Baseline Perineural Invasion is Associated with Shorter Time to Progression in Men with Prostate Cancer Undergoing Active Surveillance: Results from the REDEEM Study

Journal of Urology

Volumn 194, Issue 5, 2015, Pages 1258-1263

  Moreira, Daniel M ^a   Fleshner, Neil E ^b   Freedland, Stephen J ^c,d  

^a MAYO CLINIC   (United States)

^b UNIVERSITY HEALTH NETWORK   (Canada)

^c CEDARS SINAI MEDICAL CENTER   (United States)

^d DURHAM VA MEDICAL CENTER   (United States)

Author keywords

disease progression; neoplasm invasiveness; prostate specific antigen; prostatic neoplasms; risk

Indexed keywords

PROSTATE SPECIFIC ANTIGEN; DUTASTERIDE; STEROID 5ALPHA REDUCTASE INHIBITOR;

ADULT; AGED; ARTICLE; CANCER EPIDEMIOLOGY; CANCER GROWTH; CANCER RISK; CANCER SIZE; CANCER SURVIVAL; GLEASON SCORE; HUMAN; MAJOR CLINICAL STUDY; MALE; PERINEURAL INVASION; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; PROPORTIONAL HAZARDS MODEL; PROSTATE BIOPSY; PROSTATE CANCER; PROSTATE VOLUME; RACE; RETROSPECTIVE STUDY; TRANSRECTAL ULTRASONOGRAPHY; ADJUVANT THERAPY; BIOPSY; CANCER STAGING; CONTROLLED STUDY; DISEASE COURSE; DISEASE FREE SURVIVAL; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; FOLLOW UP; MIDDLE AGED; ORAL DRUG ADMINISTRATION; PATHOLOGY; PERINEUM; PROSTATECTOMY; PROSTATIC NEOPLASMS; RANDOMIZED CONTROLLED TRIAL; TIME; TREATMENT OUTCOME; TUMOR INVASION; VERY ELDERLY;

5-ALPHA REDUCTASE INHIBITORS; ADMINISTRATION, ORAL; AGED; AGED, 80 AND OVER; BIOPSY; DISEASE PROGRESSION; DISEASE-FREE SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DUTASTERIDE; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM STAGING; PERINEUM; PROSTATECTOMY; PROSTATIC NEOPLASMS; RADIOTHERAPY, ADJUVANT; TIME FACTORS; TREATMENT OUTCOME;

EID: 84943663840     PISSN: 00225347     EISSN: 15273792     Source Type: Journal    
DOI: 10.1016/j.juro.2015.04.113     Document Type: Article

References (22)

1. G. Fromont, J. Godet, C. Pires, and et al. Biological significance of perineural invasion (PNI) in prostate cancer Prostate 72 2012 542
2. C. Liebig, G. Ayala, J.A. Wilks, and et al. Perineural invasion in cancer: a review of the literature Cancer 115 2009 3379
3. A. de la Taille, A. Katz, E. Bagiella, and et al. Perineural invasion on prostate needle biopsy: an independent predictor of final pathologic stage Urology 54 1999 1039
4. M.K. Tollefson, R.J. Karnes, E.D. Kwon, and et al. Prostate cancer Ki-67 (MIB-1) expression, perineural invasion, and gleason score as biopsy-based predictors of prostate cancer mortality: the Mayo model Mayo Clin Proc 89 2014 308
5. L. Masieri, M. Lanciotti, G. Nesi, and et al. Prognostic role of perineural invasion in 239 consecutive patients with pathologically organ-confined prostate cancer Urol Int 85 2010 396
6. A.D. Merrilees, P.B. Bethwaite, G.L. Russell, and et al. Parameters of perineural invasion in radical prostatectomy specimens lack prognostic significance Mod Pathol 21 2008 1095
7. J.C. Ng, M.O. Koch, J.K. Daggy, and et al. Perineural invasion in radical prostatectomy specimens: lack of prognostic significance J Urol 172 2004 2249
8. P. Harnden, M.D. Shelley, H. Clements, and et al. The prognostic significance of perineural invasion in prostatic cancer biopsies: a systematic review Cancer 109 2007 13
9. F.Y. Feng, Y. Qian, M.H. Stenmark, and et al. Perineural invasion predicts increased recurrence, metastasis, and death from prostate cancer following treatment with dose-escalated radiation therapy Int J Radiat Oncol Biol Phys 81 2011 e361
10. C. Beard, D. Schultz, M. Loffredo, and et al. Perineural invasion associated with increased cancer-specific mortality after external beam radiation therapy for men with low- and intermediate-risk prostate cancer Int J Radiat Oncol Biol Phys 66 2006 403
11. J.A. Cohn, P.P. Dangle, C.E. Wang, and et al. The prognostic significance of perineural invasion and race in men considering active surveillance BJU Int 114 2014 75
12. C.P. Filson, F.R. Schroeck, Z. Ye, and et al. Variation in use of active surveillance among men undergoing expectant treatment for early stage prostate cancer J Urol 192 2014 75
13. N.E. Fleshner, M.S. Lucia, B. Egerdie, and et al. Dutasteride in localised prostate cancer management: the REDEEM randomised, double-blind, placebo-controlled trial Lancet 379 2012 1103
14. D. Margel, I. Nandy, T.H. Wilson, and et al. Predictors of pathological progression among men with localized prostate cancer undergoing active surveillance: a sub-analysis of the REDEEM study J Urol 190 2013 2039
15. T. Al-Hussain, H.B. Carter, and J.I. Epstein Significance of prostate adenocarcinoma perineural invasion on biopsy in patients who are otherwise candidates for active surveillance J Urol 186 2011 470
16. J.O. DeLancey, D.P. Wood Jr., C. He, and et al. Evidence of perineural invasion on prostate biopsy specimen and survival after radical prostatectomy Urology 81 2013 354
17. B.T. Ristau, J.J. Tomaszewski, Y.F. Chen, and et al. Prostate biopsy perineural invasion is not independently associated with positive surgical margins following radical retropubic prostatectomy World J Urol 2014 Epub ahead of print
18. C. Trpkov, A. Yilmaz, and K. Trpkov Perineural invasion in prostate cancer patients who are potential candidates for active surveillance: validation study Urology 84 2014 149
19. A.S. Moussa, J. Li, M. Soriano, and et al. Prostate biopsy clinical and pathological variables that predict significant grading changes in patients with intermediate and high grade prostate cancer BJU Int 103 2009 43
20. A.S. Moussa, M.W. Kattan, R. Berglund, and et al. A nomogram for predicting upgrading in patients with low- and intermediate-grade prostate cancer in the era of extended prostate sampling BJU Int 105 2010 352
21. G.E. Ayala, H. Dai, M. Ittmann, and et al. Growth and survival mechanisms associated with perineural invasion in prostate cancer Cancer Res 64 2004 6082
22. C. Magnon, S.J. Hall, J. Lin, and et al. Autonomic nerve development contributes to prostate cancer progression Science 341 2013 1236361