T2N0 squamous cell carcinoma, adenocarcinoma, or large cell carcinoma of the lung. LCSG Protocol 771. Chest 106, S287-S292 (1994
    • (1994) LCSG Protocol 771. Chest , vol.106 , pp. S287-S292
    • Gail, M.H.1
  • 9
    • 0027995441 scopus 로고
    • Surgical adjuvant therapy for stage II and stage III adenocarcinoma and large cell undifferentiated carcinoma
    • Holmes EC. Surgical adjuvant therapy for stage II and stage III adenocarcinoma and large cell undifferentiated carcinoma. Chest 106(6), S293-S296 (1994
    • (1994) Chest , vol.106 , Issue.6 , pp. S293-S296
    • Holmes, E.C.1
  • 10
    • 0026653868 scopus 로고
    • Interleukin-2 and interferon-Alpha in the treatment of patients with advanced non-small cell lung cancer
    • Jansen RL, Slingerland R, Goey SH, Franks CR, Bolhuis RL, Stoter G. Interleukin-2 and interferon-Alpha in the treatment of patients with advanced non-small cell lung cancer. J. Immunother. 12(1), 70-73 (1992
    • (1992) J. Immunother , vol.12 , Issue.1 , pp. 70-73
    • Jansen, R.L.1    Slingerland, R.2    Goey, S.H.3    Franks, C.R.4    Bolhuis, R.L.5    Stoter, G.6
  • 11
    • 79960110662 scopus 로고    scopus 로고
    • Randomized phase III trial of paclitaxel/ carboplatin with or without pf-3512676 (toll-like receptor 9 agonist) as first-line treatment for advanced non-small cell lung cancer
    • Hirsh V, Paz-Ares L, Boyer M., et al. Randomized Phase III trial of paclitaxel/ carboplatin with or without PF-3512676 (toll-like receptor 9 agonist) as first-line treatment for advanced non-small cell lung cancer. J. Clin. Oncol. 29(19), 2667-2674 (2011
    • (2011) J. Clin. Oncol , vol.29 , Issue.19 , pp. 2667-2674
    • Hirsh, V.1    Paz-Ares, L.2    Boyer, M.3
  • 12
    • 84855184648 scopus 로고    scopus 로고
    • A phase III randomized study of gemcitabine and cisplatin with or without pf-3512676 (tlr9 agonist) as first-line treatment of advanced non-small cell lung cancer
    • Manegold C, Van Zandwijk N, Szczesna A., et al A Phase III randomized study of gemcitabine and cisplatin with or without PF-3512676 (TLR9 agonist) as first-line treatment of advanced non-small cell lung cancer. Ann. Oncol. 23(1), 72-77 (2012
    • (2012) Ann. Oncol , vol.23 , Issue.1 , pp. 72-77
    • Manegold, C.1    Van Zandwijk, N.2    Szczesna, A.3
  • 13
    • 84887121328 scopus 로고    scopus 로고
    • Talactoferrin alfa versus placebo in patients with refractory advanced non-small-cell lung cancer (fortis-m trial
    • Ramalingam S, Crawford J, Chang A., et al. Talactoferrin alfa versus placebo in patients with refractory advanced non-small-cell lung cancer (FORTIS-M trial). Ann. Oncol. 24, 2875-2890 (2013
    • (2013) Ann. Oncol , vol.24 , pp. 2875-2890
    • Ramalingam, S.1    Crawford, J.2    Chang, A.3
  • 14
    • 84922365301 scopus 로고    scopus 로고
    • Magrit, a double-blind, randomized, placebo-controlled phase III study to assess the efficacy of the recmage-A3 + as15 cancer immunotherapeutic as adjuvant therapy in patients with resected mage-A3-positive non-small cell lung cancer (NSCLC
    • Abstract 1173O
