Concept and setup for intraoperative imaging of tumorous tissue via Attenuated Total Reflection spectrosocopy with Quantum Cascade Lasers

Progress in Biomedical Optics and Imaging - Proceedings of SPIE

Volumn 9412, Issue , 2015, Pages

  Geiger, Florian B ^a,b   Koerdel, Martin ^b   Schick, Anton ^b   Heimann, Axel ^c   Matiasek, Kaspar ^d   Herkommer, Alois M ^a  

^a UNIVERSITY OF STUTTGART   (Germany)

^b SIEMENS AG   (Germany)

^c JOHANNES GUTENBERG UNIVERSITY   (Germany)

^d UNIVERSITY OF MUNICH   (Germany)

Author keywords

Attenuated total reflection (ATR); Fourier transform infrared spectroscopy (FTIR); Hyperspectral imaging; Mid infrared (MIR) spectroscopy; Quantum cascade laser; Tissue differentiation; Tumor recognition

Indexed keywords

DIAGNOSIS; ELECTROMAGNETIC WAVE REFLECTION; FOURIER TRANSFORM INFRARED SPECTROSCOPY; INFRARED DEVICES; INFRARED SPECTROSCOPY; MEDICAL IMAGING; QUANTUM CASCADE LASERS; SEMICONDUCTOR LASERS; SPECTROSCOPY; TUMORS;

ATTENUATED TOTAL REFLECTIONS; HYPERSPECTRAL IMAGING; MID-INFRARED SPECTROSCOPY; TISSUE DIFFERENTIATION; TUMOR RECOGNITION;

TISSUE;

EID: 84943280005     PISSN: 16057422     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1117/12.2081837     Document Type: Conference Paper

References (65)

