-
1
-
-
84882781441
-
Pazopanib versus sunitinib in metastatic renal-cell carcinoma
-
Motzer RJ, Hutson TE, Cella D, et al. Pazopanib versus sunitinib in metastatic renal-cell carcinoma. N Engl J Med 2013; 369:722-731.
-
(2013)
N Engl J Med
, vol.369
, pp. 722-731
-
-
Motzer, R.J.1
Hutson, T.E.2
Cella, D.3
-
2
-
-
84942991426
-
Switch: A randomized sequential open-label study to evaluate efficacy and safety of sorafenib (so) followed by sunitinib (su) versus sunitinib followed by sorafenib in the treatment of metastatic rcc
-
[Epub ahead of print]
-
Eichelberg C, Vervenne WL, De Santis M, et al. SWITCH: a randomized sequential open-label study to evaluate efficacy and safety of sorafenib (SO) followed by sunitinib (SU) versus sunitinib followed by sorafenib in the treatment of metastatic RCC. Eur Urol 2015. [Epub ahead of print]. doi: 10.1016/j.eururo .2015.04.017. 3.
-
(2015)
Eur Urol
-
-
Eichelberg, C.1
Vervenne, W.L.2
De Santis, M.3
-
3
-
-
84926149358
-
Depth of remission is a prognostic factor for survival in patients with metastatic renal cell carcinoma
-
This stud y defines the prognostic role of deep tumour repsonse in mRCC
-
Grünwald V, McKay RR, Krajewski KM, et al. Depth of remission is a prognostic factor for survival in patients with metastatic renal cell carcinoma. Eur Urol 2015; 67:952-958. This stud y defines the prognostic role of deep tumour repsonse in mRCC.
-
(2015)
Eur Urol
, vol.67
, pp. 952-958
-
-
Grünwald, V.1
McKay, R.R.2
Krajewski, K.M.3
-
4
-
-
84879294107
-
The progression free survival-plateau with vascular endothelial growth factor receptor inhibitors is there more to come
-
Grünwald V, Merseburger AS. The progression free survival-plateau with vascular endothelial growth factor receptor inhibitors: is there more to come Eur J Cancer 2013; 49:2504-2511.
-
(2013)
Eur J Cancer
, vol.49
, pp. 2504-2511
-
-
Grünwald, V.1
Merseburger, A.S.2
-
5
-
-
84858766182
-
The blockade of immune checkpoints in cancer immunotherapy
-
Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer 2012; 12:252-264.
-
(2012)
Nat Rev Cancer
, vol.12
, pp. 252-264
-
-
Pardoll, D.M.1
-
6
-
-
10344220548
-
Costimulatory b7-h1 in renal cell carcinoma patients: Indicator of tumor aggressiveness and potential therapeutic target
-
A pivotal finding of the study is the unfavourable prognosis of PD-L1 positive mRCC
-
Thompson RH, Gillett MD, Cheville JC, et al. Costimulatory B7-H1 in renal cell carcinoma patients: indicator of tumor aggressiveness and potential therapeutic target. Proc Natl Acad Sci U S A 2004; 101:17174-1 7179. A pivotal finding of the study is the unfavourable prognosis of PD-L1 positive mRCC.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 17174-17179
-
-
Thompson, R.H.1
Gillett, M.D.2
Cheville, J.C.3
-
7
-
-
34250177269
-
Pd-1 is expressed by tumorinfiltrating immune cells and is associated with poor outc ome for patients with renal cell carcinoma
-
Thompson RH, Dong H, Lohse CM, et al. PD-1 is expressed by tumorinfiltrating immune cells and is associated with poor outc ome for patients with renal cell carcinoma. Clin Cancer Res 2007; 13:1757-1761.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 1757-1761
-
-
Thompson, R.H.1
Dong, H.2
Lohse, C.M.3
-
8
-
-
84904024273
-
Association of pd-1 pd-1 ligands and other features of the tumor immune microenvironment with response to anti-pd-1 therapy
-
This is among the first articles exploring the relationship of PD-L1 topography in different tumour types. It provides relevant insights on how to define PD-L1 positivity and its colocalization to immune cells. It is a current milestone for al l who are dealing with the issue of biomarker development of PD-L1
-
Taube JM, Klein A, Brahmer JR, et al. Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy. Clin Cancer Res 2014; 20:5064-5074. This is among the first articles exploring the relationship of PD-L1 topography in different tumour types. It provides relevant insights on how to define PD-L1 positivity and its colocalization to immune cells. It is a current milestone for al l who are dealing with the issue of biomarker development of PD-L1.
