Noninvasive prenatal testing by nanopore sequencing of maternal plasma DNA: Feasibility assessment

Clinical Chemistry

Volumn 61, Issue 10, 2015, Pages 1305-1306

  Cheng, Suk Hang ^a,b   Jiang, Peiyong ^a,b   Sun, Kun ^a,b   Cheng, Yvonne K Y ^a   Chan, K C Allen ^a,b   Leung, Tak Y ^a   Chiu, Rossa W K ^a,b   Lo, Y M Dennis ^a,b  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

DNA FRAGMENT; EDETIC ACID; GENOMIC DNA; DNA;

AMNIOCENTESIS; ANEUPLOIDY; CLINICAL LABORATORY; DNA DETERMINATION; DNA SEQUENCE; FEMALE; GENE DOSAGE; GENE MAPPING; HUMAN; HUMAN GENOME; LETTER; MATERNAL PLASMA; NANOPORE; NONINVASIVE PRENATAL TESTING; PREGNANT WOMAN; PRENATAL SCREENING; X CHROMOSOME; Y CHROMOSOME; BLOOD; GENETIC SCREENING; MALE; PREGNANCY; PRENATAL DIAGNOSIS; PROCEDURES;

DNA; FEMALE; GENETIC TESTING; HUMANS; MALE; NANOPORES; PREGNANCY; PRENATAL DIAGNOSIS; SEQUENCE ANALYSIS, DNA;

EID: 84942927070     PISSN: 00099147     EISSN: 15308561     Source Type: Journal    
DOI: 10.1373/clinchem.2015.245076     Document Type: Letter

References (4)

1. Dondorp W, de Wert G, Bombard Y, Bianchi DW, Bergmann C, Borry P, et al. Non-invasive prenatal testing for aneuploidy and beyond: Challenges of responsible innovation in prenatal screening. Eur J Hum Genet [Epub ahead of print 2015 Mar 18].
2. Chiu RWK, Chan KCA, Gao Y, Lau VYM, Zheng W, Leung TY, et al. Noninvasive prenatal diagnosis of fetal chromosomal aneuploidy by massively parallel genomic sequencing of DNA in maternal plasma. Proc Natl Acad Sci U S A 2008;105:20458-63.
3. Jain M, Fiddes IT, Miga KH, Olsen HE, Paten B, Akeson M. Improved data analysis for the minion nanopore sequencer. Nat Methods 2015;12:351-6.
4. Lo YMD, Chan KCA, Sun H, Chen EZ, Jiang P, Lun FMF, et al. Maternal plasma DNA sequencing reveals the genome-wide genetic and mutational profile of the fetus. Sci Transl Med 2010;2:61ra91.