메뉴 건너뛰기




Volumn 11, Issue 9, 2015, Pages

Adipose Tissue Is a Neglected Viral Reservoir and an Inflammatory Site during Chronic HIV and SIV Infection

(25)  Damouche, Abderaouf a,b,c   Lazure, Thierry d   Avettand Fènoël, Véronique e,f   Huot, Nicolas g   Dejucq Rainsford, Nathalie h   Satie, Anne Pascale h   Mélard, Adeline e,f   David, Ludivine e,f   Gommet, Céline b   Ghosn, Jade e   Noel, Nicolas a,b,c,d   Pourcher, Guillaume i,j   Martinez, Valérie i   Benoist, Stéphane d   Béréziat, Véronique k,l   Cosma, Antonio a,b,c   Favier, Benoit a,b,c   Vaslin, Bruno a,b,c   Rouzioux, Christine e,f   Capeau, Jacqueline k,l   more..


Author keywords

[No Author keywords available]

Indexed keywords

ADIPOCYTE; ADIPOSE TISSUE; ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; IMMUNOCHEMISTRY; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MACACA FASCICULARIS; MALE; MIDDLE AGED; NONHUMAN; PHENOTYPE; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; SIMIAN IMMUNODEFICIENCY VIRUS; STROMAL VASCULAR FRACTION; VIRUS LOAD; ANIMAL; CD4+ T LYMPHOCYTE; CELL CULTURE; COCULTURE; DISEASE CARRIER; HOST PATHOGEN INTERACTION; IMMUNOLOGY; INNATE IMMUNITY; ISOLATION AND PURIFICATION; MACROPHAGE; METABOLISM; PANNICULITIS; PATHOLOGY; PHYSIOLOGY; STROMA CELL; VIROLOGY;

EID: 84943559036     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1005153     Document Type: Article
Times cited : (178)

References (88)
  • 1
    • 55949084601 scopus 로고    scopus 로고
    • Inflammatory and Coagulation Biomarkers and Mortality in Patients with HIV Infection
    • Kuller LH, Tracy R, Belloso W, Wit S De, Drummond F, Lane HC, et al. Inflammatory and Coagulation Biomarkers and Mortality in Patients with HIV Infection. PLoS Med. 2008;5: 1496–1508. doi: 10.1371/journal.pmed.0050203
    • (2008) PLoS Med , vol.5 , pp. 1496-1508
    • Kuller, L.H.1    Tracy, R.2    Belloso, W.3    Wit, S.D.4    Drummond, F.5    Lane, H.C.6
  • 2
    • 79551614790 scopus 로고    scopus 로고
    • HIV Infection, Inflammation, and Aging
    • Deeks SG, HIV Infection, Inflammation, and Aging. Annu Rev Med. 2011;62: 141–055. doi: 10.1146/annurev-med-042909-093756 21090961
    • (2011) Annu Rev Med , vol.62 , pp. 055-141
    • Deeks, S.G.1
  • 3
    • 84885753789 scopus 로고    scopus 로고
    • Systemic effects of inflammation on health during chronic HIV infection
    • Deeks SG, Tracy R, Douek DC, Systemic effects of inflammation on health during chronic HIV infection. Immunity. 2013;39: 633–45. doi: 10.1016/j.immuni.2013.10.001 24138880
    • (2013) Immunity , vol.39 , pp. 633-645
    • Deeks, S.G.1    Tracy, R.2    Douek, D.C.3
  • 4
    • 39349088126 scopus 로고    scopus 로고
    • Relationship between T Cell Activation and CD4+ T Cell Count in HIV-Seropositive Individuals with Undetectable Plasma HIV RNA Levels in the Absence of Therapy
    • Hunt PW, Brenchley J, Sinclair E, Mccune JM, Roland M, Page-shafer K, et al. Relationship between T Cell Activation and CD4+ T Cell Count in HIV-Seropositive Individuals with Undetectable Plasma HIV RNA Levels in the Absence of Therapy. J Infect Dis. 2008;197: 126–133. doi: 10.1086/524143 18171295
    • (2008) J Infect Dis , vol.197 , pp. 126-133
    • Hunt, P.W.1    Brenchley, J.2    Sinclair, E.3    Mccune, J.M.4    Roland, M.5    Page-shafer, K.6
  • 5
    • 84895070040 scopus 로고    scopus 로고
    • + T-cell counts in HIV controller patients
    • Noel N, Boufassa F, Lécuroux C, Saez-Cirion A, Bourgeois C, Dunyach-Remy C, et al. Elevated IP10 levels are associated with immune activation and low CD4+ T-cell counts in HIV controller patients. AIDS. 2014;28: 467–76. doi: 10.1097/QAD.0000000000000174 24378753
    • (2014) AIDS , vol.28 , pp. 467-476
    • Noel, N.1    Boufassa, F.2    Lécuroux, C.3    Saez-Cirion, A.4    Bourgeois, C.5    Dunyach-Remy, C.6
  • 6
    • 84866498069 scopus 로고    scopus 로고
    • Redefining the viral reservoirs that prevent HIV-1 eradication
    • Eisele E, Siliciano RF, Redefining the viral reservoirs that prevent HIV-1 eradication. Immunity. 2012;37: 377–88. doi: 10.1016/j.immuni.2012.08.010 22999944
    • (2012) Immunity , vol.37 , pp. 377-388
    • Eisele, E.1    Siliciano, R.F.2
  • 7
    • 84861096473 scopus 로고    scopus 로고
    • Detection of HIV-1 RNA in seminal plasma samples from treated patients with undetectable HIV-1 RNA in blood plasma on a 2002–2011 survey
    • Lambert-Niclot S, Tubiana R, Beaudoux C, Lefebvre G, Caby F, Bonmarchand M, et al. Detection of HIV-1 RNA in seminal plasma samples from treated patients with undetectable HIV-1 RNA in blood plasma on a 2002–2011 survey. AIDS. 2012;26: 971–5. doi: 10.1097/QAD.0b013e328352ae09 22382146
    • (2012) AIDS , vol.26 , pp. 971-975
    • Lambert-Niclot, S.1    Tubiana, R.2    Beaudoux, C.3    Lefebvre, G.4    Caby, F.5    Bonmarchand, M.6
  • 8
    • 77953724307 scopus 로고    scopus 로고
    • Simian immunodeficiency virus-infected macaques treated with highly active antiretroviral therapy have reduced central nervous system viral replication and inflammation but persistence of viral DNA
