Tramadol for postoperative pain treatment in children

Cochrane Database of Systematic Reviews

Volumn 2015, Issue 3, 2015, Pages

  Schnabel, Alexander ^a   Reichl, Sylvia U ^b   Meyer Frießem, Christine ^c   Zahn, Peter K ^c   Pogatzki Zahn, Esther ^d  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b PARACELSUS MEDICAL UNIVERSITY   (Austria)

^c RUHR UNIVERSITY BOCHUM   (Germany)

^d UNIVERSITY HOSPITAL MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

FENTANYL; MORPHINE; NALBUPHINE; OPIATE; PETHIDINE; PLACEBO; TRAMADOL; NARCOTIC ANALGESIC AGENT;

ADOLESCENT; CHILD; CONTINUOUS INFUSION; DRUG EFFICACY; DRUG SAFETY; EVIDENCE BASED MEDICINE; HUMAN; OUTCOME ASSESSMENT; PAIN SEVERITY; PATIENT CONTROLLED ANALGESIA; PERIOPERATIVE PERIOD; POSTOPERATIVE ANALGESIA; POSTOPERATIVE CARE; POSTOPERATIVE NAUSEA AND VOMITING; POSTOPERATIVE PAIN; PRIORITY JOURNAL; REVIEW; RISK BENEFIT ANALYSIS; SURGICAL TECHNIQUE; SYSTEMATIC REVIEW; FEMALE; INFANT; MALE; META ANALYSIS; PAIN, POSTOPERATIVE; PRESCHOOL CHILD; RANDOMIZED CONTROLLED TRIAL (TOPIC);

ADOLESCENT; ANALGESICS, OPIOID; CHILD; CHILD, PRESCHOOL; FEMALE; FENTANYL; HUMANS; INFANT; MALE; MEPERIDINE; MORPHINE; NALBUPHINE; PAIN, POSTOPERATIVE; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TRAMADOL;

EID: 84942811659     PISSN: None     EISSN: 1469493X     Source Type: Journal    
DOI: 10.1002/14651858.CD009574.pub2     Document Type: Review

References (80)

