Hyperhomocysteinemia: A missing link to dysfunctional HDL via paraoxanase-1

Canadian Journal of Physiology and Pharmacology

Volumn 93, Issue 9, 2015, Pages 755-763

  Givvimani, Srikanth ^a   Kundu, Sourav ^a   Pushpakumar, Sathnur ^a   Doyle, Vivian ^a   Narayanan, Nithya ^a   Winchester, Lee J ^a   Veeranki, Sudhakar ^a   Metreveli, Naira ^a   Tyagi, Suresh C ^a  

^a University of Louisville School of Medicine   (United States)

Author keywords

Akt; Atherosclerosis; Cx 37 and 40; eNOS; Homocysteine; MMP 9

Indexed keywords

CONNEXIN 37; CONNEXIN 40; DIMETHYL AMINO HYDROLASE 2; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENZYME; GAP JUNCTION PROTEIN; GELATINASE B; HIGH DENSITY LIPOPROTEIN; HOMOCYSTEINE; HYDROLASE; N(G),N(G) DIMETHYLARGININE; PARAOXANASE 1; PROTEIN KINASE B; UNCLASSIFIED DRUG; AMIDASE; ARGININE; ARYLDIALKYLPHOSPHATASE; DIMETHYLARGININASE; N,N-DIMETHYLARGININE; NOS3 PROTEIN, MOUSE; PON1 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROGENIC DIET; ATHEROSCLEROSIS; CONTROLLED STUDY; DISORDERS OF LIPOPROTEIN METABOLISM; HEART LEFT VENTRICLE FUNCTION; HEART VENTRICLE FUNCTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPERHOMOCYSTEINEMIA; MEAN ARTERIAL PRESSURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSTHORACIC ECHOCARDIOGRAPHY; VASCULAR REMODELING; ANALOGS AND DERIVATIVES; ANIMAL; BIOSYNTHESIS; BLOOD; BLOOD PRESSURE; CHEMICALLY INDUCED; DEFICIENCY; FIBROSIS; GENETICS; KNOCKOUT MOUSE; MALE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; VASCULAR ENDOTHELIUM;

AMIDOHYDROLASES; ANIMALS; ARGININE; ARYLDIALKYLPHOSPHATASE; ATHEROSCLEROSIS; BLOOD PRESSURE; CONNEXINS; DIET, ATHEROGENIC; ENDOTHELIUM, VASCULAR; FIBROSIS; HYPERHOMOCYSTEINEMIA; LIPOPROTEINS, HDL; MALE; MATRIX METALLOPROTEINASE 9; MICE; MICE, KNOCKOUT; NITRIC OXIDE SYNTHASE TYPE III; PROTO-ONCOGENE PROTEINS C-AKT; VENTRICULAR DYSFUNCTION, LEFT;

EID: 84943518203     PISSN: 00084212     EISSN: 12057541     Source Type: Journal    
DOI: 10.1139/cjpp-2014-0491     Document Type: Article

References (30)

