Progesterone and sexual differentiation of the developing brain

Neuroplasticity, Development, and Steroid Hormone Action

Volumn , Issue , 2001, Pages 343-360

  Wagner, Christine K ^a   Quadros, Princy S ^b  

^a STATE UNIVERSITY OF NEW YORK   (United States)

^b UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84943649449     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (87)

1. Arnold, A.P. and Gorski, R.A., Gonadal steroid induction of structural sex differences in the central nervous system, Ann. Rev. Neurosci., 7, 413, 1984.
2. Breedlove, S.M., Sexual dimorphism in the vertebrate nervous system, J. Neurosci., 12, 4133, 1992.
3. Fitch, R.S. and Denenberg, V.H., A role for ovarian hormones in sexual differentiation of the brain, Behav. Brain Sci., 21, 311, 1998.
4. Kato, J. and Onouchi, T., Progestin receptors in female rat brain and hypophysis in the development from fetal to postnatal stages, Endocrinology, 113, 29, 1983.
5. Kato, J., Hirata, S., Nozawa, A., and Mouri, N., The ontogeny of gene expression of progestin receptors in the female rat brain, J. Steroid Biochem. Mol. Biol., 47, 173, 1993.
6. Wagner, C.K., Pfau, J.L., Quadros, P.S., Nakayama, A.Y., Wade, G.N., De Vries, G.J., and Lopez, V., Distribution of progesterone receptor immunoreactivity in the fetal and neonatal rat forebrain, Soc. Neurosci. Abstr., 26, 591, 2000.
7. McNeilly, A.S., Suckling on the control of gonadotropin secretion, in: Knobil, E., Neill, J.D., Eds., Physiology of Reproduction, Raven Press, New York, vol. 2, 2323, 1988.
8. Peppe, G.J. and Rothchild, I., The effect of hypophysectomy on day 12 of pregnancy on the serum progesterone level and time of parturition in the rat, Endocrinology, 91, 1380, 1972.
9. Sanyal, M.K.J., Secretion of progesterone during gestation in the rat, Endocrinology, 79, 179, 1978.
10. Cooke, B., Hegstrom, C.D., Villeneuve, L.S., and Breedlove, S.M., Sexual differentiation of the vetebrate brain: principles and mechanisms, Front. Neuroendocrinol., 19, 323, 1998.
11. Chen, J.J. and Bliss, D.K., Effect of sequential preoptic and mammillary lesions on male rat sexual behavior, J. Comp. Physiol. Psychol., 87, 841, 1974.
12. de Jonge, F.H., Louwerse, A.L., Ooms, M.P., Evers, P., Endert, E., and van de Poll, N.E., Lesions of the SDN-POA inhibit sexual behavior of male Wistar rats, Brain Res. Bull., 23, 483, 1989.
13. Ginton, A. and Merari, A., Long range effects of MPOA lesion on mating behavior in the male rat, Brain Res., 120, 158, 1977.
14. Heimer, L. and Larsson, K., Impairment of mating behavior in male rats following lesions in the preoptic-anterior hypothalamic continuum, Brain Res., 3, 248, 1966/67.
15. Davis, E.C., Popper, P., and Gorski, R.A., The role of apoptosis in sexual differentiation of the rat sexually dimorphic nucleus of the preoptic area, Brain Res., 734, 10, 1996.
16. Gorski, R.A., Gordon, J.H., Shryne, J.E., and Southam, A.M., Evidence for a morphological sex difference within the medial preoptic area of the rat brain, Brain Res., 148, 333, 1978.
17. Gorski, R.A., Csernus, V.J., and Jacobson, C.D., Sexual dimorphism in the preoptic area. Reproduction and development, Adv. Physiol. Sci., 15, 121, 1981.
18. Jacobson, C.D., Shryne, J.E., Shapiro, F., and Gorski, R.A., Ontogeny of the sexually dimorphic nucleus of the preoptic area, J. Comp. Neurol., 193, 541, 1980.
19. Jacobson, C.D. and Gorski, R.A., Neurogenesis of the sexually dimorphic nucleus of the preoptic area in the rat, J. Comp. Neurol., 196, 519, 1981.
20. Dodson, R.E. and Gorski, R.A., Testosterone proprionate administration prevents the loss of neurons within the central part of the medial preoptic nucleus, J. Neurobiol., 24, 80, 1992.
21. Simerly, R.B., Swanson, L.W., and Gorski, R.A., Demonstration of a sexual dimorphism in the distribution of serotonin-immunoreactive fibers in the medial preoptic nucleus of the rat, J. Comp. Neurol., 225, 151, 1984.
