Combined targeting of high-mobility group box-1 and interleukin-8 to control micrometastasis potential in gastric cancer

International Journal of Cancer

Volumn 137, Issue 7, 2015, Pages 1598-1609

  Chung, Hye Won ^a   Jang, Sunphil ^a   Kim, Hoguen ^b   Lim, Jong Baeck ^a  

^a Yonsei University College of Medicine   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

Author keywords

EMT; gastric cancer; HMGB1; IL 8; metastasis

Indexed keywords

ADVANCED GLYCATION END PRODUCT RECEPTOR; HIGH MOBILITY GROUP B1 PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; HMGB1 PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE; MOK PROTEIN, HUMAN; TUMOR ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GROWTH; CELL INVASION; CELL MOTILITY; CONTROLLED STUDY; DRUG TARGETING; EPITHELIAL MESENCHYMAL TRANSITION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MAJOR CLINICAL STUDY; MALE; MICROMETASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; STOMACH CANCER; STOMACH CARCINOGENESIS; TUMOR XENOGRAFT; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; BLOOD; GENETIC TRANSFECTION; GENETICS; METABOLISM; MOLECULARLY TARGETED THERAPY; NUDE MOUSE; PATHOLOGY; SIGNAL TRANSDUCTION; STOMACH TUMOR; TUMOR CELL LINE; XENOGRAFT;

ANIMALS; ANTIGENS, NEOPLASM; CELL LINE, TUMOR; EPITHELIAL-MESENCHYMAL TRANSITION; HETEROGRAFTS; HMGB1 PROTEIN; HUMANS; INTERLEUKIN-8; MALE; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED BALB C; MICE, NUDE; MITOGEN-ACTIVATED PROTEIN KINASES; MOLECULAR TARGETED THERAPY; NEOPLASM MICROMETASTASIS; NF-KAPPA B; STOMACH NEOPLASMS; TRANSFECTION;

EID: 84943425276     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.29539     Document Type: Article

References (35)

