Development and evaluation of monoclonal antibodies for paxilline

Toxins

Volumn 7, Issue 10, 2015, Pages 3903-3915

  Maragos, Chris M ^a  

^a U S DEPARTMENT OF AGRICULTURE   (United States)

Author keywords

Antibody; Immunoassay; Mycotoxin; Paxilline; Silage; Tremorgen

Indexed keywords

MONOCLONAL ANTIBODY; PAXILLINE; INDOLE DERIVATIVE; MYCOTOXIN;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; ELECTROSPRAY; ENZYME LINKED IMMUNOSPOT ASSAY; FEMALE; IC50; IMMUNIZATION; LIMIT OF DETECTION; LIMIT OF QUANTITATION; MASS SPECTROMETRY; MOUSE; NONHUMAN; PENICILLIUM; SENSITIVITY ANALYSIS; SOLID PHASE EXTRACTION; ANIMAL; CALIBRATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETIC PROCEDURES; IMMUNOLOGY; MAIZE; MICROBIOLOGY; PROCEDURES; STANDARD;

ANIMALS; ANTIBODIES, MONOCLONAL, MURINE-DERIVED; BIOSENSING TECHNIQUES; CALIBRATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; INDOLES; LIMIT OF DETECTION; MICE; MYCOTOXINS; REFERENCE STANDARDS; ZEA MAYS;

EID: 84942759572     PISSN: None     EISSN: 20726651     Source Type: Journal    
DOI: 10.3390/toxins7103903     Document Type: Article

References (34)

