Kikuchi disease, macrophage activation syndrome, and systemic juvenile arthritis: A new case associated with a mutation in the perforin gene

Scandinavian Journal of Rheumatology

Volumn 44, Issue 5, 2015, Pages 429-430

  Marsili, M ^a   Nozzi, M ^a   Onofrillo, D ^b   Sieni, E ^c   Chiarelli, F ^a   Breda, L ^a  

^a UNIVERSITY OF CHIETI   (Italy)

^b SPIRITO SANTO HOSPITAL   (Italy)

^c UNIVERSITY OF FLORENCE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; CHOLESTEROL; CYCLOSPORIN; FERRITIN; HEMOGLOBIN; LACTATE DEHYDROGENASE; METHYLPREDNISOLONE; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; TRIACYLGLYCEROL; ANTIRHEUMATIC AGENT; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; PERFORIN;

ADOLESCENT; CASE REPORT; CHOLESTEROL BLOOD LEVEL; CORTICOSTEROID THERAPY; DISEASE ASSOCIATION; ERYTHROCYTE SEDIMENTATION RATE; FEMALE; FEVER; GENE; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERTRANSAMINASEMIA; JUVENILE RHEUMATOID ARTHRITIS; KIKUCHI DISEASE; LABORATORY TEST; LETTER; LEUKOCYTE COUNT; LYMPH NODE BIOPSY; LYMPHADENOPATHY; MACROPHAGE ACTIVATION SYNDROME; MONOCYTE; NUCLEAR MAGNETIC RESONANCE IMAGING; PERFORIN GENE; PRIORITY JOURNAL; PROTHROMBIN TIME; SYSTEMIC JUVENILE ARTHRITIS; TRIACYLGLYCEROL BLOOD LEVEL; ARTHRITIS, JUVENILE; GENETICS; HISTIOCYTIC NECROTIZING LYMPHADENITIS; MUTATION; SYNDROME; TREATMENT OUTCOME;

ADOLESCENT; ANTIRHEUMATIC AGENTS; ARTHRITIS, JUVENILE; FEMALE; HISTIOCYTIC NECROTIZING LYMPHADENITIS; HUMANS; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; MACROPHAGE ACTIVATION SYNDROME; MUTATION; PERFORIN; SYNDROME; TREATMENT OUTCOME;

EID: 84943256236     PISSN: 03009742     EISSN: 15027732     Source Type: Journal    
DOI: 10.3109/03009742.2015.1033009     Document Type: Letter

References (6)

1. Cheng CY, Sheng WH, Lo YC, Chung CS, Chen YC, Chang SC. Clinical presentations, laboratory results and outcomes of patients with Kikuchis disease: emphasis on the association between recurrent Kikuchis disease and autoimmune diseases. J Microbiol Immunol Infect 2010; 43: 366-71.
2. Ramanan AV, Wynn RF, Kelsey A, Baildam EM. Systemic juvenile idiopathic arthritis, Kikuchis disease and haemophagocytic lymphohistiocytosis-is there a link? Case report and literature review. Rheumatology (Oxford) 2003; 42: 596-8.
3. Lin YW, Horiuchi H, Ueda I, Nambu M. Recurrent hemophagocytic lymphohistiocytosis accompanied by Kikuchis disease. Leuk Lymphoma 2007; 48: 2447-51.
4. Lim GY, Cho B, Chung NG. Hemophagocytic lymphohistiocytosis preceded by Kikuchi disease in children. Pediatr Radiol 2008; 38: 756-61.
5. Ravelli A, Grom AA, Beherens EM, Cron RQ. Macrophage activation syndrome as part of systemic juvenile idiopathic arthritis: diagnosis, genetics, pathophysiology and treatment. Genes Immun 2012: 13:289-98.
6. Vastert SJ, van Wijk R, DUrbano LE, de Vooght KM, de Jager W, Ravelli A, et al. Mutations in the perforin gene can be linked to macrophage activation syndrome in patients with systemic onset juvenile idiopathic arthritis. Rheumatology (Oxford) 2010; 49: 441-9.