22. Simerly, R.B., Swanson, L.W., and Gorski, R.A., The cells of origin of a sexually dimorphic serotonergic input into the medial preoptic nucleus of the rat, Brain Res., 324, 185, 1984.
23. Hammer, R.P., Jr., The sexually dimorphic region of the preoptic area in rats contains denser opiate receptor binding sites in females, Brain Res., 308, 172, 1984.
24. Hammer, R.P., Jr., µ-opiate receptor binding in the medial preoptic area is cyclic and sexually dimorphic, Brain Res., 515, 187, 1990.
25. Wagner, C.K., Nakayama, A.Y., and De Vries, G.J., Role of testosterone, estrogen and progesterone in the sexual differentiation of the rat medial preoptic nucleus, Soc. Neurosci. Abstr., 24, 550, 1998.
26. Warren, D.W., Haltmeyer, G.C., and Eik-Nes, K.B., Testosterone in fetal rat testis, Biol. Reprod., 8, 560, 1973.
27. Whalen, R.E. and Olsen, K.L., Role of aromatization in sexual differentiation: effects of prenatal ATD treatment and neonatal castration, Horm. Behav., 15, 107, 1981.
28. Weisz, J. and Ward, I.L., Plasma testosterone and progesterone titers of pregnant rats, their male and female fetuses and neonatal offspring, Endocrinology, 106, 306, 1980.
29. Corbier, P., Kerdelhue, B., Picon, R., and Roffi, J., Changes in testicular weight and serum gonadotropin and testosterone levels before, during, and after birth in the perinatal rat, Endocrinology, 103, 1985, 1978.
30. Rhoda, J., Corbier, P., and Roffi, J., Gonadal steroid concentration in serum and hypothalamus of the rat at birth: aromatization of testosterone to 17β-estradiol, Endocrinology, 114, 1754, 1984.
31. Lonstein, J.S., Quadros, P.S., and Wagner, C.K., Effects of neonatal RU486 on adult sexual, parental, and fearful behavior in rats, Behav. Neurosci., 115, 58, 2001.
32. Resko, J.A., Feder, H.H., and Goy, R.W., Androgen concentrations in plasma and testis of developing rats, J. Endocrinol., 40, 485, 1968.
33. 17-20lyase, and P450 aromatase in fetal mouse gonads, Endocrinology, 135, 262, 1994.
34. Quattropani, S.L. and Weisz, J., Conversion of progesterone to estrone and estradiol in vitro by the ovary on the infantile rat in relation to development of its interstitial tissue, Endocrinology, 93, 1269, 1973.
35. Warren, D.W., Haltmeyer, G.C., and Eik-Nes, K.B., The effect of gonadotropins on the fetal and neonatal rat testis, Endocrinology, 96, 1226, 1975.
36. George, F.W. and Ojeda, S.R., Changes in aromatase activity in the rat brain during embryonic, neonatal, and infantile development. Endocrinology, 111, 522, 1982.
37. Lephart, E.D., Simpson, E.R., McPhaul, M.J., Kilgore, M.W., Wilson, J.D., and Ojeda, S.R., Brain aromatase cytochrome P-450 messenger RNA levels and enzyme activity during prenatal and perinatal development in the rat, Mol. Brain Res., 16, 187, 1992.
38. MacLusky, N.J., Philip, A., Hurlburt, C., and Naftolin, F., Estrogen formation in the developing rat brain: sex differences in aromatase activity during early post-natal life, Psychoneuroendocrinology, 10, 355, 1985.
39. Lauber, M.E., Sarasin, A., and Lichtensteiger, W., Transient sex differences of aromatase (CYP19) mRNA expression in the developing rat brain, Neuroendocrinology, 66, 173, 1997.
40. McAbee, M.D. and DonCarlos, L.L., Ontogeny of region-specific sex difference in androgen receptor messenger ribonucleic acid in the rat forebrain, Endocrinology, 139, 1738, 1998.
41. DonCarlos, L.L. and Handa, R.J., Developmental profile of estrogen receptor mRNA in the preoptic area of male and female neonatal rats, Dev. Brain Res., 79, 283, 1994.
42. DonCarlos, L.L., Developmental profile and regulation of estrogen receptor mRNA in the preoptic area prenatal rats, Dev. Brain Res., 94, 224, 1996.
43. Corbier, P., Roffi, J., and Rhoda, J., Female sexual behavior in male rats: effect of hour of castration at birth, Physiol. Behav., 30, 613, 1983.