    • Vansteenkiste JF, Cho BC, Vanakesa T., et al. MAGRIT, a double-blind, randomized, placebo-controlled Phase III study to assess the efficacy of the recMAGE-A3 + AS15 cancer immunotherapeutic as adjuvant therapy in patients with resected MAGE-A3-positive non-small cell lung cancer (NSCLC). Ann. Oncol. 25(Suppl 4), Abstract 1173O (2014
    • (2014) Ann. Oncol , vol.25
    • Vansteenkiste, J.F.1    Cho, B.C.2    Vanakesa, T.3
  • 15
    • 84891373760 scopus 로고    scopus 로고
    • Tecemotide (l-blp25) versus placebo after chemoradiotherapy for stage III non-smallcell lung cancer (start): A randomised, double-blind, phase 3 trial
    • Butts C, Socinski MA, Mitchell PL., et al. Tecemotide (L-BLP25) versus placebo after chemoradiotherapy for stage III non-smallcell lung cancer (START): a randomised, double-blind, Phase 3 trial. Lancet Oncol. 15(1), 59-68 (2014
    • (2014) Lancet Oncol , vol.15 , Issue.1 , pp. 59-68
    • Butts, C.1    Socinski, M.A.2    Mitchell, P.L.3
  • 16
    • 84895784043 scopus 로고    scopus 로고
    • A phase III study of belagenpumatucel-l therapeutic tumor cell vaccine for non-small cell lung cancer (NSCLC
    • Abstract LBA 7081
    • Giaccone G, Bazhenova L, Nemunaitis J., et al A Phase III study of belagenpumatucel-L therapeutic tumor cell vaccine for non-small cell lung cancer (NSCLC). Eur. J. Cancer. 47(Suppl 2), Abstract LBA 7081 (2013
    • (2013) Eur. J. Cancer , vol.47
    • Giaccone, G.1    Bazhenova, L.2    Nemunaitis, J.3
  • 17
    • 84943746201 scopus 로고    scopus 로고
    • Time, a phase 2b/3 study evaluating tg4010 in combination with first-line therapy in advanced non-small lung cancer (NSCLC) phase 2b results
    • Abstract 1055PD
    • Quoix E, Losonczy G, Forget F., et al. TIME, a Phase 2B/3 study evaluating TG4010 in combination with first-line therapy in advanced non-small lung cancer (NSCLC). Phase 2B results. Ann. Oncol. 25(Suppl 4), Abstract 1055PD (2014
    • (2014) Ann. Oncol , vol.25
    • Quoix, E.1    Losonczy, G.2    Forget, F.3
  • 18
    • 0029099362 scopus 로고
    • Identification of mage-1 and mage-4 proteins in spermatogonia and primary spermatocytes of testis
    • Takahashi K, Shichijo S, Noguchi M, Hirohata M, Itoh K. Identification of MAGE-1 and MAGE-4 proteins in spermatogonia and primary spermatocytes of testis. Cancer Res. 55(16), 3478-3482 (1995
    • (1995) Cancer Res , vol.55 , Issue.16 , pp. 3478-3482
    • Takahashi, K.1    Shichijo, S.2    Noguchi, M.3    Hirohata, M.4    Itoh, K.5
  • 19
    • 0347364737 scopus 로고    scopus 로고
    • Melanoma associated antigen (mage)-A3 expression in stages i and II non-small cell lung cancer: Results of a multi-center study
    • Sienel W, Varwerk C, Linder A., et al. Melanoma associated antigen (MAGE)-A3 expression in stages I and II non-small cell lung cancer: results of a multi-center study. Eur. J. Cardiothorac. Surg. 25(1), 131-134 (2004
    • (2004) Eur. J. Cardiothorac. Surg , vol.25 , Issue.1 , pp. 131-134
    • Sienel, W.1    Varwerk, C.2    Linder, A.3
  • 20
    • 0346238665 scopus 로고    scopus 로고
    • Cisplatin-based adjuvant chemotherapy in patients with completely resected non-small cell lung cancer
    • The International Adjuvant Lung Cancer Trial Collaborative Group
