Resolution of a giant pigment epithelial detachment with half-dose aflibercept

Retinal Cases and Brief Reports

Volumn 9, Issue 4, 2015, Pages 269-272

  Nagiel, Aaron ^a   Sadda, Srinivas R ^b   Schwartz, Steven D ^a   Sarraf, David ^a  

^a JULES STEIN EYE INSTITUTE   (United States)

^b DOHENY EYE INSTITUTE   (United States)

Author keywords

aflibercept; connective tissue growth factor; fundus autofluorescence; optical coherence tomography; pigment epithelial detachment; retinal pigment epithelium tear; vascular endothelial growth factor

Indexed keywords

AFLIBERCEPT; VASCULOTROPIN ANTIBODY; ANGIOGENESIS INHIBITOR; HYBRID PROTEIN; VASCULOTROPIN RECEPTOR;

AGE RELATED MACULAR DEGENERATION; AGED; ARMENIAN (PEOPLE); CASE REPORT; CONFERENCE PAPER; DIABETES MELLITUS; EYE EXAMINATION; EYE PHOTOGRAPHY; FEMALE; FLUORESCENCE ANGIOGRAPHY; FOLLOW UP; HUMAN; HYPERTENSION; NEOVASCULAR AGE RELATED MACULAR DEGENERATION; RETINA DETACHMENT; RETINA TEAR; SCOTOMA; SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY; VISUAL ACUITY; VISUAL ACUITY CHART; VISUAL DISORDER; COMPLICATION; MACULAR DEGENERATION; PATHOLOGY; RETINAL DETACHMENT; RETINAL PIGMENT EPITHELIUM; TREATMENT OUTCOME;

AGED; ANGIOGENESIS INHIBITORS; FEMALE; HUMANS; MACULAR DEGENERATION; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; RECOMBINANT FUSION PROTEINS; RETINAL DETACHMENT; RETINAL PIGMENT EPITHELIUM; TREATMENT OUTCOME;

EID: 84943156916     PISSN: 19351089     EISSN: 19371578     Source Type: Journal    
DOI: 10.1097/ICB.0000000000000184     Document Type: Conference Paper

References (11)

1. Sarraf D, Joseph A, Rahimy E,. Retinal pigment epithelial tears in the era of intravitreal pharmacotherapy: Risk factors, pathogenesis, prognosis and treatment (an American Ophthalmological Society thesis). Trans Am Ophthalmol Soc 2014; 112: 142-159.
2. Chang LK, Flaxel CJ, Lauer AK, Sarraf D,. RPE tears after pegaptanib treatment in age-related macular degeneration. Retina 2007; 27: 857-863.
3. Shah CP, Hsu J, Garg SJ,. Retinal pigment epithelial tear after intravitreal bevacizumab injection. Am J Ophthalmol 2006; 142: 1070-1072.
4. Doguizi S, Ozdek S,. Pigment epithelial tears associated with anti-VEGF therapy: Incidence, long-Term visual outcome, and relationship with pigment epithelial detachment in age-related macular degeneration. Retina 2014; 34: 1156-1162.
5. Chiang A, Chang LK, Yu F, Sarraf D,. Predictors of anti-vegf-Associated retinal pigment epithelial tear using fa and oct analysis. Retina 2008; 28: 1265-1269.
6. Nagiel A, Freund KB, Spaide RF,. Mechanism of retinal pigment epithelium tear formation following intravitreal anti-vascular endothelial growth factor therapy revealed by spectral-domain optical coherence tomography. Am J Ophthalmol 2013; 156: 981-988.
7. Clemens CR, Bastian N, Alten F,. Prediction of retinal pigment epithelial tear in serous vascularized pigment epithelium detachment. Acta Ophthalmol (Copenh) 2014; 92: e50-e56.
8. Chan CK, Meyer CH, Gross JG,. Retinal pigment epithelial tears after intravitreal bevacizumab injection for neovascular age-related macular degeneration. Retina 2007; 27: 541-551.
9. Van Geest RJ, Lesnik-Oberstein SY, Tan HS,. A shift in the balance of vascular endothelial growth factor and connective tissue growth factor by bevacizumab causes the angiofibrotic switch in proliferative diabetic retinopathy. Br J Ophthalmol 2012; 96: 587-590.
10. Kuiper EJ, Van Nieuwenhoven FA, de Smet MD,. The angio-fibrotic switch of VEGF and CTGF in proliferative diabetic retinopathy. PLoS One 2008; 3: e2675.
11. Sato T, Ooto S, Suzuki M, Spaide RF,. Retinal pigment epithelial tear after intravitreal aflibercept for neovascular age-related macular degeneration. Ophthalmic Surg Lasers Imaging Retina 2015; 46: 87-90.