    • Zink MC, Brice AK, Kelly KM, Queen SE, Gama L, Li M, et al. Simian immunodeficiency virus-infected macaques treated with highly active antiretroviral therapy have reduced central nervous system viral replication and inflammation but persistence of viral DNA. J Infect Dis. 2010;202: 161–70. doi: 10.1086/653213 20497048
    • (2010) J Infect Dis , vol.202 , pp. 161-170
    • Zink, M.C.1    Brice, A.K.2    Kelly, K.M.3    Queen, S.E.4    Gama, L.5    Li, M.6
  • 9
    • 33845532053 scopus 로고    scopus 로고
    • Microbial translocation is a cause of systemic immune activation in chronic HIV infection
    • Brenchley JM, Price DA, Schacker TW, Asher TE, Silvestri G, Rao S, et al. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med. 2006;12: 1365–1371. 17115046
    • (2006) Nat Med , vol.12 , pp. 1365-1371
    • Brenchley, J.M.1    Price, D.A.2    Schacker, T.W.3    Asher, T.E.4    Silvestri, G.5    Rao, S.6
  • 10
    • 38549149823 scopus 로고    scopus 로고
    • Immune activation and inflammation in HIV-1 infection : causes and consequences
    • Appay V, Sauce D, Immune activation and inflammation in HIV-1 infection : causes and consequences. J Pathol. 2008;214: 231–241. doi: 10.1002/path.2276 18161758
    • (2008) J Pathol , vol.214 , pp. 231-241
    • Appay, V.1    Sauce, D.2
  • 11
    • 84879295275 scopus 로고    scopus 로고
    • HIV-associated chronic immune activation
    • Paiardini M, Müller-Trutwin M, HIV-associated chronic immune activation. Immunol Rev. 2013;254: 78–101. doi: 10.1111/imr.12079 23772616
    • (2013) Immunol Rev , vol.254 , pp. 78-101
    • Paiardini, M.1    Müller-Trutwin, M.2
  • 12
    • 84867955049 scopus 로고    scopus 로고
    • Human immunodeficiency virus and the gastrointestinal immune system: does highly active antiretroviral therapy restore gut immunity?
    • Costiniuk CT, Angel JB, Human immunodeficiency virus and the gastrointestinal immune system: does highly active antiretroviral therapy restore gut immunity? Mucosal Immunol. 2012;5: 596–604. doi: 10.1038/mi.2012.82 22929559
    • (2012) Mucosal Immunol , vol.5 , pp. 596-604
    • Costiniuk, C.T.1    Angel, J.B.2
  • 13
    • 2942650969 scopus 로고    scopus 로고
    • Adipose tissue as an endocrine organ
    • Kershaw EE, Flier JS, Adipose tissue as an endocrine organ. J Clin Endocrinol Metab. 2004;89: 2548–2556. 15181022
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 2548-2556
    • Kershaw, E.E.1    Flier, J.S.2
  • 14
    • 66849106645 scopus 로고    scopus 로고
    • RANTES release by human adipose tissue in vivo and evidence for depot-specific differences
    • Madani R, Karastergiou K, Ogston NC, Miheisi N, Bhome R, Haloob N, et al. RANTES release by human adipose tissue in vivo and evidence for depot-specific differences. Am J Physiol Endocrinol Metab. 2009;296: E1262–8. doi: 10.1152/ajpendo.90511.2008 19240255
    • (2009) Am J Physiol Endocrinol Metab , vol.296 , pp. 8-1262
    • Madani, R.1    Karastergiou, K.2    Ogston, N.C.3    Miheisi, N.4    Bhome, R.5    Haloob, N.6
  • 17
    • 0030735542 scopus 로고    scopus 로고
    • Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo
    • Mohamed-Ali V, Goodrick S, Rawesh A, Katz DR, Miles JM, Yudkin JS, et al. Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo. J Clin Endocrinol Metab. 1997;82: 4196–200. doi: 10.1210/jcem.82.12.4450 9398739
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 4196-4200
    • Mohamed-Ali, V.1    Goodrick, S.2    Rawesh, A.3    Katz, D.R.4    Miles, J.M.5    Yudkin, J.S.6
  • 18
    • 0031762908 scopus 로고    scopus 로고
    • Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid
    • Fried SK, Bunkin DA, Greenberg AS, Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid. J Clin Endocrinol Metab. 1998;83: 847–50. doi: 10.1210/jcem.83.3.4660 9506738
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 847-850
    • Fried, S.K.1    Bunkin, D.A.2    Greenberg, A.S.3
  • 19
    • 77949493588 scopus 로고    scopus 로고
    • Leptin and adiponectin: from energy and metabolic dysbalance to inflammation and autoimmunity
    • Stofkova A, Leptin and adiponectin: from energy and metabolic dysbalance to inflammation and autoimmunity. Endocr Regul. 2009;43: 157–68. 19908934
    • (2009) Endocr Regul , vol.43 , pp. 157-168
    • Stofkova, A.1
  • 21
    • 79151484704 scopus 로고    scopus 로고
    • Adipokines in inflammation and metabolic disease
    • Ouchi N, Parker JL, Lugus JJ, Walsh K, Adipokines in inflammation and metabolic disease. Nat Publ Gr. Nature Publishing Group; 2011;11: 85–97. doi: 10.1038/nri2921
    • (2011) Nat Publ Gr , vol.11 , pp. 85-97
    • Ouchi, N.1    Parker, J.L.2    Lugus, J.J.3    Walsh, K.4
  • 23
    • 79151475165 scopus 로고    scopus 로고
    • Immunometabolism: an emerging frontier
    • Mathis D, Shoelson SE, Immunometabolism: an emerging frontier. Nat Rev Immunol. 2011;11: 81. doi: 10.1038/nri2922 21469396
    • (2011) Nat Rev Immunol , vol.11 , pp. 81
    • Mathis, D.1    Shoelson, S.E.2
  • 25
    • 84875346292 scopus 로고    scopus 로고
    • Previews A New “‘ Immunological ‘” Role for Adipocytes in Obesity