    • The International Adjuvant Lung Cancer Trial Collaborative Group, Arriagada R, Bergman B., et al. Cisplatin-based adjuvant chemotherapy in patients with completely resected non-small cell lung cancer. N. Engl. J. Med. 350, 351-360 (2004
    • (2004) N. Engl. J. Med , vol.350 , pp. 351-360
    • Arriagada, R.1    Bergman, B.2
  • 21
    • 84880755387 scopus 로고    scopus 로고
    • Adjuvant mage-A3 immunotherapy in resected non-small cell lung cancer: Phase II randomized study results
    • Vansteenkiste J, Zielinski M, Linder A., et al. Adjuvant MAGE-A3 immunotherapy in resected non-small cell lung cancer: Phase II randomized study results. J. Clin. Oncol. 31, 2396-2403 (2013
    • (2013) J. Clin. Oncol , vol.31 , pp. 2396-2403
    • Vansteenkiste, J.1    Zielinski, M.2    Linder, A.3
  • 22
    • 27244449289 scopus 로고    scopus 로고
    • Randomized phase iib trial of blp25 liposome vaccine in stage iiib and IV non-small cell lung cancer
    • Butts C, Murray N, Maksymiuk A., et al. Randomized Phase IIB trial of BLP25 liposome vaccine in stage IIIB and IV non-small cell lung cancer. J. Clin. Oncol. 23, 6674-6681 (2005
    • (2005) J. Clin. Oncol , vol.23 , pp. 6674-6681
    • Butts, C.1    Murray, N.2    Maksymiuk, A.3
  • 24
    • 81255127285 scopus 로고    scopus 로고
    • Therapeutic vaccination with tg4010 and first-line chemotherapy in advanced non-small cell lung cancer: A controlled phase 2b trial
    • Quoix E, Ramlau R, Westeel V., et al. Therapeutic vaccination with TG4010 and first-line chemotherapy in advanced non-small cell lung cancer: a controlled Phase 2B trial. Lancet Oncol. 12, 1125-1133 (2011
    • (2011) Lancet Oncol , vol.12 , pp. 1125-1133
    • Quoix, E.1    Ramlau, R.2    Westeel, V.3
  • 25
    • 33750586798 scopus 로고    scopus 로고
    • Phase II study of belagenpumatucel-l, a transforming growth factor beta-2 antisense gene-modified allogeneic tumor cell vaccine in non-small cell lung cancer
    • Nemunaitis J, Dillman RO, Schwarzenberger PO., et al. Phase II study of belagenpumatucel-L, a transforming growth factor beta-2 antisense gene-modified allogeneic tumor cell vaccine in non-small cell lung cancer. J. Clin. Oncol. 24, 4721-4730 (2006
    • (2006) J. Clin. Oncol , vol.24 , pp. 4721-4730
    • Nemunaitis, J.1    Dillman, R.O.2    Schwarzenberger, P.O.3
  • 26
    • 0031775979 scopus 로고    scopus 로고
    • A novel cancer vaccine composed of humanrecombinant epidermal growth factor linked to a carrier protein: Report of a pilot clinical trial
    • Gonzalez G, Crombet T, Catala M., et al A novel cancer vaccine composed of humanrecombinant epidermal growth factor linked to a carrier protein: report of a pilot clinical trial. Ann. Oncol. 9, 431-435 (1998
    • (1998) Ann. Oncol , vol.9 , pp. 431-435
    • Gonzalez, G.1    Crombet, T.2    Catala, M.3
  • 27
    • 41149159650 scopus 로고    scopus 로고
    • Phase II randomized controlled trial of an epidermal growth factor vaccine in advanced non-small cell lung cancer
    • Neninger Vinageras E, De La Torre A, Osorio Rodriguez M., et al. Phase II randomized controlled trial of an epidermal growth factor vaccine in advanced non-small cell lung cancer. J. Clin. Oncol. 26, 1452-1458 (2008
