Inactivation of ventral hippocampus interfered with cued-fear acquisition but did not influence later recall or discrimination

Behavioural Brain Research

Volumn 296, Issue , 2016, Pages 249-253

  Chen, Veronica M ^a   Foilb, Allison R ^a   Christianson, John P ^a  

^a BOSTON COLLEGE   (United States)

Author keywords

Fear; Hippocampus; Muscimol; Ptsd; Rat; Safety

Indexed keywords

MUSCIMOL; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; ASSOCIATION; BRAIN FUNCTION; BRAIN REGION; DISCRIMINATION LEARNING; FEAR; FREEZING; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECALL; VENTRAL HIPPOCAMPUS; ANIMAL; CONDITIONING; DRUG EFFECTS; HIPPOCAMPUS; PERCEPTIVE DISCRIMINATION; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; BEHAVIOR, ANIMAL; CONDITIONING (PSYCHOLOGY); CUES; DISCRIMINATION (PSYCHOLOGY); FEAR; GABA-A RECEPTOR AGONISTS; HIPPOCAMPUS; MALE; MENTAL RECALL; MUSCIMOL; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84942531815     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2015.09.008     Document Type: Article

References (22)

1. Maren S., Phan K.L., Liberzon I. The contextual brain: implications for fear conditioning, extinction and psychopathology. Nat. Rev. Neurosci. 2013, 14:417-428.
2. Jovanovic T., Norrholm S.D., Blanding N.Q., Davis M., Duncan E., Bradley B., Ressler K.J. Impaired fear inhibition is a biomarker of PTSD but not depression. Depress Anxiety 2010, 27:244-251.
3. Bast T., Zhang W.N., Feldon J. The ventral hippocampus and fear conditioning in rats: different anterograde amnesias of fear after tetrodotoxin inactivation and infusion of the GABA(A) agonist muscimol. Exp. Brain Res. 2001, 139:39-52.
4. Zhang W.N., Bast T., Feldon J. The ventral hippocampus and fear conditioning in rats: different anterograde amnesias of fear after infusion of N-methyl-d-aspartate or its noncompetitive antagonist MK-801 into the ventral hippocampus. Behav. Brain Res. 2001, 126:159-174.
5. Esclassan F., Coutureau E., Di Scala G., Marchand A.R. Differential contribution of dorsal and ventral hippocampus to trace and delay fear conditioning. Hippocampus 2009, 19:33-44.
6. Czerniawski J., Ree F., Chia C., Otto T. Dorsal versus ventral hippocampal contributions to trace and contextual conditioning: differential effects of regionally selective NMDA receptor antagonism on acquisition and expression. Hippocampus 2012, 22:1528-1539.
7. Cox D., Czerniawski J., Ree F., Otto T. Time course of dorsal and ventral hippocampal involvement in the expression of trace fear conditioning. Neurobiol. Learn. Mem. 2013, 106:316-323.
8. Zhang W.N., Bast T., Xu Y., Feldon J. Temporary inhibition of dorsal or ventral hippocampus by muscimol: distinct effects on measures of innate anxiety on the elevated plus maze, but similar disruption of contextual fear conditioning. Behav. Brain. Res. 2014, 262:47-56.
9. Richmond M.A., Yee B.K., Pouzet B., Veenman L., Rawlins J.N., Feldon J., Bannerman D.M. Dissociating context and space within the hippocampus: effects of complete, dorsal, and ventral excitotoxic hippocampal lesions on conditioned freezing and spatial learning. Behav. Neurosci. 1999, 113:1189-1203.
10. Wang S.H., Finnie P.S., Hardt O., Nader K. Dorsal hippocampus is necessary for novel learning but sufficient for subsequent similar learning. Hippocampus 2012, 22:2157-2170.
11. Bouton M.E., King D.A. Contextual control of the extinction of conditioned fear: tests for the associative value of the context. J. Exp. Psychol. Anim. Behav. Process. 1983, 9:248-265.
12. Orsini C.A., Kim J.H., Knapska E., Maren S. Hippocampal and prefrontal projections to the basal amygdala mediate contextual regulation of fear after extinction. J. Neurosci. 2011, 31:17269-17277.
13. Hobin J.A., Ji J., Maren S. Ventral hippocampal muscimol disrupts context-specific fear memory retrieval after extinction in rats. Hippocampus 2006, 16:174-182.
14. Heldt S.A., Coover G.D., Falls W.A. Posttraining but not pretraining lesions of the hippocampus interfere with feature-negative discrimination of fear-potentiated startle. Hippocampus 2002, 12:774-786.
15. Myers K.M., Davis M. AX+, BX- discrimination learning in the fear-potentiated startle paradigm: possible relevance to inhibitory fear learning in extinction. Learn. Mem. 2004, 11:464-475.
16. Amat J., Baratta M.V., Paul E., Bland S.T., Watkins L.R., Maier S.F. Medial prefrontal cortex determines how stressor controllability affects behavior and dorsal raphe nucleus. Nat. Neurosci. 2005, 8:365-371.
17. Christianson J.P., Jennings J.H., Ragole T., Flyer J.G., Benison A.M., Barth D.S., Watkins L.R., Maier S.F. Safety signals mitigate the consequences of uncontrollable stress via a circuit involving the sensory insular cortex and bed nucleus of the stria terminalis. Biol. Psychiatry. 2011, 70:458-464.
18. Maren S., Holt W.G. Hippocampus and Pavlovian fear conditioning in rats: muscimol infusions into the ventral, but not dorsal, hippocampus impair the acquisition of conditional freezing to an auditory conditional stimulus. Behav. Neurosci. 2004, 118:97-110.
19. Sierra-Mercado D., Padilla-Coreano N., Quirk G.J. Dissociable roles of prelimbic and infralimbic cortices, ventral hippocampus, and basolateral amygdala in the expression and extinction of conditioned fear. Neuropsychopharmacology 2011, 36:529-538.
20. Holland P.C., Lamoureux J.A., Han J.S., Gallagher M. Hippocampal lesions interfere with Pavlovian negative occasion setting. Hippocampus 1999, 9:143-157.
21. Likhtik E., Stujenske J.M., Topiwala M.A., Harris A.Z., Gordon J.A. Prefrontal entrainment of amygdala activity signals safety in learned fear and innate anxiety. Nat. Neurosci. 2014, 17:106-113.
22. Orsini C.A., Maren S. Neural and cellular mechanisms of fear and extinction memory formation. Neurosci. Biobehav. Rev. 2012, 36:1773-1802.