Sensitivity, specificity, and positivity predictors of the pneumococcal urinary antigen test in community-acquired pneumonia

Annals of the American Thoracic Society

Volumn 12, Issue 10, 2015, Pages 1482-1489

  Molinos, Luis ^a   Zalacain, Rafael ^b   Menéndez, Rosario ^c   Reyes, Soledad ^c   Capelastegui, Alberto ^d   Cillóniz, Catia ^e   Rajas, Olga ^f   Borderías, Luis ^g   Martín Villasclaras, Juan J ^h   Bello, Salvador ⁱ   Alfageme, Inmaculada ^j   De Castro, Felipe Rodríguez ^k   Rello, Jordi ^l   Ruiz Manzano, Juan ^m   Gabarrús, Albert ^e   Musher, Daniel M ⁿ   Torres, Antoni ^e  

^a HOSPITAL UNIVERSITARIO CENTRAL DE ASTURIAS   (Spain)

^b HOSPITAL DE CRUCES   (Spain)

^c HOSPITAL UNIVERSITARIO LA FE   (Spain)

^d HOSPITAL DE GALDAKAO   (Spain)

^e UNIVERSITY OF BARCELONA   (Spain)

^f HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

^g HOSPITAL SAN JORGE   (Spain)

^h HOSPITAL REGIONAL UNIVERSITARIO DE MÁLAGA   (Spain)

ⁱ HOSPITAL UNIVERSITARIO MIGUEL SERVET   (Spain)

^j HOSPITAL UNIVERSITARIO DE VALME   (Spain)

^k HOSPITAL UNIVERSITARIO DE GRAN CANARIA DR NEGRÍN   (Spain)

^l HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^m HOSPITAL UNIVERSITARI GERMANS TRIAS I PUJOL   (Spain)

ⁿ MICHAEL E DEBAKEY VETERANS AFFAIRS MEDICAL CENTER   (United States)

more..

Author keywords

Community acquired pneumonia; Pneumococcal urinary antigen; Positive predictor factors; Sensitivity; Specificity

Indexed keywords

SODIUM; ANTIINFECTIVE AGENT; BACTERIAL POLYSACCHARIDE;

AGED; ANTIBIOTIC THERAPY; AREA UNDER THE CURVE; ARTICLE; BREATHING RATE; CHILL; CHRONIC LIVER DISEASE; COMMUNITY ACQUIRED PNEUMONIA; DIAGNOSTIC TEST ACCURACY STUDY; DIAGNOSTIC VALUE; DIASTOLIC BLOOD PRESSURE; FEMALE; HEART RATE; HOSPITAL PATIENT; HUMAN; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; OBSERVATIONAL STUDY; PLEURA EFFUSION; PLEURISY; PNEUMOCOCCAL URINARY ANTIGEN TEST; PROSPECTIVE STUDY; RECEIVER OPERATING CHARACTERISTIC; SENSITIVITY AND SPECIFICITY; SERODIAGNOSIS; SEX RATIO; SODIUM BLOOD LEVEL; STREPTOCOCCUS PNEUMONIA; SYSTOLIC BLOOD PRESSURE; THORAX PAIN; UREA NITROGEN BLOOD LEVEL; URINALYSIS; CLINICAL TRIAL; COMMUNITY ACQUIRED INFECTION; MIDDLE AGED; MULTIVARIATE ANALYSIS; PNEUMOCOCCAL INFECTION; PNEUMONIA, PNEUMOCOCCAL; PROGNOSIS; STATISTICAL MODEL; STREPTOCOCCUS PNEUMONIAE; URINE; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ANTI-BACTERIAL AGENTS; COMMUNITY-ACQUIRED INFECTIONS; FEMALE; HUMANS; LOGISTIC MODELS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PNEUMOCOCCAL INFECTIONS; PNEUMONIA, PNEUMOCOCCAL; POLYSACCHARIDES, BACTERIAL; PROGNOSIS; PROSPECTIVE STUDIES; SENSITIVITY AND SPECIFICITY; STREPTOCOCCUS PNEUMONIAE;

EID: 84943596610     PISSN: 23296933     EISSN: 23256621     Source Type: Journal    
DOI: 10.1513/AnnalsATS.201505-304OC     Document Type: Article

References (36)

