In vivo anti-inflammatory effect of H1 antihistamines in allergic rhinitis: A randomized clinical trial

Balkan Medical Journal

Volumn 32, Issue 4, 2015, Pages 352-358

  Bocşan, Corina I ^a   Bujor, Adriana I ^a   Miron, Nicolae ^a   Vesa, Ştefan C ^a   Deleanu, Diana ^a   Buzoianu, Anca D ^a  

^a IULIU HATIEGANU UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

Author keywords

Allergic rhinitis; Cytokines; Histamine H1 antagonists

Indexed keywords

DESLORATADINE; IMMUNOGLOBULIN E; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; LEVOCETIRIZINE; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTHMA; CONTROLLED STUDY; FEMALE; HOUSE DUST ALLERGY; HUMAN; IMMUNOGLOBULIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; NOSE OBSTRUCTION; OCULAR PRURITUS; PERENNIAL RHINITIS; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; RHINORRHEA; SENSITIZATION; SNEEZING; SYMPTOM; TREATMENT DURATION;

EID: 84943544652     PISSN: 21463123     EISSN: 21463131     Source Type: Journal    
DOI: 10.5152/balkanmedj.2015.15884     Document Type: Article

References (30)

1. Bousquet J, Khaltaev N, Cruz AA, Denburg J, Fokkens WJ, Togias A, et al; World Health Organization; GA(2)LEN; AllerGen. Allergic rhinitis and its impact on asthma. Allergy 2008;63(Suppl 86):8-160.
2. Bauchau V, Durham SR. Prevalence and rate of diagnosis of allergic rhinitis in Europe. Eur Respir J 2004;24:758-64.
3. Leynaert B, Neukirch C, Kony S, Guénégou A, Bousquet J, Aubier M, et al. Association between asthma and rhinitis according to atopic sensitization in a population-based study. J Allergy Clin Immunol 2004;113:86-93.
4. Min YG. The pathophysiology, diagnosis and treatment of allergic rhinitis. Allergy Asthma Immunol Res 2010;2:65-76.
5. Okayama Y, Kawakami T. Development, migration, and survival of mast cells. Immunol Res 2006;34:97-115.
6. Prussin C, Metcalfe DD. IgE, mast cells, basophils, and eosinophils. J Allergy Clin Immunol 2003;111(Suppl 2):S486-94.
7. Amin K. The role of mast cells in allergic inflammation. Respir Med 2012;106:9-14.
8. Bradding P, Roberts JA, Britten KM, Montefort S, Djukanovic R, Mueller R, et al. Interleukin-4, -5, and -6 and tumor necrosis factor-alpha in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines. Am J Respir Cell Mol Biol 1994;10:471-80.
9. Bradding P. The role of the mast cell in asthma: a reassessment. Curr Opin Allergy Clin Immunol 2003;3:45-50.
10. Lee NA, Gelfand EW, Lee JJ. Pulmonary T cells and eosinophils: conspirators or independent triggers of allergic respiratory pathology? J Allergy Clin Immunol 2001;107:945-57.
11. Wagenmann M, Schumacher L, Bachert C. The time course of the bilateral release of cytokines and mediators after unilateral nasal allergen challenge. Allergy 2005;60:1132-8.
12. Ohkubo K, Ikeda M, Pawankar R, Gotoh M, Yagi T, Okuda M. Mechanisms of IL-6, IL-8, and GM-CSF release in nasal secretions of allergic patients after nasal challenge. Rhinology 1998;36:156-61.
13. Bachert C, van Kempen M, van Cauwenberge P. Regulation of proinflammatory cytokines in seasonal allergic rhinitis. Int Arch Allergy Immunol 1999;118:375-9.
14. Benson M, Wennergren G, Fransson M, Cardell LO. Altered levels of the soluble IL-1, IL-4 and TNF receptors, as well as the IL-1 receptor antagonist, in intermittent allergic rhinitis. Int Arch Allergy Immunol 2004;134:227-32.
