A prospective, observational pilot study of the use of urinary antimicrobial peptides in diagnosing emergency department patients with positive urine cultures

Academic Emergency Medicine

Volumn 22, Issue 10, 2015, Pages 1226-1230

  Caterino, Jeffrey M ^a   Hains, David S ^b   Camargo, Carlos A ^c   Quraishi, Sadeq A ^c   Saxena, Vijay ^d   Schwaderer, Andrew L ^d  

^a THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d NATIONWIDE CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA DEFENSIN; BETA DEFENSIN 2; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; HUMAN ALPHA DEFENSIN 5; HUMAN NEUTROPHIL PEPTIDE 1-3; POLYPEPTIDE ANTIBIOTIC AGENT; UNCLASSIFIED DRUG; VITAMIN D;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; EMERGENCY PATIENT; EMERGENCY WARD; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HIGH RISK PATIENT; HUMAN; MALE; OBSERVATIONAL STUDY; PILOT STUDY; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN EXPRESSION; PROTEIN URINE LEVEL; URINARY TRACT INFECTION; URINE CULTURE; AREA UNDER THE CURVE; HOSPITAL EMERGENCY SERVICE; MICROBIOLOGICAL EXAMINATION; MIDDLE AGED; NONPARAMETRIC TEST; PROCEDURES; RECEIVER OPERATING CHARACTERISTIC; SENSITIVITY AND SPECIFICITY; URINALYSIS; URINARY TRACT INFECTIONS; URINE;

ADULT; AGED; ALPHA-DEFENSINS; AREA UNDER CURVE; EMERGENCY SERVICE, HOSPITAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; MALE; MICROBIOLOGICAL TECHNIQUES; MIDDLE AGED; PILOT PROJECTS; PROSPECTIVE STUDIES; ROC CURVE; SENSITIVITY AND SPECIFICITY; STATISTICS, NONPARAMETRIC; URINALYSIS; URINARY TRACT INFECTIONS;

EID: 84943455354     PISSN: 10696563     EISSN: 15532712     Source Type: Journal    
DOI: 10.1111/acem.12770     Document Type: Article

References (10)

1. Caterino JM, Ting SA, Sisbarro SG, Espinola JA, Camargo CA Jr,. Age, nursing home residence, and presentation of urinary tract infection in U.S. emergency departments, 2001-2008. Acad Emerg Med 2012; 19: 1173-80.
2. Ducharme J, Neilson S, Ginn JL,. Can urine cultures and reagent test strips be used to diagnose urinary tract infection in elderly emergency department patients without focal urinary symptoms? CJEM 2007; 9: 87-92.
3. Lammers RL, Gibson S, Kovacs D, Sears W, Strachan G,. Comparison of test characteristics of urine dipstick and urinalysis at various test cutoff points. Ann Emerg Med 2001; 38: 505-12.
4. Zasloff M,. Antimicrobial peptides, innate immunity, and the normally sterile urinary tract. J Am Soc Nephrol 2007; 18: 2810-6.
5. Spencer JD, Schwaderer AL, Becknell B, Watson J, Hains DS,. The innate immune response during urinary tract infection and pyelonephritis. Pediatr Nephrol 2014; 29: 1139-49.
6. Chromek M, Slamova Z, Bergman P, et al., The antimicrobial peptide cathelicidin protects the urinary tract against invasive bacterial infection. Nature Med 2006; 12: 636-41.
7. Hooton TM, Roberts PL, Cox ME, Stapleton AE,. Voided midstream urine culture and acute cystitis in premenopausal women. N Engl J Med 2013; 369: 1883-91.
8. Hooton TM, Bradley SF, Cardenas DD, et al., Diagnosis, prevention, and treatment of catheter-associated urinary tract infection in adults: 2009 International Clinical Practice Guidelines from the Infectious Diseases Society of America. Clin Infect Dis 2010; 50: 625-63.
9. Hlatky MA, Greenland P, Arnett DK, et al., Criteria for evaluation of novel markers of cardiovascular risk: a scientific statement from the American Heart Association. Circulation 2009; 119: 2408-16.
10. van der Starre WE, van Nieuwkoop C, Thomson U, et al., Urinary proteins, vitamin D and genetic polymorphisms as risk factors for febrile urinary tract infection and relation with bacteremia: a case control study. PLoS One 2015; 10: e0121302.