1. Almirall J, Bolíbar I, Vidal J, Sauca G, Coll P, Niklasson B, Bartolomé M, Balanzó X. Epidemiology of community-acquired pneumonia in adults: a population-based study. Eur Respir J 2000;15:757-763.
2. Brown PD, Lerner SA. Community-acquired pneumonia. Lancet 1998;352:1295-1302.
3. Rosón B, Carratalà J, Verdaguer R, Dorca J, Manresa F, Gudiol F. Prospective study of the usefulness of sputum Gram stain in the initial approach to community-acquired pneumonia requiring hospitalization. Clin Infect Dis 2000;31:869-874.
4. Afshar N, Tabas J, Afshar K, Silbergleit R. Blood cultures for community-acquired pneumonia: are they worthy of two quality measures? A systematic review. J Hosp Med 2009;4:112-123.
5. Heffron R. Pneumonia, with special reference to pneumococcus lobar pneumonia. Cambridge, MA: Harvard University Press; 1939.
6. Said MA, Johnson HL, Nonyane BA, Deloria-Knoll M, OBrien KL, Andreo F, Beovic B, Blanco S, Boersma WG, Boulware DR, et al.; AGEDD Adult Pneumococcal Burden Study Team. Estimating the burden of pneumococcal pneumonia among adults: a systematic review and meta-analysis of diagnostic techniques. PLoS One 2013;8:e60273.
7. Mandell LA, Wunderink RG, Anzueto A, Bartlett JG, Campbell GD, Dean NC, Dowell SF, File TM Jr, Musher DM, Niederman MS, et al.; Infectious Diseases Society of America; American Thoracic Society. Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults. Clin Infect Dis 2007;44:S27-S72.
8. Lim WS, Baudouin SV, George RC, Hill AT, Jamieson C, Le Jeune I, Macfarlane JT, Read RC, Roberts HJ, Levy ML, et al.; Pneumonia Guidelines Committee of the BTS Standards of Care Committee. BTS guidelines for the management of community acquired pneumonia in adults: update 2009. Thorax 2009;64:iii1-iii55.
9. Menéndez R, Torres A, Aspa J, Capelastegui A, Prat C, Rodríguez de Castro F; Sociedad Española de Neumología y Cirugía Torácica. Community acquired pneumonia: new guidelines of the Spanish Society of Chest Diseases and Thoracic Surgery (SEPAR).Arch Bronconeumol 2010;46:543-558 (In Spanish).
10. Woodhead M, Blasi F, Ewig S, Garau J, Huchon G, Ieven M, Ortqvist A, Schaberg T, Torres A, van der Heijden G, et al.; Joint Taskforce of the European Respiratory Society and European Society for Clinical Microbiology and Infectious Diseases. Guidelines for the management of adult lower respiratory tract infections: full version. Clin Microbiol Infect 2011;17:E1-E59.
11. Murdoch DR, Laing RT, Mills GD, Karalus NC, Town GI, Mirrett S, Reller LB. Evaluation of a rapid immunochromatographic test for detection of Streptococcus pneumoniae antigen in urine samples from adults with community-acquired pneumonia. J ClinMicrobiol 2001;39:3495-3498.
12. Domínguez J, Galí N, Blanco S, Pedroso P, Prat C, Matas L, Ausina V. Detection of Streptococcus pneumoniae antigen by a rapid immunochromatographic assay in urine samples. Chest 2001;119: 243-249.
13. Marcos MA, Jiménez de Anta MT, de la Bellacasa JP, González J, Martínez E, García E, Mensa J, de Roux A, Torres A. Rapid urinary antigen test for diagnosis of pneumococcal community-acquired pneumonia in adults. Eur Respir J 2003;21:209-214.
14. Rosón B, Fernández-Sabé N, Carratalà J, Verdaguer R, Dorca J, Manresa F, Gudiol F. Contribution of a urinary antigen assay (Binax NOW) to the early diagnosis of pneumococcal pneumonia. Clin Infect Dis 2004;38:222-226.
15. Briones ML, Blanquer J, Ferrando D, Blasco ML, Gimeno C, Marín J. Assessment of analysis of urinary pneumococcal antigen by immunochromatography for etiologic diagnosis of communityacquired pneumonia in adults. Clin Vaccine Immunol 2006;13: 1092-1097.
16. Genné D, Siegrist HH, Lienhard R. Enhancing the etiologic diagnosis of community-acquired pneumonia in adults using the urinary antigen assay (Binax NOW). Int J Infect Dis 2006;10:124-128.
17. Sordé R, Falcó V, Lowak M, Domingo E, Ferrer A, Burgos J, Puig M, Cabral E, Len O, Pahissa A. Current and potential usefulness of pneumococcal urinary antigen detection in hospitalized patients with community-acquired pneumonia to guide antimicrobial therapy. Arch Intern Med 2011;171:166-172.
18. Falguera M, Ruiz-González A, Schoenenberger JA, Touzón C, Gázquez I, Galindo C, Porcel JM. Prospective, randomised study to compare empirical treatment versus targeted treatment on the basis of the urine antigen results in hospitalised patients with communityacquired pneumonia. Thorax 2010;65:101-106.
