Electro-acupuncture decreases 5-HT, CGRP and increases NPY in the brain-gut axis in two rat models of Diarrhea-predominant irritable bowel syndrome(D-IBS)

BMC Complementary and Alternative Medicine

Volumn 15, Issue 1, 2015, Pages

  Sun, Jianhua ^a   Wu, Xiaoliang ^a,e   Meng, Yunfang ^b   Cheng, Jie ^c   Ning, Houxu ^d   Peng, Yongjun ^a   Pei, Lixia ^a   Zhang, Wei ^c  

^a AFFILIATED HOSPITAL OF NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

^c NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

^d THE AFFILIATED BRAIN HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^e Jiangsu Province Hospital of Chinese Medicine   (China)

Author keywords

5 hydroxytryptamine (5 HT); Brain gut axis (BGA); Calcitonin gene related peptide (CGRP); Diarrhea predominant irritable bowel syndrome (D IBS); Electro acupuncture (EA); Neuro peptide Y (NPY)

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; NEUROPEPTIDE Y; SEROTONIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; BRAIN GUT AXIS; CONTROLLED STUDY; DESCENDING COLON; DIARRHEA PREDOMINANT IRRITABLE BOWEL SYNDROME; ELECTROACUPUNCTURE; HYPOTHALAMUS; INTESTINE; IRRITABLE COLON; MALE; MOLECULAR PATHOLOGY; NONHUMAN; RAT; SPINAL CORD; ACUPUNCTURE; ANIMAL; COLON; DIARRHEA; DISEASE MODEL; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; SPRAGUE DAWLEY RAT;

ACUPUNCTURE THERAPY; ANIMALS; BRAIN; CALCITONIN GENE-RELATED PEPTIDE; COLON; DIARRHEA; DISEASE MODELS, ANIMAL; HYPOTHALAMUS; IRRITABLE BOWEL SYNDROME; MALE; NEUROPEPTIDE Y; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN; SPINAL CORD;

EID: 84942598243     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/s12906-015-0863-5     Document Type: Article

References (11)

1. Sun JH, Wu XL, Xia C, Xu LZ, Pei LX, Li H, et al. Clinical evaluation of Soothing Gan and invigorating Pi acupuncture treatment on diarrhea-predominant irritable bowel syndrome. Chin J Integr Med. 2011;17:780-5.
2. Manheimer E, Susan Wieland L, Cheng K, Li SM, Shen X, Berman BM, et al. Acupuncture for irritable bowel syndrome: systematic review and meta-analysis. Am J Gastroenterol. 2012;107(6):835-47.
3. Zou N, Lv H, Li J, Yang N, Xue H, Zhu J, et al. Changes in brain G proteins and colonic sympathetic neural signaling in chronic-acute combined stress rat model of irritable bowel syndrome (IBS). Transl Res. 2008;152(6):283-9.
4. Liang C, Luo H, Liu Y, Cao J, Xia H. Plasma hormones facilitated the hypermotility of the colon in a chronic stress rat model. PLoS ONE. 2012;7(2), e31774.
5. 5 Zhong-ren Li. (Chinese). Experimental Acupuncture(Chinese). Traditional Chinese Medicine Press (Chinese), 2003. (ISBN 9787801564443)
6. Bengtson MB, Rønning T, Vatn MH, Harris JR. Irritable bowel syndrome in twins: genes and environment. Gut. 2006;55(12):1754-9.
7. Sugaya N, Nomura S. Relationship between cognitive appraisals of symptoms and negative mood for subtypes of irritable bowel syndrome[J]. BioPsychoSocial Medicine. 2008;2:9-15.
8. Shiotani A. Role of allergy in irritable bowel syndrome. Nihon Rinsho. 2006;64(8):1532-5.
9. Grenham S, Clarke G, Cryan JF, Dinan TG. Brain-gut-microbe communication in health and disease. Front Physiol. 2011;2:94.
10. Siegert F, Nieber K. New therapeutical approaches for treatment of irritable bowel syndrome. Med Monatsschr Pharm[J]. 2010;33(8):285-92.
11. Asagarasu A, Matsui T, Hayashi H, Tamaoki S, Yamauchi Y, Minato K, et al. Discovery of a novel 5-HT(3) antagonist/5-HT(1A)agonist3-amino-5,6,7,8-tetrahydro-2-{4-[4-(quinolin-2-yl)piperazin-1-yl]butyl}quinazolin-4(3H)-one (TZB-30878) as an orally bioavailable agent for irritable bowel syndrome. J Med Chem. 2010;53(21):7549-63.