1. Mai, K., Yazdi, H., and Isotalo, P., "Resection margin status in lumpectomy specimens of infiltrating lobular carcinoma," Breast Cancer Research and Treatment 60, 29-33 (March 2000).
2. Lacroix, M., Abi-Said, D., Fourney, D., Gokaslan, Z., Shi, W., DeMonte, F., Lang, F., McCutcheon, I., Hassenbusch, S., Holland, E., Hess, K., Michael, C., Miller, D., and Sawaya, R., "A multivariate analysis of 416 patients with glioblastoma multiform: Prognosis, extent of resection, and survival," J. of Neurosurgery 95, 190-198 (August 2001).
3. Chagpar, A., Martin, R., Hagendoorn, L., Chao, C., and McMasters, K., "Lumpectomy margins are affected by tumor size and histologic subtype but not by biopsy technique," The American J. of Surgery 188, 399-402 (October 2004).
4. Kim, Y.-J., Bochem, N., Ketter, R., Henn, W., and Feiden, W., "Meningeome-multiparametrische risikostratifizierung und grading," Pathologe 29, 428-433 (September 2008).
5. Dener, C., Inan, A., Sen, M., and Demirci, S., "Interoperative frozen section for margin assessment in breast conserving energy," Scandinavian J. of Surgery 98(1), 34-40 (2009).
6. Stupp, R., Reni, M., Gatta, G., Mazzab, E., and Vecht, C., "Anaplastic astrocytoma in adults," Critical Reviews in Oncology/Hematology 63, 72-80 (2007).
7. Juhl, H., [Chirurgie], ch. 2, D. Henne-Bruns, B. Kremer, M. Dürig. 3. Auflage. Georg Thieme Verlag, Stuttgart (2008).
8. Jacobs, L., "Positive margins: The challenge continues for breast surgeons," Annals of Surgical Oncology 15, 1271-1272 (March 2008).
9. Stelling, A., Salzer, S., Kirsch, M., Sobottka, S., Geiger, K., Koch, E., Schackert, G., and Steiner, G., "Intraoperative optical diagnostics with vibrational spectroscopy," Analytical and Bioanalytical Chemistry 400, 2745-2753 (July 2011).
10. Gajjar, K., Heppenstall, L., Pang, W., Ashton, K., Trevisan, J., Patel, I., Llabjani, V., Stringfellow, H., Martin-Hirsch, P., Dawsonb, T., and Martin, F., "Diagnostic segregation of human brain tumours using fourier-transform infrared and/or raman spectroscopy coupled with discriminant analysis," Analytical Methods 5, 89-102 (September 2013).
11. Smitt, M. and Horst, K., "Association of clinical and pathologic variables with lumpectomy surgical margin status after preoperative diagnosis or excisional biopsy of invasive breast cancer," Annals of Surgical Oncology 14, 1040-1044 (March 2007).
12. Kirsch, M., Schackert, G., Salzer, R., and Krafft, C., "Raman spectroscopic imaging for in vivo detection of cerebral brain metastases," Analytical and Bioanalytical Chemistry 398, 1707-1713 (August 2010).
13. Diem, M., Mazur, A., Lenau, K., Schubert, J., Bird, B., Miljkovic, M., Krafft, C., and Popp, J., "Molecular pathology via ir and raman spectral imaging," J. of Biophotonics 6, 855-886 (December 2013).
14. Lu, G. and Fei, B., "Medical hyperspectral imaging: A review," J. of biomedical optics 19, 10901 (January 2014).
15. Moch, H., Komminoth, P., Zimmermann, D., Odermatt, B., Probst-Hensch, N., and Bopp, M., [Pathologie], ch. Pathologie: Aufgaben und Methoden (Kapitel 1), Hrsg.: W. Böcker, H. Denk, Ph. U. Heitz, H. Moch. Elsevier Urban & Fischer, München (2008).
16. Bhargava, R., "Towards a practical fourier transform infrared chemical imaging protocol for cancer histopathology," Analytical and Bioanalytical Chemistry 389, 1155-1169 (September 2007).
17. Helenon, O., Correas, J., Balleyguier, C., Ghouadni, M., and Cornud, F., "Ultrasound of renal tumors," European Radiology 11, 1890-1901 (October 2001).
18. Kramme, R., [Medizintechnik], Springer Medizin Verlag, 3 ed. (2007).
19. Afanasyeva, N., Kolyakov, S., Artioushenko, V., Sokolov, V., and Frank, G., "Minimally invasive and ex-vivo diagnostics of breast cancer tissues by fiber optic evanescent-wave fourier transform ir (few-ftir) spectroscopy," Proc. SPIE 3250, Optical Biopsy II, San Jose, CA, USA 3250, 140-147 (April 1998).
20. Wu, J., Xu, Y., Sun, C., Soloway, R., Xu, D., Wu, Q., Sun, K., Weng, S., and Xu, G., "Distinguishing malignant from normal oral tissues using ftir fiber-optic techniques," Biopolymers 62(4), 185-192 (2001).
21. Bindig, U., Wäsche, W., Zelianos, K., and Müller, G., "Fiber-optical and microscopic detection of malignant tissue by use of infrared spectrometry," Biomedical Optics 7, 100-108 (Januar 2002).
22. Bindig, U., Frank, F., Gersonde, I., Meinke, M., Zelianeos, K., Katzir, A., and Müller, G., "Fiber-optic and microscopic infrared biodiagnostics," Laser Physics 13(1), 96-105 (2003).
23. Bindig, U., Gersonde, I., Meinke, M., Becker, Y., and Müller, G., "Fibre-optic ir-spectroscopy for biomedical diagnostics," Spectroscopy: An Int. J. 17(2/3), 323-344 (2003).
24. Heise, H., Kuepper, L., Pittermann, W., and Stuecker, M., "Epidermal in vivo and in vitro studies by attenuated total reflection mid-infrared spectroscopy using flexible silver halide fibre-probes," J. of Molecular Structure 651-653, 127-132 (June 2003).