19. Gutiérrez F, MasiáM, Rodríguez JC, Ayelo A, Soldán B, Cebrián L, Mirete C, Royo G, Hidalgo AM. Evaluation of the immunochromatographic Binax NOW assay for detection of Streptococcus pneumoniae urinary antigen in a prospective study of community-acquired pneumonia in Spain. Clin Infect Dis 2003;36: 286-292.
20. Smith MD, Derrington P, Evans R, Creek M, Morris R, Dance DA, Cartwright K. Rapid diagnosis of bacteremic pneumococcal infections in adults by using the Binax NOW Streptococcus pneumoniae urinary antigen test: a prospective, controlled clinical evaluation. J Clin Microbiol 2003;41:2810-2813.
21. Ishida T, Hashimoto T, Arita M, Tojo Y, Tachibana H, Jinnai M. A 3-year prospective study of a urinary antigen-detection test for Streptococcus pneumoniae in community-acquired pneumonia: utility and clinical impact on the reported etiology. J Infect Chemother 2004;10:359-363.
22. Fine MJ, Auble TE, Yealy DM, Hanusa BH, Weissfeld LA, Singer DE, Coley CM, Marrie TJ, Kapoor WN. A prediction rule to identify lowrisk patients with community-acquired pneumonia. N Engl J Med 1997;336:243-250.
23. Lim WS, van der Eerden MM, Laing R, Boersma WG, Karalus N, Town GI, Lewis SA, Macfarlane JT. Defining community acquired pneumonia severity on presentation to hospital: an international derivation and validation study. Thorax 2003;58:377-382.
24. Fang GD, Fine M, Orloff J, Arisumi D, Yu VL, Kapoor W, Grayston JT, Wang SP, Kohler R, Muder RR, et al. New and emerging etiologies for community-acquired pneumonia with implications for therapy: a prospective multicenter study of 359 cases. Medicine (Baltimore) 1990;69:307-316.
25. Musher DM, Roig IL, Cazares G, Stager CE, Logan N, Safar H. Can an etiologic agent be identified in adults who are hospitalized for community-acquired pneumonia: results of a one-year study. J Infect 2013;67:11-18.
26. Restrepo MI, Mortensen EM, Velez JA, Frei C, Anzueto A. A comparative study of community-acquired pneumonia patients admitted to the ward and the ICU. Chest 2008;133:610-617.
27. Kalin M, Ortqvist A, Almela M, Aufwerber E, Dwyer R, Henriques B, Jorup C, Julander I, Marrie TJ, Mufson MA, et al. Prospective study of prognostic factors in community-acquired bacteremic pneumococcal disease in 5 countries. J Infect Dis 2000;182: 840-847.
28. Selickman J, Paxos M, File TM Jr, Seltzer R, Bonilla H. Performance measure of urinary antigen in patients with Streptococcus pneumoniae bacteremia. Diagn Microbiol Infect Dis 2010;67: 129-133.
29. Engel MF, van Velzen M, Hoepelman AI, Thijsen S, Oosterheert JJ. Positive urinary antigen tests for Streptococcus pneumoniae in community-acquired pneumonia: a 7-year retrospective evaluation of health care cost and treatment consequences. Eur J Clin Microbiol Infect Dis 2013;32:485-492.
30. Yu VL. A Clinical Solution to Antimicrobial Resistance in Communityacquired Pneumonia: Narrowing the Spectrum of Antimicrobial Therapy: Comment on Current and Potential Usefulness of Pneumococcal Urinary Antigen Detection in Hospitalized Patients with Community-acquired Pneumonia to Guide Antimicrobial Therapy. Arch Intern Med 2011;171:172-173.
31. Cillóniz C, Ewig S, Ferrer M, Polverino E, Gabarrús A, Puig de la Bellacasa J, Mensa J, Torres A. Community-acquired polymicrobial pneumonia in the intensive care unit: aetiology and prognosis. Crit Care 2011;15:R209.
32. Musher DM, Thorner AR. Community-acquired pneumonia. N Engl J Med 2014;371:1619-1628.
33. Cillóniz C, Polverino E, Ewig S, Aliberti S, Gabarrús A, Menéndez R, Mensa J, Blasi F, Torres A. Impact of age and comorbidity on cause and outcome in community-acquired pneumonia. Chest 2013;144:999-1007.
34. Postma DF, van Werkhoven CH, van Elden LJ, Thijsen SF, Hoepelman AI, Kluytmans JA, Boersma WG, Compaijen CJ, van der Wall E, Prins JM, et al.; CAP-START Study Group. Antibiotic treatment strategies for community-acquired pneumonia in adults. N Engl J Med 2015; 372:1312-1323.
35. Blaschke AJ. Interpreting assays for the detection of Streptococcus pneumoniae. Clin Infect Dis 2011;52:S331-S337.
36. Klugman KP, Madhi SA, Albrich WC. Novel approaches to the identification of Streptococcus pneumoniae as the cause of community-acquired pneumonia. Clin Infect Dis 2008;47: S202-S206.