1. Ali SM, Shahrbano S, Ulhaq TS. Tramadol for pain relief in children undergoing adenotonsillectomy a comparison with dextromethorphan. Laryngoscope 2008 Sep;118(9):1547-9.
2. Antila H, Manner T, Kuurila K, Salanterä S, Kujala R, Aantaa R. Ketoprofen and tramadol for analgesia during early recovery after tonsillectomy in children. Paediatric Anaesthesia 2006 May;16(5):548-53.
3. Barsoum MW. Comparison of the efficacy and tolerability of tramadol, pethidine and nalbuphine in children with postoperative pain. Clinical Drug Investigation 1995;9(4):183-90.
4. Bösenberg AT, Ratcliffe S. The respiratory effects of tramadol in children under halothane an anaesthesia. Anaesthesia. 1998 Oct;53(10):960-4.
5. Chiaretti A, Viola L, Pietrini D, Piastra M, Savioli A, Tortorolo L, et al. Preemptive analgesia with tramadol and fentanyl in pediatric neurosurgery. Child's Nervous System 2000 Feb;16(2):93-9.
6. Cocelli LP, Ugur BK, Durucu C, Kul S, Arik H, Mumbuc S. Comparison of pre-emptive tonsillar lodge infiltration with ropivacaine versus intravenous tramadol in pediatric tonsillectomies a randomized placebo-controlled study. International Journal of Pediatric Otorhinolaryngology 2012 May;76(5):653-7.
7. Ekemen S, Yelken B, Ilhan H, Tokar B. A comparison of analgesic efficacy of tramadol and pethidine for management of postoperative pain in children a randomized, controlled study. Pediatric Surgery International 2008 Jun;24(6):695-8.
8. Engelhardt T, Steel E, Johnston G, Veitch DY. Tramadol for pain relief in children undergoing tonsillectomy a comparison with morphine. Paediatric Anaesthesia 2003 Mar;13(3):249-52.
9. Ertugrul F, Akbas M, Karsli B, Kayacan N, Bulut F, Trakya A. Pain relief for children after adenotonsillectomy. Journal of International Medical Research 2006 Nov-Dec;34(6):648-54.
10. Hullett BJ, Chambers NA, Pascoe EM, Johnson C. Tramadol vs morphine during adenotonsillectomy for obstructive sleep apnea in children. Paediatric Anaesthesia 2006 Jun;16(6):648-53.
11. Moyao-García D, Hernández-Palacios JC, Ramírez-Mora JC, Nava-Ocampo AA. A pilot study of nalbuphine versus tramadol administered through continuous intravenous infusion for postoperative pain control in children. Acta Biomedica 2009 Aug;80(2):124-30.
12. Ozalevli M, Unlügenç H, Tuncer U, Güneş Y, Ozcengiz D. Comparison of morphine and tramadol by patient-controlled analgesia for postoperative analgesia after tonsillectomy in children. Paediatric Anaesthesia 2005 Nov;15(11):979-84.
13. Ozer Z, Görür K, Altunkan AA, Bilgin E, Camdeviren H, Oral U. Efficacy of tramadol versus meperidine for pain relief and safe recovery after adenotonsillectomy. European Journal of Anaesthesiology 2003 Nov;20(11):920-4.
14. Ozköse Z, Akçabay M, Kemaloglu YK, Sezenler S. Relief of posttonsillectomy pain with low-dose tramadol given at induction of anesthesia in children. International Journal of Pediatric Otorhinolaryngology 2000 Jul 14;53(3):207-14.
15. Payne KA, Roelofse JA. Tramadol drops in children: analgesic efficacy, lack of respiratory effects, and normal recovery times. Anesthesia Progress 1999 Summer;46(3):91-6.
16. Roelofse JA, Payne KA. Oral tramadol analgesic efficacy in children following multiple dental extractions. European Journal of Anaesthesiology 1999 Jul;16(7):441-7.
17. Schäffer J, Piepenbrock S, Kretz FJ, Schönfeld C. Nalbuphine and tramadol for the control of postoperative pain in children. Anaesthesist 1986 Jul;35(7):408-13.
18. Umuroglu T, Eti Z, Ciftçi H, Yilmaz Gögüş F. Analgesia for adenotonsillectomy in children: a comparison of morphine, ketamine and tramadol. Paediatric Anaesthesia 2004 Jul;14(7):568-73.
19. van den Berg AA, Montoya-Pelaez LF, Halliday EM, Hassan I, Baloch MS. Analgesia for adenotonsillectomy in children and young adults a comparison of tramadol, pethidine and nalbuphine. European Journal of Anaesthesiology 1999 Mar;16(3):186-94.
20. Viitanen H, Annila P. Analgesic efficacy of tramadol 2 mg kg(-1) for paediatric day-case adenoidectomy. British Journal of Anaesthesia 2001 Apr, 86(4):572-5.
