Investigation into hippocampal nerve cell damage through the mineralocorticoid receptor in mice

Molecular Medicine Reports

Volumn 12, Issue 5, 2015, Pages 7211-7220

  Sasaki, Kenroh ^a   Yoshizaki, Fumihiko ^a  

^a TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Comet assay; Glucocorticoid receptor; Hippocampus; Mineralocorticoid receptor; Stress; Terminal deoxynucleotidyl transferase mediated dUTP nick end labeling

Indexed keywords

ALDOSTERONE; CHOLESTEROL; CREATININE; DNA; FLUDROCORTISONE; GLUCOCORTICOID RECEPTOR; HYDROCORTISONE; MINERALOCORTICOID RECEPTOR; SPIRONOLACTONE;

ADD ON THERAPY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN ATROPHY; BRAIN DAMAGE; CELLULAR, SUBCELLULAR AND MOLECULAR BIOLOGICAL PHENOMENA AND FUNCTIONS; COMET ASSAY; CONTROLLED STUDY; CYTOTOXICITY; DEGRANULATION; DNA FRAGMENTATION; DRUG EFFICACY; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL CA2 REGION; HIPPOCAMPAL CA3 REGION; HIPPOCAMPUS; KLUVER BARRERA STAINING; MALE; MONOTHERAPY; MOUSE; NERVE CELL LESION; NERVE CELL NECROSIS; NEUROPATHOLOGY; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PYKNOSIS; PYRAMIDAL NERVE CELL; STAINING; TUNEL ASSAY; ANIMAL; METABOLISM; PATHOLOGY; PHYSIOLOGY;

ANIMALS; APOPTOSIS; CA3 REGION, HIPPOCAMPAL; DNA FRAGMENTATION; HYDROCORTISONE; MALE; MICE; RECEPTORS, MINERALOCORTICOID;

EID: 84943637149     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2015.4406     Document Type: Article

References (19)

1. Sherin JE and Nemeroff CB: Post-traumatic stress disorder: The neurobiological impact of psychological trauma. Dialogues Clin Neurosci 13: 263-278, 2011.
2. Hwang IK, Yoo KY, Nam YS, Choi JH, Lee IS, Kwon YG, Kang TC, Kim YS, and Won MH: Mineralocorticoid and glucocorticoid receptor expressions in astrocytes and microglia in the gerbil hippocampal CA1 region after ischemic insult. Neurosci Res 54: 319-327, 2006.
3. Sánchez MM, Young LJ, Plotsky PM and Insel TR: Distribution of corticosteroid receptors in the rhesus brain: relative absence of glucocorticoid receptors in the hippocampal formation. J Neurosci 20: 4657-4668, 2000.
4. Sousa N, Lukoyanov NV, Madeira MD, Almeida OF and Paula-Barbosa MM: Reorganization of the morphology of hippocampal neurites and synapses after stress-induced damage correlates with behavioral improvement. Neuroscience 97: 253-266, 2000.
5. Han F, Ozawa H, Matsuda K, Nishi M and Kawata M: Colocalization of mineralocorticoid receptor and glucocorticoid receptor in the hippocampus and hypothalamus. Neurosci Res 51: 371-381, 2005.
6. Paxinos G and Franklin KBJ: The Mouse Brain in Stereotaxic Coordinates. Compact Third Edition. Academic Press, Waltham, 2008.
7. Funder JW: Mineralocorticoid receptors in the central nervous system. J Steroid Biochem Mol Biol 56: 179-183, 1996.
8. Connell JM and Davies E: The new biology of aldosterone. J Endocrinol 186: 1-20, 2005.
9. Hu Z, Yuri K, Ozawa H, Lu H and Kawata M: The in vivo time course for elimination of adrenalectomy-induced apoptotic profiles from the granule cell layer of the rat hippocampus. J Neurosci 17: 3981-3989, 1997.
10. Krugers HJ, van der Linden S, van Olst E, Alfarez DN, Maslam S, Lucassen PJ and Joëls M: Dissociation between apoptosis, neurogenesis, and synaptic potentiation in the dentate gyrus of adrenalectomized rats. Synapse 61: 221-230, 2007.
11. de Kloet ER: Hormones, brain and stress. Endocr Regul 37: 51-68, 2003.
12. Rogalska J: Mineralocorticoid and glucocorticoid receptors in hippocampus: their impact on neurons survival and behavioral impairment after neonatal brain injury. Vitam Horm 82: 391-419, 2010.
13. Ladd CO, Huot RL, Thrivikraman KV, Nemeroff CB and Plotsky PM: Long-term adaptations in glucocorticoid receptor and mineralocorticoid receptor mRNA and negative feedback on the hypothalamo-pituitary-adrenal axis following neonatal maternal separation. Biol Psychiatry 55: 367-375, 2004.
14. Pascual-Le Tallec L and Lombès M: The mineralocorticoid receptor: A journey exploring its diversity and specificity of action. Mol Endocrinol 19: 2211-2221, 2005.
15. Fuller PJ and Young MJ: Mechanisms of mineralocorticoid action. Hypertension 46: 1227-1235, 2005.
16. Connell JM and Davies E: The new biology of aldosterone. J Endocrinol 186: 1-20, 2005.
17. Sun Y, Zhang J, Lu L, Chen SS, Quinn MT and Weber KT. Aldosterone-induced inflammation in the rat heart: role of oxidative stress. Am J Pathol 161: 1773-1781, 2002.
18. Sam F, Xie Z, Ooi H, Kerstetter DL, Colucci WS, Singh M and Singh K: Mice lacking osteopontin exhibit increased left ventricular dilation and reduced fibrosis after aldosterone infusion. Am J Hypertens 17: 188-193, 2004.
19. Pitt B, Zannad F, Remme WJ, Cody R, Castaigne A, Perez A, Palensky J and Wittes J; Randomized Aldactone Evaluation Study Investigators: The effect of spironolactone on morbidity and mortality in patients with severe heart failure. N Engl J Med 341: 709-717, 1999.