15. Bachert C, Wagenmann M, Hauser U. Proinflammatory cytokines: measurement in nasal secretion and induction of adhesion receptor expression. Int Arch Allergy Immunol 1995;107:106-8.
16. Bachert C. A review of the efficacy of desloratadine, fexofenadine, and levocetirizine in the treatment of nasal congestion in patients with allergic rhinitis. Clin Ther 2009;31:921-44.
17. Ciprandi G, Cirillo I, Vizzaccaro A, Tosca MA. Levocetirizine improves nasal obstruction and modulates cytokines pattern in patients with seasonal allergic rhinitis: a pilot study. Clin Exp Allergy 2004;34:958-64.
18. Heinzerling L, Mari A, Bergmann KC, Bresciani M, Burbach G, Darsow U, et al. The skin prick test - European standards. Clin Transl Allergy 2013;3:3.
19. Ciprandi G, Cirillo I, Vizzaccaro A, Civardi E, Barberi S, Allen M, et al. Desloratadine and Levocetirizine improve nasal symptoms, airflow, and allergic inflammation in patients with perennial allergic rhinitis: a pilot study. Int Immunopharmacol 2005;5:1800-8.
20. Gosset P, Tillie-Leblond I, Malaquin F, Durieu J, Wallaert B, Tonnel AB. Interleukin-8 secretion in patients with allergic rhinitis after an allergen challenge: interleukin-8 is not the main chemotactic factor present in nasal lavages. Clin Exp Allergy 1997;27:379-88.
21. Gröger M, Klemens C, Wendt S, Becker S, Canis M, Havel M, et al. Mediators and cytokines in persistent allergic rhinitis and nonallergic rhinitis with eosinophilia syndrome. Int Arch Allergy Immunol 2012;159:171-8.
22. Maiti R, Rahman J, Jaida J, Allala U, Palani A. Rupatadine and levocetirizine for seasonal allergic rhinitis: a comparative study of efficacy and safety. Arch Otolaryngol Head Neck Surg 2010;136:796-800.
23. Deruaz C, Leimgruber A, Berney M, Pradervand E, Spertini F. Levocetirizine better protects than desloratadine in a nasal provocation with allergen. J Allergy Clin Immunol 2004;113:669-76.
24. Leurs R, Church MK, Taglialatela M. H1-antihistamines: inverse agonism, anti-inflammatory actions and cardiac effects. Clin Exp Allergy 2002;32:489-98.
25. Gillard M, Christophe B, Wels B, Peck M, Massingham R, Chatelain P. H1 antagonists: receptor affinity versus selectivity. Inflamm Res 2003;52(Suppl 1):S49-50.
26. Tworek D, Bocheńska-Marciniak M, Kupczyk M, Górski P, Kuna P. The effect of 4 weeks treatment with desloratadine (5mg daily) on levels of interleukin (IL)-4, IL-10, IL-18 and TGF beta in patients suffering from seasonal allergic rhinitis. Pulm Pharmacol Ther 2007;20:244-9.
27. Reinartz SM, Overbeek SE, Kleinjan A, van Drunen CM, Braunstahl GJ, Hoogsteden HC, et al. Desloratadine reduces systemic allergic inflammation following nasal provocation in allergic rhinitis and asthma patients. Allergy 2005;60:1301-7.
28. Valero A, Justicia JL, Anton E, Dordal T, Fernández-Parra B, Lluch M, et al. Epidemiology of allergic rhinitis caused by grass pollen or house-dust mites in Spain. Am J Rhinol Allergy 2011;25:e123-8.
29. Sala-Cunill A, Bartra J, Dalmau G, Tella R, Botey E, Raga E, et al; Comitè de Allergia. Prevalence of asthma and severity of allergic rhinitis comparing 2 perennial allergens: house dust mites and Parietaria judaica pollen. J Investig Allergol Clin Immunol 2013;23:145-51.
30. Sohn SW, Lee HS, Park HW, Chang YS, Kim YK, Cho SH, et al. Evaluation of cytokine mRNA in induced sputum from patients with allergic rhinitis: relationship to airway hyperresponsiveness. Allergy 2008;63:268-73.