    • (2008) J. Clin. Oncol , vol.26 , pp. 1452-1458
    • Neninger Vinageras, E.1    De La Torre, A.2    Osorio Rodriguez, M.3
  • 28
    • 84904386095 scopus 로고    scopus 로고
    • A randomized, multicenter, placebocontrolled clinical trial of racotumomabalum vaccine as switch maintenance therapy in advanced non-small cell lung cancer patients
    • Alfonso S, Valdes-Zayas A, Santiesteban ER., et al A randomized, multicenter, placebocontrolled clinical trial of racotumomabalum vaccine as switch maintenance therapy in advanced non-small cell lung cancer patients. Clin. Cancer Res. 20(14), 3660-3671 (2014
    • (2014) Clin. Cancer Res , vol.20 , Issue.14 , pp. 3660-3671
    • Alfonso, S.1    Valdes-Zayas, A.2    Santiesteban, E.R.3
  • 29
    • 84859158384 scopus 로고    scopus 로고
    • Targeting the pd-1/b7-h1(pd-l1) pathway to activate anti-Tumor immunity
    • Topalian SL, Drake CG, Pardoll DM. Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-Tumor immunity. Curr. Opin. Immunol. 24, 207-212 (2012
    • (2012) Curr. Opin. Immunol , vol.24 , pp. 207-212
    • Topalian, S.L.1    Drake, C.G.2    Pardoll, D.M.3
  • 30
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • Hodi FS, ODay SJ, McDermott DF., et al. Improved survival with ipilimumab in patients with metastatic melanoma. N. Engl. J. Med. 363, 711-723 (2010
    • (2010) N. Engl. J. Med , vol.363 , pp. 711-723
    • Hodi, F.S.1    ODay, S.J.2    McDermott, D.F.3
  • 31
    • 84863911486 scopus 로고    scopus 로고
    • Ipilimumab in combination with paclitaxel and carboplatin as first-line treatment in stage IIib/IV non-small cell lung cancer: Results from a randomized, double-blind, multicenter phase II study
    • Lynch TJ, Bondarenko I, Luft A., et al. Ipilimumab in combination with paclitaxel and carboplatin as first-line treatment in stage IIIB/IV non-small cell lung cancer: results from a randomized, double-blind, multicenter Phase II study. J. Clin. Oncol. 30, 2046-2055 (2012
    • (2012) J. Clin. Oncol , vol.30 , pp. 2046-2055
    • Lynch, T.J.1    Bondarenko, I.2    Luft, A.3
  • 32
    • 73149092567 scopus 로고    scopus 로고
    • Guidelines for the evaluation of immune therapy activity in solid tumors: Immunerelated response criteria
    • Wolchok JD, Hoos A, ODay S., et al. Guidelines for the evaluation of immune therapy activity in solid tumors: immunerelated response criteria. Clin. Cancer Res. 15, 7412-7420 (2009
    • (2009) Clin. Cancer Res , vol.15 , pp. 7412-7420
    • Wolchok, J.D.1    Hoos, A.2    ODay, S.3
  • 33
    • 84943797542 scopus 로고    scopus 로고
    • Randomised phase II clinical trial comparing tremelimumab (cp-675206) with best supportive care (bsc) following first-line platinum-based therapy in patients (pts) with advanced non-small cell lung cancer (NSCLC
    • Suppl), Abstract 8071
    • Zatloukal P, Heo DS, Park K., et al. Randomised Phase II clinical trial comparing tremelimumab (CP-675206) with best supportive care (BSC) following first-line platinum-based therapy in patients (pts) with advanced non-small cell lung cancer (NSCLC). J. Clin. Oncol. 27(Suppl), Abstract 8071 (2015