44. Brand, T., Kroonen, J., Mos, J., and Slob, A.K., Adult partner preference and sexual behavior of male rats affected by perinatal endocrine manipulations, Horm. Behav., 25, 323, 1991.
45. Clemens, L.G. and Glaude, B.A., Feminine sexual behavior in rats enhanced by prenatal inhibition of androgen aromatization, Horm. Behav., 11, 190, 1978.
46. Döhler, K.-D., Coquelin, A., Davis, F., Hines, M., Shryne, J.E., and Gorski, R.A., Pre- and postnatal influence of testosterone proprionate and diethylstilbestrol on differentiation of the sexually dimorphic nucleus of the preoptic area in male and female rats, Brain Res., 302, 291, 1984.
47. Houtsmuller, E.J., Brand, T., de Jonge, F.H., Joosten, R.N., van de Poll, N.E., and Slob, A.K., SDN-POA volume, sexual behavior, and partner preference of male rats affected by perinatal treatment with ATD, Physiol. Behav., 56, 535, 1994.
48. Rhees, R.W., Shryne, J.E., and Gorski, R.A., Onset of the hormone-sensitive perinatal period for sexual differentiation of the sexually dimorphic nucleus of the preoptic area in female rats, J. Neurobiol., 21, 781, 1990.
49. Rhees, R.W., Shryne, J.E., and Gorski, R.A., Termination of the hormone-sensitive period for differentiation of the sexually dimorphic nucleus of the preoptic area in male and female rats, Dev. Brain Res., 52, 17, 1990.
50. Simerly, R.B., Swanson, L.W., and Gorski, R.A., Reversal of the sexually dimorphic distribution of serotonin-immunoreactive fibers in the medial preoptic nucleus by treatment with perinatal androgen, Brain Res., 340, 91, 1985.
51. Hammer, R.P., Jr., Ontogeny of opiate receptors in the rat medial preoptic area: critical periods in regional development, Int. J. Devel. Neurosci., 3, 541, 1985.
52. Hammer, R.P., Jr., The sex hormone-dependent development of opiate receptors in the rat medial preoptic area, Brain Res., 360, 65, 1985.
53. Collaer, M.L. and Hines, M., Human behavioral sex differences: a role for gonadal hormones during early development? Psych. Bull., 118, 55, 1995.
54. Hines, M.A., Abnormal sexual development and psychosexual issues, Bailliere’s Clin. Endoc. Metab., 12, 173, 1998.
55. Money, J. and Ehrhardt, A.A., Man and Woman, Boy and Girl. The Differentiation and Dimorphism of Gender Identity from Conception to Maturity, Baltimore, Johns Hopkins University Press, 1972.
56. Helleday, J., Edman, G., and Ritzen, E.M., Personality characteristics and platelet MAO activity in women with congenital adrenal hyperplasia (CAH), Psychoneuroendocrinology, 18, 343,1993.
57. Resnick, S.M., Psychological functioning in individuals with congenital adrenal hyperplasia: early hormonal influences on cognition and personality, Ph.D. thesis, University of Minnesota, Dissertation Abstracts International, 44 642B, 1983.
58. Dittman, R.W., Kappes, M.E., and Kappes, M.H., Sexual behavior in adolescent and adult females with congenital adrenal hyperplasia, Psychoneuroendocrinology, 17, 1, 1992.
59. Meyer-Bahlburgh, H.F.L., Ehrhardt, A.A., and Rosen, L.R., Prenatal estrogens and the development of homosexual orientation, Devel. Psychol., 31, 12, 1995.
60. Money, J., Schwartz, M., and Lewis, V.G., Adult erotosexual status and fetal hormonal masculinization and demasculinization: 46, XX congenital virilizing adrenal hyperplasia and 46, XY androgen insensitivity syndrome compared, Psychoneuroendocrinology, 9, 405, 1984.
61. DeLacoste-Utamsing, C. and Holloway, R.L., Sexual dimorphism in the human corpus callosum, Science, 216, 1431, 1982.
62. Allen, L.S. and Gorski, R.A., Sexual dimorphism of the anterior commissure and massa intermedia of the human brain, J. Comp. Neurol., 312, 97, 1991.
63. Swaab, D.F. and Fliers, E.A., sexually dimorphic nucleus in the human brain, Science, 228, 1112, 1985.
64. Allen, L.S., Hines, M., Shryne, E., and Gorski, R.A., Two sexually dimorphic cell groups in the human brain, J. Neurosci., 9, 497, 1989.