1. Kalluri R, Weinberg RA,. The basics of epithelial-mesenchymal transition. J Clin Invest 2009; 119: 1420-8.
2. Thiery JP,. Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2002; 2: 442-54.
3. Rhim AD, Mirek ET, Aiello NM, et al., EMT and dissemination precede pancreatic tumor formation. Cell 2012; 148: 349-61.
4. Gretschel S, Siegel R, Estévez-Schwarz L, et al., Surgical strategies for gastric cancer with synchronous peritoneal carcinomatosis. Br J Surg 2006; 93: 1530-5.
5. Kim MA, Lee HS, Lee HE, et al., Prognostic importance of epithelial-mesenchymal transition-related protein expression in gastric carcinoma. Histopathology 2009; 54: 442-51.
6. Yoo YA, Kang MH, Lee HJ, et al., Sonic hedgehog pathway promotes metastasis and lymphangiogenesis via activation of akt, EMT, and MMP-9 pathway in gastric cancer. Cancer Res 2011; 71: 7061-70.
7. Yin Y, Grabowska AM, Clarke PA, et al., Helicobacter pylori potentiates epithelial mesenchymal transition in gastric cancer: links to soluble HB-EGF, gastrin and matrix metalloproteinase-7. Gut 2010; 59: 1037-45.
8. Mignogna MD, Fedele S, Lo Russo L, et al., Immune activation and chronic inflammation as the cause of malignancy in oral lichen planus: is there any evidence? Oral Oncol 2004; 40: 120-30.
9. Nannuru KC, Singh RK,. Tumor-stromal interactions in bone metastasis. Curr Osteoporos Rep 2010; 8: 105-13.
10. Birchmeier W, Behrens J,. Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness. Biochim Biophys Acta 1994; 1198: 11-26.
11. Chung HW, Jang S, Lim JB,. Clinical implications and diagnostic usefulness of correlation between soluble major histocompatibility complex class I chain-related molecule and protumorigenic cytokines in pancreatic ductal adenocarcinoma. Cancer 2013; 119: 233-44.
12. Wu Y, Zhou BP,. Inflammation: a driving force speeds cancer metastasis. Cell Cycle 2009; 8: 3267-73.
13. Fernando RI, Castillo MD, Litzinger M, et al., IL-8 signaling plays a critical role in the epithelial-mesenchymal transition of human carcinoma cells. Cancer Res 2011; 71: 5296-306.
14. Matsuo Y, Ochi N, Sawai H, et al., Cxcl8/IL-8 and cxcl12/SDF-1alpha co-operatively promote invasiveness and angiogenesis in pancreatic cancer. Int J Cancer 2009; 124: 853-61.
15. Lotze MT, Tracey KJ,. High-mobility group box 1 protein (hmgb1): nuclear weapon in the immune arsenal. Nat Rev Immunol 2005; 5: 331-42.
16. Tang D, Kang R, Zeh HJ, III, et al., High-mobility group box 1 and cancer. Biochim Biophys Acta 2010; 1799: 131-40.
17. Taguchi A, Blood DC, del Toro G, et al., Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases. Nature 2000; 405: 354-60.
18. Schlueter C, Weber H, Meyer B, et al., Angiogenetic signaling through hypoxia: HMGB1: an angiogenetic switch molecule. Am J Pathol 2005; 166: 1259-63.
19. Palumbo R, Sampaolesi M, De Marchis F, et al., Extracellular HMGB1, a signal of tissue damage, induces mesoangioblast migration and proliferation. J Cell Biol 2004; 164: 441-9.
20. Chung HW, Lee SG, Kim H, et al., Serum high mobility group box-1 (hmgb1) is closely associated with the clinical and pathologic features of gastric cancer. J Transl Med 2009; 7: 38-48.
21. Correa P,. Human gastric carcinogenesis: a multistep and multifactorial process-first American Cancer Society Award lecture on cancer epidemiology and prevention. Cancer Res 1992; 52: 6735-40.
22. Kuniyasu H, Oue N, Wakikawa A, et al., Expression of receptors for advanced glycation end-products (RAGE) is closely associated with the invasive and metastatic activity of gastric cancer. J Pathol 2002; 196: 163-70.
23. Ku JL, Park JG,. Biology of SNU cell lines. Cancer Res Treat 2005; 37: 1-19.
24. Rosivatz E, Becker I, Specht K, et al., Differential expression of the epithelial-mesenchymal transition regulators Snail, Sip1, and Twist in gastric cancer. Am J Pathol 2002; 161: 1881-91.
25. Bolós V, Peinado H, Pérez-Moreno MA, et al., The transcription factor slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and e47 repressors. J Cell Sci 2003; 116: 499-511.
26. Li CW, Xia W, Huo L, et al., Epithelial-mesenchymal transition induced by TNF-α requires NF-κB-mediated transcriptional upregulation of Twist1. Cancer Res 2012; 72: 1290-300.
27. Sims GP, Rowe DC, Rietdijk ST, et al., HMGB1 and RAGE in inflammation and cancer. Annu Rev Immunol 2010; 28: 367-88.
28. Zhang L, Chen W, Li X,. A novel anticancer effect of butein: inhibition of invasion through the erk1/2 and NF-kappa B signaling pathways in bladder cancer cells. FEBS Lett 2008; 582: 1821-8.
29. Hwang WL, Yang MH, Tsai ML, et al., Snail regulates interleukin-8 expression, stem cell-like activity, and tumorigenicity of human colorectal carcinoma cells. Gastroenterology 2011; 141: 279-91.
30. Lynch J, Nolan S, Slattery C, et al., High-mobility group box protein 1: a novel mediator of inflammatory-induced renal epithelial-mesenchymal transition. Am J Nephrol 2010; 32: 590-602.
31. Andersson U, Wang H, Palmblad K, et al., High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes. J Exp Med 2000; 192: 565-70.
32. Kew RR, Penzo M, Habiel DM, et al., The IKKα-dependent NF-κB p52/RelB noncanonical pathway is essential to sustain a cxcl12 autocrine loop in cells migrating in response to HMGB1. J Immunol 2012; 188: 2380-6.
33. Konno H, Ohta M, Baba M, et al., The role of circulating IL-8 and VEGF protein in the progression of gastric cancer. Cancer Sci 2003; 94: 735-40.
34. Ning Y, Manegold PC, Hong YK, et al., Interleukin-8 is associated with proliferation, migration, angiogenesis and chemosensitivity in vitro and in vivo in colon cancer cell line models. Int J Cancer 2011; 128: 2038-49.
35. Dejean E, Foisseau M, Lagarrigue F, et al., ALK+ALCLs induce cutaneous, HMGB-1-dependent IL-8/cxcl8 production by keratinocytes through NF-κB activation. Blood 2012; 119: 4698-707.