-
(2014)
Clin Cancer Res
, vol.20
, pp. 5064-5074
-
-
Taube, J.M.1
Klein, A.2
Brahmer, J.R.3
-
9
-
-
84929572937
-
Nivolumab for metastatic renal cell carcinoma: Results of a randomized phase II trial
-
It is a key for PD-1 inhibition in mRCC. It provides insights into the role of dose and tumour response to nivolumab in mRCC, while maintaining tolerability
-
Motzer RJ, Rini BI, McDermott DF, et al. Nivolumab for metastatic renal cell carcinoma: results of a randomized phase II trial. J Clin Oncol 2015; 33:1430-1437. It is a key for PD-1 inhibition in mRCC. It provides insights into the role of dose and tumour response to nivolumab in mRCC, while maintaining tolerability.
-
(2015)
J Clin Oncol
, vol.33
, pp. 1430-1437
-
-
Motzer, R.J.1
Rini, B.I.2
McDermott, D.F.3
-
10
-
-
84880710451
-
Nivolumab (anti-pd-1; Bms-936558; ono-4538) in patients with advanced solid tumors: Survival and long-term safety in a phase i trial
-
abstr 3002
-
Topalian SL, Sznol M, Brah mer JR, et al. Nivolumab (anti-PD-1; BMS-936558; ONO-4538) in patients with advanced solid tumors: survival and long-term safety in a phase I trial. J Clin Oncol 2013; 31: (suppl; abstr 3002).
-
(2013)
J Clin Oncol
, vol.31
-
-
Topalian, S.L.1
Sznol, M.2
Brahmer, J.R.3
-
11
-
-
84862903106
-
Safety and activity of anti-pd-l1 antibody in patients with advanced cancer
-
Brahmer JR , Tykodi SS, Chow LQM, et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med 2012; 366:2455-2465.
-
(2012)
N Engl J Med
, vol.366
, pp. 2455-2465
-
-
Brahmer, J.R.1
Tykodi, S.S.2
Chow, L.Q.M.3
-
12
-
-
84880264878
-
Clinical activity, safety, and biomarkers of mpdl3280a, an engineered pd-l1 antibody in patients with metastatic renal cell carcinoma (mrcc
-
abstr 4505
-
Cho DC, Sosman JA, Sznol M, et al. Clinical activity, safety, and biomarkers of MPDL3280A, an engineered PD-L1 antibody in patients with metastatic renal cell carcinoma (mRCC). J Clin Oncol 2013; 31: (suppl; abstr 4505).
-
(2013)
J Clin Oncol
, vol.31
-
-
Cho, D.C.1
Sosman, J.A.2
Sznol, M.3
-
13
-
-
84862859820
-
Safety, activity, and immune correlates of anti-pd-1 antibody in cancer
-
Topalian SL, Hodi F S, Brahmer JR, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med 2012; 366:2443-2454.
-
(2012)
N Engl J Med
, vol.366
, pp. 2443-2454
-
-
Topalian, S.L.1
Hodi, F.S.2
Brahmer, J.R.3
-
14
-
-
37349072460
-
Ipilimumab ( anti-ctla4 antibody) causes regression of metastatic renal cell cancer associated with enteritis and hypophysitis
-
This is the reference trial for single-Agent ipilimumab activity in mRCC
-
Yang JC, Hughes M, Kammula U, et al. Ipilimumab ( anti-CTLA4 antibody) causes regression of metastatic renal cell cancer associated with enteritis and hypophysitis. J Immunother 2007; 30:825-830. This is the reference trial for single-Agent ipilimumab activity in mRCC.