1. Sings, H.; Singh, S. Tremorgenic and nontremorgenic 2,3-fused indole diterpenoids. In The Alkaloids; Cordell, G.A., Ed.; Elsevier Academic Press: New York, NY, USA, 2003; pp. 51–163.
2. Cole, R.J. Tremorgenic mycotoxins. In Mycotoxins in Human and Animal Health; Rodricks, J.V.,Hesseltine, C.W., Mehlman, M.A., Eds.; Pathotox Publishers, Inc.: Park Forest South, IL, USA, 1977; pp. 583–595.
3. Cole, R.J. Fungal tremorgens. J. Food Prot. 1981, 44, 715–722.
4. Betina, V. Mycotoxins Chemical, Biological and Environmental Aspects; Elsevier Science Publishing Company, Inc.: New York, NY, USA, 1989; pp. 353–387.
5. Nozawa, K. Tremorgenic mycotoxins having indoloditerpene moiety. Mycotoxins 1993, 37, 17–21.
6. Cole, R.J.; Kirksey, J.W.; Well, J.M. A new tremorgenic metabolite from Penicillium paxilli. Can. J. Microbiol. 1974, 20, 1159–1162.
7. Knaus, H.G.; McManus, O.B.; Lee, S.H.; Schmalhofer, W.A.; Garcia-Calvo, M.; Helms, L.M.H.; Sanchez, M.; Giangiacomo, K.; Reuben, J.P. Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels. Biochemistry 1994, 33, 5819–5828.
8. Zhou, Y.; Lingle, C.J. Paxilline inhibits BK channels by an almost exclusively closed-channel block mechanism. J. Gen. Physiol. 2014, 144, 415–440.
9. McLeay, L.M.; Smith, B.L.; Munday-Finch, S.C. Tremorgenic mycotoxins paxilline, penitrem and lolitrem B, the non-tremorgenic 31-epilolitrem B and electromyographic activity of the reticulum and rumen of sheep. Res. Vet. Sci. 1999, 66, 119–127.
10. Imlach, W.L.; Finch, S.C.; Dunlop, J.; Meredith, A.L.; Aldrich, R.W.; Dalziel, J.E. The molecular mechanism of ryegrass staggers a neurological disorder of K+ channels. J. Pharmacol. Exp. Ther. 2008, 327, 657–664.
11. Cole, R.J.; Dorner, J.W.; Lansden, J.A.; Cox, R.H.; Pape, C.; Cunfer, B.; Nicholson, S.S.; Bedell, D.M. Paspalum staggers: Isolation and identification of tremorgenic metabolites from sclerotia of Claviceps paspali. J. Agric. Food Chem. 1977, 25, 1197–1201.
12. Sabater-Vilar, M.; Nijmeijer, S.; Fink-Gremmels, J. Genotoxicity assessment of five tremorgenic mycotoxins (fumitremorgen B, paxilline, penitrem A, verruculogen, and verrucosidin) produced by molds isolated from fermented meats. J. Food Prot. 2003, 66, 2123–2129.
13. Gürbüzel, M.; Uysal, H.; Kizilet, H. Assessment of genotoxicity of the mycotoxin paxilline using the somatic mutation and recombination test in Drosophila melanogaster. Fresenius Environ. Bull. 2010, 19, 1038–1041.
14. Andersen, B.; Frisvad, J.C. Natural occurrence of fungi and fungal metabolites in moldy tomatoes. J. Agric. Food Chem. 2004, 52, 7507–7513.
15. Porter, J.K. Analysis of endophyte toxins: Fescue and other grasses toxic to livestock. J. Anim. Sci. 1995, 73, 871–880.
16. Garthwaite, I.; Miles, C.O.; Towers, N.R. Immunological detection of the indole diterpenoid tremorgenic mycotoxins. In Proceedings of the Second International Symposium on Acremonium/Grass Interactions; Hume, D.E., Latch, G.C.M., Easton, H.S., Eds.; AgResearch, Grasslands Research Centre: Palmerston North, New Zealand, 1993; pp. 77–80.
17. Fueki, S.; Tokiwano, T.; Toshima, H.; Oikawa, H. Biosynthesis of indole diterpenes, emindole, and paxilline: Involvement of a common intermediate. Org. Lett. 2004, 6, 2697–2700.
18. Liu, C.; Noike, M.; Minami, A.; Oikawa, H.; Dairi, T. Functional analysis of a prenyltransferase gene (paxD) in the paxilline biosynthetic gene cluster. Appl. Microbiol. Biotechnol. 2014, 98, 199–206.
19. Selala, M.I.; Musuku, A.; Schepens, P.J.C. Isolation and determination of paspalitrem-type tremorgenic mycotoxins using liquid chromatography with diode-array detection. Anal. Chim. Acta 1991, 244, 1–8.
20. Young, C.; Itoh, Y.; Johnson, R.; Garthwaite, I.; Miles, C.O.; Munday-Finch, S.C.; Scott, B. Paxilline-negative mutants of Penicillium paxilli generated by heterologous and homologous plasmid integration. Curr. Genetics 1998, 33, 368–377.
21. Maragos, C. Photoreaction of indole-containing mycotoxins to fluorescent products. Mycotoxin Res. 2009, 25, 67–75.
22. Salminen, S.O.; Grewal, P.S. Does decreased mowing frequency enhance alkaloid production in endophytic tall fescue and perennial ryegrass? J. Chem. Ecol. 2002, 28, 939–950.
23. Uhlig, S.; Egge-Jacobsen, W.; Vrålstad, T.; Miles, C.O. Indole-diterpenoid profiles of Claviceps paspali and Claviceps purpurea from high-resolution Fourier transform Orbitrap mass spectrometry. Rapid Commun. Mass Spectrom. 2014, 28, 1621–1634.
24. Vishwanath, V.; Sulyok, M.; Labuda, R.; Bicker, W.; Krska, R. Simultaneous determination of 186 fungal and bacterial metabolites in indoor matrices by liquid chromatography/tandem mass spectrometry. Anal. Bioanal. Chem. 2009, 395, 1355–1372.
25. Garthwaite, I.; Miles, C.O.; Towers, N.R. An immunological approach to the study of the ryegrass staggers syndrome. Bull. OILB/SROP 1994, 17, 175–180.
26. Miles, C.O.; Wilkins, A.L.; Garthwaite, I.; Ede, R.M.; Munday-Finch, S.C. Immunochemical techniques in natural products chemistry: Isolation and structure determination of a novel indole-diterpenoid aided by TLC-ELISAgram. J. Org. Chem. 1995, 60, 6067–6069.
27. Randox Food Diagnostics. Available online: http://www.randoxfooddiagnostics.com/mycotoxinarray (accessed on 29 July 2015).
28. Kim, E.K.; Maragos, C.M.; Kendra, D.F. Liquid chromatographic determination of fumonisins B1, B2, and B3 in corn silage. J. Agric. Food Chem. 2004, 52, 196–200.
29. Miles, C.O.; Wilkins, A.L.; Gallagher, R.T.; Hawkes, A.D.; Munday, S.C.; Towers, N.R. Synthesis and tremorgenicity of paxitriols and lolitriol: Possible biosynthetic precursors of lolitrem B. J. Agric. Food Chem. 1992, 40, 234–238.
30. Lau, H.P.; Gaur, P.K.; Chu, F.S. Preparation and characterization of aflatoxin B2a-hemiglutarate and its use for the production of antibody against aflatoxin B1. J. Food Saf. 1981, 3, 1–13.
31. Chu, F.S.; Hsia, S.; Sun, P.S. Preparation and characterization of aflatoxin B1-1-(O-carboxymethyl) oxime. J. AOAC 1977, 60, 791–794.
32. Maragos, C.M.; Kurtzman, C.; Busman, M.; Price, N.; McCormick, S. Development and evaluation of monoclonal antibodies for the glucoside of T-2 toxin (T2-Glc). Toxins 2013, 5, 1299–1313.
33. Hoogenraad, N.; Newman, T.; Hoogenraad, J. The effect of pre-injection of mice with pristane on ascites tumour formation and monoclonal antibody production. J. Immunol. Methods 1983, 61, 317–320.
34. Maragos, C.M.; McCormick, S.P. Monoclonal antibodies for the mycotoxins deoxynivalenol and 3-acetyl-deoxynivalenol. Food Agric. Immunol. 2000, 12, 181–192.