Inhibition of histone methyltransferases SUV39H1 and G9a leads to neuroprotection in an in vitro model of cerebral ischemia

Journal of Cerebral Blood Flow and Metabolism

Volumn 35, Issue 10, 2015, Pages 1640-1647

  Schweizer, Sophie ^a   Harms, Christoph ^a   Lerch, Heike ^a   Flynn, Jennifer ^a   Hecht, Jochen ^a   Yildirim, Ferah ^a   Meisel, Andreas ^a   Märschenz, Stefanie ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

BDNF; G9a; histone methylation; ischemia; SUV39H1

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CHAETOCIN; GLUCOSE; HISTONE DEACETYLASE; HISTONE METHYLTRANSFERASE; HISTONE METHYLTRANSFERASE G9A; HISTONE METHYLTRANSFERASE SUV39H1; K 252A; NEUROPROTECTIVE AGENT; OXYGEN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; HISTONE LYSINE METHYLTRANSFERASE; ISOENZYME; LACTATE DEHYDROGENASE; PIPERAZINE DERIVATIVE;

ANIMAL CELL; ARTICLE; BRAIN ISCHEMIA; CELL SURVIVAL; CONTROLLED STUDY; ENZYME INHIBITION; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; IN VITRO STUDY; METABOLIC STRESS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RAT; RNA INTERFERENCE; UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; BRAIN CORTEX; BRAIN HYPOXIA; CELL COUNT; CELL CULTURE; DEFICIENCY; ENZYMOLOGY; FEMALE; METABOLISM; PATHOLOGY; PREGNANCY; WISTAR RAT;

ANIMALS; BRAIN ISCHEMIA; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL COUNT; CELL SURVIVAL; CELLS, CULTURED; CEREBRAL CORTEX; FEMALE; GLUCOSE; HISTONE-LYSINE N-METHYLTRANSFERASE; HYPOXIA, BRAIN; ISOENZYMES; L-LACTATE DEHYDROGENASE; NEUROPROTECTIVE AGENTS; PIPERAZINES; PREGNANCY; RATS; RATS, WISTAR; RNA INTERFERENCE;

EID: 84942981270     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2015.99     Document Type: Article

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