    • Hruskova Z, Biswas SK, Previews A New “‘ Immunological ‘” Role for Adipocytes in Obesity. CMET. Elsevier; 2013;17: 315–317. doi: 10.1016/j.cmet.2013.02.015
    • (2013) CMET , vol.17 , pp. 315-317
    • Hruskova, Z.1    Biswas, S.K.2
  • 26
    • 0348230958 scopus 로고    scopus 로고
    • Obesity is associated with macrophage accumulation in adipose tissue
    • Weisberg SP, Mccann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW, Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest. 2003;112: 1796–1808. doi: 10.1172/JCI200319246 Introduction 14679176
    • (2003) J Clin Invest , vol.112 , pp. 1796-1808
    • Weisberg, S.P.1    Mccann, D.2    Desai, M.3    Rosenbaum, M.4    Leibel, R.L.5    Ferrante, A.W.6
  • 27
    • 68349150756 scopus 로고    scopus 로고
    • CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity
    • Nishimura S, Manabe I, Nagasaki M, Eto K, Yamashita H, Ohsugi M, et al. CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat Med. 2009;15: 914–920. doi: 10.1038/nm.1964 19633658
    • (2009) Nat Med , vol.15 , pp. 914-920
    • Nishimura, S.1    Manabe, I.2    Nagasaki, M.3    Eto, K.4    Yamashita, H.5    Ohsugi, M.6
  • 28
    • 70349563430 scopus 로고    scopus 로고
    • Interplay between human adipocytes and T lymphocytes in obesity: CCL20 as an adipochemokine and T lymphocytes as lipogenic modulators
    • Duffaut C, Zakaroff-Girard A, Bourlier V, Decaunes P, Maumus M, Chiotasso P, et al. Interplay between human adipocytes and T lymphocytes in obesity: CCL20 as an adipochemokine and T lymphocytes as lipogenic modulators. Arter Thromb Vasc Biol. 2009;29: 1608–1614.
    • (2009) Arter Thromb Vasc Biol , vol.29 , pp. 1608-1614
    • Duffaut, C.1    Zakaroff-Girard, A.2    Bourlier, V.3    Decaunes, P.4    Maumus, M.5    Chiotasso, P.6
  • 29
    • 68349148211 scopus 로고    scopus 로고
    • Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters
    • Feuerer M, Herrero L, Cipolletta D, Naaz A, Wong J, Nayer A, et al. Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med. Nature Publishing Group; 2009;15: 1–11. doi: 10.1038/nm.2002
    • (2009) Nat Med , vol.15 , pp. 1-11
    • Feuerer, M.1    Herrero, L.2    Cipolletta, D.3    Naaz, A.4    Wong, J.5    Nayer, A.6
  • 30
    • 84875280888 scopus 로고    scopus 로고
    • Article Class II Major Histocompatibility Complex Plays an Essential Role in Obesity-Induced Adipose Inflammation
    • Deng T, Lyon CJ, Minze LJ, Lin J, Zou J, Liu JZ, et al. Article Class II Major Histocompatibility Complex Plays an Essential Role in Obesity-Induced Adipose Inflammation. Cell Metab. Elsevier Inc.; 2013;17: 411–422. doi: 10.1016/j.cmet.2013.02.009 23473035
    • (2013) Cell Metab , vol.17 , pp. 411-422
    • Deng, T.1    Lyon, C.J.2    Minze, L.J.3    Lin, J.4    Zou, J.5    Liu, J.Z.6
  • 31
    • 42449097289 scopus 로고    scopus 로고
    • Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes
    • Guilherme A, Virbasius J V, Puri V, Czech MP, Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. Nat Rev Mol Cell Biol. 2008;9: 367–77. doi: 10.1038/nrm2391 18401346
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 367-377
    • Guilherme, A.1    Virbasius, J.V.2    Puri, V.3    Czech, M.P.4
  • 32
    • 26244448904 scopus 로고    scopus 로고
    • A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: role of free fatty acids and tumor necrosis factor alpha
    • Suganami T, Nishida J, Ogawa Y, A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: role of free fatty acids and tumor necrosis factor alpha. Arterioscler Thromb Vasc Biol. 2005;25: 2062–8. doi: 10.1161/01.ATV.0000183883.72263.13 16123319
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 2062-2068
    • Suganami, T.1    Nishida, J.2    Ogawa, Y.3
  • 33
    • 33749366275 scopus 로고    scopus 로고
    • HIV-1 infection alters gene expression in adipose tissue, which contributes to HIV- 1/HAART-associated lipodystrophy
    • Giralt M, Domingo P, Guallar JP, Rodriguez de la Concepción ML, Alegre M, Domingo JC, et al. HIV-1 infection alters gene expression in adipose tissue, which contributes to HIV- 1/HAART-associated lipodystrophy. Antivir Ther. 2006;11: 729–40. 17310817
    • (2006) Antivir Ther , vol.11 , pp. 729-740
    • Giralt, M.1    Domingo, P.2    Guallar, J.P.3    Rodriguez de la Concepción, M.L.4    Alegre, M.5    Domingo, J.C.6
  • 35
    • 84861659153 scopus 로고    scopus 로고
    • Effects of ritonavir-boosted darunavir, atazanavir and lopinavir on adipose functions and insulin sensitivity in murine and human adipocytes
    • Capel E, Auclair M, Caron-Debarle M, Capeau J, Effects of ritonavir-boosted darunavir, atazanavir and lopinavir on adipose functions and insulin sensitivity in murine and human adipocytes. Antivir Ther. 2012;17: 549–56. doi: 10.3851/IMP1988 22293506
    • (2012) Antivir Ther , vol.17 , pp. 549-556
    • Capel, E.1    Auclair, M.2    Caron-Debarle, M.3    Capeau, J.4
  • 36
    • 77952420363 scopus 로고    scopus 로고
    • HIV-associated lipodystrophy: from fat injury to premature aging