-
(2007)
J Immunother
, vol.30
, pp. 825-830
-
-
Yang, J.C.1
Hughes, M.2
Kammula, U.3
-
15
-
-
84879777241
-
Nivolumab plus ipilimumab in advanced melanoma
-
This is the proof of concept for dual checkpoint inhibition and provides first clinical evidence for this approach
-
Wolchok JD, Kluger H, Callahan MK, et al. Nivolumab plus ipilimumab in advanced melanoma. N Engl J Med 2013; 369:122-133. This is the proof of concept for dual checkpoint inhibition and provides first clinical evidence for this approach.
-
(2013)
N Engl J Med
, vol.369
, pp. 122-133
-
-
Wolchok, J.D.1
Kluger, H.2
Callahan, M.K.3
-
16
-
-
84914148032
-
Phase i study of nivolumab in combination with ipilimumab in metastatic renal cell carcinoma (mrcc
-
abstr 4504
-
Hammers H, Plimack ER, Infante JR, et al. Phase I study of nivolumab in combination with ipilimumab in metastatic renal cell carcinoma (mRCC). J Clin Oncol 32: 2014; 5s: (suppl; abstr 4504).
-
(2014)
J Clin Oncol
, vol.32
, pp. 5s
-
-
Hammers, H.1
Plimack, E.R.2
Infante, J.R.3
-
17
-
-
48649107474
-
Efficacy of everolimus in advanced renal cell carcinoma: A double-blind, randomised, placebo-controlled phase III trial
-
Motzer RJ, Escudier BJ, Oudard S, et al. Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial. Lancet 2 008; 372:449-456.
-
(2008)
Lancet
, vol.372
, pp. 449-456
-
-
Motzer, R.J.1
Escudier, B.J.2
Oudard, S.3
-
18
-
-
84876974877
-
Axitinib versus sorafenib as secondline treatment for advanced renal cell carcinoma: Overall survival analysis and updated results from a ran domised phase 3 trial
-
Motzer RJ, Escudier B, Tomszak P, et al. Axitinib versus sorafenib as secondline treatment for advanced renal cell carcinoma: overall survival analysis and updated results from a ran domised phase 3 trial. Lancet Oncol 2013; 14:552-562.
-
(2013)
Lancet Oncol
, vol.14
, pp. 552-562
-
-
Motzer, R.J.1
Escudier, B.2
Tomszak, P.3
-
19
-
-
84914176528
-
Nivolumab (anti-pd-1; Bms-936558; ono-4538) in combination with sunitinib or pazopanib in patients (pts) with metastatic renal cell carcinoma (mrcc
-
abstr 5010
-
Amin A, Plimack ER, Infante JR, et al. Nivolumab (anti-PD-1; BMS-936558; ONO-4538) in combination with sunitinib or pazopanib in patients (pts) with metastatic renal cell carcinoma (mRCC). J Clin Oncol 32: 2014; 5s: (suppl; abstr 5010).
-
(2014)
J Clin Oncol
, vol.32
, pp. 5s
-
-
Amin, A.1
Plimack, E.R.2
Infante, J.R.3
-
20
-
-
84938313517
-
Safety and efficacy of mpdl3280a (anti-pdl1) in combination with bevacizumab and/or chemotherapy in patients with locally advanced or met astatic solid tumors
-
Lieu C,Bendell JC,Powderly JD,et al. Safety and efficacy of MPDL3280A (anti-PDL1) in combination with bevacizumab and/or chemotherapy in patients with locally advanced or met astatic solid tumors Ann Oncol 2014 25: (suppl-4): iv361-iv372. 10.1093/annonc/mdu342.
-
(2014)
Ann Oncol
, vol.25
, pp. iv361-iv372
-
-
Lieu, C.1
Bendell, J.C.2
Powderly, J.D.3
-
21
-
-
84940487291
-
Immune correlates and long term follow up of a phase ia study of mpdl3280a, an engineered pd-l1 antibody, in patients with metastatic renal cell carcinoma (mrcc
-
McDermott DF, Sznol M, Sosman JA, et al. Immune correlates and long term follow up of a phase Ia study of mpdl3280a, an engineered pd-l1 antibody, in patients with metastatic renal cell carcinoma (MRCC). Ann Oncol 2014; 25: (suppl-4): iv280-iv304. 10.1093/annonc/mdu337.
-
(2014)
Ann Oncol
, vol.25
, pp. iv280-iv304
-
-
McDermott, D.F.1
Sznol, M.2
Sosman, J.A.3
|