21. Aguirre Córcoles E, Durán González ME, Zambudio GA, González Celdrán R, Castaño Collado I, Cárceles Barón MD, et al. [Post-surgical paediatric pain Nursing- PCA vs continuous I.V. infusion of tramadol]. Cir Pediatria 2003 Jan;16(1):30-3.
22. Akkaya T, Bedirli N, Ceylan T, Matkap E, Gulen G, Elverici O, et al. Comparison of intravenous and peritonsillar infiltration of tramadol for postoperative pain relief in children following adenotonsillectomy. European Journal of Anaesthesiology 2009 Apr, 26(4):333-7.
23. Alencar AJ, Sanudo A, Sampaio VM, Góis RP, Benevides FA, Guinsburg R. Efficacy of tramadol versus fentanyl for postoperative analgesia in neonates. Archives of Diseases in Childhood. Fetal and Neonatal Edition 2012 Jan;97(1):F24-9.
24. Altunkaya H, Ozer Y, Kargi E, Babuccu O. Comparison of local anaesthetic effects of tramadol with prilocaine for minor surgical procedures. British Journal of Anaesthesia 2003 Mar;90(3):320-2.
25. Apiliogullari S, Kara I, Senaran H, Duman A, Celik JB. Combined spinal and light general anaesthesia for children undergoing developmental hip dysplasia surgery: Single centre experience. Regional Anesthesia and Pain Medicine 2011.
26. Bedirli N, Akcabay M, Emik U. The effects of intraoperative single dosage tramadol or dexmedetomidine on postoperative analgesia, sedation and emerge reactions in pediatric patients undergoing adenotonsillectomy. Regional Anesthesia and Pain Medicine 2011.
27. Borazan H, Sahin O, Kececioglu A, Uluer MS, Et T, Otelcioglu S. Prevention of propofol injection pain in children: A comparison of pre-treatment with tramadol and propofol-lidocaine mixture. International Journal of Medical Sciences 2012;9(6):492-7.
28. Chu YC, Lin SM, Hsieh YC, Chan KH, Tsou MY. Intraoperative administration of tramadol for postoperative nurse-controlled analgesia resulted in earlier awakening and less sedation than morphine in children after cardiac surgery. Anesthesia and Analgesia 2006 Jun;102(6):1668-73.
29. Courtney MJ, Cabraal D. Tramadol vs diclofenac for posttonsillectomy analgesia. Archives of Otolaryngology--Head & Neck Surgery 2001 Apr, 127(4):385-8.
30. Demiraran Y, Kocaman B, Akman RY. A comparison of the postoperative analgesic efficacy of single-dose epidural tramadol versus morphine in children. British Journal of Anaesthesia 2005 Oct;95(4):510-3.
31. Finkel JC, Rose JB, Schmitz ML, Birmingham PK, Ulma GA, Gunter JB, et al. An evaluation of the efficacy and tolerability of oral tramadol hydrochloride tablets for the treatment of postsurgical pain in children. Anesthesia and Analgesia 2002 Jun;94(6):1469-73.
32. Griessinger N, Rösch W, Schott G, Sittl R. Tramadol infusion for pain therapy following bladder exstrophy surgery in pediatric wards. Urologe A 1997 Nov;36(6):552-6.
33. Güneş Y, Gündüz M, Unlügenç H, Ozalevli M, Ozcengiz D. Comparison of caudal vs intravenous tramadol administered either preoperatively or postoperatively for pain relief in boys. Paediatric Anaesthesia 2004 Apr, 14(4):324-8.
34. Khosravi MB, Khezri S, Azemati S. Tramadol for pain relief in children undergoing herniotomy: a comparison with ilioinguinal and iliohypogastric blocks. Paediatric Anaesthesia 2006 Jan;16(1):54-8.
35. Macarone Palmieri A, Meglio M, Testa D, Salafia M, Iasiello A. Anesthesiologic and surgical problems in adenotonsillectomy in pediatric patients. Our current trend. Minerva Anestesiologica 1998 Dec;64(12):545-52.
36. Metodiev Y, Gavrilova N. Analgesic efficacy of ultrasound-guided transversus abdominis plane block after open appenedectomy in children. Regional Anesthesia and Pain Medicine 2011.
37. Mikhel'son VA, Zhirkova IuV, Beliaeva ID, Stepanenko SM, Manerova AF, Butyleva OIu. [Postoperative analgesia with tramadol in newborn children using the method of continuous intravenous infusion]. Anesteziologiia i Reanimatologiia 2003 Jan-Feb;1:24-8.
38. Oliveira EDS, Micheletti LG, Sakata RK, Iwata NM, Do Amaral JLG. A comparative study of postoperative analgesia of tramadol or fentanyl in pediatric patients anesthetic induction. Pediatric Anesthesia 2000;413(1-2):89-92.