    • Caron-Debarle M, Lagathu C, Boccara F, Vigouroux C, Capeau J, HIV-associated lipodystrophy: from fat injury to premature aging. Trends Mol Med. Elsevier Ltd; 2010;16: 218–29. doi: 10.1016/j.molmed.2010.03.002 20400373
    • (2010) Trends Mol Med , vol.16 , pp. 218-229
    • Caron-Debarle, M.1    Lagathu, C.2    Boccara, F.3    Vigouroux, C.4    Capeau, J.5
  • 37
    • 84861695648 scopus 로고    scopus 로고
    • HIV-1 Tat protein impairs adipogenesis and induces the expression and secretion of proinflammatory cytokines in human SGBS adipocytes
    • Díaz-Delfín J, Domingo P, Wabitsch M, Giralt M, Villarroya F, HIV-1 Tat protein impairs adipogenesis and induces the expression and secretion of proinflammatory cytokines in human SGBS adipocytes. Antivir Ther. 2012;17: 529–40. doi: 10.3851/IMP2021 22301094
    • (2012) Antivir Ther , vol.17 , pp. 529-540
    • Díaz-Delfín, J.1    Domingo, P.2    Wabitsch, M.3    Giralt, M.4    Villarroya, F.5
  • 38
    • 84861145431 scopus 로고    scopus 로고
    • Effects of rilpivirine on human adipocyte differentiation, gene expression, and release of adipokines and cytokines
    • Díaz-Delfín J, Domingo P, Mateo MG, Gutierrez MDM, Domingo JC, Giralt M, et al. Effects of rilpivirine on human adipocyte differentiation, gene expression, and release of adipokines and cytokines. Antimicrob Agents Chemother. 2012;56: 3369–75. doi: 10.1128/AAC.00104-12 22430974
    • (2012) Antimicrob Agents Chemother , vol.56 , pp. 3369-3375
    • Díaz-Delfín, J.1    Domingo, P.2    Mateo, M.G.3    Gutierrez, M.D.M.4    Domingo, J.C.5    Giralt, M.6
  • 40
    • 4344656133 scopus 로고    scopus 로고
    • Altered fat differentiation and adipocytokine expression are inter-related and linked to morphological changes and insulin resistance in HIV-1-infected lipodystrophic patients
    • Jan V, Cervera P, Maachi M, Baudrimont M, Kim M, Vidal H, et al. Altered fat differentiation and adipocytokine expression are inter-related and linked to morphological changes and insulin resistance in HIV-1-infected lipodystrophic patients. Antivir Ther. 2004;9: 555–64. 15456087
    • (2004) Antivir Ther , vol.9 , pp. 555-564
    • Jan, V.1    Cervera, P.2    Maachi, M.3    Baudrimont, M.4    Kim, M.5    Vidal, H.6
  • 41
    • 0942265682 scopus 로고    scopus 로고
    • Increased systemic and adipose tissue cytokines in patients with HIV-associated lipodystrophy
    • Johnson JA, Albu JB, Engelson ES, Fried SK, Inada Y, Ionescu G, et al. Increased systemic and adipose tissue cytokines in patients with HIV-associated lipodystrophy. Am J Physiol Endocrinol Metab. 2004;286: E261–71. doi: 10.1152/ajpendo.00056.2003 14532165
    • (2004) Am J Physiol Endocrinol Metab , vol.286 , pp. 71-261
    • Johnson, J.A.1    Albu, J.B.2    Engelson, E.S.3    Fried, S.K.4    Inada, Y.5    Ionescu, G.6
  • 44
    • 0037032926 scopus 로고    scopus 로고
    • HIV and antiretroviral drug distribution in plasma and fat tissue of HIV-infected patients with lipodystrophy
    • Dupin N, Buffet M, Marcelin A-G, Lamotte C, Gorin I, Ait-Arkoub Z, et al. HIV and antiretroviral drug distribution in plasma and fat tissue of HIV-infected patients with lipodystrophy. AIDS. 2002;16: 2419–24. 12461415
    • (2002) AIDS , vol.16 , pp. 2419-2424
    • Dupin, N.1    Buffet, M.2    Marcelin, A.-G.3    Lamotte, C.4    Gorin, I.5    Ait-Arkoub, Z.6
  • 45
    • 0036673024 scopus 로고    scopus 로고
    • Human adipose cells express CD4, CXCR4, and CCR5 [corrected] receptors: a new target cell type for the immunodeficiency virus-1?
    • Hazan U, Romero IA, Cancello R, Valente S, Perrin V, Mariot V, et al. Human adipose cells express CD4, CXCR4, and CCR5 [corrected] receptors: a new target cell type for the immunodeficiency virus-1? FASEB J. 2002;16: 1254–6. doi: 10.1096/fj.01-0947fje 12153994
    • (2002) FASEB J , vol.16 , pp. 1254-1256
    • Hazan, U.1    Romero, I.A.2    Cancello, R.3    Valente, S.4    Perrin, V.5    Mariot, V.6
  • 46
    • 1642369404 scopus 로고    scopus 로고
    • In vitro infection of human primary adipose cells with HIV-1: a reassessment
    • Munier S, Borjabad A, Lemaire M, Mariot V, Hazan U, In vitro infection of human primary adipose cells with HIV-1: a reassessment. AIDS. 2003;17: 2537–9. doi: 10.1097/01.aids.0000096866.36052.84 14600528
    • (2003) AIDS , vol.17 , pp. 2537-2539
    • Munier, S.1    Borjabad, A.2    Lemaire, M.3    Mariot, V.4    Hazan, U.5
  • 47
    • 14644390274 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha stimulates HIV-1 production in primary culture of human adipocytes
    • Maurin T, Saillan-Barreau C, Cousin B, Casteilla L, Doglio A, Pénicaud L, Tumor necrosis factor-alpha stimulates HIV-1 production in primary culture of human adipocytes. Exp Cell Res. 2005;304: 544–51. doi: 10.1016/j.yexcr.2004.12.003 15748898
    • (2005) Exp Cell Res , vol.304 , pp. 544-551
    • Maurin, T.1    Saillan-Barreau, C.2    Cousin, B.3    Casteilla, L.4    Doglio, A.5    Pénicaud, L.6
  • 48
    • 84890021241 scopus 로고    scopus 로고
    • HIV-1 Vpr induces adipose dysfunction in vivo through reciprocal effects on PPAR/GR co-regulation
