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Volumn 58, Issue 11, 2015, Pages 2637-2646

Central GLP-1 receptor signalling accelerates plasma clearance of triacylglycerol and glucose by activating brown adipose tissue in mice

Author keywords

Brown adipose tissue; Exendin 4; GLP 1; Mice; Triacylglycerol

Indexed keywords

EXENDIN 4; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; GLUCOSE; TRIACYLGLYCEROL; UNCOUPLING PROTEIN 1; GLUCAGON LIKE PEPTIDE 1; INCRETIN; INSULIN; ION CHANNEL; MITOCHONDRIAL PROTEIN; PEPTIDE; UCP1 PROTEIN, MOUSE; VENOM;

EID: 84942991914     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-015-3727-0     Document Type: Article
Times cited : (107)

References (31)
  • 1
    • 80052645534 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 analogues for Type 2 diabetes mellitus: current and emerging agents
    • COI: 1:CAS:528:DC%2BC3MXhsVOjtr7N, PID: 21902291
    • Gallwitz B (2011) Glucagon-like peptide-1 analogues for Type 2 diabetes mellitus: current and emerging agents. Drugs 71:1675–1688
    • (2011) Drugs , vol.71 , pp. 1675-1688
    • Gallwitz, B.1
  • 2
    • 0031836542 scopus 로고    scopus 로고
    • Differential effects of intracerebroventricular glucagon-like peptide-1 on feeding and energy expenditure regulation
    • COI: 1:CAS:528:DyaK1cXktVyksbY%3D, PID: 9663452
    • Hwa JJ, Ghibaudi L, Williams P, Witten MB, Tedesco R, Strader CD (1998) Differential effects of intracerebroventricular glucagon-like peptide-1 on feeding and energy expenditure regulation. Peptides 19:869–875
    • (1998) Peptides , vol.19 , pp. 869-875
    • Hwa, J.J.1    Ghibaudi, L.2    Williams, P.3    Witten, M.B.4    Tedesco, R.5    Strader, C.D.6
  • 3
    • 13344282056 scopus 로고    scopus 로고
    • A role for glucagon-like peptide-1 in the central regulation of feeding
    • COI: 1:CAS:528:DyaK28XivVKgsA%3D%3D, PID: 8538742
    • Turton MD, O'Shea D, Gunn I et al (1996) A role for glucagon-like peptide-1 in the central regulation of feeding. Nature 379:69–72
    • (1996) Nature , vol.379 , pp. 69-72
    • Turton, M.D.1    O'Shea, D.2    Gunn, I.3
  • 4
    • 31044456099 scopus 로고    scopus 로고
    • Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage
    • COI: 1:CAS:528:DC%2BD2MXhtlSqtLvL, PID: 16322793
    • Knauf C, Cani PD, Perrin C et al (2005) Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage. J Clin Invest 115:3554–3563
    • (2005) J Clin Invest , vol.115 , pp. 3554-3563
    • Knauf, C.1    Cani, P.D.2    Perrin, C.3
  • 5
    • 50949094723 scopus 로고    scopus 로고
    • Arcuate glucagon-like peptide 1 receptors regulate glucose homeostasis but not food intake
    • COI: 1:CAS:528:DC%2BD1cXps1OisrY%3D, PID: 18487451
    • Sandoval DA, Bagnol D, Woods SC, D'Alessio DA, Seeley RJ (2008) Arcuate glucagon-like peptide 1 receptors regulate glucose homeostasis but not food intake. Diabetes 57:2046–2054
    • (2008) Diabetes , vol.57 , pp. 2046-2054
    • Sandoval, D.A.1    Bagnol, D.2    Woods, S.C.3    D'Alessio, D.A.4    Seeley, R.J.5
  • 6
    • 77954891541 scopus 로고    scopus 로고
    • GLP-1 treatment reduces endogenous insulin resistance via activation of central GLP-1 receptors in mice fed a high-fat diet
    • COI: 1:CAS:528:DC%2BC3cXhtVOhtLzP, PID: 20530733
    • Parlevliet ET, de Leeuw van Weenen JE, Romijn JA, Pijl H (2010) GLP-1 treatment reduces endogenous insulin resistance via activation of central GLP-1 receptors in mice fed a high-fat diet. Am J Physiol Endocrinol Metab 299:E318–E324
    • (2010) Am J Physiol Endocrinol Metab , vol.299 , pp. E318-E324
    • Parlevliet, E.T.1    de Leeuw van Weenen, J.E.2    Romijn, J.A.3    Pijl, H.4
  • 7
    • 84884183691 scopus 로고    scopus 로고