    • (2015) J. Clin. Oncol , vol.27
    • Zatloukal, P.1    Heo, D.S.2    Park, K.3
  • 34
    • 84937639107 scopus 로고    scopus 로고
    • Long-Term survival, clinical activity, and safety of nivolumab (anti-pd-1; Bms-936558; ono-4538) in patients (pts) with advanced non-small cell lung cancer (NSCLC
    • Suppl
    • Gettinger S, Horn L, Gandhi L., et al. Long-Term survival, clinical activity, and safety of nivolumab (anti-PD-1; BMS-936558; ONO-4538) in patients (pts) with advanced non-small cell lung cancer (NSCLC). Int. J. Radiat. Oncol. Biol. Phys. 90(Suppl), S34 (2014
    • (2014) Int. J. Radiat. Oncol. Biol. Phys , vol.90 , pp. S34
    • Gettinger, S.1    Horn, L.2    Gandhi, L.3
  • 35
    • 84937635597 scopus 로고    scopus 로고
    • First-line monotherapy with nivolumab (anti-dp-1; Bms-936558; ono-4538) in advanced non-small cell lung cancer (NSCLC): Safety, efficacy, and correlation of outcomes with pd-l1 status
    • Suppl
    • Rizvi NA, Shepherd FA, Antonia SJ., et al. First-line monotherapy with Nivolumab (anti-DP-1; BMS-936558; ONO-4538) in advanced non-small cell lung cancer (NSCLC): safety, efficacy, and correlation of outcomes with PD-L1 status. Int. J. Radiat. Oncol. Biol. Phys. 90(Suppl), S31 (2014
    • (2014) Int. J. Radiat. Oncol. Biol. Phys , vol.90 , pp. S31
    • Rizvi, N.A.1    Shepherd, F.A.2    Antonia, S.J.3
  • 36
    • 84924907300 scopus 로고    scopus 로고
    • Antitumor activity of pembrolizumab (pembro; Mk-3475) and correlation with programmed dath ligand (pd-l1) expression in a pooled analysis of patients (pts) with advanced non-small cell lung cancer (NSCLC
    • Suppl 4
    • Garon EB, Gandhi L, Rizvi NA., et al. Antitumor activity of pembrolizumab (pembro; MK-3475) and correlation with programmed dath ligand (PD-L1) expression in a pooled analysis of patients (pts) with advanced non-small cell lung cancer (NSCLC). Ann. Oncol. 25(Suppl 4), v1-v41 (2014
    • (2014) Ann. Oncol , vol.25 , pp. v1-v41
    • Garon, E.B.1    Gandhi, L.2    Rizvi, N.A.3
  • 37
    • 84937595375 scopus 로고    scopus 로고
    • Biomarkers associated with clinical activity of pd-l1 blockade in non-small cell lung cancer (NSCLC) in a phase i study of mpdl3280a
    • Soria JC, Gettinger S, Gordon M., et al. Biomarkers associated with clinical activity of PD-L1 blockade in non-small cell lung cancer (NSCLC) in a Phase I study of MPDL3280A. Ann. Oncol. 25(Suppl 4), iv426-iv470 (2014
    • (2014) Ann. Oncol , vol.25 , pp. iv426-iv470
    • Soria, J.C.1    Gettinger, S.2    Gordon, M.3
  • 38
    • 84907651084 scopus 로고    scopus 로고
    • Clinical activity and biomarkers of medi4736, an anti-pd-l1 antibody, in patients with NSCLC
    • Brahmer JR, Rizvi NA, Lutzky J., et al. Clinical activity and biomarkers of MEDI4736, an anti-PD-L1 antibody, in patients with NSCLC. J. Clin. Oncol. 32(Suppl 5), S511 (2014
    • (2014) J. Clin. Oncol , vol.32 , pp. S511
    • Brahmer, J.R.1    Rizvi, N.A.2    Lutzky, J.3
  • 39
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-pd-1 antibody in cancer