    • Agarwal N, Iyer D, Patel SG, Sekhar R V, Phillips TM, Schubert U, et al. HIV-1 Vpr induces adipose dysfunction in vivo through reciprocal effects on PPAR/GR co-regulation. Sci Transl Med. 2013;5: 213ra164. doi: 10.1126/scitranslmed.3007148
    • (2013) Sci Transl Med , vol.5
    • Agarwal, N.1    Iyer, D.2    Patel, S.G.3    Sekhar, R.V.4    Phillips, T.M.5    Schubert, U.6
  • 49
    • 1342289537 scopus 로고    scopus 로고
    • HIV-1 Nef protein in the nucleus influences adipogenesis as well as viral transcription through the peroxisome proliferator-activated receptors
    • Otake K, Omoto S, Yamamoto T, Okuyama H, Okada H, Okada N, et al. HIV-1 Nef protein in the nucleus influences adipogenesis as well as viral transcription through the peroxisome proliferator-activated receptors. AIDS. 2004;18: 189–98. 15075535
    • (2004) AIDS , vol.18 , pp. 189-198
    • Otake, K.1    Omoto, S.2    Yamamoto, T.3    Okuyama, H.4    Okada, H.5    Okada, N.6
  • 50
    • 84903748998 scopus 로고    scopus 로고
    • HIV protein Nef causes dyslipidemia and formation of foam cells in mouse models of atherosclerosis
    • Cui HL, Ditiatkovski M, Kesani R, Bobryshev Y V, Liu Y, Geyer M, et al. HIV protein Nef causes dyslipidemia and formation of foam cells in mouse models of atherosclerosis. FASEB J. 2014;28: 2828–39. doi: 10.1096/fj.13-246876 24642731
    • (2014) FASEB J , vol.28 , pp. 2828-2839
    • Cui, H.L.1    Ditiatkovski, M.2    Kesani, R.3    Bobryshev, Y.V.4    Liu, Y.5    Geyer, M.6
  • 51
    • 77957276242 scopus 로고    scopus 로고
    • Adaptive immunity and adipose tissue biology
    • Kaminski DA, Randall TD, Adaptive immunity and adipose tissue biology. Trends Immunol. 2010;31: 384–390. doi: 10.1016/j.it.2010.08.001 20817556
    • (2010) Trends Immunol , vol.31 , pp. 384-390
    • Kaminski, D.A.1    Randall, T.D.2
  • 52
    • 74049159942 scopus 로고    scopus 로고
    • Subcutaneous and visceral adipose tissue: structural and functional differences
    • Ibrahim MM, Subcutaneous and visceral adipose tissue: structural and functional differences. Obes Rev. 2010;11: 11–18. doi: 10.1111/j.1467-789X.2009.00623.x 19656312
    • (2010) Obes Rev , vol.11 , pp. 11-18
    • Ibrahim, M.M.1
  • 53
    • 0031062761 scopus 로고    scopus 로고
    • Chemoattractant factors (IP-10, MIP-1alpha, IL-16) mRNA expression in mononuclear cells from different tissues during acute SIVmac251 infection of macaques
    • Chéret A, Le Grand R, Caufour P, Neildez O, Matheux F, Théodoro F, et al. Chemoattractant factors (IP-10, MIP-1alpha, IL-16) mRNA expression in mononuclear cells from different tissues during acute SIVmac251 infection of macaques. J Med Primatol. 1997;26: 19–26. 9271185
    • (1997) J Med Primatol , vol.26 , pp. 19-26
    • Chéret, A.1    Le Grand, R.2    Caufour, P.3    Neildez, O.4    Matheux, F.5    Théodoro, F.6
  • 54
    • 0344631687 scopus 로고    scopus 로고
    • RANTES, IFN-gamma, CCR1, and CCR5 mRNA expression in peripheral blood, lymph node, and bronchoalveolar lavage mononuclear cells during primary simian immunodeficiency virus infection of macaques
    • Chéret A, Le Grand R, Caufour P, Neildez O, Matheux F, Théodoro F, et al. RANTES, IFN-gamma, CCR1, and CCR5 mRNA expression in peripheral blood, lymph node, and bronchoalveolar lavage mononuclear cells during primary simian immunodeficiency virus infection of macaques. Virology. 1999;255: 285–93. doi: 10.1006/viro.1998.9558 10069954
    • (1999) Virology , vol.255 , pp. 285-293
    • Chéret, A.1    Le Grand, R.2    Caufour, P.3    Neildez, O.4    Matheux, F.5    Théodoro, F.6
  • 55
    • 84892888299 scopus 로고    scopus 로고
    • Semen CD4+ T cells and macrophages are productively infected at all stages of SIV infection in macaques
    • Bernard-Stoecklin S, Gommet C, Corneau AB, Guenounou S, Torres C, Dejucq-Rainsford N, et al. Semen CD4+ T cells and macrophages are productively infected at all stages of SIV infection in macaques. PLoS Pathog. 2013;9: e1003810. doi: 10.1371/journal.ppat.1003810 24348253
    • (2013) PLoS Pathog , vol.9 , pp. 1003810
    • Bernard-Stoecklin, S.1    Gommet, C.2    Corneau, A.B.3    Guenounou, S.4    Torres, C.5    Dejucq-Rainsford, N.6
  • 56
    • 77956400503 scopus 로고    scopus 로고
    • Increased CD4+ T cell levels during IL-7 administration of antiretroviral therapy-treated simian immunodeficiency virus-positive macaques are not dependent on strong proliferative responses
    • Leone A, Rohankhedkar M, Okoye A, Legasse A, Axthelm MK, Villinger F, et al. Increased CD4+ T cell levels during IL-7 administration of antiretroviral therapy-treated simian immunodeficiency virus-positive macaques are not dependent on strong proliferative responses. J Immunol. 2010;185: 1650–9. doi: 10.4049/jimmunol.0902626 20622118
    • (2010) J Immunol , vol.185 , pp. 1650-1659
    • Leone, A.1    Rohankhedkar, M.2    Okoye, A.3    Legasse, A.4    Axthelm, M.K.5    Villinger, F.6
  • 57
    • 84872772721 scopus 로고    scopus 로고
    • Distribution and compartmentalization of human circulating and tissue-resident memory T cell subsets