    • BMP7 activates brown adipose tissue and reduces diet-induced obesity only at subthermoneutrality
    • COI: 1:CAS:528:DC%2BC3sXhsFWqsL%2FP, PID: 24066098
    • Boon MR, van den Berg SA, Wang Y et al (2013) BMP7 activates brown adipose tissue and reduces diet-induced obesity only at subthermoneutrality. PLoS One 8, e74083
    • (2013) PLoS One , vol.8
    • Boon, M.R.1    van den Berg, S.A.2    Wang, Y.3
  • 8
    • 84894412290 scopus 로고    scopus 로고
    • Metformin lowers plasma triglycerides by promoting VLDL-triglyceride clearance by brown adipose tissue in mice
    • COI: 1:CAS:528:DC%2BC2cXjs1Kns7Y%3D, PID: 24270984
    • Geerling JJ, Boon MR, van der Zon GC et al (2014) Metformin lowers plasma triglycerides by promoting VLDL-triglyceride clearance by brown adipose tissue in mice. Diabetes 63:880–891
    • (2014) Diabetes , vol.63 , pp. 880-891
    • Geerling, J.J.1    Boon, M.R.2    van der Zon, G.C.3
  • 9
    • 79751503329 scopus 로고    scopus 로고
    • Brown adipose tissue activity controls triglyceride clearance
    • COI: 1:CAS:528:DC%2BC3MXps1aisw%3D%3D, PID: 21258337
    • Bartelt A, Bruns OT, Reimer R et al (2011) Brown adipose tissue activity controls triglyceride clearance. Nat Med 17:200–205
    • (2011) Nat Med , vol.17 , pp. 200-205
    • Bartelt, A.1    Bruns, O.T.2    Reimer, R.3
  • 10
    • 84893849860 scopus 로고    scopus 로고
    • Interplay between FGF21 and insulin action in the liver regulates metabolism
    • COI: 1:CAS:528:DC%2BC2cXis1ersLg%3D, PID: 24401271
    • Emanuelli B, Vienberg SG, Smyth G et al (2014) Interplay between FGF21 and insulin action in the liver regulates metabolism. J Clin Invest 124:515–527
    • (2014) J Clin Invest , vol.124 , pp. 515-527
    • Emanuelli, B.1    Vienberg, S.G.2    Smyth, G.3
  • 11
    • 84920700786 scopus 로고    scopus 로고
    • Brown adipose tissue takes up plasma triglycerides mostly after lipolysis
    • COI: 1:CAS:528:DC%2BC2MXktFaqsw%3D%3D, PID: 25351615
    • Khedoe PP, Hoeke G, Kooijman S et al (2015) Brown adipose tissue takes up plasma triglycerides mostly after lipolysis. J Lipid Res 56:51–59
    • (2015) J Lipid Res , vol.56 , pp. 51-59
    • Khedoe, P.P.1    Hoeke, G.2    Kooijman, S.3
  • 12
    • 84868013714 scopus 로고    scopus 로고
    • Direct control of brown adipose tissue thermogenesis by central nervous system glucagon-like peptide-1 receptor signaling
    • COI: 1:CAS:528:DC%2BC38Xhsl2it7rN, PID: 22933116
    • Lockie SH, Heppner KM, Chaudhary N et al (2012) Direct control of brown adipose tissue thermogenesis by central nervous system glucagon-like peptide-1 receptor signaling. Diabetes 61:2753–2762
    • (2012) Diabetes , vol.61 , pp. 2753-2762
    • Lockie, S.H.1    Heppner, K.M.2    Chaudhary, N.3
  • 13
    • 84907495079 scopus 로고    scopus 로고
    • GLP-1 agonism stimulates brown adipose tissue thermogenesis and browning through hypothalamic AMPK
    • COI: 1:CAS:528:DC%2BC2cXhslWiurjJ, PID: 24917578
    • Beiroa D, Imbernon M, Gallego R et al (2014) GLP-1 agonism stimulates brown adipose tissue thermogenesis and browning through hypothalamic AMPK. Diabetes 63:3346–3358
    • (2014) Diabetes , vol.63 , pp. 3346-3358
    • Beiroa, D.1    Imbernon, M.2    Gallego, R.3
  • 14
    • 82255181871 scopus 로고    scopus 로고
    • Stimulatory effect of insulin on glucose uptake by muscle involves the central nervous system in insulin-sensitive mice
    • COI: 1:CAS:528:DC%2BC38XpvFOitw%3D%3D, PID: 22028182
    • Coomans CP, Biermasz NR, Geerling JJ et al (2011) Stimulatory effect of insulin on glucose uptake by muscle involves the central nervous system in insulin-sensitive mice. Diabetes 60:3132–3140
    • (2011) Diabetes , vol.60 , pp. 3132-3140
    • Coomans, C.P.1    Biermasz, N.R.2    Geerling, J.J.3