1. Assanasen, C., Mineo, C., Seetharam, D., Yuhanna, I. S., Marcel, Y. L., Connelly, M. A., et al. 2005. Cholesterol binding, efflux, and a PDZ-interacting domain of scavenger receptor-BI mediate HDL-initiated signaling. J. Clin. Invest. 115(4): 969-977. doi:10.1172/JCI23858, 10.1172/JCI200523858.PMID: 15841181.
2. Bao, X. M., Wu, C. F., and Lu, G. P. 2010. Atorvastatin inhibits homocysteineinduced dysfunction and apoptosis in endothelial progenitor cells. Acta Pharmacol. Sin. 31(4): 476-484. doi:10.1038/aps.2010.22.PMID:20305681.
3. Bonetti, P. O., Lerman, L. O., and Lerman, A. 2003. Endothelial dysfunction: a marker of atherosclerotic risk. Arterioscler. Thromb. Vasc. Biol. 23(2): 168- 175. doi:10.1161/01.ATV.0000051384.43104.FC.PMID:12588755.
4. Calabresi, L., Gomaraschi, M., and Franceschini, G. 2003. Endothelial protection by high-density lipoproteins: from bench to bedside. Arterioscler. Thromb. Vasc. Biol. 23(10): 1724-1731. doi:10.1161/01.ATV.0000094961.74697.54.PMID: 12969988.
5. Eren, E., Yilmaz, N., and Aydin, O. 2013. Functionally defective high-density lipoprotein and paraoxonase: a couple for endothelial dysfunction in atherosclerosis. Cholesterol, 2013: 792090. doi:10.1155/2013/792090.PMID:24222847.
6. Fernandez-Hernando, C., Ackah, E., Yu, J., Suarez, Y., Murata, T., Iwakiri, Y., et al. 2007. Loss of Akt1 leads to severe atherosclerosis and occlusive coronary artery disease. Cell Metab. 6(6): 446-457. doi:10.1016/j.cmet.2007.10.007. PMID:18054314.
7. Ferretti, G., Bacchetti, T., Marotti, E., and Curatola, G. 2003. Effect of homocysteinylation on human high-density lipoproteins: a correlation with paraoxonase activity. Metabolism, 52(2): 146-151. doi:10.1053/meta.2003.50033. PMID:12601623.
8. Givvimani, S., Narayanan, N., Armaghan, F., Pushpakumar, S., and Tyagi, S. C. 2013. Attenuation of conducted vasodilation in skeletal muscle arterioles during hyperhomocysteinemia. Pharmacology, 91(5-6): 287-296. doi:10.1159/ 000350394. PMID:23736684.
9. Gotlieb, A. I. 2005. Atherosclerosis and acute coronary syndromes. Cardiovasc. Pathol. 14(4): 181-184. doi:10.1016/j.carpath.2005.03.007.PMID:16009315.
10. Jakubowski, H. 1997. Metabolism of homocysteine thiolactone in human cell cultures. Possible mechanism for pathological consequences of elevated homocysteine levels. J. Biol. Chem. 272(3): 1935-1942. PMID:8999883.
11. Jakubowski, H. 2006. Pathophysiological consequences of homocysteine excess. J. Nutr. 136(6 Suppl.): 1741S-1749S. PMID:16702349.
12. Kumar, A. 2014. Correlation of serum paraoxonase activities in known cases of 130 elderly hypertensive South Asian aged 56-64 years: a hospital based study. Asian Pac. J. Trop. Dis. 4(Suppl. 1): S330-S335. doi:10.1016/S2222- 1808(14)60465-5.
13. Kwak, B. R., Mulhaupt, F., Veillard, N., Gros, D. B., and Mach, F. 2002. Altered pattern of vascular connexin expression in atherosclerotic plaques. Arterioscler. Thromb. Vasc. Biol. 22(2): 225-230. doi:10.1161/hq0102.104125.PMID: 11834520.
14. Li, D., and Mehta, J. L. 2003. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors protect against oxidized low-density lipoprotein-induced endothelial dysfunction. Endothelium, 10(1): 17-21. doi:10.1080/10623320303355. PMID:12699073.
15. Liu, L. H., Guo, Z., Feng, M., Wu, Z. Z., He, Z. M., and Xiong, Y. 2012. Protection of DDAH2 overexpression against homocysteine-induced impairments of DDAH/ADMA/NOS/NO pathway in endothelial cells. Cell. Physiol. Biochem. 30(6): 1413-1422. doi:10.1159/000343329.PMID:23171931.