    • Sathaliyawala T, Kubota M, Yudanin N, Turner D, Camp P, Thome JJC, et al. Distribution and compartmentalization of human circulating and tissue-resident memory T cell subsets. Immunity. Elsevier Inc.; 2013;38: 187–97. doi: 10.1016/j.immuni.2012.09.020 23260195
    • (2013) Immunity , vol.38 , pp. 187-197
    • Sathaliyawala, T.1    Kubota, M.2    Yudanin, N.3    Turner, D.4    Camp, P.5    Thome, J.J.C.6
  • 58
    • 65249134069 scopus 로고    scopus 로고
    • Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus
    • Gebhardt T, Wakim LM, Eidsmo L, Reading PC, Heath WR, Carbone FR, Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus. Nat Immunol. 2009;10: 524–30. doi: 10.1038/ni.1718 19305395
    • (2009) Nat Immunol , vol.10 , pp. 524-530
    • Gebhardt, T.1    Wakim, L.M.2    Eidsmo, L.3    Reading, P.C.4    Heath, W.R.5    Carbone, F.R.6
  • 59
    • 79959783758 scopus 로고    scopus 로고
    • Defining macrophage phenotype and function in adipose tissue
    • Dalmas E, Clément K, Guerre-Millo M, Defining macrophage phenotype and function in adipose tissue. Trends Immunol. 2011;32: 307–14. doi: 10.1016/j.it.2011.04.008 21616718
    • (2011) Trends Immunol , vol.32 , pp. 307-314
    • Dalmas, E.1    Clément, K.2    Guerre-Millo, M.3
  • 60
    • 84867007875 scopus 로고    scopus 로고
    • Adipogenic/lipid, inflammatory, and mitochondrial parameters in subcutaneous adipose tissue of untreated HIV-1-infected long-term nonprogressors: significant alterations despite low viral burden
    • Vidal F, Domingo P, Villarroya F, Giralt M, López-Dupla M, Gutiérrez M, et al. Adipogenic/lipid, inflammatory, and mitochondrial parameters in subcutaneous adipose tissue of untreated HIV-1-infected long-term nonprogressors: significant alterations despite low viral burden. J Acquir Immune Defic Syndr. 2012;61: 131–7. doi: 10.1097/QAI.0b013e31825c3a68 22580565
    • (2012) J Acquir Immune Defic Syndr , vol.61 , pp. 131-137
    • Vidal, F.1    Domingo, P.2    Villarroya, F.3    Giralt, M.4    López-Dupla, M.5    Gutiérrez, M.6
  • 61
    • 22744451308 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 (HIV-1) Vpr-regulated cell death: insights into mechanism
    • Muthumani K, Choo AY, Premkumar A, Hwang DS, Thieu KP, Desai BM, et al. Human immunodeficiency virus type 1 (HIV-1) Vpr-regulated cell death: insights into mechanism. Cell Death Differ. 2005;12 Suppl 1: 962–70. doi: 10.1038/sj.cdd.4401583 15832179
    • (2005) Cell Death Differ , vol.12 , pp. 962-970
    • Muthumani, K.1    Choo, A.Y.2    Premkumar, A.3    Hwang, D.S.4    Thieu, K.P.5    Desai, B.M.6
  • 62
    • 38749103477 scopus 로고    scopus 로고
    • Human immunodeficiency virus (HIV)-1 viral protein R suppresses transcriptional activity of peroxisome proliferator-activated receptor {gamma} and inhibits adipocyte differentiation: implications for HIV-associated lipodystrophy
    • Shrivastav S, Kino T, Cunningham T, Ichijo T, Schubert U, Heinklein P, et al. Human immunodeficiency virus (HIV)-1 viral protein R suppresses transcriptional activity of peroxisome proliferator-activated receptor {gamma} and inhibits adipocyte differentiation: implications for HIV-associated lipodystrophy. Mol Endocrinol. 2008;22: 234–47. doi: 10.1210/me.2007-0124 17932108
    • (2008) Mol Endocrinol , vol.22 , pp. 234-247
    • Shrivastav, S.1    Kino, T.2    Cunningham, T.3    Ichijo, T.4    Schubert, U.5    Heinklein, P.6
  • 63
    • 80053543793 scopus 로고    scopus 로고
    • Adipose-derived stromal cells: Their identity and uses in clinical trials, an update
    • Casteilla L, Planat-Benard V, Laharrague P, Cousin B, Adipose-derived stromal cells: Their identity and uses in clinical trials, an update. World J Stem Cells. 2011;3: 25–33. doi: 10.4252/wjsc.v3.i4.25 21607134
    • (2011) World J Stem Cells , vol.3 , pp. 25-33
    • Casteilla, L.1    Planat-Benard, V.2    Laharrague, P.3    Cousin, B.4
  • 65
    • 78651235761 scopus 로고    scopus 로고
    • Mesenchymal stem cell derived hematopoietic cells are permissive to HIV-1 infection
    • Nazari-Shafti TZ, Freisinger E, Roy U, Bulot CT, Senst C, Dupin CL, et al. Mesenchymal stem cell derived hematopoietic cells are permissive to HIV-1 infection. Retrovirology. 2011;8: 3. doi: 10.1186/1742-4690-8-3 21226936
    • (2011) Retrovirology , vol.8 , pp. 3
    • Nazari-Shafti, T.Z.1    Freisinger, E.2    Roy, U.3    Bulot, C.T.4    Senst, C.5    Dupin, C.L.6
  • 66
    • 71949109156 scopus 로고    scopus 로고
    • Dynamics of viral replication in blood and lymphoid tissues during SIVmac251 infection of macaques
    • Mannioui A, Bourry O, Sellier P, Delache B, Brochard P, Andrieu T, et al. Dynamics of viral replication in blood and lymphoid tissues during SIVmac251 infection of macaques. Retrovirology. 2009;6: 106. doi: 10.1186/1742-4690-6-106 19930655
    • (2009) Retrovirology , vol.6 , pp. 106
    • Mannioui, A.1    Bourry, O.2    Sellier, P.3    Delache, B.4    Brochard, P.5    Andrieu, T.6
  • 67
    • 84861209845 scopus 로고    scopus 로고
    • Impact of short-term HAART initiated during the chronic stage or shortly post-exposure on SIV infection of male genital organs