  • 15
    • 0031010389 scopus 로고    scopus 로고
    • Particle size determines the specificity of apolipoprotein E-containing triglyceride-rich emulsions for the LDL receptor versus hepatic remnant receptor in vivo
    • COI: 1:CAS:528:DyaK2sXkt1yjsbk%3D, PID: 9215536
    • Rensen PC, Herijgers N, Netscher MH, Meskers SC, van Eck M, van Berkel TJ (1997) Particle size determines the specificity of apolipoprotein E-containing triglyceride-rich emulsions for the LDL receptor versus hepatic remnant receptor in vivo. J Lipid Res 38:1070–1084
    • (1997) J Lipid Res , vol.38 , pp. 1070-1084
    • Rensen, P.C.1    Herijgers, N.2    Netscher, M.H.3    Meskers, S.C.4    van Eck, M.5    van Berkel, T.J.6
  • 16
    • 84860522959 scopus 로고    scopus 로고
    • Estimation of activity related energy expenditure and resting metabolic rate in freely moving mice from indirect calorimetry data
    • PID: 22574139
    • Van Klinken JB, van den Berg SA, Havekes LM, van Willems DK (2012) Estimation of activity related energy expenditure and resting metabolic rate in freely moving mice from indirect calorimetry data. PLoS One 7, e36162
    • (2012) PLoS One , vol.7
    • Van Klinken, J.B.1    van den Berg, S.A.2    Havekes, L.M.3    van Willems, D.K.4
  • 17
    • 0034218936 scopus 로고    scopus 로고
    • Central exendin-4 infusion reduces body weight without altering plasma leptin in (fa/fa) Zucker rats
    • COI: 1:CAS:528:DC%2BD3cXlslehsbo%3D, PID: 10933308
    • Al-Barazanji KA, Arch JR, Buckingham RE, Tadayyon M (2000) Central exendin-4 infusion reduces body weight without altering plasma leptin in (fa/fa) Zucker rats. Obes Res 8:317–323
    • (2000) Obes Res , vol.8 , pp. 317-323
    • Al-Barazanji, K.A.1    Arch, J.R.2    Buckingham, R.E.3    Tadayyon, M.4
  • 18
    • 65949097938 scopus 로고    scopus 로고
    • Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity
    • COI: 1:CAS:528:DC%2BD1MXlvVGntrY%3D, PID: 19420258
    • Nogueiras R, Perez-Tilve D, Veyrat-Durebex C et al (2009) Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity. J Neurosci 29:5916–5925
    • (2009) J Neurosci , vol.29 , pp. 5916-5925
    • Nogueiras, R.1    Perez-Tilve, D.2    Veyrat-Durebex, C.3
  • 19
    • 84934438544 scopus 로고    scopus 로고
    • Adipose organ nerves revealed by immunohistochemistry
    • PID: 18516554
    • Giordano A, Frontini A, Cinti S (2008) Adipose organ nerves revealed by immunohistochemistry. Methods Mol Biol 456:83–95
    • (2008) Methods Mol Biol , vol.456 , pp. 83-95
    • Giordano, A.1    Frontini, A.2    Cinti, S.3
  • 20
    • 84857461922 scopus 로고    scopus 로고
    • Regulation of adipocyte formation by GLP-1/GLP-1R signaling
    • COI: 1:CAS:528:DC%2BC38Xisl2ltbs%3D, PID: 22207759
    • Challa TD, Beaton N, Arnold M, Rudofsky G, Langhans W, Wolfrum C (2012) Regulation of adipocyte formation by GLP-1/GLP-1R signaling. J Biol Chem 287:6421–6430
    • (2012) J Biol Chem , vol.287 , pp. 6421-6430
    • Challa, T.D.1    Beaton, N.2    Arnold, M.3    Rudofsky, G.4    Langhans, W.5    Wolfrum, C.6
  • 21
    • 33750922694 scopus 로고    scopus 로고
    • Sustained activation of the mammalian target of rapamycin nutrient sensing pathway is associated with hepatic insulin resistance, but not with steatosis, in mice
    • COI: 1:CAS:528:DC%2BD28XhtFylt7nE, PID: 17006666
    • Korsheninnikova E, van der Zon GC, Voshol PJ et al (2006) Sustained activation of the mammalian target of rapamycin nutrient sensing pathway is associated with hepatic insulin resistance, but not with steatosis, in mice. Diabetologia 49:3049–3057
    • (2006) Diabetologia , vol.49 , pp. 3049-3057
    • Korsheninnikova, E.1    van der Zon, G.C.2    Voshol, P.J.3
  • 23
    • 0035248116 scopus 로고    scopus 로고