39. Osifo OD, Aghahowa ES. Safety profile and efficacy of commonly used analgesics in surgical neonates in Benin City, Nigeria. American Journal of Perinatology 2008 Nov;25(10):617-22.
40. Ostreĭkov IF, Sen'kov VN, Kurilova ES, Bershinskiĭ VP, Pivovarov SA, Babaev BD. [Use of tramadol during minor surgical interventions in children]. Anesteziologiia i Reanimatologiia 1993 May-Jun;3:28-31.
41. Pendeville PE, Von Montigny S, Dort JP, Veyckemans F. Double-blind randomized study of tramadol vs. paracetamol in analgesia after day-case tonsillectomy in children. European Journal of Anaesthesiology 2000 Sep;17(9):576-82.
42. Sun Y, Xu W, Hu J, Xu W, Bai J, Zhang M. Combination effect of tramadol and low dose propofol on emergence agitation in children receiving sevoflurane for adenotonsillectomy procedure. Journal of Shanghai Jiaotong University 2010;1.
43. Allegaert K, Rochette A, Veyckemans F. Developmental pharmacology of tramadol during infancy: ontogeny, pharmacogenetics and elimination clearance. Paediatric Anaesthesia 2011;21(3):266-73. [PUBMED: 20723094]
44. Andrews K, Fitzgerald M. Wound sensitivity as a measure of analgesic effects following surgery in human neonates and infants. Pain 2002;99(1-2):185-95. [PUBMED: 12237196]
45. Awad IT, Moore M, Rushe C, Elburki A, O'Brien K, Warde D. Unplanned hospital admission in children undergoing day-case surgery. European Journal of Anaesthesiology 2004;21(5):379-83. [PUBMED: 15141796]
46. Bamigbade TA, Langford RM. Tramadol hydrochloride: an overview of current use. Hospital Medicine 1998;59(5):373-6. [PUBMED: 9722388]
47. Bosenberg AT, Ratcliffe S. The respiratory effects of tramadol in children under halothane an anaesthesia. Anaesthesia 1998;53(10):960-4. [PUBMED: 9893539]
48. Bozkurt P. Use of tramadol in children. Paediatric Anaesthesia 2005;15(12):1041-7. [PUBMED: 16324021]
49. Dadure C, Bringuier S, Raux O, Rochette A, Troncin R, Canaud N, et al. Continuous peripheral nerve blocks for postoperative analgesia in children: feasibility and side effects in a cohort study of 339 catheters. Canadian Journal of Anaesthesia = Journal Canadien d'Anesthesie 2009;56(11):843-50. [PUBMED: 19697092]
50. Dayer P, Collart L, Desmeules J. The pharmacology of tramadol. Drugs 1994;47 Suppl 1:3-7. [PUBMED: 7517823]
51. Franck LS, Cox S, Allen A, Winter I. Parental concern and distress about infant pain. Archives of Disease in Childhood. Fetal and Neonatal Edition 2004;89(1):F71-5. [PUBMED: 14711862]
52. Glaser R, Kiecolt-Glaser JK, Marucha PT, MacCallum RC, Laskowski BF, Malarkey WB. Stress-related changes in proinflammatory cytokine production in wounds. Archives of General Psychiatry 1999;56(5):450-6. [PUBMED: 10232300]
53. Groenewald CB, Rabbitts JA, Schroeder DR, Harrison TE. Prevalence of moderate-severe pain in hospitalized children. Paediatric Anaesthesia 2012;22(7):661-8. [PUBMED: 22332912]
54. Hennies HH, Friderichs E, Schneider J. Receptor binding, analgesic and antitussive potency of tramadol and other selected opioids. Arzneimittel-Forschung 1988;38(7):877-80. [PUBMED: 2849950]
55. Higgins JPT, Green S, editors. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration.
56. Hirschfeld G, Zernikow B. Variability of "optimal" cut points for mild, moderate, and severe pain: neglected problems when comparing groups. Pain 2013;154(1):154-9. [PUBMED: 23182623]
57. Kharasch S, Saxe G, Zuckerman B. Pain treatment: opportunities and challenges. Archives of Pediatrics & Adolescent Medicine 2003;157(11):1054-6. [PUBMED: 14609892]
58. Lintz W, Barth H, Osterloh G, Schmidt-Bothelt E. Pharmacokinetics of tramadol and bioavailability of enteral tramadol formulations. 3rd Communication: suppositories. Arzneimittel-Forschung 1998;48(9):889-99. [PUBMED: 9793614]
59. Michelet D, Andreu-Gallien J, Bensalah T, Hilly J, Wood C, Nivoche Y, et al. A meta-analysis of the use of nonsteroidal antiinflammatory drugs for pediatric postoperative pain. Anesthesia and Analgesia 2012;114(2):393-406. [PUBMED: 22104069]
60. Murthy BV, Pandya KS, Booker PD, Murray A, Lintz W, Terlinden R. Pharmacokinetics of tramadol in children after i.v. or caudal epidural administration. British Journal of Anaesthesia 2000;84(3):346-9. [PUBMED: 10793594]