    • Moreau M, Le Tortorec A, Deleage C, Brown C, Denis H, Satie A-P, et al. Impact of short-term HAART initiated during the chronic stage or shortly post-exposure on SIV infection of male genital organs. PLoS One. 2012;7: e37348. doi: 10.1371/journal.pone.0037348 22615988
    • (2012) PLoS One , vol.7 , pp. 37348
    • Moreau, M.1    Le Tortorec, A.2    Deleage, C.3    Brown, C.4    Denis, H.5    Satie, A.-P.6
  • 68
  • 69
    • 84922611542 scopus 로고    scopus 로고
    • B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers
    • Fukazawa Y, Lum R, Okoye AA, Park H, Matsuda K, Bae JY, et al. B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers. Nat Med. 2015;21: 132–9. doi: 10.1038/nm.3781 25599132
    • (2015) Nat Med , vol.21 , pp. 132-139
    • Fukazawa, Y.1    Lum, R.2    Okoye, A.A.3    Park, H.4    Matsuda, K.5    Bae, J.Y.6
  • 70
    • 84863112442 scopus 로고    scopus 로고
    • Interleukin-7 regulates adipose tissue mass and insulin sensitivity in high-fat diet-fed mice through lymphocyte-dependent and independent mechanisms
    • Lucas S, Taront S, Magnan C, Fauconnier L, Delacre M, Macia L, et al. Interleukin-7 regulates adipose tissue mass and insulin sensitivity in high-fat diet-fed mice through lymphocyte-dependent and independent mechanisms. PLoS One. 2012;7: e40351. doi: 10.1371/journal.pone.0040351 22768283
    • (2012) PLoS One , vol.7 , pp. 40351
    • Lucas, S.1    Taront, S.2    Magnan, C.3    Fauconnier, L.4    Delacre, M.5    Macia, L.6
  • 72
    • 79953046341 scopus 로고    scopus 로고
    • Inflammatory Mechanisms in Obesity
    • Gregor MF, Hotamisligil S, Inflammatory Mechanisms in Obesity. Annu Rev Immunol. 2011;29: 415–445. doi: 10.1146/annurev-immunol-031210-101322 21219177
    • (2011) Annu Rev Immunol , vol.29 , pp. 415-445
    • Gregor, M.F.1    Hotamisligil, S.2
  • 73
    • 84937883002 scopus 로고    scopus 로고
    • Human adipose tissue as a reservoir for memory CD4+ T cells and HIV
    • Couturier J, Suliburk JW, Brown JM, Luke DJ, Agarwal N, Yu X, et al. Human adipose tissue as a reservoir for memory CD4+ T cells and HIV. AIDS. 2015;29: 667–74. doi: 10.1097/QAD.0000000000000599 25849830
    • (2015) AIDS , vol.29 , pp. 667-674
    • Couturier, J.1    Suliburk, J.W.2    Brown, J.M.3    Luke, D.J.4    Agarwal, N.5    Yu, X.6
  • 75
    • 12544256168 scopus 로고    scopus 로고
    • Human immunodeficiency virus protease inhibitors accumulate into cultured human adipocytes and alter expression of adipocytokines
    • Vernochet C, Azoulay S, Duval D, Guedj R, Cottrez F, Vidal H, et al. Human immunodeficiency virus protease inhibitors accumulate into cultured human adipocytes and alter expression of adipocytokines. J Biol Chem. 2005;280: 2238–43. doi: 10.1074/jbc.M408687200 15525648
    • (2005) J Biol Chem , vol.280 , pp. 2238-2243
    • Vernochet, C.1    Azoulay, S.2    Duval, D.3    Guedj, R.4    Cottrez, F.5    Vidal, H.6
  • 76
    • 79958779542 scopus 로고    scopus 로고
    • Downregulation of CD38 activation markers by atorvastatin in HIV patients with undetectable viral load
    • De Wit S, Delforge M, Necsoi CV, Clumeck N, Downregulation of CD38 activation markers by atorvastatin in HIV patients with undetectable viral load. AIDS. 2011;25: 1332–3. doi: 10.1097/QAD.0b013e328347c083 21508802
    • (2011) AIDS , vol.25 , pp. 1332-1333
    • De Wit, S.1    Delforge, M.2    Necsoi, C.V.3    Clumeck, N.4
  • 77
    • 84864311097 scopus 로고    scopus 로고
    • Statin therapy decreases serum levels of high-sensitivity C-reactive protein and tumor necrosis factor-α in HIV-infected patients treated with ritonavir-boosted protease inhibitors
    • Calza L, Trapani F, Bartoletti M, Manfredi R, Colangeli V, Borderi M, et al. Statin therapy decreases serum levels of high-sensitivity C-reactive protein and tumor necrosis factor-α in HIV-infected patients treated with ritonavir-boosted protease inhibitors. HIV Clin Trials. 13: 153–61. doi: 10.1310/hct1303-153 22592095
    • HIV Clin Trials , vol.13 , pp. 153-161
    • Calza, L.1    Trapani, F.2    Bartoletti, M.3    Manfredi, R.4    Colangeli, V.5    Borderi, M.6
  • 78
    • 84897829351 scopus 로고    scopus 로고
    • Sex differences in adipose tissue: It is not only a question of quantity and distribution
    • Fuente-Martín E, Argente-Arizón P, Ros P, Argente J, Chowen JA, Sex differences in adipose tissue: It is not only a question of quantity and distribution. Adipocyte. 2013;2: 128–34. doi: 10.4161/adip.24075 23991358
    • (2013) Adipocyte , vol.2 , pp. 128-134
    • Fuente-Martín, E.1    Argente-Arizón, P.2    Ros, P.3    Argente, J.4    Chowen, J.A.5
  • 79
    • 0034284924 scopus 로고    scopus 로고
    • Sensitive and robust one-tube real-time reverse transcriptase-polymerase chain reaction to quantify SIV RNA load: comparison of one- versus two-enzyme systems
    • Hofmann-Lehmann R, Swenerton RK, Liska V, Leutenegger CM, Lutz H, McClure HM, et al. Sensitive and robust one-tube real-time reverse transcriptase-polymerase chain reaction to quantify SIV RNA load: comparison of one- versus two-enzyme systems. AIDS Res Hum Retroviruses. 2000;16: 1247–57. doi: 10.1089/08892220050117014 10957722