    • The peripheral sympathetic nervous system in human obesity
    • PID: 12119635
    • van Baak MA (2001) The peripheral sympathetic nervous system in human obesity. Obes Rev 2:3–14
    • (2001) Obes Rev , vol.2 , pp. 3-14
    • van Baak, M.A.1
  • 24
    • 34347345996 scopus 로고    scopus 로고
    • Brain-adipose tissue neural crosstalk
    • COI: 1:CAS:528:DC%2BD2sXnsFKrsrg%3D, PID: 17521684
    • Bartness TJ, Song CK (2007) Brain-adipose tissue neural crosstalk. Physiol Behav 91:343–351
    • (2007) Physiol Behav , vol.91 , pp. 343-351
    • Bartness, T.J.1    Song, C.K.2
  • 25
    • 0028867442 scopus 로고
    • Distribution of GLP-1 binding sites in the rat brain: evidence that exendin-4 is a ligand of brain GLP-1 binding sites
    • COI: 1:STN:280:DyaK287kvFKnsg%3D%3D, PID: 8563978
    • Goke R, Larsen PJ, Mikkelsen JD, Sheikh SP (1995) Distribution of GLP-1 binding sites in the rat brain: evidence that exendin-4 is a ligand of brain GLP-1 binding sites. Eur J Neurosci 7:2294–2300
    • (1995) Eur J Neurosci , vol.7 , pp. 2294-2300
    • Goke, R.1    Larsen, P.J.2    Mikkelsen, J.D.3    Sheikh, S.P.4
  • 26
    • 0347989317 scopus 로고    scopus 로고
    • Brown adipose tissue: function and physiological significance
    • COI: 1:CAS:528:DC%2BD2cXotl2qsQ%3D%3D, PID: 14715917
    • Cannon B, Nedergaard J (2004) Brown adipose tissue: function and physiological significance. Physiol Rev 84:277–359
    • (2004) Physiol Rev , vol.84 , pp. 277-359
    • Cannon, B.1    Nedergaard, J.2
  • 27
    • 84868307468 scopus 로고    scopus 로고
    • GLP-1 receptor activation inhibits VLDL production and reverses hepatic steatosis by decreasing hepatic lipogenesis in high-fat-fed APOE*3-Leiden mice
    • COI: 1:CAS:528:DC%2BC38XhslajtLrE, PID: 23133675
    • Parlevliet ET, Wang Y, Geerling JJ et al (2012) GLP-1 receptor activation inhibits VLDL production and reverses hepatic steatosis by decreasing hepatic lipogenesis in high-fat-fed APOE*3-Leiden mice. PLoS One 7, e49152
    • (2012) PLoS One , vol.7
    • Parlevliet, E.T.1    Wang, Y.2    Geerling, J.J.3
  • 29
    • 84859360922 scopus 로고    scopus 로고
    • The glucagon-like peptide 1 (GLP-1) analogue, exendin-4, decreases the rewarding value of food: a new role for mesolimbic GLP-1 receptors
    • COI: 1:CAS:528:DC%2BC38XlsFKktbk%3D, PID: 22492036
    • Dickson SL, Shirazi RH, Hansson C, Bergquist F, Nissbrandt H, Skibicka KP (2012) The glucagon-like peptide 1 (GLP-1) analogue, exendin-4, decreases the rewarding value of food: a new role for mesolimbic GLP-1 receptors. J Neurosci 32:4812–4820
    • (2012) J Neurosci , vol.32 , pp. 4812-4820
    • Dickson, S.L.1    Shirazi, R.H.2    Hansson, C.3    Bergquist, F.4    Nissbrandt, H.5    Skibicka, K.P.6
  • 30
    • 84871425638 scopus 로고    scopus 로고
    • Below thermoneutrality, changes in activity do not drive changes in total daily energy expenditure between groups of mice
    • COI: 1:CAS:528:DC%2BC38Xhs1Cjs7fI, PID: 23140644
    • Virtue S, Even P, Vidal-Puig A (2012) Below thermoneutrality, changes in activity do not drive changes in total daily energy expenditure between groups of mice. Cell Metab 16:665–671
    • (2012) Cell Metab , vol.16 , pp. 665-671
    • Virtue, S.1    Even, P.2    Vidal-Puig, A.3
  • 31
    • 84924365670 scopus 로고    scopus 로고
    • Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development
    • COI: 1:CAS:528:DC%2BC2MXhtF2ks77P, PID: 25754609
    • Berbee JF, Boon MR, Khedoe PP et al (2015) Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development. Nat Commun 6:6356
    • (2015) Nat Commun , vol.6 , pp. 6356
    • Berbee, J.F.1    Boon, M.R.2    Khedoe, P.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.