Kynurenine causes vasodilation and hypotension induced by activation of KCNQ-encoded voltage-dependent K+ channels

Journal of Pharmacological Sciences

Volumn 129, Issue 1, 2015, Pages 31-37

  Sakakibara, Kensuke ^a   Feng, Guo Gang ^a   Li, Jiazheng ^a   Akahori, Takahiko ^a   Yasuda, Yoshitaka ^a   Nakamura, Emi ^a   Hatakeyama, Noboru ^a   Fujiwara, Yoshihiro ^a   Kinoshita, Hiroyuki ^a  

^a AICHI MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Hypotension; Kynurenine; Vasodilation; Voltage dependent K+ channels encoded by the KCNQ gene family

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; FAMPRIDINE; FLUPIRTINE; KYNURENINE; LINOPIRDINE; PHENYLEPHRINE; POTASSIUM CHANNEL KCNQ; VOLTAGE GATED POTASSIUM CHANNEL; INDOLE DERIVATIVE; POTASSIUM CHANNEL BLOCKING AGENT; PYRIDINE DERIVATIVE;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; FEMALE; GENE; HEMODYNAMICS; HUMAN; HUMAN TISSUE; HYPERPOLARIZATION; HYPOTENSION; KCNQ GENE; MALE; MODULATION; NONHUMAN; PROTEIN SYNTHESIS INHIBITION; RAT; VASCULAR SMOOTH MUSCLE; VASODILATATION; ANIMAL; ANTAGONISTS AND INHIBITORS; ARTERY; CHEMICALLY INDUCED; DOSE RESPONSE; DRUG EFFECTS; GENETICS; IN VITRO STUDY; PHYSIOLOGY; WISTAR RAT;

ANIMALS; ARTERIES; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; HYPOTENSION; IN VITRO TECHNIQUES; INDOLES; KYNURENINE; MALE; MUSCLE, SMOOTH, VASCULAR; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS, VOLTAGE-GATED; PYRIDINES; RATS, WISTAR; VASODILATION;

EID: 84943349588     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1016/j.jphs.2015.07.042     Document Type: Article

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