Analysis of tissue plasminogen activator eligibility by sex in the Greater Cincinnati/Northern Kentucky stroke study

Stroke

Volumn 46, Issue 3, 2015, Pages 717-721

  Madsen, Tracy E ^a   Khoury, Jane C ^b,c   Alwell, Kathleen A ^b   Moomaw, Charles J ^b   Kissela, Brett M ^b   De Los Rios La Rosa, Felipe ^b,d   Woo, Daniel ^b   Adeoye, Opeolu ^b   Flaherty, Matthew L ^b   Khatri, Pooja ^b   Ferioli, Simona ^b   Kleindorfer, Dawn ^b  

^a BROWN UNIVERSITY   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^c CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^d Department of Neurology Sanna Healthcare Network   (Peru)

Author keywords

Healthcare disparities; Hypertension; Sex characteristics; Stroke; Thrombolytic therapy

Indexed keywords

ALTEPLASE; ENALAPRIL; GLYCERYL TRINITRATE; LABETALOL; LISINOPRIL; FIBRINOLYTIC AGENT; TISSUE PLASMINOGEN ACTIVATOR;

AGED; ANTIHYPERTENSIVE THERAPY; ARTERIOVENOUS MALFORMATION; ARTICLE; BLACK PERSON; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; CONTINUOUS INFUSION; FEMALE; HEART INFARCTION; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; MEDICAL SOCIETY; NATIONAL INSTITUTES OF HEALTH STROKE SCALE; PRACTICE GUIDELINE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SEX DIFFERENCE; SYSTOLIC BLOOD PRESSURE; COMPLICATION; ETHNIC GROUP; ETHNOLOGY; FIBRINOLYTIC THERAPY; KENTUCKY; MIDDLE AGED; OHIO; PATHOPHYSIOLOGY; PATIENT PARTICIPATION; PROCEDURES; STROKE; TREATMENT OUTCOME; VERY ELDERLY;

AGED; AGED, 80 AND OVER; BRAIN ISCHEMIA; ETHNIC GROUPS; FEMALE; FIBRINOLYTIC AGENTS; HUMANS; HYPERTENSION; KENTUCKY; MALE; MIDDLE AGED; OHIO; PATIENT PARTICIPATION; RETROSPECTIVE STUDIES; SEX FACTORS; STROKE; THROMBOLYTIC THERAPY; TISSUE PLASMINOGEN ACTIVATOR; TREATMENT OUTCOME;

EID: 84943188430     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.114.006737     Document Type: Article

References (16)

1. Reeves M, Bhatt A, Jajou P, Brown M, Lisabeth L. Sex differences in the use of intravenous rt-PA thrombolysis treatment for acute ischemic stroke: a meta-analysis. Stroke. 2009;40:1743-1749. doi: 10.1161/STROKEAHA.108.543181.
2. Reeves MJ, Fonarow GC, Zhao X, Smith EE, Schwamm LH; Get With The Guidelines-Stroke Steering Committee & Investigators. Quality of care in women with ischemic stroke in the GWTG program. Stroke. 2009;40:1127-1133. doi: 10.1161/STROKEAHA.108.543157.
3. Foerch C, Misselwitz B, Humpich M, Steinmetz H, Neumann-Haefelin T, Sitzer M; Arbeitsgruppe Schlaganfall Hessen. Sex disparity in the access of elderly patients to acute stroke care. Stroke. 2007;38:2123-2126. doi: 10.1161/STROKEAHA.106.478495.
4. Reid JM, Dai D, Gubitz GJ, Kapral MK, Christian C, Phillips SJ. Gender differences in stroke examined in a 10-year cohort of patients admitted to a Canadian teaching hospital. Stroke. 2008;39:1090-1095. doi: 10.1161/STROKEAHA.107.495143.
5. de Ridder I, Dirks M, Niessen L, Dippel D; PRACTISE Investigators. Unequal access to treatment with intravenous alteplase for women with acute ischemic stroke. Stroke. 2013;44:2610-2612. doi: 10.1161/STROKEAHA.113.002263.
6. de Los Rios la Rosa F, Khoury J, Kissela BM, Flaherty ML, Alwell K, Moomaw CJ, et al. Eligibility for intravenous recombinant tissuetype plasminogen activator within a population: the Effect of the European Cooperative Acute Stroke Study (ECASS) III trial. Stroke. 2012;43:1591-1595. doi: 10.1161/STROKEAHA.111.645986.
7. Broderick J, Brott T, Kothari R, Miller R, Khoury J, Pancioli A, et al. The Greater Cincinnati/Northern Kentucky Stroke Study: preliminary frst-ever and total incidence rates of stroke among blacks. Stroke. 1998;29:415-421.
8. Jauch EC, Saver JL, Adams HP Jr, Bruno A, Connors JJ, Demaerschalk BM, et al; American Heart Association Stroke Council; Council on Cardiovascular Nursing; Council on Peripheral Vascular Disease; Council on Clinical Cardiology. Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2013;44:870-947. doi: 10.1161/STR.0b013e318284056a.
9. Hacke W, Kaste M, Bluhmki E, Brozman M, Dávalos A, Guidetti D, et al; ECASS Investigators. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med. 2008;359:1317-1329. doi: 10.1056/NEJMoa0804656.
10. Weiss A, Beloosesky Y, Kenett RS, Grossman E. Systolic blood pressure during acute stroke is associated with functional status and longterm mortality in the elderly. Stroke. 2013;44:2434-2440. doi: 10.1161/STROKEAHA.113.001894.
11. Niewada M, Kobayashi A, Sandercock PA, Kaminski B, Czlonkowska A; International Stroke Trial Collaborative Group. Infuence of gender on baseline features and clinical outcomes among 17, 370 patients with confrmed ischaemic stroke in the international stroke trial. Neuroepidemiology. 2005;24:123-128. doi: 10.1159/000082999.
12. Ahmed N, Wahlgren N, Brainin M, Castillo J, Ford GA, Kaste M, et al. Relationship of blood pressure, antihypertensive therapy, and outcome in ischemic stroke treated with intravenous thrombolysis: retrospective analysis from Safe Implementation of Thrombolysis in Stroke-International Stroke Thrombolysis Register (SITS-ISTR). Stroke. 2009;40:2442-2449. doi: 10.1161/STROKEAHA.109.548602.
13. Del Zoppo GJ, Saver JL, Jauch EC, Adams HP Jr; American Heart Association Stroke Council. Expansion of the time window for treatment of acute ischemic stroke with intravenous tissue plasminogen activator: a science advisory from the American Heart Association/American Stroke Association. Stroke. 2009;40:2945-2948. doi: 10.1161/STROKEAHA.109.192535.
14. Chen CI, Iguchi Y, Grotta JC, Garami Z, Uchino K, Shaltoni H, et al. Intravenous TPA for very old stroke patients. Eur Neurol. 2005;54:140-144. doi: 10.1159/000089086.
15. Costello CA, Campbell BC, Perez de la Ossa N, Zheng TH, Sherwin JC, Weir L, et al. Age over 80 years is not associated with increased hemorrhagic transformation after stroke thrombolysis. J Clin Neurosci. 2012;19:360-363. doi: 10.1016/j.jocn. 2011.08.014.
16. Willey JZ, Petersen N, Dhamoon MS, Stillman J, Boden-Albala B, Elkind MS, et al. Safety of thrombolysis in patients over the age of 80. Neurologist. 2012;18:99-101. doi: 10.1097/NRL.0b013e318248ea3c.