25. Li, Q.-B., Xu, Z., Zhang, N.-W., Zhang, L., Wang, F., Yang, L.-M., Wang, J.-S., Zhou, S., Zhang, Y.-F., Zhou, X.-S., Shi, J.-S., and J.-G., W., "In vivo and in situ detection of colorectal cancer using fourier transform infrared spectroscopy," World J. of Gastroenterology 11, 327-330 (Januar 2005).
26. Mackanos, M. and Contag, C., "Fiber-optic probes enable cancer detection with ftir spectroscopy," Trends in Biotechnology 28, 317-323 (June 2010).
27. Liu, Y., Xu, Y., Liu, Y., Zhang, Y., Wang, D., Xiu, D., Xu, Z., Zhou, X., Wu, J., and Ling, X., "Detection of cervical metastatic lymph nodes in papillary thyroid carcinoma by fourier transform infrared spectroscopy," British J. of Surgery 98, 380-384 (March 2011).
28. Steiner, G. and Kirsch, M., "Optical spectroscopic methods for intraoperative diagnosis," Analytical and Bioanalytical Chemistry 406, 21-25 (January 2014).
29. Yao, H., Shi, X., and Zhang, Y., "The use of ftir-atr spectrometry for evaluation of surgical resection margin in colorectal cancer: A pilot study of 56 samples," J. of Spectroscopy 2014, Article ID 213890, 1-4 (2011).
30. Yano, K., Ohoshima, S., Gotou, Y., Kumaido, K., Moriguchi, T., and Katayama, H., "Direct measurement of human lung cancerous and noncancerous tissues by fourier transform infrared microscopy: Can an infrared microscope be used as a clinical tool?," Analytical Biochemistry 287, 218-225 (Dezember 2000).
31. Lasch, P., Haensch, W., Lewis, E., Kidder, L., and Naumann, D., "Characterization of colorectal adenocarcinoma sections by spatially resolved ft-ir microspectroscopy," Appl. Spectroscopy 56(1), 1-9 (2002).
32. Chang, J.-I., Huang, Y.-B., Wu, P.-C., Chen, C.-C., Huang, S.-C., and Tsaib, Y.-H., "Characterization of human cervical precancerous tissue through the fourier transform infrared microscopy with mapping method," Gynecologic Oncology 91(3), 577-583 (2003).
33. Gazi, E., Dwyer, J., P., G., Ghanbari-Siahkali, A., Wade, A., Miyan, J., Lockyer, N., Vickerman, J., Clarke, N., Shanks, J., Scott, L., Hart, C., and Brown, M., "Applications of fourier transform infrared microspectroscopy in studies of benign prostate and prostate cancer. a pilot study.," J. of Pathology 201, 99-108 (September 2003).
34. Steiner, G., Shaw, A., Choo-Smith, L., Abuid, M., Schackert, G., Sobottka, S., Steller, W., Salzer, R., and Mantsch, H., "Distinguishing and grading human gliomas by ir spectroscopy," Biopolymers 72(6), 464-471 (2003).
35. Yano, K., Sakamoto, Y., Hirosawa, N., Tonooka, S., Katayama, H., Kumaido, K., and Satomi, A., "Applications of fourier transform infrared spectroscopy, fourier transform infrared microscopy and near-infrared spectroscopy to cancer research," Spectroscopy 17(2-3), 315-321 (2003).
36. Lasch, P., Wolfgang Haensch, W., Naumann, D., and Diem, M., "Imaging of colorectal adenocarcinoma using ft-ir microspectroscopy and cluster analysis," Biochimica et Biophysica Acta 1688, 176-186 (March 2004).
37. Wood, B., Chiriboga, L., Yee, H., Quinn, M., McNaughton, D., and Diem, M., "Fourier transform infrared (ftir) spectral mapping of the cervical transformation zone, and dysplastic squamous epithelium," Gynecologic Oncology 93, 59-68 (April 2004).
38. Beleitesa, C., Steiner, G., Sowab, M., Baumgartner, R., Sobottka, S., Schackertc, G., and Salzer, R., "Classification of human gliomas by infrared imaging spectroscopy and chemometric image processing," Vibrational Spectroscopy 38, 143-149 (July 2005).
39. Fernandez, D., Bhargava, R., Hewitt, S., and Levin, I., "Infrared spectroscopic imaging for histopathologic recognition," Nature Biotechnology 23, 469-474 (April 2005).
40. Amharref, N., Beljebbar, A., Dukic, S., Venteo, L., Schneider, L., Pluot, M., Vistelle, R., and Manfait, M., "Brain tissue characterisation by infrared imaging in a rat glioma model," Biochimica et Biophysica Acta 1758, 892-899 (July 2006).
41. Fabian, H., Thi, N., Eiden, M., Lasch, P., Schmitt, J., and Naumann, D., "Diagnosing benign and malignant lesions in breast tissue sections by using ir-microspectroscopy," Biochimica et Biophysica Acta 1758(7), 874-882 (2006).
42. Krafft, C., Sobottka, S., Geiger, K., Schackert, G., and Salzer, R., "Classification of malignant gliomas by infrared spectroscopic imaging and linear discriminant analysis," Analytical and Bioanalytical Chemistry 387, 1669-1677 (March 2007).
43. Beljebbar, A., Amharref, N., Leveques, A., Dukic, S., Venteo, L., Schneider, L., Pluot, M., and Manfait, M., "Modeling and quantifying biochemical changes in c6 tumor gliomas by fourier transform infrared imaging," Analytical Chemistry 80, 8406-8415 (November 2008).
44. Ali, K., Lu, Y., Christensen, C., May, T., Hyett, C., Griebel, R., Fourney, D., Meguro, K., Resch, L., and Sharma, R., "Fourier transform infrared spectromicroscopy and hierarchical cluster analysis of human meningiomas," Int. J. of Molecular Medicine 21, 297-301 (March 2008).