61. Niesters M, Overdyk F, Smith T, Aarts L, Dahan A. Opioid-induced respiratory depression in paediatrics: a review of case reports. British Journal of Anaesthesia 2013;110(2):175-82. [PUBMED: 23248093]
62. Orliaguet G, Hamza J, Couloigner V, Denoyelle F, Loriot MA, Broly F, et al. A case of respiratory depression in a child with ultrarapid CYP2D6 metabolism after tramadol. Pediatrics 2015. [PUBMED: 25647677]
63. Page MG, Stinson J, Campbell F, Isaac L, Katz J. Identification of pain-related psychological risk factors for the development and maintenance of pediatric chronic postsurgical pain. Journal of Pain Research 2013;6:167-80. [PUBMED: 23503375]
64. Payne KA, Roelofse JA, Shipton EA. Pharmacokinetics of oral tramadol drops for postoperative pain relief in children aged 4 to 7 years--a pilot study. Anesthesia Progress 2002;49(4):109-12. [PUBMED: 12779111]
65. The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). 5.3. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2014.
66. Romsing J, Walther-Larsen S. Postoperative pain in children: a survey of parents' expectations and perceptions of their children's experiences. Paediatric Anaesthesia 1996;6(3):215-8. [PUBMED: 8732613]
67. Russell P, von Ungern-Sternberg BS, Schug SA. Perioperative analgesia in pediatric surgery. Current Opinion in Anaesthesiology 2013;26(4):420-7. [PUBMED: 23756911]
68. Scaife JM, Campbell I. A comparison of the outcome of day-care and inpatient treatment of paediatric surgical cases. Journal of Child Psychology and Psychiatry, and Allied Disciplines 1988;29(2):185-98. [PUBMED: 3372615]
69. Schnabel A, Reichl SU, Zahn PK, Pogatzki-Zahn E. Nalbuphine for postoperative pain treatment in children. Cochrane Database of Systematic Reviews 2014;7:CD009583. [PUBMED: 25079857]
70. Schunemann HJ, Oxman AD, Brozek J, Glasziou P, Bossuyt P, Chang S, et al. GRADE: assessing the quality of evidence for diagnostic recommendations. Evidence-Based Medicine 2008;13(6):162-3. [PUBMED: 19043023]
71. Scott LJ, Perry CM. Tramadol: a review of its use in perioperative pain. Drugs 2000;60(1):139-76. [PUBMED: 10929933]
72. Segerdahl M, Warren-Stomberg M, Rawal N, Brattwall M, Jakobsson J. Children in day surgery: clinical practice and routines. The results from a nation-wide survey. Acta Anaesthesiologica Scandinavica 2008;52(6):821-8. [PUBMED: 18498436]
73. Standing JF, Savage I, Pritchard D, Waddington M. Diclofenac for acute pain in children. Cochrane Database of Systematic Reviews 2009, (4):CD005538. [PUBMED: 19821348]
74. Stanko D, Bergesio R, Davies K, Hegarty M, von Ungern-Sternberg BS. Postoperative pain, nausea and vomiting following adeno-tonsillectomy - a long-term follow-up. Paediatric Anaesthesia 2013;23(8):690-6. [PUBMED: 23668258]
75. Subramanyam R, Chidambaran V, Ding L, Myer CM 3rd, Sadhasivam S. Anesthesia- and opioids-related malpractice claims following tonsillectomy in USA: LexisNexis claims database 1984-2012. Paediatric Anaesthesia 2014;24(4):412-20. [PUBMED: 24417679]
76. Tarkkila P, Tuominen M, Lindgren L. Comparison of respiratory effects of tramadol and pethidine. European Journal of Anaesthesiology 1998;15(1):64-8. [PUBMED: 9522144]
77. Taylor EM, Boyer K, Campbell FA. Pain in hospitalized children: a prospective cross-sectional survey of pain prevalence, intensity, assessment and management in a Canadian pediatric teaching hospital. Pain Research & Management 2008;13(1):25-32. [PUBMED: 18301813]
78. Vickers MD, O'Flaherty D, Szekely SM, Read M, Yoshizumi J. Tramadol: pain relief by an opioid without depression of respiration. Anaesthesia 1992;47(4):291-6. [PUBMED: 1519677]
79. Walker SM, Franck LS, Fitzgerald M, Myles J, Stocks J, Marlow N. Long-term impact of neonatal intensive care and surgery on somatosensory perception in children born extremely preterm. Pain 2009;141(1-2):79-87. [PUBMED: 19026489]
80. Weisman SJ, Bernstein B, Schechter NL. Consequences of inadequate analgesia during painful procedures in children. Archives of Pediatrics & Adolescent Medicine 1998;152(2):147-9. [PUBMED: 9491040]