Cholesterol accumulation in hepatocytes overactivates nicotinamide adenine dinucleotide phosphate (NADPH) oxidase but abrogates protection response of the hepatocyte growth factor (HGF);La acumulación de colesterol en hepatocitos sobreactiva el fosfato de dinucleótido de adenina y nicotinamida (NADPH) oxidasa pero abroga la respuesta de protección del factor de crecimiento de hepatocitos (HGF)

Gaceta Medica de Mexico

Volumn 151, Issue 4, 2015, Pages 456-464

  López Reyes, Alberto G ^a,b   Martínez Flores, Karina ^b   Clavijo Cornejo, Denise ^b   Nuño Lámbarri, Natalia ^a   Palestino Domínguez, Mayrel ^a   Souza, Verónica ^a,c   Bucio, Leticia ^a,c   Panduro, Arturo ^c,d   Miranda, Roxana U ^a,c   Gómez Quiroz, Luis Enrique ^a,c   Gutiérrez Ruiz, María Concepción ^a,c  

^a DEPARTAMENTO DE QUÍMICA   (Mexico)

^b INSTITUTO NACIONAL DE REHABILITACIÓN   (Mexico)

^c PROMEP SEP   (Mexico)

^d UNIVERSITY OF GUADALAJARA   (Mexico)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SCATTER FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; LIVER CELL; LIVER INJURY; LIVER PROTECTION; MOUSE; NONHUMAN; OBESITY; STEATOSIS; ANIMAL; C57BL MOUSE; MALE; METABOLISM; PHYSIOLOGY;

ANIMALS; CHOLESTEROL; HEPATOCYTE GROWTH FACTOR; HEPATOCYTES; MALE; MICE; MICE, INBRED C57BL; NADPH OXIDASE;

EID: 84942757988     PISSN: 00163813     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Popkin BM, Adair LS, Ng SW. Global nutrition transition and the pandemic of obesity in developing countries. Nut Rev. 2012;70(1):3-21.
2. Koo SH. Nonalcoholic fatty liver disease: molecular mechanisms for the hepatic steatosis. Clin Mol Hepatol. 2013;19(3):210-5.
3. Marí M, Caballero F, Colell A, et al. Mitochondrial free cholesterol loading sensitizes to TNF-and Fas-mediated steatohepatitis. Cell Metab. 2006;4(3):185-98.
4. Gutiérrez Ruiz MC, Domínguez Pérez M, Rodríguez González S, Nuno Lámbarri N, Licona Retama C, Gómez-Quiroz LE. [High cholesterol diet modifies the repairing effect of the hepatocyte growth factor]. Gac Med Mex. 2012;148(3):236-42.
5. Caballero F, Fernández A, De Lacy AM, Fernández-Checa JC, Caballería J, García-Ruiz C. Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH. J Hepatol. 2009;50(4):789-96.
6. Ikonen E. Cellular cholesterol trafficking and compartmentalization. Nat Rev Mol Cell Biol. 2008;9(2):125-38.
7. Thorgeirsson SS. The central role of the c-Met pathway in rebuilding the liver. Gut. 2012;61(8):1105-6.
8. Valdes-Arzate A, Luna A, Bucio L, et al. Hepatocyte growth factor protects hepatocytes against oxidative injury induced by ethanol metabolism. Free Radic Biol Med. 2009;47(4):424-30.
9. Trusolino L, Bertotti A, Comoglio PM. MET signalling: principles and functions in development, organ regeneration and cancer. Nat Rev Mol Cell Biol. 2010;11(12):834-48.
10. Enriquez-Cortina C, Almonte-Becerril M, Clavijo-Cornejo D, et al. Hepatocyte growth factor protects against isoniazid/rifampicin-induced oxidative liver damage. Toxicol Sci. 2013;135(1):26-36.
11. Marquardt JU, Seo D, Gomez-Quiroz LE, et al. Loss of c-Met accelerates development of liver fibrosis in response to CCl(4) exposure through deregulation of multiple molecular pathways. Biochim Biophys Acta. 2012;1822(6):942-51.
12. Kaposi-Novak P, Lee JS, Gómez-Quiroz L, Coulouarn C, Factor VM, Thorgeirsson SS. Met-regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotype. J Clin Invest. 2006;116(6):1582-95.
13. Takami T, Kaposi-Novak P, Uchida K, et al. Loss of hepatocyte growth factor/c-Met signaling pathway accelerates early stages of N-nitrosodi-ethylamine induced hepatocarcinogenesis. Cancer Res. 2007;67(20): 9844-51.
14. Clavijo-Cornejo D, Enriquez-Cortina C, Lopez-Reyes A, et al. Biphasic regulation of the NADPH oxidase by HGF/c-Met signaling pathway in primary mouse hepatocytes. Biochimie. 2013;95(6):1177-84.
15. Bedard K, Krause KH. The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev. 2007;87(1): 245-313.
16. Gomez-Quiroz LE, Factor VM, Kaposi-Novak P, Coulouarn C, Conner EA, Thorgeirsson SS. Hepatocyte-specific c-Met deletion disrupts redox homeostasis and sensitizes to Fas-mediated apoptosis. J Biol Chem. 2008;283(21):14581-9.
17. Gomez-Quiroz LE, Paris R, Lluis JM, et al. Differential modulation of interleukin 8 by interleukin 4 and interleukin 10 in HepG2 cells treated with acetaldehyde. Liver Int. 2005;25(1):122-30.
18. Pescatore LA, Bonatto D, Forti FL, Sadok A, Kovacic H, Laurindo FR. Protein disulfide isomerase is required for platelet-derived growth factor-induced vascular smooth muscle cell migration, Nox1 NADPH oxidase expression, and RhoGTPase activation. J Biol Chem. 2012; 287(35):29290-300.
19. Fernández Cantón, Sonia B. MN, Yura A, Viguri Uribe R. Sobrepeso y obesidad en menores de 20 años de edad en México. Bol Med Hosp Infant Mex. 2011;68:79-81.
20. OMS. Dieta, Nutrición y Prevención de enfermedades crónicas. Informe de una consulta Mixta de Expertos OMS. 2003.
21. Roth GA, Fihn SD, Mokdad AH, Aekplakorn W, Hasegawa T, Lim SS. High total serum cholesterol, medication coverage and therapeutic control: an analysis of national health examination survey data from eight countries. Bull World Health Organ. 2010;89(2):92-101.
22. González G, Fernández JD, Sánchez J, Rodríguez JJ, Quintero AG. Colesterolemia en adolescentes sexo femenino de morelos, México. Revista Chilena de Nutrición. 2005; 32(2):134-41.
23. Juárez-Muñoz IE, Anaya-Florez MS, Mejía-Arangure JM, et al. Niveles séricos de colesterol y lipoproteínas y frecuencia de hipercolesterolemia en un grupo de adolescentes de la Ciudad de México. Bol Med Hosp Infant Mex. 2006;63:162-8.
24. Klaassen CD, Reisman SA. Nrf2 the rescue: effects of the antioxidative/ electrophilic response on the liver. Toxicol Appl Pharmacol. 2010; 244(1):57-65.
25. Niture SK, Kaspar JW, Shen J, Jaiswal AK. Nrf2 signaling and cell survival. Toxicol Appl Pharmacol. 2010;244(1):37-42.
26. Vollrath V, Wielandt AM, Iruretagoyena M, Chianale J. Role of Nrf2 in the regulation of the Mrp2 (ABCC2) gene. Biochem J. 2006;395(3): 599-609.