    • Topalian SL, Hodi FS, Brahmer JR., et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N. Engl. J. Med. 366, 2443-2454 (2012
    • (2012) N. Engl. J. Med , vol.366 , pp. 2443-2454
    • Topalian, S.L.1    Hodi, F.S.2    Brahmer, J.R.3
  • 40
    • 84924901863 scopus 로고    scopus 로고
    • Activity and safety of nivolumab, an anti-pd-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (checkmate 063): A phase 2, single-Arm trial
    • Rizvi NA, Mazieres J, Planchard D., et al. Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): a Phase 2, single-Arm trial. Lancet Oncol. 16(3), 257-265 (2015
    • (2015) Lancet Oncol , vol.16 , Issue.3 , pp. 257-265
    • Rizvi, N.A.1    Mazieres, J.2    Planchard, D.3
  • 41
    • 84862903106 scopus 로고    scopus 로고
    • Safety and activity of anti-pd-l1 antibody in patients with advanced cancer
    • Brahmer JR, Tykodi SS, Chow LQ., et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N. Engl. J. Med. 366, 2455-2465 (2012
    • (2012) N. Engl. J. Med , vol.366 , pp. 2455-2465
    • Brahmer, J.R.1    Tykodi, S.S.2    Chow, L.Q.3
  • 42
    • 57849117384 scopus 로고    scopus 로고
    • New response evaluation criteria in solid tumours: Revised recist guideline (version 11
    • Eisenhauer EA, Therasse P, Bogaerts J., et al. New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur. J. Cancer 45, 228-247 (2009
    • (2009) Eur. J. Cancer , vol.45 , pp. 228-247
    • Eisenhauer, E.A.1    Therasse, P.2    Bogaerts, J.3
  • 45
    • 84881128653 scopus 로고    scopus 로고
    • Developing a common language for tumor response to immunotherapy: Immune-related response criteria using unidimensional measurements
    • Nishino M, Giobbie-Hurder A, Gargano M, Suda M, Ramaiya NH, Hodi FS. Developing a common language for tumor response to immunotherapy: immune-related response criteria using unidimensional measurements. Reserve. Clin. Cancer Res. 19, 3936-3943 (2015
    • (2015) Reserve. Clin. Cancer Res , vol.19 , pp. 3936-3943
    • Nishino, M.1    Giobbie-Hurder, A.2    Gargano, M.3    Suda, M.4    Ramaiya, N.H.5    Hodi, F.S.6
  • 48
    • 84880720167 scopus 로고    scopus 로고
    • Predictive gene signature in magea3 antigen-specific cancer immunotherapy
    • Ulloa-Montoya F, Louahed J, Dizier B., et al. Predictive gene signature in MAGEA3 antigen-specific cancer immunotherapy. J. Clin. Oncol. 31, 2388-2395 (2013
    • (2013) J. Clin. Oncol , vol.31 , pp. 2388-2395
    • Ulloa-Montoya, F.1    Louahed, J.2    Dizier, B.3
  • 50
    • 84906903314 scopus 로고    scopus 로고
    • Ramucirumab plus docetaxel versus placebo plus docetaxel for second-line treatment of stage IV non-small-cell lung cancer after disease progression on platinum-based therapy (revel): A multicentre, doubleblind, randomised phase 3 trial
    • Garon EB, Ciuleanu TE, Arrieta O., et al. Ramucirumab plus docetaxel versus placebo plus docetaxel for second-line treatment of stage IV non-small-cell lung cancer after disease progression on platinum-based therapy (REVEL): a multicentre, doubleblind, randomised Phase 3 trial. Lancet 384, 665-673 (2014
    • (2014) Lancet , vol.384 , pp. 665-673
    • Garon, E.B.1    Ciuleanu, T.E.2    Arrieta, O.3
  • 51