65. Byne W., Lasco, M.S., Kemether, E., Shinwari, A., Edgar, M.A., Morgello, S., Jones, L.B., and Tobet, S., The interstitial nuclei of the human anterior hypothalamus: an investigation of sexual variation in volume and cell size, number, and density, Brain Res., 856, 254, 2000.
66. LeVay, S., A difference in hypothalamic structure between heterosexual and homosexual men, Science, 253, 1034, 1991.
67. MacDonald, G.J. and Matt, D.W., Adrenal and placental steroid secretion during pregnancy in the rat, Endocrinology, 114, 2068, 1984.
68. Butcher, R.L., Collins, W.E., and Fugo, N.W., Plasma concentrations of LH, FSH, prolactin, progesterone and estradiol-17β through the 4-day estrous cycle of the rat, Endocrinology, 94, 1704, 1974.
69. Quadros, P.S. and Wagner, C.K., unpublished observations, 2000.
70. Martin, C.E., Cake, M.H., Hartmann, P.E., and Cook, I.F., Relationship between foetal corticosteroids, maternal progesterone and parturition in the rat, Acta Endocrinol., 84, 167, 1977.
71. 3H]-progesterone to androgen by rat testis during the second half of fetal life, Endocrinology, 78, 245, 1966.
72. Schlegel, R.J., Farias, E., Russo, N.C., Moore, J.R., and Gardner, L.I., Structural changes in the fetal gonads and gonaducts during maturation of an enzyme, steroid 3 β-ol-dehydrogenase, in the gonads, adrenal cortex, and placenta of fetal rats, Endocrinology, 81, 565, 1967.
73. Döhler, K.-D. and Wuttke, W., Changes with age in levels of serum gonadotropins, prolactin, and gonadal steroids in prepubertal male and female rats, Endocrinology, 97, 898, 1974.
74. Franz, J.R., Hull, E.M., Snyder, A.M., and Roth, J.A., The effect of maternal progesterone on brain monoamine oxidase activity of neonatal rats, Brain Res., 158, 397, 1978.
75. Betrabet, S.S., Shikary, Z.K., Toddywalla, V.S., Toddywalla, S.P., Patel, D., and Saxena, B.N., Transfer of Norethisterone (NET) and Levonorgestrel (LNG) from a single tablet into the infant’s circulation through the mother’s milk, Contraception, 35, 517, 1987.
76. Toddywalla, V.S., Patel, S.B., Betrabet, S.S., Kulkarni, R.D., Saxena, B.N., Is timeinterval between mini-pill ingestion and breastfeeding essential? Contraception, 51, 193, 1995.
77. Lopez, V. and Wagner, C.K., Transient expression of progesterone receptor immunoreactivity in the developing neocortex, Soc. Neurosci. Abstr., 26, 591, 2000.
78. Quadros, P.S., De Vries, G.J., and Wagner, C.K., Sex difference in progesterone receptor expression in the ventromedial nucleus is independent of neonatal gonadal hormones, Soc. Neurosci. Abstr., 26, 591, 2000.
79. Arai, Y. and Gorski, R.A., Protection against the neural organizing effect of exogenous androgen in the neonatal female rat, Endocrinology, 82, 1005, 1968.
80. Hull, E.M., Franz, J.R., Snyder, A.M., and Nishita, J.K., Perinatal progesterone and learning, social, and reproductive behavior in rats, Physiol. Behav., 24, 251, 1980.
81. Hull, E.M., Effects of neonatal exposure to progesterone in sexual behavior of male and female rats, Physiol. Behav., 26, 401, 1981.
82. Snyder, A.M., Hull, E.M., and Roth, J.A., The effect of maternal progesterone injections on fetal development of brain monoamine oxidase of rats, Brain Res., 170, 194, 1979.
83. Ehrhardt, A.A. and Meyer-Bahlburg, H.F., Effects of prenatal sex hormones on gender-related behavior, Science, 211, 1312, 1981.
84. Reinisch, J.M., Prenatal exposure to synthetic progestins increases potential for aggression in humans, Science, 211, 1171, 1981.
85. Dalton, K., Prenatal progesterone and educational attainments, Br. J. Psychiatry, 129, 438, 1976.
86. Ehrhardt, A.A., Grisanti, G.C., and Meyer-Bahlburg, H.F., Prenatal exposure to medroxyprogesterone acetate (MPA) in girls, Psychoneuroendocrinology, 2, 391, 1977.
87. Ehrhardt, A. A, Meyer-Bahlburg, H.F., Feldman, J.F., and Ince, S.E., Sex-dimorphic behavior in childhood subsequent to prenatal exposure to exogenous progestogens and estrogens, Arch. Sex Behav., 13, 457, 1984.