Intracellular Survival of Leishmania major Depends on Uptake and Degradation of Extracellular Matrix Glycosaminoglycans by Macrophages

PLoS Pathogens

Volumn 11, Issue 9, 2015, Pages 1-20

  Naderer, Thomas ^a,b   Heng, Joanne ^a   Saunders, Eleanor C ^a   Kloehn, Joachim ^a   Rupasinghe, Thusitha W ^a   Brown, Tracey J ^b   McConville, Malcolm J ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOSAMINOGLYCAN; HYALURONIC ACID; ACYLTRANSFERASE; GLUCOSAMINE ACETYLTRANSFERASE; N ACETYLGLUCOSAMINE; PROTOZOAL PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW DERIVED MACROPHAGE; CARBON SOURCE; CONTROLLED STUDY; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; FEMALE; HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHY; LEISHMANIA MAJOR; LEISHMANIASIS; MACROPHAGE; MASS SPECTROMETRY; MOUSE; NONHUMAN; PARASITE SURVIVAL; PARASITE VIRULENCE; PROMASTIGOTE; PROTEIN DEGRADATION; SKIN DEFECT; WESTERN BLOTTING; ANIMAL; BAGG ALBINO MOUSE; CELL CULTURE; CELL SURVIVAL; GENE DELETION; GENETICS; GERMFREE ANIMAL; GROWTH, DEVELOPMENT AND AGING; HOST PARASITE INTERACTION; HYDROLYSIS; IMMUNOLOGY; KINETICS; LEISHMANIA MEXICANA; LYSOSOME; MALE; METABOLISM; PARASITOLOGY; PATHOLOGY; PHAGOCYTOSIS; PHYSIOLOGY; SKIN LEISHMANIASIS; SPECIES DIFFERENCE;

ACETYLGLUCOSAMINE; ACETYLTRANSFERASES; ANIMALS; CELL SURVIVAL; CELLS, CULTURED; EXTRACELLULAR MATRIX; GENE DELETION; GLYCOSAMINOGLYCANS; HOST-PARASITE INTERACTIONS; HYDROLYSIS; KINETICS; LEISHMANIA MAJOR; LEISHMANIA MEXICANA; LEISHMANIASIS, CUTANEOUS; LYSOSOMES; MACROPHAGES; MALE; MICE, INBRED BALB C; PHAGOCYTOSIS; PROTOZOAN PROTEINS; SPECIES SPECIFICITY; SPECIFIC PATHOGEN-FREE ORGANISMS;

EID: 84943575508     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1005136     Document Type: Article

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