    • 84892967581 scopus 로고    scopus 로고
    • Docetaxel plus nintedanib versus docetaxel plus placebo in patients with previously treated non-small-cell lung cancer (lumelung 1): A phase 3, double-blind, randomized controlled trial
    • Reck M, Kaiser R, Mellemgaard A., et al. Docetaxel plus nintedanib versus docetaxel plus placebo in patients with previously treated non-small-cell lung cancer (LUMELung 1): a Phase 3, double-blind, randomized controlled trial. Lancet Oncol. 15, 143-155 (2014
    • (2014) Lancet Oncol , vol.15 , pp. 143-155
    • Reck, M.1    Kaiser, R.2    Mellemgaard, A.3
  • 52
    • 84943736960 scopus 로고    scopus 로고
    • Clinical activity, safety and biomarkers of pd-l1 blockade in non-small cell lung cancer (NSCLC): Additional analyses from a clinical study of the engineered antibody mpdl3280a (anti-pdl1
    • Suppl), Abstract 3408
    • Soria JC, Cruz C, Bahleda R., et al. Clinical activity, safety and biomarkers of PD-L1 blockade in non-small cell lung cancer (NSCLC): additional analyses from a clinical study of the engineered antibody MPDL3280A (anti-PDL1). Eur. J. Cancer. 49(Suppl), Abstract 3408 (2013
    • (2013) Eur. J. Cancer , vol.49
    • Soria, J.C.1    Cruz, C.2    Bahleda, R.3
  • 53
    • 84937108473 scopus 로고    scopus 로고
    • Smoking history and response to nivolumab in patients wiht advanced NSCLC
    • Abstract 1229PD
    • Hellmann M D, Creelan B C, Woo K., et al. Smoking history and response to nivolumab in patients wiht advanced NSCLC. Ann. Oncol. 25(Suppl 4), Abstract 1229PD (2014
    • (2014) Ann. Oncol , vol.25
    • Hellmann, M.D.1    Creelan, B.C.2    Woo, K.3
  • 54
    • 84938313517 scopus 로고    scopus 로고
    • Nivolumab (anti-pd-1; Bms-936558, ono-4538) in combination with platinumbased doublet chemotherapy or erlotinib in advanced non-small cell lung cancer (NSCLC
    • Abstract 1054PD
    • Gettinger S, Rizvi N, Chow LQ., et al. Nivolumab (anti-PD-1; BMS-936558, ONO-4538) in combination with platinumbased doublet chemotherapy or erlotinib in advanced non-small cell lung cancer (NSCLC). Ann. Oncol. 25(Suppl 4), Abstract 1054PD (2014
    • (2014) Ann. Oncol , vol.25
    • Gettinger, S.1    Rizvi, N.2    Chow, L.Q.3
  • 55
    • 84879777241 scopus 로고    scopus 로고
    • Nivolumab plus ipilimumab in advanced melanoma
    • Wolchok JD, Kluger H, Callahan MK., et al. Nivolumab plus ipilimumab in advanced melanoma. N. Engl. J. Med. 369, 122-133 (2013
    • (2013) N. Engl. J. Med , vol.369 , pp. 122-133
    • Wolchok, J.D.1    Kluger, H.2    Callahan, M.K.3
  • 56
    • 84937639783 scopus 로고    scopus 로고
    • Safety and efficacy of first-line nivolumab (anti-pd-1; Bms-936558; ono-4538) and ipilimumab in non-small cell lung cancer (NSCLC
    • Suppl
    • Antonia SJ, Gettinger S, Goldman J., et al. Safety and efficacy of first-line nivolumab (anti-PD-1; BMS-936558; ONO-4538) and ipilimumab in non-small cell lung cancer (NSCLC). Int. J. Radiat. Oncol. Biol. Phys. 90(Suppl), S32 (2014
    • (2014) Int. J. Radiat. Oncol. Biol. Phys , vol.90 , pp. S32
    • Antonia, S.J.1    Gettinger, S.2    Goldman, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.