Ancient Gunpowder and Novel Insights Team Up Against Heart Failure with Preserved Ejection Fraction

Journal of the American College of Cardiology

Volumn 66, Issue 15, 2015, Pages 1683-1686

  Paulus, Walter J ^a   Van Heerebeek, Loek ^a,b  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b ONZE LIEVE VROUWE GASTHUIS   (Netherlands)

Author keywords

nitrate; nitric oxide; nitrite

Indexed keywords

NITRITE; SODIUM NITRITE;

BODY MASS; CAUSAL ATTRIBUTION; COMORBIDITY; DRUG EFFECT; EXERCISE INTOLERANCE; HEART FAILURE WITH PRESERVED EJECTION FRACTION; HEART HEMODYNAMICS; HEART STROKE VOLUME; HUMAN; LUNG ARTERY PRESSURE; MICROANGIOPATHY; NOTE; OBESITY; PHYSICAL PARAMETERS; PRIORITY JOURNAL; SYSTEMIC VASCULAR RESISTANCE; DRUG EFFECTS; EXERCISE TOLERANCE; FEMALE; HEART FAILURE; HEART LEFT VENTRICLE FUNCTION; HEART VENTRICLE; MALE; PATHOPHYSIOLOGY;

EXERCISE TOLERANCE; FEMALE; HEART FAILURE; HEART VENTRICLES; HUMANS; MALE; SODIUM NITRITE; STROKE VOLUME; VENTRICULAR FUNCTION, LEFT;

EID: 84943275781     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2015.08.028     Document Type: Editorial

References (13)

1. B.A. Borlaug, K.E. Koepp, and V. Melenovsky Sodium nitrite improves exercise hemodynamics and ventricular performance in heart failure with preserved ejection fraction J Am Coll Cardiol 66 2015 1672 1682
2. R. Vanderpool, and M.T. Gladwin Harnessing the nitrate-nitrite-nitric oxide pathway for therapy of heart failure with preserved ejection fraction Circulation 131 2015 334 336
3. L. Van Heerebeek, N. Hamdani, I. Falcão-Pires, and et al. Low myocardial protein kinase G activity in heart failure with preserved ejection fraction Circulation 126 2012 830 839
4. W.J. Paulus, and C. Tschoepe A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation J Am Coll Cardiol 62 2013 263 271
5. W.J. Paulus Culprit mechanism(s) for exercise intolerance in heart failure with normal ejection fraction J Am Coll Cardiol 56 2010 864 866
6. B.A. Borlaug, T.P. Olson, C.S. Lam, and et al. Global cardiovascular reserve dysfunction in heart failure with preserved ejection fraction J Am Coll Cardiol 56 2010 845 854
7. M.T. Maeder, B.R. Thompson, H.P. Brunner-La Rocca, and et al. Hemodynamic basis of exercise limitation in patients with heart failure and normal ejection fraction J Am Coll Cardiol 56 2010 855 863
8. S.F. Mohammed, S. Hussain, S.A. Mirzayev, and et al. Coronary microvascular rarefaction and myocardial fibrosis in heart failure with preserved ejection fraction Circulation 131 2015 550 559
9. M.R. Zile, C.F. Baicu, J.S. Ikonomidis, and et al. Myocardial stiffness in patients with heart failure and a preserved ejection fraction: contributions of collagen and titin Circulation 131 2015 1247 1259
10. P. Mohan, D.L. Brutsaert, W.J. Paulus, and et al. Myocardial contractile response to nitric oxide and cGMP Circulation 93 1996 1223 1229
11. M. Santos, A.R. Opotowsky, A.M. Shah, and et al. Central cardiac limit to aerobic capacity in patients with exertional pulmonary venous hypertension: implications for heart failure with preserved ejection fraction Circ Heart Fail 8 2015 278 285
12. B.P. Dhakal, R. Malhotra, R.M. Murphy, and et al. Mechanisms of exercise intolerance in heart failure with preserved ejection fraction: the role of abnormal peripheral oxygen extraction Circ Heart Fail 8 2015 286 294
13. D.W. Kitzman, B. Nicklas, W.E. Kraus, and et al. Skeletal muscle abnormalities and exercise intolerance in older patients with heart failure and preserved ejection fraction Am J Physiol Heart Circ Physiol 306 2014 H1364 H1370