16. Marsillach, J., Camps, J., Ferre, N., Beltran, R., Rull, A., Mackness, B., et al. 2009. Paraoxonase-1 is related to inflammation, fibrosis and PPAR delta in experimental liver disease. BMC Gastroenterol. 9: 3. doi:10.1186/1471-230X-9-3. PMID:19144177.
17. Mineo, C., Yuhanna, I. S., Quon, M. J., and Shaul, P. W. 2003. High density lipoprotein-induced endothelial nitric-oxide synthase activation is mediated by Akt and MAP kinases. J. Biol. Chem. 278(11): 9142-9149. doi:10.1074/jbc. M211394200. PMID:12511559.
18. Mudau, M., Genis, A., Lochner, A., and Strijdom, H. 2012. Endothelial dysfunction: the early predictor of atherosclerosis. Cardiovasc. J. Afr. 23(4): 222-231. doi:10.5830/CVJA-2011-068.PMID:22614668.
19. Munjal, C., Givvimani, S., Qipshidze, N., Tyagi, N., Falcone, J. C., and Tyagi, S. C. 2011. Mesenteric vascular remodeling in hyperhomocysteinemia. Mol. Cell. Biochem. 348(1-2): 99-108. doi:10.1007/s11010-010-0643-y.PMID:21076854.
20. Narayanan, N., Pushpakumar, S. B., Givvimani, S., Kundu, S., Metreveli, N., James, D., et al. 2014. Epigenetic regulation of aortic remodeling in hyperhomocysteinemia. FASEB J. 28(8): 3411-3422. doi:10.1096/fj.14-250183.PMID: 24739303.
21. Perla-Kajan, J., and Jakubowski, H. 2010. Paraoxonase 1 protects against protein N-homocysteinylation in humans. FASEB J. 24(3): 931-936. doi:10.1096/fj.09- 144410. PMID:19880629.
22. Pfenniger, A., Chanson, M., and Kwak, B. R. 2013. Connexins in atherosclerosis. Biochim. Biophys. Acta, 1828(1): 157--166.
23. Shih, D. M., Gu, L., Xia, Y. R., Navab, M., Li, W. F., Hama, S., et al. 1998. Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis. Nature, 394(6690): 284-287. doi:10.1038/28406.PMID:9685159.
24. Shih, D. M., Xia, Y. R., Wang, X. P., Miller, E., Castellani, L. W., Subbanagounder, G., et al. 2000. Combined serum paraoxonase knockout/apolipoprotein E knockout mice exhibit increased lipoprotein oxidation and atherosclerosis. J. Biol. Chem. 275(23): 17527-17535. doi:10.1074/jbc.M910376199.PMID:10748217.
25. -/- mice. Am. J. Physiol. Lung Cell. Mol. Physiol. 299(3): L301-L311. doi:10.1152/ajplung.00065. 2010. PMID:20581102.
26. Tward, A., Xia, Y. R., Wang, X. P., Shi, Y. S., Park, C., Castellani, L. W., et al. 2002. Decreased atherosclerotic lesion formation in human serum paraoxonase transgenic mice. Circulation, 106(4): 484-490. doi:10.1161/01.CIR.0000023623. 87083. 4F. PMID:12135950.
27. Tyagi, S. C. 1999. Homocyst(e)ine and heart disease: pathophysiology of extracellular matrix. Clin. Exp. Hypertens. 21(3): 181-198. doi:10.3109/10641969909068660. PMID:10225475.
28. Xie, H. N., Guo, H., Wang, C. C., Wang, H. Q., Li, Y., and Li, W. M. 2011. [Role of homocysteine in the pathogenesis of alcoholic cardiomyopathy]. Zhonghua Yi Xue Za Zhi, 91(4): 272-276. PMID:21418875. [In Chinese].
29. Yan, T. T., Li, Q., Zhang, X. H., Wu, W. K., Sun, J., Li, L., et al. 2010. Homocysteine impaired endothelial function through compromised vascular endothelial growth factor/Akt/endothelial nitric oxide synthase signalling. Clin. Exp. Pharmacol. Physiol. 37(11): 1071-1077. doi:10.1111/j.1440-1681.2010.05438.x. PMID:20698860.
30. Yuhanna, I. S., Zhu, Y., Cox, B. E., Hahner, L. D., Osborne-Lawrence, S., Lu, P., et al. 2001. High-density lipoprotein binding to scavenger receptor-BI activates endothelial nitric oxide synthase. Nat. Med. 7(7): 853-857. doi:10.1038/89986. PMID:11433352.