45. Bird, B., Bedrossian, K., Laver, N., Miljkovic, M., Romeo, M., and Diem, M., "Detection of breast micrometastases in axillary lymph nodes by infrared micro-spectral imaging," Analyst 134, 1067-1076 (April 2009).
46. Sobottka, S., Geiger, K., Salzer, R., Schackert, G., and Krafft, C., "Suitability of infrared spectroscopic imaging as an intraoperative tool in cerebral glioma surgery," Analytical and Bioanalytical Chemistry 393, 187-195 (January 2009).
47. Benard, A., Desmedt, C., Durbecq, V., Rouas, G., Larsimont, D., Sotiriou, C., and Goormaghtigh, E., "Discrimination between healthy and tumor tissues on formalin-fixed paraffin-embedded breast cancer samples using ir imaging," Spectroscopy 24(1-2), 67-72 (2010).
48. Travo, A., Piot, O., Wolthuis, R., Gobinet, C., Manfait, M., Bara, J., Forgue-Lafitte, M., and Jeannesson, P., "Ir spectral imaging of secreted mucus: A promising new tool for the histopathological recognition of human colonic adenocarcinomas," Histopathology 56, 921-931 (June 2010).
49. Nasse, M., Walsh, M., Mattson, E., Reininger, R., Kajdacsy-Balla, A., Macias, V., Bhargava, R., and Hirschmugl, C., "High-resolution fourier-transform infrared chemical imaging with multiple synchrotron beams," Nature Methods 8, 413-416 (March 2011).
50. Bird, B., Miljkovic, M., Remiszewski, S., Akalin, A., Kon, M., and Diem, M., "Infrared spectral histopathology (shp): A novel diagnostic tool for the accurate classification of lung cancer," Laboratory Investigation 92, 1358-1373 (September 2012).
51. Nallala, J., Piot, O., Diebold, M., Gobinet, C., Bouche, O., Manfait, M., and Sockalingum, G., "Infrared imaging as a cancer diagnostic tool: introducing a new concept of spectral barcodes for identifying molecular changes in colon tumors," Cytometry A 83, 294-300 (March 2013).
52. Das, K., Kendall, C., Isabelle, M., Fowler, C., Christie-Brown, J., and Stone, N., "Ftir of touch imprint cytology: A novel tissue diagnostic technique," J. of Photochemistry and Photobiology B 92, 160-164 (September 2008).
53. Siebert, F. and Hildebrandt, P., [Vibrational Spectroscopy in Life Science], Wiley-VCH Verlag, 1 ed. (2008).
54. Griffiths, P. and De Haseth, J., [Fourier Transform Infrared Spectrometry], Chemical Analysis: A Series of Monographs on Analytical Chemistry and Its Applications, John Wiley & Sons, 2 ed. (April 2007).
55. Fahrenfort, J., "A new principle for the production of useful infra-red reflection spectra of organic compounds," Spectrochimica Acta 17(7), 698-709 (1961).
56. Kazarian, S. and Chan, K., "Micro-and macro-attenuated total reflection fourier transform infrared spectroscopic imaging," Appl. Spectroscopy 64, 135A-152A (May 2010).
57. Milosevic, M., [Internal Reflection and ATR Spectroscopy], Chemical Analysis: A Series of Monographs on Analytical Chemistry and Its Applications, John Wiley & Sons, 1 ed. (Juni 2012).
58. Pleitez, M., von Lilienfeld-Toal, H., and Maentele, W., "Infrared spectroscopic analysis of human interstitial fluid in vitro and in vivo using ft-ir spectroscopy and pulsed quantum cascade lasers (qcl): Establishing a new approach to non invasive glucose measurement," Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 85, 61-65 (January 2012).
59. Brandstetter, M., Sumalowitsch, T., Genner, A., Posch, A., Herwig, C., Drolz, A., Fuhrmann, V., Perkmann, T., and Lendl, B., "Reagent-free monitoring of multiple clinically relevant parameters in human blood plasma using a mid-infrared quantum cascade laser based sensor system," Analyst 138, 4022-4028 (July 2013).
60. Bassan, P., Weida, M., Rowlette, J., and Gardner, P., "Large scale infrared imaging of tissue micro arrays (tmas) using a tunable quantum cascade laser (qcl) based microscope," Analyst 139, 3856-3859 (August 2014).
61. Kroeger, N., Egl, A., Engel, M., Gretz, N., Haase, K., Herpich, I., Kraenzlin, B., Neudecker, S., Pucci, A., Schoenhals, A., Vogt, J., and Petrich, W., "Quantum cascade laser-based hyperspectral imaging of biological tissue," J. of biomedical optics 19, 111607 (November 2014).
62. Levin, W. and Bhargava, R., "Fourier transform infrared vibrational spectroscopic imaging: integrating microscopy and molecular recognition," Annual Review of Physical Chemistry 56, 429-474 (2005).
63. Jackson, M., Choo, L., Watson, P., Halliday, W., and Mantsch, H., "Beware of connective tissue proteins: Assignment and implications of collagen absorptions in infrared spectra of human tissues," Biochimica et Biophysics Acta 1270, 1-6 (January 1995).
64. Wong, P., Papavassiliou, E., and Rigas, B., "Phosphodiester stretching bands in the infrared spectra of human tissues and cultured cells," Appl. Spectroscopy 45, 1563-1567 (September 1991).
65. Movasaghi, Z., Rehman, S., and Rehman, I., "Fourier transform infrared (ftir) spectroscopy of biological tissues," Applied Spectroscopy Reviews 43, 134-179 (February 2008).