Ligand-Based Discovery of a New Scaffold for Allosteric Modulation of the μ-Opioid Receptor

Journal of Chemical Information and Modeling

Volumn 55, Issue 9, 2015, Pages 1836-1843

  Bisignano, Paola ^a   Burford, Neil T ^b   Shang, Yi ^a   Marlow, Brennica ^a   Livingston, Kathryn E ^c   Fenton, Abigail M ^c   Rockwell, Kristin ^b   Budenholzer, Lauren ^d   Traynor, John R ^c   Gerritz, Samuel W ^b   Alt, Andrew ^b   Filizola, Marta ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^d YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESSENTIAL OILS; LIGANDS; STRUCTURAL OPTIMIZATION;

ALLOSTERIC MODULATION; ALLOSTERIC MODULATORS; CHINESE HAMSTER OVARY; DELTA-OPIOID RECEPTOR; G PROTEIN ACTIVATION; LEAD OPTIMIZATION; OPIOID RECEPTORS; STARTING COMPOUNDS;

PULSE AMPLITUDE MODULATION;

BMS-986121; BMS-986122; LIGAND; MU OPIATE RECEPTOR; PROTEIN BINDING; SULFONE; THIAZOLE DERIVATIVE;

AGONISTS; ALLOSTERISM; ANIMAL; BIOLOGICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; CHO CELL LINE; CRICETULUS; DRUG DELIVERY SYSTEM; DRUG DEVELOPMENT; DRUG EFFECTS; HAMSTER; STRUCTURE ACTIVITY RELATION;

ALLOSTERIC REGULATION; ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; DRUG DELIVERY SYSTEMS; DRUG DISCOVERY; LIGANDS; MODELS, BIOLOGICAL; MOLECULAR STRUCTURE; PROTEIN BINDING; RECEPTORS, OPIOID, MU; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONES; THIAZOLES;

EID: 84942517281     PISSN: 15499596     EISSN: 1549960X     Source Type: Journal    
DOI: 10.1021/acs.jcim.5b00388     Document Type: Article

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