    • (2000) AIDS Res Hum Retroviruses , vol.16 , pp. 1247-1257
    • Hofmann-Lehmann, R.1    Swenerton, R.K.2    Liska, V.3    Leutenegger, C.M.4    Lutz, H.5    McClure, H.M.6
  • 80
    • 20144387661 scopus 로고    scopus 로고
    • Antiinflammatory profiles during primary SIV infection in African green monkeys are associated with protection against AIDS
    • Kornfeld C, Ploquin MJ-Y, Pandrea I, Faye A, Onanga R, Apetrei C, et al. Antiinflammatory profiles during primary SIV infection in African green monkeys are associated with protection against AIDS. J Clin Invest. 2005;115: 1082–91. doi: 10.1172/JCI23006 15761496
    • (2005) J Clin Invest , vol.115 , pp. 1082-1091
    • Kornfeld, C.1    Ploquin, M.J.-Y.2    Pandrea, I.3    Faye, A.4    Onanga, R.5    Apetrei, C.6
  • 81
    • 37049038007 scopus 로고    scopus 로고
    • Dynamics of T-cell responses and memory T cells during primary simian immunodeficiency virus infection in cynomolgus macaques
    • Karlsson I, Malleret B, Brochard P, Delache B, Calvo J, Le Grand R, et al. Dynamics of T-cell responses and memory T cells during primary simian immunodeficiency virus infection in cynomolgus macaques. J Virol. 2007;81: 13456–68. doi: 10.1128/JVI.01619-07 17913797
    • (2007) J Virol , vol.81 , pp. 13456-13468
    • Karlsson, I.1    Malleret, B.2    Brochard, P.3    Delache, B.4    Calvo, J.5    Le Grand, R.6
  • 82
    • 66349103438 scopus 로고    scopus 로고
    • HIV-DNA in rectal cells is well correlated with HIV-DNA in blood in different groups of patients, including long-term non-progressors
    • Avettand-Fenoel V, Prazuck T, Hocqueloux L, Melard A, Michau C, Kerdraon R, et al. HIV-DNA in rectal cells is well correlated with HIV-DNA in blood in different groups of patients, including long-term non-progressors. AIDS. 2008;22: 1880–2. doi: 10.1097/QAD.0b013e32830fbdbc 18753926
    • (2008) AIDS , vol.22 , pp. 1880-1882
    • Avettand-Fenoel, V.1    Prazuck, T.2    Hocqueloux, L.3    Melard, A.4    Michau, C.5    Kerdraon, R.6
  • 83
    • 61749103775 scopus 로고    scopus 로고
    • LTR real-time PCR for HIV-1 DNA quantitation in blood cells for early diagnosis in infants born to seropositive mothers treated in HAART area (ANRS CO 01)
    • Avettand-Fènoël V, Chaix M-L, Blanche S, Burgard M, Floch C, Toure K, et al. LTR real-time PCR for HIV-1 DNA quantitation in blood cells for early diagnosis in infants born to seropositive mothers treated in HAART area (ANRS CO 01). J Med Virol. 2009;81: 217–23. doi: 10.1002/jmv.21390 19107966
    • (2009) J Med Virol , vol.81 , pp. 217-223
    • Avettand-Fènoël, V.1    Chaix, M.-L.2    Blanche, S.3    Burgard, M.4    Floch, C.5    Toure, K.6
  • 84
    • 84877750020 scopus 로고    scopus 로고
    • A single HIV-1 cluster and a skewed immune homeostasis drive the early spread of HIV among resting CD4+ cell subsets within one month post-infection
    • Bacchus C, Cheret A, Avettand-Fenoël V, Nembot G, Mélard A, Blanc C, et al. A single HIV-1 cluster and a skewed immune homeostasis drive the early spread of HIV among resting CD4+ cell subsets within one month post-infection. PLoS One. 2013;8: e64219. doi: 10.1371/journal.pone.0064219 23691172
    • (2013) PLoS One , vol.8 , pp. 64219
    • Bacchus, C.1    Cheret, A.2    Avettand-Fenoël, V.3    Nembot, G.4    Mélard, A.5    Blanc, C.6
  • 86
    • 0025913304 scopus 로고
    • Orchitis and human immunodeficiency virus type 1 infected cells in reproductive tissues from men with the acquired immune deficiency syndrome
    • Pudney J, Anderson D, Orchitis and human immunodeficiency virus type 1 infected cells in reproductive tissues from men with the acquired immune deficiency syndrome. Am J Pathol. 1991;139: 149–60. 1853930
    • (1991) Am J Pathol , vol.139 , pp. 149-160
    • Pudney, J.1    Anderson, D.2
  • 87
    • 61849118067 scopus 로고    scopus 로고
    • Human prostate supports more efficient replication of HIV-1 R5 than X4 strains ex vivo
    • Le Tortorec A, Satie A-P, Denis H, Rioux-Leclercq N, Havard L, Ruffault A, et al. Human prostate supports more efficient replication of HIV-1 R5 than X4 strains ex vivo. Retrovirology. 2008;5: 119. doi: 10.1186/1742-4690-5-119 19117522
    • (2008) Retrovirology , vol.5 , pp. 119
    • Le Tortorec, A.1    Satie, A.-P.2    Denis, H.3    Rioux-Leclercq, N.4    Havard, L.5    Ruffault, A.6
  • 88
    • 84929629839 scopus 로고    scopus 로고
    • Detection of Simian Immunodeficiency Virus in Semen, Urethra, and Male Reproductive Organs during Efficient Highly Active Antiretroviral Therapy
    • Matusali G, Dereuddre-Bosquet N, Le Tortorec A, Moreau M, Satie A-P, Mahé D, et al. Detection of Simian Immunodeficiency Virus in Semen, Urethra, and Male Reproductive Organs during Efficient Highly Active Antiretroviral Therapy. J Virol. 2015;89: 5772–87. doi: 10.1128/JVI.03628-14 25833047
    • (2015) J Virol , vol.89 , pp. 5772-5787
    • Matusali, G.1    Dereuddre-Bosquet, N.2    Le Tortorec, A.3    Moreau, M.4    Satie, A.-P.5    Mahé, D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.